Emergency Medicine

Question 1

Reversal of major bleed in a patient on Apixaban

Answer 1

Four-Factor Prothrombin Complex Concentrate (Andexanet) - contains factors II, VII, IX, X and protein C & S

Question 2

Factor VIII replacement for head trauma

Answer 2

#of factor VIII units required = (weight in kg) x desired % increase in factor activity) x 0.5
Want 100% factor level = 50IU/kg