Embryology Flashcards
major event during gastrulation essential for formation of the NS
notochord development
ectoderm above notochord becomes
neuroectoderm
sonic hedgehog (Shh)
factor influencing floorplate neurons
mutations in Shh lead to:
loss of notochordal induction
medulloblastoma
basal cell carcinoma
anterior neuropore becomes
lamina terminalis
hindbrain specified into rhombomeres by influence of
Hox Genes
sulcus limitans
demarcates a dorsal alar plate from ventral basal plate
glioblasts
non neuronal cells of the CNS
radial glia
neurons migrate along these
ganglia and sensory part of VIII arise from
otic placode
ventricular zone eventually becomes
ependymal layer
marginal zone forms
white matter
alar plate becomes
dorsal horn
basal plate becomes
ventral horn
5 secondary brain vesicles
telencephalon, diencephalon, mesencephalon, metencephalon, myelencephalon
myelencephalon
medulla
medial to lateral functional component columns
GSE, GVE, SVE, SL, GVA/SVA, GSA, SSA
alar plate derivatives of pons
solitary nucleus, cochlear/vestibular nuclei, spinal and principle trigeminal nuclei, pontine nuclei
basal plate derivatives of pons
abducems nucleus, facial and trigeminal motor nuclei, superior salivatory nucleus
cerebellum derived from
rhombic lip
external granular layer gives rise to
internal granule cells, stellate cells, basket cells
neuroblasts in ventricular zone gives rise to
purkinje cells, cerebellar nuclei and golgi cells
development of thalamus
outside-first sequence
hypothalamus develops from
neuroblasts of intermediate zone
