Flashcards in Emerging Diseases Deck (24):
What were the emerging diseases mentioned in the lectures?
Human papilloma virus
Why is human papilloma virus an emerging disease?
large portion of people exposed
many people have it
How is human papilloma virus contracted?
How does human papilloma virus access cells?
capsid proteins L1 and L2
Where does human papilloma virus replicate?
What can human papilloma virus cause?
recurrent respiratory papillomatosis
giant condyloma of Buschke-Lowenstein
Can human papilloma virus cause cancer?
Yes, but only a few strains out of over a 100 total.
What determines whether human papilloma can cause cancer?
the level of genome integration of viral into human
Why is tuberculosis an emerging disease?
immunosuppressed (vulnerable) - i.e. HIV
drug resistant strains
How is tuberculosis spread?
What does tuberculosis infect first?
Rarer types of tuberculosis (2)
Skeletal tuberculosis (10-20%) - Pott's disease
How does the cell-mediated response cause damage when combating tuberculosis infection?
Forms granulomas around bacteria -> necrotic & caseous
- damages respiratory tissue
What does skeletal tuberculosis cause?
What does CNS tuberculosis cause?
Granulomas in brain
-> other problems...
Why is avian flu an emerging disease?
Antigenic drift - no immunity/vaccine
Close proximity of pigs and birds -> deadly strain?
How are avian flu strains named?
Types of hemagglutin and neuraminidase antigens on surface.
What is hemagglutin?
Antigen found on the surface of avian flu viruses - releases the virus from cells
What is neuraminidase?
Antigen found on the surface of avian flu viruses - allows virus to attach to host cells
What does avian flu cause in the lungs of infected humans?
Haemorrhage, necrosis and alveolar damage
What does avian flu cause in the liver of infected humans?
Lobular necrosis, tubular necrosis
What does avian flu cause in the kidneys of infected humans?
Acute tubular necrosis
What does avian flu cause in the brain of infected humans?
Edema (abnormal accumulation of fluid) and demyelination.