Emergency Medicine Flashcards
(172 cards)
What is the approach to posioning?
ABCD3EFG
- A Airway (consider stabilizing C-spine) - perform endotracheal intubation if unable to protect airway (aspiration imminent)
- B Breathing
- C Circulation
- D1 Drugs - ACLS as necessary to resuscitate the patient, universal antidotes
- D2 Draw bloods
- D3 Decontamination (decrease absorption)
- E Expose (look for specific toxidromes)/Examine the patient
- F Full vitals, ECG monitor, Foley, X-rays
- G Give specific antidotes and treatment
Essential tests for poisoning?
Essential tests:
- CBC, electrolytes, BUN/Cr, glucose, INR/PTT, osmolality
- ABGs, O2 sat +/- co-oximetry (if suspect CO poisoning)
- ASA, acetaminophen, EtOH levels
Other potential tests for poisoning?
- Drug levels – this is NOT a serum drug screen
- Ca2+, Mg2+, PO43–
- Protein, albumin, lactate, ketones, liver enzymes, CK – depending on drug and clinical feature
Ddx for increased AG metabolic acidosis?
“GOLDMARK”
- Glycols* (ethylene glycol, propylene glycol)
- Oxoproline (metabolite of acetaminophen)*
- L-lactate
- D-lactate (acetaminophen, short bowel syndrome, propylene glycol infusions for lorazepam & phenobarbital)
- Methanol*
- ASA*
- Renal failure
- Ketoacidosis (DKA, EtOH*, starvation)
What are the universal antidotes?
DON’T – Dextrose, Oxygen, Naloxone, Thiamine give before dextrose
Signs and symptoms of minor withdrawal from opioids?
Minor withdrawal may present as lacrimation, rhinorrhea, diaphoresis, yawning, piloerection, HTN, and tachycardia
Signs and symptoms of severe withdrawal from opioids?
Severe withdrawal may present as hot and cold flashes, arthralgias, myalgias, N/V, and abdominal cramp
A necessary cofactor for glucose metabolism; may worsen Wernicke’s encephalopathy if glucose given before
Thiamine
Ddx for increased osmolar gap?
“MAE DIE” (if it ends in “-ol”, it will likely increase the osmolar gap)
- Methanol
- Acetone
- Ethanol
- Diuretics (glycerol, mannitol, sorbitol)
- Isopropanol
- Ethylene glycol
Ddx for decreased AG?
- Electrolyte imbalance (increased Na+/K+/Mg2+)
- Hypoalbuminemia (50% fall in albumin ~5.5 mmol/L decrease in the AG)
- Lithium, bromine elevation
- Paraproteins (multiple myeloma)
Drugs/meds to consider if hypoventilating (high pCO2)?
CNS depressants (opioids, sedative-hypnotic agents, phenothiazines, EtOH)
Ddx for decreased AG?
- Carboxyhemoglobin
- Methemoglobin
- Sulfmethemoglobin
Ddx for normal AG?
- Renal HCO3- loss: renal tubular acidosis, hyperparathyroidism
- GI HCO3- loss: diarrhea, fistula
- Other: NS infusion, acetazolamide, hyperkalemia, hypoaldosteronism
Drugs/meds to consider if hyperventilating (low pCO2)?
Salicylates, CO, other asphyxiants
Drugs/meds to consider if hyperkalemic?
Hyperkalemia: Digitalis glycosides, fluoride, potassium
Drugs/meds to consider if hypokalemca?
Hypokalemia: Theophylline, caffeine, β-adrenergic agents, soluble barium salts, diuretics, insulin
Drugs/meds to consider if hypoglycemic?
Hypoglycemia: Oral hypoglycemic agents, insulin, EtOH, ASA
Drugs/meds to consider if wide QRS complex?
Wide QRS complex: TCAs, quinidine, other class Ia and Ic antidysrhythmic agents
Drugs/meds to consider if prolonged QT interval?
Prolonged QT interval: Terfenadine, astemizole, antipsychotics
Drugs/meds to consider if atrioventricular block?
Atrioventricular block: Ca2+ antagonists, digitalis glycosides, phenylpropanolamine
What to look for on abdominal Xray for poisoning?
“CHIPES”: Calcium, Chloral hydrate, CCl4, Heavy metals, Iron, Potassium, Enteric coated Salicylates, and some foreign bodies
Contraindications for single dose activated charcoal?
Unprotected airway, late presentation aer ingestion, small bowel obstruction, poor toxin adsorption
Indications for whole bowel irrigation?
- Awake, alert, can be nursed upright OR intubated and airway protected
- Delayed release product
- Drug/toxin not bound to charcoal
- Drug packages (if any evidence of breakage emergency surgery)
- Recent toxin ingestion
Contraindications for whole bowel irrigation?
Evidence of ileus, perforation, or obstruction