Emergency medicine Flashcards

(321 cards)

1
Q

What is epiglottitis?

A

Acute inflammation of the epiglottis

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2
Q

Causes of epiglottitis?

A

Bacterial infection is most common

Streptococcus, staphylococcus, Haemophilus influenzae B, pseudomonas, moraxella catarrhalis

Viral; HSV

Thermal injury

Inhaled foreign body

Chemotherapy reaction

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3
Q

Why is epiglottis less common in UK?

A

Hib vaccination

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4
Q

Symptoms of epiglottitis?

A

Sore throat
Odynophagia
Dysphagia
Fevers
Dyspnoea

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5
Q

Signs of epiglottis?

A

Drooling
Hot potato muffled speech
Cervical lymphadenopathy
Tenderness over hyoid bone
Tripod sign
Stridor
Respiratory distress

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6
Q

Differentials for epiglottitis?

A

Viral pharyngitis
Peritonsillar abscess
Bacterial tracheitis
Croup

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7
Q

Investigations for epiglottitis?

A

Clinical diagnosis, do not examine if suspected

Lateral neck X-ray; thumb sign

Throat swab

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8
Q

Management of epiglottitis?

A

A to E assessment
ENT/ Anaesthetic management of airway
Keep patient upright
High flow oxygen
Nebulised adrenaline
IV dexamethasone

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9
Q

Complications of epiglottitis?

A

Airway obsruction
Death
Abscess formation
Sepsis
Mediastinitis
Pneumonia

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10
Q

Triggers for sickle cell crises?

A

Infection
Hypoxia
Dehydration
Strenuous exercise
Cold exposure
Stress
Alcohol/ smokking
High altitudes

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11
Q

Presentations of sickle cell crises?

A

Acute painful crises (vaso-occlusive crises); severe bone pain, swelling of hands/ feet
Acute chest syndrome; cough, SOB, chest pain, fevers
Priapism
Acute anaemia; myalgia, fever, headache, arthralgia, SOB, palpitations, syncope
Acute stroke
Infection

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12
Q

Investigations to diagnose sickle cell crises?

A

ECG
Urinalysis
PSV swabs, sputum MC&S and viral PCR
ABG
FBC, U+E, LFT, Coagulation, bone profile, CRP, G+S, LDH
Blood cultures
Chest Xray
CT head

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13
Q

Management of acute painful crises?

A

Pain relief (paracetamol/ NSAIDs, SC morphine)
Keep warm and hydrated
Refer to haematology
Thromboprophylaxis

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14
Q

Management of acute chest syndrome?

A

Supplementary oxygen to maintain sats over 96%
IV broad spectrum antibiotics (co-amoxiclav, clarithromycin)
Top up/ exchange transfusion

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15
Q

Management of priapism?

A

Urology
Analgesia
Oral hydration
Encourage to pass urine and catheterise if necessary
Consider drainage

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16
Q

Management of acute anaemia?

A

Identify causes
Transfusion may be required

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17
Q

Management of acute splenic sequesteration?

A

Splenectomy

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18
Q

What infections are those on iron chelation more at risk of ?

A

Yersinia
Klebsiella

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19
Q

What is acute pancreatitis?

A

Inflammation affecting the pancreas with local/ distant tissue/ organ invovlement

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20
Q

Epidemiology of acute pancreatitis?

A

Most commonly caused by gallstones
1-3% mortality
80% have mild self limiting disease

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21
Q

Causes of acute pancreatitis?

A

Idiopathic
Ethanol
Trauma
Steroids
Mumps
Autoimmune disease
Scorpion stings
Hypercalcaemia, hypertriglycerideaemia, hypothermia
ERCP
Drugs; thiazide, azathioprine, sulphonamide

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22
Q

How is severity of acute pancreatitis assessed?

A

Glasgow score; each of the criteria scores 1 point, 3 or more predicts severe pancreatitis and should be calculated within 48 hours from admission

PaO2 <8kPa
Age >55 years
Neutrophils >15
Calcium <2
Urea >16
LDH >600 or AST >200
Albumin <32
Glucose >10

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23
Q

Signs and symptoms of acute pancreatitis?

A

Epigastric pain which radiates to the back
Nausea and vomiting
Diarrhoea
Abdominal tenderness
Peritonism, rebound tenderness
Abdominal distention
Fever, tachycardia, hypotension
Grey turner’s sign; bruising in flanks
Cullen’s sign; periumbilical bruising
Fox’s sign; bruising over inguinal ligament

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24
Q

Signs for haemorrhagic pancreatitis?

A

Grey turner’s sign; bruising in flanks
Cullen’s sign; periumbilical bruising
Fox’s sign; bruising over inguinal ligament

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25
Differentials for acute pancreatits?
ACS Perforated peptic ulcer Ruptured abdominal aortic aneurysm Bowel obstruction Cholecystitis
26
Investigations for acute pancreatitis?
ABG, ECG, pregnancy test, capillary blood glucose FBC, CRP, LFT, amylase, lipase, LDH, bone profile Blood cultures Coagulation Lipid profile Autoimmune markers Abdominal USS, CXR, CT with contrast, MRCP
27
Management of pancreatitis?
Catheterise and monitor urine input/ output Consider NG tube IV fluid resuscitation , crystalloids Analgesia Antiemetics Laparoscopic cholecystectomy, debridement of necrotic tissue
28
Complications of pancreatitis?
Pancreatic pseudocyst Pancreatic necrosis Peripancreatic fluid collections Haemorrhage Pancreatic fistulae Acute respiratory distress syndrome AKI DIC Multi organ failure Hyperglycaemia
29
What is advanced life support?
Guideline based approach to treating patients who have had a cardiac arrest to improve chances of successful resuscitation and survival
30
Where can cardiac arrests occur?
Out of hospital In hospital
31
Causes of cardiac arrest?
Hypoxia Hypovolaemia Hypokalaemia, Hyperkalaemia Hypothermia, Hypothermia Thromboembolism Tamponade Tension pneumothorax Toxins
32
Classification of cardiac arrests?
Depends on whether rhythm is shockable or non shockable Shockable rhythm; pulseless ventricular tachycardia, ventricular tachycardia Non shockable rhythm; pulseless electrical activity, asystole
33
What is PEA?
Organised cardiac electrical activity in the absence of of any palpable pulse Survival is unlikely unless reversible cause and identified and treated effectively
34
When should defibrillation not be performed?
If doubt whether rhythm is shockable or non shockable
35
Management of shockable rhythm?
Attempt defibrillation if VT or VF is identified Immediately resume CPR after first shock at 30:2 Continue CPR for 2 minutes and pause to check for pulse If no pulse give a second shock Continue CPR for 2 minutes and pause to check for pulse Give a third shock Continue CPR for 2 minutes and give 1mg adrenaline or 300mg amiodarone Give repeat doses of adrenaline every 3-5 minutes After 5 shocks give further dose of 150mg of amiodarone
36
Management of non shockable rhythm?
Start CPR at 30:2 Give 1mg IV adrenaline, repeat dose every 3-5 minutes
37
Causes of airway compramise?
Angioedema Anaphylaxis Thermal injury Neck haematoma Wheeze Surgical emphysema Reduced conciousness
38
Simple manoeuvres to secure airway?
Suction; if visible vomit, blood, secretions, foreign body Turn patient onto side if actively vomiting Head tilt/ chin lift Place pillow under neck Aim for sniffing position Jaw thrust
39
What can be used as airway adjunct?
Oropharyngeal airway; Guedel, Nasopharyngeal airway
40
What is a supraglottic airway?
Laryngeal mask airway, i- Gel that sits on top of larynx
41
What is an endotracheal tube?
Used for prolonged ventilation and acts as a protected airway
42
Examples of surgical airways?
Tracheostomy Cricothyroidotomy
43
What is alcohol withdrawal?
When a patient who is dependant on alcohol suddenly stops or drastically reduces alcohol consumption
44
Epidemiology of alcohol misuse?
Affects 24% of the UK population
45
Pathophysiology of alcohol dependance?
Chronic exposure to alcohol causes tolerance to its effects, reduced GABA activity and increased glutamate activity
46
Signs and symptoms of alcohol withdrawal?
6-12 hours from last drink; Insomnia, tremor, anxiety, agitation, nausea, vomiting, sweating, palpitations 12-24 hours; visual hallucinations, auditory hallucinations, tactile disturbance (sensation of crawling bugs) 24-48 hours; alcohol withdrawal seizures 48-72 hours; delirium tremens Delirium, agitation, hallucinations, delusions, tachycardia, hypertension, hyperthermia, diaphoresis, coarse tremor
47
Differentials for alcohol withdrawal?
Benzodiazepine withdrawal Sepsis Hepatic encephalopathy Psychosis Hypoglycaemia
48
Investigations to diagnose alcohol withdrawal?
ECG Capillary blood glucose FBC, CRP, LFT, Bone profile, blood culture CXR, CT head
49
Management of alcohol withdrawal?
Use Clinical Institute Withdrawal Assessment of Alcohol scoring system to assess symptoms and guide prescription of benzodiazepines Chlordiazepoxide (long acting) is first line Oxazepam/ lorazepam are used in patients with liver disease Treat seizures with short acting benzodiazepines, IV lorazepam Pabrinex to prevent Wernicke's encephalopathy
50
What is an anastomotic leak?
Post operative complication which occurs as a result of a defect in the joint between two hollow viscera that allows contents to leak into the abdomen
51
Epidemiology of anastomotic leak?
Occur 3-5 days post operatively Frequency depends on location of surgery
52
Causes of anastomotic leak?
Emergency surgery Prolonged operative time Peritoneal contamination during surgery Immunosuppressant medication IBD Smoking Alcohol excess Diabetes Obese/ malnourished patients
53
Signs and symptoms of anastomotic leaks?
Progressive worsening of abdominal pain Prolonged ileus Tenderness on palpation of abdomen Peritonism Abdominal distention Fevers Tachycardia Hypotension Delirium Nausea and Vomiting
54
Differentials for anastomotic leak?
Post operative ileus Surgical site infection Intra-abdominal abscess
55
Investigations to diagnose anastomotic leak?
Blood gas; raised lactate Blood cultures FBC, CRP, clotting, group and save CT with contrast
56
Management of anastomotic leak?
Nil by mouth IV fluids Monitor input and output IV antibiotics TPN Surgery/ emergency laparotomy
57
Complications of anastomotic leak?
Sepsis Ileus Abscess formation Increased postoperative mortality
58
What is aortic dissection?
Tear in the tunica intima of the aorta creates a false lumen through which blood can flow between inner and outer layers of the aortic walls
59
Risk factors for aortic dissection?
Hypertension Connective tissue disease Valvular heart disease Cocaine/ amphetamine use Male over 50 years
60
Stanford classification of aortic dissection?
Type A; involves ascending aorta, arch of aorta Type B; involves descending aorta
61
Clinical features of aortic dissection?
Sudden onset tearing chest pain/ intrascapular pain that radiates to the back Bowel/ limb ischaemia Renal failure Syncope
62
Signs of aortic dissection?
Radio-femoral delay Radio-radial delay Blood pressure differential between arms
63
Investigations to diagnose aortic dissection?
CT angiogram ECG Echo; pericardial effusion CXR; widened mediastinum Troponin and D-dimer may be elevated
64
Prognosis of aortic dissection?
Prompt diagnosis and treatment as rupture carries 80% mortality
65
Management of aortic dissection?
Resuscitation Cardiac monitoring Strict blood pressure control Type A; requires surgical managements Type B; managed conservatively with BP control, endovascular/ open repair may be required
66
Complications of aortic dissection?
Death due to internal haemorrhage Rupture End organ damage Cardiac tamponade Stroke Limb ischaemia Mesenteric ischaemia
67
What is central abdominal pain?
Discomfort or pain in the mid section of the abdomen
68
What is a burn?
Injury to skin caused by heat, electricity, chemicals and radiation
69
Groups at high risk of burns?
Young children, under 5 years Elderly patients Reduced mobility/ sensory impairment Patients with reduced sense of danger (Dementia, learning difficulty)
70
Causes of burns?
Thermal burns; flames, hot objects Chemical burns; acids, alkalis, organic compounds Electrical burns; high/ low voltage
71
Classification of burns?
Superficial epidermal burns; affects only epidermis, skin is erythematous and painful but not blistered, rapid CRT Superficial dermal burns; affects epidermis and upper layer of dermis, erythematous, painful blistered skin with delayed CRT Deep dermal burns; affects all layers of the dermis but not underlying subcutaneous tissue, dry, blotchy, blistered painful skin that does not blanch under pressure Full thickness burns; extend to SC tissue and may involve muscle and bone, skin is white or black and may feel rubbery/ leathery/ waxy and is not painful Complex; >15% of BSA or affect critical area (face, perineum, hands, feet, genitals) and all chemical and electrical burns Non-complex; <15% BSA, partial thickness
72
Signs and symptoms of burns?
Pain Erythema Swelling Blistering and peeling of skin Respiratory distress Hypotension Tachycardia
73
Differentials of burns?
Cellulitis Stevens- Johnson Syndrome Toxic Epidermal Necrolysis Pyoderma gangrenosum
74
What is Wallace rule of 9?
Divides areas of the body into multiples of 9 of the TBSA Head- 9% Whole arm-9% Front of torso-18% Back of torso-18% Whole leg-18%
75
Methods of estimating TBSA?
Wallace tule of 9's Palmar method Lund and Browder method
76
Complications of burns?
EARLY Dehydration, hypovolaemic shock Rhabdomyolysis AKI Electrolyte imbalance Hypothermia Respiratory distress due to smoke inhalation Curling's ulcer Infection, sepsis Arrhythmia Loss of limbs if amputation necessary Death LATE Scarring Chronic pain Contractures Low mood Anxiety, PTSD
77
Epidemiology of C-spine injury?
4% of trauma patients Higher risk in those with decreased consciousness C2 and C7 are most commonly fractured vertebrae
78
Causes of C-spine injury?
Road traffic accidents Falls Sports related injury Assaults Osteoporotic compression fractures
79
What makes a patient high risk following a C-spine injury as per Canadian C-spine rule?
Age over 65 Dangerous mechanism of injury Paraesthesia in upper or lower limb
80
What makes patient low risk following C-spine injury as per Canadian C-spine rule?
Accident is a minor rear end motor vehicle collision Comfortable in sitting position No midline cervical spine tenderness Delayed onset of neck pain Unable to rotate neck 45 degrees to left and right
81
Signs and symptoms of C-spine injury?
Neck pain Mid line cervical tenderness Focal neurological deficit Limited range of motion in neck movements Haematoma/ oedema around cervical vertebrae Sensory/ motor deficits- paralysis may affect trunk, upper and lower limb Peripheral paraesthesia Incontinence
82
Investigations to diagnose C-spine injury?
Assess high or low risk as per Canadian C-spine rule CT of neck If neurological abnormalities do MRI
83
Management of C-spine injury?
Imobilise and place in neck collar IV morphine for pain control Neurosurgical and spinal surgical review
84
What is choking?
Foreign object becomes lodged in a patients airway causing acute airway obstruction that is life threatening
85
Risk factors for choking?
Dysphagia Poor dentition Eating when not upright Alcohol intoxication Extremes of age Risky foods
86
Signs and symptoms of choking?
Gagging, choking, distress Unable to speak, breathe or cough Clutching or pointing at neck Stridor Wheezing Respiratory distress Cyanosis Attempts o cough a quiet or silent Loss of consciousness
87
Differentials for choking?
Anaphylaxis Asthma exacerbation Syncope
88
Management of choking?
Encourage coughing Give 5 back blows between shoulder blades with heel of hand and patient leaning forward 5 abdominal thrusts Sequence until dislodged
89
Signs and symptoms of benzodiazepine overdose?
Slurred speech Lethargy Ataxia Reduced levels of consciousness (may compromise airway) Respiratory depression Large overdoses may cause hypotension, bradycardia and hypothermia
90
Management of benzodiazepine overdose?
A to E assessment Consider risk of aspiration pneumonia Flumazenil
91
What medication is used to counteract benzodiazepines?
Flumazenil- useful in iatrogenic overdose
92
Caution of use of Flumazenil?
Risk of seizures, used in ITU/ HDU Avoid in epilepsy, chronic benzodiazepine use
93
Signs and symptoms of beta blocker overdose?
Small overdoses may be asymptomatic Bradycardia Hypotension Drowsiness Confusion Seizures Coma Bronchospasm Cardiac arrest
94
ECG changes in beta blocker overdose?
Prolonged PR interval Bradycardia (most common) Heart block QRS widening (especially propranolol) which may progress to ventricular arrhythmias QT prolongation (especially sotalol) with risk of torsades de pointes
95
Management of beta blocker overdose?
Resuscitation Correct glucose Activated charcoal if within 1 hour Symptomatic bradycardia; atropine Glucagon High dose insulin
96
Signs and symptoms of NMDA toxicity?
Nausea and vomiting Hallucinations, agitation and psychosis Delirium Hyperreflexia Tremor Hyperthermia Diaphoresis Flushing Mydriasis Tachycardia Hypertension
97
Complications of NMDA toxicity?
Arrhythmias Rhabdomyolysis Seizures Cardiovascular collapse Hyponatraemia Serotonin syndrome Acute renal failure Disseminated intravascular coagulation Coma
98
Management of NMDA toxicity?
Resuscitation Benzodiazepines Cooling if hyperthermic If hyponatraemic fluid restriction and hypertonic saline Labetolol Dantrolene
99
Management of organophosphate poisoning?
Remove clothing Protect airway Intubation and ventilation Gastric lavage Give IV atropine Pralidoxine
100
Signs and symptoms of cyanide poisoning?
Nausea and vomiting Headache Tachycardia Hypertension Tachypnoea Loss of consciousness Seizures Respiratory depression
101
Management of cyanide poisoning?
Decontamination Intubation and ventilation High flow oxygen Dicobalt edetate
102
Antidote for cyanide?
Dicobalt edetate
103
Sensitive indicator for cyanide poisoning?
Lactate over 10
104
What is compartment syndrome?
Inflammation of injured muscle causes an increase in pressure within fascial compartment As pressure rises circulation is cut off leading to tissue damage and necrosis
105
Cause of compartment syndrome?
Fractures; commonly tibial, forearm, wrist Crush injuries Constrictive dressings/ plaster casts Prolonged immobilisation Reperfusion of ischaemic limb
106
Signs and symptoms of compartment syndrome?
Severe pain out of proportion of initial injury Passive stretching of affected muscles exacerbates pain Paraesthesia Pallor Pulselessness Paralysis Coolness of the affected limb The area may feel tense on palpation
107
Differentials for compartment syndrome?
DVT Cellulitis Acute limb ischaemia
108
Investigations to diagnose compartment syndrome?
Measure intracompartmental pressures- typically around 40mmHg Creatinine kinase U+E, FBC, LFT, clotting, group and save ECG
109
Management of compartment syndrome?
Surgical management; fasciotomies Analgesia Monitor neurovascular status Monitor other limbs
110
Complications of compartment syndrome?
Rhabdomyolysis Limb amputation Volkmann contracture
111
Triggers of asthma exacerbation?
Cold air and exercise Pollution and cigarette smoke Allergens Chemical irritants Medications; NSAIDs, beta blockers
112
What type of reaction is an acute asthma exacerbation?
Type 1 hypersensitivity reaction
113
Symptoms of acute asthma attack?
Wheeze Difficulty breathing Struggling to eat, speak or sleep due to breathlessness Cough Chest tightness Dizziness
114
Signs of acute asthma attack?
Tachypnoea Increased work of breathing Hyperinflated chest Expiratory polyphonic wheeze throughout the lung fields Decreased air entry Cyanosis Tachycardia Altered mental state, e.g. drowsiness or confusion Exhaustion Hypotension
115
Differentials for acute asthma?
Pulmonary embolism Vocal cord dysfunction Acute exacerbation of COPD GORD Anaphylaxis
116
Investigations for acute asthma?
PEFR ABG ECG FBC, CRPU+E, LFT Blood cultures CXR
117
Complications of acute asthma?
Respiratory failure Pneumothorax Status asthmaticus Death
118
Management of acute asthma asthma?
ABCDE Maintain O2 sats 94-98% Nebulised salbutamol 5mg Ipratropium bromide 500mcg 4-6 hours Prednisolone 40-50mg and continue for atleast 5 days IV magnesium sulphate; 1.2-2g over 20 minutes Aminophylline
119
Signs and symptoms of ACS?
Chest pain - typically central and crushing in nature. May radiate to left arm/neck/jaw Shortness of breath Nausea +/- vomiting Sweating and clamminess Syncope Atypical presentations are more likely in some groups (e.g. the elderly or patients with diabetes who may not experience chest pain) Pain may be epigastric rather than in the chest, or there may be no pain Acute confusion or hyperglycaemic crises are examples of atypical ACS presentations
120
Differentials for ACS?
Myocarditis Pericarditis PE Costochondritis Aortic dissection
121
Investigations to diagnose ACS?
ECG Troponin, repeat after 4-6 hours U+E, HbA1c, lipid, FBC, CRP, coagulation CXR Echo
122
Management of STEMI?
Loading dose of aspirin 300mg Second antiplatelet agent; prasugrel, clopidogrel Sublingual GTN Morphine PCI; primary if presented within 12 hours and can be offered in 2 hours
123
Management of NSTEMI and UA?
Loading dose of aspirin Antithrombin; fondaparinux Risk stratification; GRACE score Low risk patients managed medically; aspirin + ticagrelor Intermediate/ high risk managed with PCI and DAPT
124
Complications of ACS?
Ventricular arrhythmia Acute mitral regurgitation Acute heart failure Heart block Cardiogenic shock Cardiac tamponade Ventricular septal defect Dressler's syndrome
125
What is an acute exacerbation of COPD?
Acute worsening of patients baseline symptoms beyond expected day to day variation
126
Causes of exacerbation of COPD?
Viral; rhinovirus, influenza, parainfluenza, coronavirus, adenovirus, RSV Bacterial; haemophilus influenza, streptococcus pneumonia, moraxella catarrhalis, staphylococcus aureus, pseudomonas aeurginosa Nitrogen dioxide, particulates, sulphurdioxide Pneumothorax, PE, intra-abdominal pathology, heart failure, metabolic disturbance
127
Signs of exacerbation of COPD?
Worsening shortness of breath Reduced exercise tolerance/not coping at home Worsening cough (especially if increased sputum production/change in colour) Worsening wheeze and chest tightness Infective symptoms (e.g. sore throat, coryza, fevers) Lethargy Confusion Ankle swelling
128
Signs of exacerbation of COPD?
Tachypnoea and respiratory distress Tripod positioning (where patient leans slightly forward with arms propped up in front - reduces work of breathing and allows greater use of accessory muscles) Pursed lip breathing Reduced oxygen saturations from baseline Tachycardia Cyanosis Asterixis On auscultation: wheeze, reduced air entry, prolonged expiratory phase, crackles
129
Investigations to diagnose exacerbation of COPD?
ABG Sputum culture ECG FBC, CRP, U+E Blood culture CXR
130
Differentials for exacerbation of COPD?
Pneumonia Pneumothorax Pulmonary embolism Acute exacerbation of asthma Exacerbation of bronchiectasis Acute heart failure Exacerbation of interstitial lung disease Lung cancer Tuberculosis
131
Management of exacerbation of COPD?
Oxygen saturations between 88-92% Salbutamol 2.5-5mg Ipratropium 0.5mg QDS Steroids; prednisolone 30mg for 5 days, if unable to swallow IV hydrocortisone IV aminophylline Consider antibiotics if infectious
132
What is acute angle closure glaucoma?
Blockage of the angle formed by the cornea and the iris which prevents the humour from draining resulting in progressive increase in intra-ocular pressure
133
Risk factors for acute angle closure glaucoma?
Anatomical variations Older age Female sex East Asian ethnicity Medications e.g. oxybutynin, amitriptyline, tropicamide Hypermetropia (farsightedness) Family history of AACG Pupillary dilation e.g. being in a dark room
134
Symptoms of acute angle closure glaucoma?
Rapid onset of severe eye pain Blurred vision which may progress to visual loss Nausea and vomiting Headache Coloured haloes around lights
135
Signs of acute angle closure glaucoma?
Conjunctival injection in the affected eye Haziness of the cornea Mid-dilated or fixed pupil that is not reactive Globe feels hard and is tender on palpation
136
Differentials of acute angle closure glaucoma?
Open angle glaucoma Acute anterior uveitis Anterior scleritis
137
Investigations to diagnose acute angle closure glaucoma?
Slit lamp examination Ophthalmoscopy Gonioscopy; allows assessment of the angle between the iris and cornea Tonometry; >30mmHg
138
What is the gold standard for for acute angle closure glaucoma?
Goldmann applanation tonometry
139
Management of acute angle closure glaucoma?
Conservative management; Lie patient flat with their face up without pillows to relieve pressure on the angle Referral to ophthalmology Monitor symptoms and ensure analgesia and antiemetics Medical management; Dorzolaminde (carbonic anhydrase inhibitor) and timolol (beta blocker) Apraclonidine; alpha-2 agonist Polocapine; cholinergic agonist Acetazolamide Surgical management; Peripheral iridotomy Treat both eyes
140
What is anaphylaxis?
Rapid onset of life threatening airway, breathing or circulatory dysfunction as a result of an immunological reaction when patient is exposed to allergen
141
Epidemiology of anaphylaxis?
20-30 deaths per year, about half are iatrogenic due to penicillin
142
Causes of anaphylaxis?
Insect stings Nuts Other foods such as eggs or milk Latex Antibiotics (e.g. penicillins) Intravenous contrast agents Other medications (such as NSAIDs)
143
Signs and symptoms of anaphylaxis?
Airway; difficulty swallowing, breathing, stridor, hoarse voice, swelling of tongue and lips Breathing; difficulty breathing, wheeze, cough, respiratory distress, respiratory arrest Circulation; dizziness, pallor, clamminess, tachycardia, hypotension, arrhythmias, anaphylaxis, cardiac arrest Disability; sense of impending doom, confusion, agitation, loss of consciousness Exposure; erythematous patches, urtrcaria, angioedema GI manifestation; abdominal pain, incontinence, vomiting
144
Differentials for anaphylaxis?
Life threatening asthma exacerbation Other causes of angioedema; ACE inhibitors, histamine, bradykinin mediation Panic attack Vasovagal episode
145
Investigations for anaphylaxis?
ECG, ABG, mast cell tryptase
146
Management of anaphylaxis?
Remove triggers Lie patient flat and elevate legs IM adrenaline into anterolateral aspect of thigh Secure airway High flow oxygen Inhaled salbutamol/ ipratropium IV fluid bolus Repeat IM adrenaline after 5 minutes if no response Once stabilised; Oral non sedating antihistamine Observe for biphasic reaction
147
What should patients who have had anaphylaxis be given upon discharge?
2 adrenaline auto injectors Advice on trigger avoidance Refer for follow up in specialist allergy service
148
What is a biphasic reaction?
When symptoms of anaphylaxis reoccur without further exposure to trigger
149
Causes of atrial fibrillation?
Cardiac causes; Ischaemic heart disease Hypertension Valvular heart disease (including rheumatic heart disease, typically affecting the mitral valve) Heart failure Cardiomyopathies Myocarditis and pericarditis Recent cardiothoracic surgery Non-cardiac causes; Electrolyte disturbances (e.g. hypokalaemia, hypomagnesaemia) Acute infections e.g. pneumonia, sepsis Pulmonary embolism Hyperthyroidism Alcohol excess Smoking Medications (e.g. lithium)
150
Classification of AF?
Paroxysmal; episodes last < 7 days and are intermittent Persistent; episodes last > 7days Permanent; lasts > days, no further attempts to get sinus rhythm are attempted
151
Symptoms of AF?
Palpitations Chest pain or tightness Shortness of breath Reduced exercise tolerance Light-headedness Syncope Fatigue A complication of AF e.g. a stroke or transient ischaemic attack
152
Signs of AF?
Irregularly irregular pulse Radial- apical deficit Variable intensity of first heart sound on auscultation Haemodynamic instability; tachycardia, hypotension, loss of conciousness, acute pulmonary oedema
153
Differentials for AF?
Sinus tachycardia Atrial flutter Supraventricular tachycardia Multifocal atrial tachycardia
154
Investigations to diagnose AF?
ECG; absence of p waves irregularly irregular QRS Bloods; FBC, CRP, U+E, bone profile, TFT, HbA1c, LFT, Lipids, clotting screen, blood cultures CXR Echocardiogram CTPA
155
Management of AF?
AF with adverse signs; A to E approach DC cardioversion If 3 attempts are unsuccessful give 300kg IV amiodarone followed by another shock and 900mg amiodarone infusion over 24 hours Stable patients Synchronised DC cardioversion with sedation or general anaesthetic Pharmacological cardioversion with flecainide Rate control Ongoing management; Anticoagulation; DOAC
156
Complications of AF?
Embolic event Hear failure Myocardial ischaemia Tachycardia induced cardiomyopathy Increased risk of vascular dementia
157
Which groups of patients are more sensitive to CO poisoning
The elderly Young children Pregnant women People with anaemia People with cardiovascular disease
158
Signs and symptoms of carbon monoxide poisoning?
Headache Dizziness Lethargy Flushing Myalgia and weakness Confusion Nausea and vomiting Cherry red skin (rare) Tachycardia and hypotension Seizures
159
Differentials for carbon monoxide poisoning?
Migraine Viral infections Diabetic ketoacidosis
160
Investigations to diagnose carbon monoxide poisoning?
Pulse oximetry Blood gas ECG Capillary blood glucose Bloods; FBC, U+E, CK, Troponin, lactate
161
Management of carbon monoxide poisoning?
A to E assessment 100% oxygen IV fluids
162
Complications of CO poisoning?
Emotional lability and personality change Difficulty concentrating Insomnia Lethargy Movement disorders such as chorea and Parkinsonism Memory impairment and dementia Psychosis Neuropathy
163
What is cardiac tamponade?
Compression of heart by fluid accumulation in the pericardial sac which impairs cardiac filling during diastole compromising cardiac output leading to cardiac arrest
164
Causes of cardiac tamponade?
Trauma; especially penetrating injuries Iatrogenic causes; cardiothoracic surgery Pericarditis which can be secondary to malignancy, myocardial infarction, HIB, TB, connective tissue disease, radiation, CKD Aortic dissection Medication; minoxidil, hydralazine Cardiac perforation Pneumopericardium
165
Symptoms of cardiac tamponade?
Fatigue Dyspnoea Cold and clammy peripheries Confusion
166
Signs of cardiac tamponade?
Beck's triad (raised jugular venous pressure, hypotension and muffled heart sounds) Pulsus paradoxus (a decrease in systolic blood pressure by more than 10 mmHg during inspiration) Tachycardia Tachypnoea Altered mental state Hepatomegaly Pericardial friction rub Cyanosis JVP shows an absent Y descent (due to reduced diastolic filling of the ventricles)
167
What is Beck's triad?
Raised JVP Hypotension Muffled heart sounds
168
Differentials for cardiac tamponade?
Acute heart failure Constrictive pericarditis Pulmonary embolism Tension pneumothorax
169
Investigations to diagnose cardiac tamponade?
ECG; electrical alternans where height of QRS complexes alternate due to movement of heart in pericardial space FBC, CRP, U+E, coagulation, HIV testing, group and save, troponin Imaging; echocardiogram, CXR, CT Pericardiocentesis fluid for cytology
170
Management of cardiac tamponade?
Supportive therapy; oxygen, IV fluids, inotropes Pericardiocentesis Open surgical drainage Percutaneous balloon pericardiotomy, pericardiectomy Treat underlying cause
171
What is the triad for diabetic ketoacidosis?
Hyperglycaemia; >11mmol/L Ketosis; >3 mmol/L Acidosis; pH <7.3
172
Causes of DKA?
Insulin deficiency leads to hyperglycaemia which are converted to ketones which leads to ketosis
173
What proportion of T1DM first presentation is DKA?
10-20%
174
Triggers for diabetic ketoacidosis?
Infections Dehydration and fasting Missing doses of insulin Medications e.g. steroid treatment or diuretics Surgery Stroke or myocardial infarction Alcohol excess or illicit drug use Pancreatitis
175
When should patients with DKA be considered to higher dependency care?
Blood ketones > 6mmol/L Bicarbonate < 5mmol/L Blood pH < 7 Anion gap above 16 Hypokalaemia on admission GCS less than 12 Oxygen saturations < 92% in air Systolic BP < 90mmHg Brady or tachycardia (heart rate < 60 or > 100bpm)
176
Symptoms of DKA?
Nausea and vomiting Abdominal pain Polyuria Polydipsia Weakness
177
Signs of DKA?
Dry mucous membranes Hypotension Tachycardia Altered mental state (drowsiness, confusion, coma) Kussmaul's breathing (deep, sighing breathing to compensate for metabolic acidosis by blowing off carbon dioxide) Fruit-like smelling breath (due to ketosis)
178
Investigations to diagnose DKA?
Capillary blood glucose Blood or urinary ketones Urine dip and MSU ECG Venous blood gas U+E, FBC, CRP Blood cultures HbA1c
179
Management of DKA?
A to E assessment Ensure IV access Consider urinary catheterisation and monitor fluid balance IV fluids Potassium replacement Insulin 0.1 units/ kg/ hour
180
What is ethylene glycol poisoning?
Chemical in antifreeze or radiator coolant
181
Signs and symptoms of ethylene glycol poisoning?
Early; Apparent intoxication (similar to that of alcohol) Nausea and vomiting Haematemesis Seizures Ataxia Ophthalmoplegia Papilloedema Raised anion gap metabolic acidosis Pulmonary oedema Late; Acute tubular necrosis Flank pain Oligouria Hypocalcaemia Hyperkalaemia Hypomagnesaemia
182
Differentials for ethylene glycol poisoning?
Alcohol intoxication Poisoning with other substances Acute renal failure
183
Investigations to diagnose ethylene glycol poisoning?
Urine sample ECG Blood gas; metabolic acidosis with raised anion gap U+E, LFT Bone profile, hypocalcaemia Magnesium, hypomagnesaemia CT head
184
Management of ethylene glycol poisoning?
A to E assessment Monitor urine output Gastric lavage, NG aspiration Fomepizole Ethanol Haemofiltration Treat any electrolyte imbalance
185
Mechanism of action of fomepizole?
Competitive inhibitor of alcohol dehydrogenase
186
What is hyperosmolar hyperglycaemic state?
Complication of T2DM commonly seen in older patients with known diabetes
187
Key features of hyperosmolar hyperglycaemic state?
Blood glucose ≥ 30 mmol/L Serum osmolality ≥ 320 mOsm/kg Significant hypovolaemia Blood ketones ≤ 3 mmol/L pH ≥ 7.3 and bicarbonate ≥15.0 mmol/L
188
Factors that can cause hyperosmolar hyperglycaemic state?
Infection Recent trauma or surgery Acute events like stroke or MI Medications; steroids
189
Symptoms of hyperosmolar hyperglycaemic state?
Polyuria Polydipsia Nausea Lethargy Weakness Confusion Drowsiness Loss of consciousness
190
Signs of hyperosmolar hyperglycaemic state?
Tachycardia Hypotension Altered mental state Sunken eyes Dry mucous membranes
191
Investigations to diagnose hyperosmolar hyperglycaemic state?
Capillary glucose; over 30 VBG Capillary blood ketones ECG Urine dip Serum osmolality, glucose, U+E, FBC, CRP, LFT Bone profile Blood cultures CXR
192
Management of hyperosmolar hyperglycaemic state?
Fluid resuscitation; 1L of 0.9% saline over 1 hour Potassium replacement Monitor glucose, ketones, U+Es hourly and calculate serum osmolality every hour VTE prophylaxis Refer to diabetes specialist
193
Complications of hyperosmolar hyperglycaemic state?
Hypovolemic shock Cerebral oedema Thromboembolic events Acute kidney injury Cardiac arrhythmias Respiratory failure Long-term neurological sequelae
194
What is pericarditis?
Inflammation of the pericardium
195
Causes of pericarditis?
Idiopathic Viral; echovirus, enterovirus, cocksackievirus, adenovirus Bacterial; pneumococcus, staphylococcus, mycoplasma TB Dresslers syndrome Autoimmune; rheumatoid arthritis, SLE, scleroderma Uraemic pericarditis Malignancy Drugs; isoniazide, hydralazine Trauma
196
Signs and symptoms of pericarditis?
Acute onset pleuritic chest pain; relieved by leaning forward, retrosternal may radiate down left arm/ shoulder Pericardial friction rub Fever Cough Arthralgia
197
Investigations to diagnose pericarditis?
ECG; acute phase PR depression, global saddle shaped ST elevation FBC, CRP, Troponin, U+E, Echo CXR
198
Management of pericarditis?
NSAIDs Low dose colchicine Steroids in uraemic pericarditis, connective tissue disorders Aspirin is used in pericarditis post MI
199
High risk features of pericarditis?
Large pericardial effusion or tamponade Myopericarditis (elevated troponin) Immunosuppression High fevers (>38 degrees) Trauma On oral anticoagulants Subacute cause Not responding to initial treatment (after 1-2 weeks)
200
What is a pneuothorax?
Collection of air in the pleural cavity which may cause collapse of underlying lung parenchyma
201
How is pneumothorax classified?
Spontaneous Traumatic Tension
202
Symptoms of pneumothorax?
Sudden onset shortness of breath Pleuritic chest pain Dry cough Tachypnoea and increased work of breathing
203
Signs of pneumothorax?
Unilateral reduced expansion Unilateral hyper-resonance to percussion Reduced or absent breath sounds Reduced vocal resonance or tactile vocal fremitus Tracheal deviation to the contralateral side Tachycardia Hypotension Distended neck veins
204
Investigations to diagnose pneumothorax?
CXR ABG CT chest Needle aspiration
205
Management of tension pneumothorax?
Insertion of large bore cannula into second intercostal space, mid clavicular line Thoracostomy Chest drain
206
Follow up requirements for pneumothorax?
OPD in 2-4 weeks Smoking cessation No flying until 7 days post pneumothorax resolution No underwater diving
207
208
Triad of PE?
Sudden onset shortness of breath Pleuritic chest pain Haemoptysis
209
Symptoms of PE?
Sudden onset Shortness of breath Pleuritic chest pain Haemoptysis Cough Syncope RV ischaemia -> retrosternal chest pain
210
Signs of PE?
Tachypnoea Crackles o auscultation Tachycardia Hypoxia Low grade pyrexia
211
How to interpret wells score?
Less than 4; PE unlikely, perform D dimer More than 4; PE likely, CTPA or V/Q scan
212
Investigations for PE?
ECG; sinus tachycardia ABG D-dimer FBC CRP U+E LFT Coagulation Troponin CXR CTPA V/Q scan TTE
213
What is seen on CXR in PE?
Fleischner sign; enlarged pulmonary artery Hampton's sign; peripheral wedge shaped opacity Westermark sign; regional oligaemia
214
Management of PE?
Anticoagulation Embolectomy Catheter directed thrombolysis
215
Cause of status epilepticus?
Withdrawal/ interruption or change in anti-epileptic medication Non compliance with medication Seizure threshold lowering medications Intercurrent illness Metabolic abnormalities Infection Brain injury; trauma, stroke, subarachnoid haemorrhage Withdrawal from benzodiazepines, alcohol
216
Signs and symptoms of convulsive status epilepticus?
Abrupt generalised muscle stiffening (tonic phase) followed by rhythmic jerking of the muscles (clonic phase) Loss of consciousness Tongue biting - typically lateral tongue Urinary or faecal incontinence Clenched jaw Erratic eye movements Drooling Cyanosis
217
Signs and symptoms of non convulsive status epilepticus?
Reduced levels of consciousness Catatonia Behavioural changes/psychosis Subtle motor signs e.g. myoclonus, eye deviation or twitching Autonomic dysfunction Speech disturbance e.g. aphasia or perseveration
218
Features of non epileptic seizures?
Last longer Eyes closed Emotional vocalisation; crying, screaming Limbs moving in phase with each other Head and trunk moving side to side React to external stimuli Incontinence and tongue biting
219
Causes of non convulsive status epilepticus?
Encephalitis Hypoglycaemia Psychogenic pseudocoma Alcohol/ benzodiazepine withdrawal Transient global amnesia Stroke
220
Investigations to diagnose status epilepticus?
Capillary glucose Blood gas; electrolytes, lactate Urine toxicology Pregnancy test ECG FBC, CRP, U+E, bone profile, magnesium LFT, clotting, serum anticonvulsant levels, blood cultures CT head, chest x ray Lumbar puncture
221
Management of status epilepticus
Ensure patient safety Airway adjunct High flow oxygen via non-rebreather Check glucose and give pabrinex is concern around alcohol excess At 5 minutes give 4mg of IV lorazepam (rectal diazepam or buccal midazolam) At 10 minutes repeat benzodiazepine At 15 minutes IV infusion of levetiracetam, phenytoin, sodium valproate If 30 minutes GA and intubate
222
What is supraventricular tachycardia?
Tachycardia originating above the level of bundle of his with narrow complex QRS
223
Management of SVT?
Unstable; DC cardioversion if signs of shock, syncope, heart failure, myocardial ischaemia Stable Vagal manoeuvre; carotid sinus massage, valsalva manoeuvre IV 6mg adenosine, 12mg then 18mg if unsuccessful Continuous ECG If adenosine fails, beta blocker or CCB with DC cardioversion
224
Short term effects of adenosine?
Difficulty breathing Chest tightness Flushing
225
What is torsades de pointes?
Polymorphic ventricular tachycardia characterised by twisting and gradually changing amplitude QRS complexes around isoelectric line on ECG as a result of QT prolongation
226
Causes of torsades of pointes?
Congenital long QT syndrome Stress, fear, exercise Toxins; heavy metals, insecticides Ischaemia Medications; erythromycin, ketoconazole, TCA, methadone, antipsychotics Electrolyte abnormalities; hypokalaemia, hypocalcaemia, hypomagnesaemia Subarachnoid haemorrhage
227
Symptoms of torsades de pointes?
Upto 50% are asymptomatic Palpitations Lightheadedness Syncope Chest pain Nausea Cold sweats Dyspnoea Sudden cardiac death
228
Investigations to diagnose torsades the points?
ECG VBG Troponin Echo Genetic testing
229
Management of torsades de pointes?
IV fluids Correct any electrolyte imbalance IV magnesium 2g DC cardioversion Defibrillation
230
What is an upper GI bleed?
Haemorrhage in the GI tract anywhere between oesophagus and duodenum at the ligament of treitz
231
What is the most common cause of upper GI bleed?
Peptic ulcer disease
232
Causes of upper GI bleed?
Oesophageal causes; Oesophageal varices Oesophagitis Mallory- Weiss tear Oesophageal cancer Stomach causes; Peptic ulcer Gastric varices Gastritis Gastric cancer Vascular malformation Duodenal causes; Peptic ulceration Aortoenteric fistula
233
Scoring systems to classify upper GI bleed?
Glasgow blatchford score Rockall score
234
Symptoms of upper GI bleed?
Haematemesis Coffee ground vomit Melena Lightheadedness Syncope Abdominal pain Fatigue Shortness of breath Decreased exercise tolerance Palpitations
235
Signs of upper GI bleed?
Tachycardia Hypotension Prolonged capillary refill time Altered mental state Abdominal tenderness Melaena or haematochezia (fresh red blood) on rectal examination Stigmata of chronic liver disease; spider naevi, gynaecomastia, palmar erythema, caput medusae
236
Investigations to diagnose upper GI bleed?
VBG ECG FBC U+E LFT Coagulation Group and save Cross match OGD CXR
237
Which blood thinner can be continued in upper GI bleed?
Aspirin All other anticoagulation is discontinued
238
Management of upper GI bleed?
Major haemorrhage protocol Airway support Ensure adequate IV access, bloods and blood gas Fluid bolus and blood transfusion if Hb under 70 (target 70-100) Correct coagulopathy/ anticoagulation Band ligation Sclerotherapy PPI
239
Complications of upper GI bleed?
Rebleeding Aspiration of haematemesis Complications of endoscopy; perforation Death
240
What is ventricular tachycardia?
Broad complex tachycardia with HR over 100bpm, and QRS width over 120ms
241
What is myxoedema coma?
Severe decompensated hypothyroidism characterised by profound hypothermia, decreased mental status, systemic manifestations of severe hypothyroidism
242
Epidemiology of myxoedema coma?
Very rare More common in elderly women
243
Cause of myxoedema coma?
Severe untreated hypothyroidism Infection Myocardial infarction Stroke Trauma Heart failure Drugs Exposure to cold temperatures
244
Signs and symptoms of myxoedema coma?
Profound lethargy or coma Hypothermia (typically below 35°C) Bradycardia and hypotension Hypoventilation leading to respiratory failure Hypoglycaemia Hyponatraemia Generalized myxoedema
245
Differentials for myxoedema coma?
Sepsis Stroke Drug overdose
246
Investigations to diagnose myxoedema coma?
TSH, free T4 FBC U+E Blood glucose ABG
247
Management of myxoedema coma?
ITU/HDU care IV T3/T4 50-100mg IV hydrocortisone Mechanical ventilation and oxygen - if hypoventilation IV fluid - to correct hypovolaemia Correction of hypothermia Correction of hypoglycaemia Treatment of any heart failure
248
What defines an AKI?
Increase in serum creatinine by 26.5 mmol/l within 48 hrs Increase in serum creatinine > 1.5 times baseline in last 7 days Urine output under 0.5ml/kg/hr for 6 hours
249
Risk factors for AKI?
Patients with CKD Elderly patients Previous AKI Malignancy Medical conditions increasing risk of urinary obstruction (e.g. benign prostatic hyperplasia) Cognitive impairment and disability (may be reliant on others for fluid intake) Recent use of medications such as NSAIDs or ACE inhibitors Recent administration of iodine-containing contrast media
250
Causes of AKI?
Pre-renal; Hypovolaemia; dehydration, haemorrhage, GI losses, burns Renal artery stenosis Medications; NSAIDs, ACE-i, ARB, diuretics Hypotension Renal; Glomerulonephritis Nephritic syndrome Acute tubular necrosis; ischaemia, toxins, rhabdomyolysis Renal vein thrombosis Vasculitis Post renal; Ureteric stones Blocked catheter Urethral/ ureteric strictures Ureteric carcinomas Abdominal/ pelvic tumours BPH
251
Classification of AKI?
Stage 1 if any of; Creatinine rise over 26 micromol/L in 48 hours Creatinine rise to 1.5-1.99 times baseline within 7 days Urine output < 0.5ml/kg/hr over 6 hours Stage 2 if any of; Creatinine rise to 2-2.99 times baseline within 7 days Urine output < 0.5ml/kg/hr over 12 hours Stage 3 if any of; Creatinine rise to 3x baseline or higher within 7 days Creatinine rise to 354 micromol/L or more with either Acute rise of 26 micromol/L or more within 48 hours or 50% or more rise within 7 days Urine output < than 0.3 mL/kg/hour for 24 hours Anuria for 12 hours
252
Symptoms of AKI?
Symptomless Fatigue Confusion Anorexia Pruritus Nausea and vomiting
253
Signs of AKI?
Hypertension Bladder distention Hypotension and dehydration Signs of fluid overload; raised JVP, pulmonary/ peripheral oedema Fevers, sepsis, rashes, vasculitis Pericardial rub
254
Investigations to diagnose AKI?
Urinalysis ECG Blood gas U+E, FBC, U+E, Clotting, bone profile Creatinine kinase CRP Bladder scan USSKUB Renal biopsy Consider acute renal screen; ANA Double-stranded DNA Anti-nuclear cytoplasmic antibodies Anti-GBM antibodies Erythrocyte sedimentation rate Serum immunoglobulins Serum electrophoresis Serum free light chains Complement levels (C3 and C4) HIV screening Hepatitis B and C serology
255
Management of AKI?
IV fluids Assess fluid balance Catheter Screen for complications; hyperkalaemia, acidosis, pulmonary oedema Suspend nephrotoxic drugs; NSAIDs, aminoglycosides, ACE-i, ARB Consider renal replacement therapy if; Acidosis; <7.2 Electrolyte imbalance Intoxication Oedema Uraemia
256
Causes of addisonian crisis?
Infection Surgery Injury Dehydration Sudden withdrawal of exogenous steroids Sudden loss of endogenous steroids; bilateral adrenal haemorrhage, pituitary apoplexy
257
Causes of primary adrenal insufficiency?
Autoimmune Surgical removal of adrenal glands Trauma Infectious disease; TB Haemorrhage Infiltration; malignancy, sarcoidosis, amyloidosis Medications Congenital adrenal hyperplasia
258
Causes of secondary adrenal insufficiency?
Pituitary tumours (e.g. adenomas) Pituitary surgery Post-traumatic hypopituitarism Hypophysitis (autoimmune inflammation) Sheehan's syndrome (avascular necrosis of the pituitary secondary to massive postpartum haemorrhage) Radiotherapy Congenital causes Pituitary apoplexy
259
Causes of tertiary adrenal insufficinecy?
Exogenous steroid administration (most common) Hypothalamic tumours Traumatic brain injury
260
Symptoms of addisonian crisis?
Fatigue Malaise Abdominal pain Nausea and vomiting Myalgia and muscle weakness Headaches
261
Signs of addisonian crisis?
Dehydration Hypotension Hypovolaemic shock Low-grade fever Confusion or coma Seizures Signs of chronic hypoadrenalism e.g. hyperpigmentation due to increased ACTH in Addison's disease
262
Investigations to diagnose addisonian crisis?
Capillary glucose ECG VBG, ABG U+E, FBC, CRP, LFT, Cortisol, Bone profile, ACTH, TFT Short synacthen test Autoantibodies CT/ MRI Pituitary MRI
263
Management of addisonian crisis?
A to E IV/ IM hydrocortisone 100mg Regular fludrocortisone 50mg IV QDS IV glucose to correct hypoglycaemia
264
Causes of acute pulmonary oedema?
Cardiogenic; CAS, heart failure, mitral regurgitation, acute arrhythmia, myocarditis, post partum cardiomyopathy, NSAIDs, hypertensive crisis Non-cardiogenic; ARDS, renal artery stenosis, AKI, fluid overload, high altitude, neurogenic pulmonary oedema
265
Symptoms of acute pulmonary oedema?
Severe dyspnoea Orthopnoea Paroxysmal nocturnal dyspnoea (PND) Anxiety Diaphoresis Cough - may be dry or productive of pink frothy sputum Nausea
266
Signs of acute pulmonary oedema?
Respiratory distress Tachypnoea Tachycardia Raised jugular venous pressure (JVP) Inspiratory crepitations on auscultation Gallop rhythm (3rd heart sound) Peripheral oedema and hepatomegaly if secondary to right heart failure Hypotension and oliguria if in cardiogenic shock
267
Differentials for acute pulmonary oedema?
Acute exacerbation of COPD Pneumonia Pulmonary embolism
268
Investigations to diagnose acute pulmonary oedema?
ECG ABG FBC, CRP, U+E, LFT, BNP CXR, Echo
269
Symptoms of aspirin overdose?
Nausea and vomiting Tinnitus Epigastric pain Confusion Dizziness
270
Signs of aspirin overdose?
Hyperventilation Tachycardia and a bounding pulse Diaphoresis Fevers Pulmonary oedema Seizures Coma
271
Investigations to diagnose aspirin overdose?
VBG, capillary glucose ECG Urinary pH Salicylate levels U+E Paracetamol levels
272
Management of aspirin overdose?
If less than 1 hour ago give activated charcoal Fluids Correct hypokalaemia Manage hyperthermia Haemodialysis
273
274
Causes of digoxin toxicity?
Accidental or intentional overdose Deterioration in renal function Dehydration Medication interactions (e.g. macrolides, antifungals, verapamil) Electrolyte derangement (hypomagnesaemia, hypercalcaemia, hypokalaemia) Elderly patients are at greater risk of digoxin toxicity
275
Signs and symptoms of digoxin toxicity?
Dizziness Nausea and vomiting Diarrhoea Anorexia Palpitations Syncope Blurred vision Yellow-green discolouration of vision Visual haloes Confusion
276
Signs of digoxin toxicity on ECG?
Supraventricular tachycardias Atrioventricular block Frequent premature ventricular contractions Sinus bradycardia Slow atrial fibrillation Ventricular tachycardia
277
Investigations to diagnose digoxin toxicity?
ECG VBG Capillary blood glucose Digoxin level U+E, magnesium, bone profile, CRP, FBC
278
Management of digoxin toxicity?
A to E Charcoal if within 1 hour of ingestion Correct electrolyte abnormality DigiBind or DigiFab Magnesium sulphate until antidote is available
279
What is hypoglycaemia?
Blood glucose below 3.5 mmol/L
280
What is Whipple's triad?
A low blood glucose level Symptoms or signs of hypoglycaemia Resolution of symptoms/signs once blood glucose normalises
281
Causes of hypoglycaemia?
Alcohol Insulin Oral hypoglycaemic medications such as sulphonylureas Decreased oral intake Excessive exercise Insulinomas Adrenal insufficiency Reactive hypoglycaemia (e.g. after upper gastrointestinal surgery) Self-induced hypoglycaemia
282
Signs and symptoms of hypoglycaemia?
Hunger Anxiety/irritability Tremor Sweating Headache Double vision Slurred speech Confusion Decreased level of consciousness
283
Management of hypoglycaemia?
If conscious and able to swallow; 15-20g of fast acting carbohydrate 40% glucose gel Once over 4mmol/L give long acting carbohydrate If unconscious and unable to swallow; A-E 100mls of 20% glucose or 200mls of 10% IV If no IV access 1mg of IM glucagon
284
Symptoms of phaeochromocytoma?
Episodic hypertension Anxiety Weight loss Fatigue Palpitations Excessive sweating Headaches Flushing Fever Difficulty breathing (dyspnea) Abdominal pain
285
Signs of phaeochromocytoma?
Hypertension Postural hypotension Tremor Hypertensive retinopathy
286
Differentials for phaeochormocytoma?
Anxiety disorder Hyperthyroidism Essential hypertension
287
Investigations to diagnose phaeochromocytoma?
Plasma metanephrines Adrenal imagine; CT, MRI if needed PET scan
288
Management of phaeochromocytoma?
Alpha blockade; phenoxybenzamine Beta blockade Surgical removal
289
Causes of spinal cord compression?
Trauma Malignancy Infection Epidural haematoma Intervertebral disk prolapse
290
Signs of spinal cord compression?
Back pain, which is typically: Severe Progressive Aggravated by straining e.g. coughing Difficulty walking Weakness below the level compressed (typically bilateral and symmetrical) Numbness below the level compressed Urinary or faecal incontinence Urinary retention Constipation
291
Signs of spinal cord compression?
Hypertonia Hyperreflexia (although reflexes may be absent at the level compressed) Clonus Upgoing plantars Sensory loss (a "sensory level")
292
Differentials for spinal cord compression?
Transverse myelitis Cauda equina syndrome Peripheral neuropathy Spinal metastases Sciatica
293
Investigations to diagnose spinal cord compression?
MRI whole spine Whole body CT Bladder scan; retention Tumour markers Biopsy
294
Management of spinal cord compression?
Management depends on the underlying cause as well as the patient's background Patients with traumatic spinal cord injuries should be transferred to a major trauma centre General principles include: Immobilise the patient and nurse with spinal precautions (e.g. log-rolling) Regular repositioning to prevent pressure ulceration in immobile patients Analgesia for pain VTE prophylaxis Catheterise if in urinary retention Counselling and rehabilitation is key, with multidisciplinary input (e.g. physiotherapy) 16mg dexamethasone and PPI cover
295
Epidemiology of thyrotoxic storm?
More common in women and those with Grave's disease
296
Triggers for thyrotoxic storm?
Acute illness Surgery Trauma Radioactive iodine therapy
297
Symptoms of thyrotoxic storm?
Tachycardia Fever Altered mental status Sweating Tremor Nausea and vomiting
298
Differentials for thyrotoxic storm?
Sepsis Acute coronary syndrome Phaeochromocytoma
299
Investigations to diagnose thyrotoxic storm?
TFT Cardiac monitoring Sepsis 6
300
Management of thyrotoxic storm?
Symptom control; IV propanolol or digoxin if propanolol is contraindicated Reduce thyroid activity; Propylthiouracil Carbimazole Lugol's iodine- 4 hours after Propylthiouracil IV hydrocortisone If pregnancy Propylthiouracil in first trimester, carbamizole in later pregnancy
301
Causes of epistaxis?
Trauma Oxygen via nasal cannulae Recent ENT or maxillofacial surgery Tumours Inflammation, nasal polyp Illicit drug use, alcohol Medications; nasal steroids Bleeding disorders Inhaled irritants, temperature, humidity
302
Management of epistaxis?
Direct compression Sit patient forward, breathe through mouth and pinch cartilaginous part of nose for 10-15 mins Topic antiseptic; naseptin, mupirocin Cautery Lidocaine with phenylephrine Nasal packing Embolisation Tranexamic acid
303
Complications of epistaxis?
Anaemia Recurrent epistaxis Hypovolaemia Aspiration of blood and airway compromise Nasal cautery may cause septal perforation Nasal packing may lead to sinusitis, septal haematoma or pressure necrosis
304
Causes of GI tract perforation?
Upper GI tract; Oesophageal/ gastric malignancy Peptic ulcer disease Boerhaave syndrome Ingestion of sharp or caustic materials Iatrogenic Lower GI tract; Diverticulitis Colorectal cancer Bowel obstruction Colitis (e.g. inflammatory bowel disease) Appendicitis Infection (e.g. toxic megacolon secondary to C. difficile infection) Iatrogenic (e.g. abdominal surgery or colonoscopy) Mesenteric ischaemia Invasion of the bowel by other tumours
305
Symptoms of GI perforation?
Abdominal pain, which is sudden in onset and severe Nausea and vomiting Malaise Lethargy
306
Signs of GI perforation?
Peritonism e.g. guarding, rebound tenderness, rigidity on palpation of the abdomen Hypotension Tachycardia Tachypnoea Fevers
307
Differentials for GI perforation?
Non specific abdominal pain Spontaneous bacterial peritonitis Appendicitis Pancreatitis
308
Investigations to diagnose GI perforation?
Blood gas Pregnancy test FBC, CRP, LFT, U+E, Group and save, blood cultures CT with contrast CXR Abdominal Xray
309
Management of GI perforation?
Conservative; Make the patient nil by mouth Urgent surgical review May require critical care input e.g. in cases of organ failure secondary to sepsis Consider nasogastric tube insertion e.g. in severe vomiting Medical; Start IV broad spectrum antibiotics IV fluid resuscitation as required Give analgesia and antiemetics - may need to be parenteral Certain cases of perforation may be managed with medical treatment only, for example a localised diverticular perforation in a well patient Surgical; Most cases of perforation will require surgical management with a laparotomy This usually involves a thorough washout, identifying the cause of perforation and repairing the defect For example, cases of bowel perforation would usually be managed with a bowel resection and formation of a temporary stoma to protect the site of repair
310
What is hyperthermia?
Core body temperature over 38 degrees
311
Causes of hyperthermia?
Heatstroke Sepsis Endocrine; hyperthyroidism, phaeochromocytoma, adrenal crisis Drugs Malignant hyperthermia Neuroleptic malignant syndrome Serotonin syndrome Anticholinergic toxicity Status epilepticus Encephalitis Intracranial haemorrhage Stroke
312
Risk factors for hyperthermia?
Extremes of age (young children and the elderly) Obesity Physical exertion Impaired sweating Cognitive impairment Dehydration
313
Symptoms of hyperthermia?
Thirst Fatigue Weakness and lethargy Dizziness Headache Nausea and vomiting Sweating (skin may be dry in severe hyperthermia or due to certain causes e.g. anticholinergic toxicity) Muscle cramps Confusion and agitation
314
Signs of hyperthermia?
High body temperature Tachycardia Hypotension Tachypnoea Oliguria Impaired consciousness Slurred speech Seizures
315
Management of hyperthermia?
A to E Fluid resuscitation with cooled fluids Catheterise Remove excess clothing Place ice packs and spray cool water Fan skin Cold water immersion Bladder/ Gastric lavage
316
Complications of hyperthermia?
Rhabdomyolysis Lactic acidosis Disseminated intravascular coagulation Acute kidney injury Arrhythmias Liver failure Non-cardiogenic pulmonary oedema Hyperkalaemia Hypocalcaemia Death
317
What is hypothermia?
Core body temperature below 35 degrees
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Symptoms of hypothermia?
Shivering Hunger Dizziness Chills Slurred speech Paradoxical undressing
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Signs of hypothermia?
Tachycardia Tachypnoea Cool peripheries Hypotension Ataxia Reduced level of consciousness Fixed and dilated pupils
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Management of hypothermia?
A to E Passive rewarming; remove wet/ cold clothing, blanket Active rewarming; bair hugger, warm IV fluids Cardiac monitoring, rectal temperature Extracorporeal rewarming
321