En-do-crime

Question 1

Hashimoto

Answer 1

Auto

Lympho

Question 2

Markers for hashimoto

Answer 2

Tug antibody

Tpo

Question 3

Invasive fibrous thyroiditis

Wood thyroid

Answer 3

Riedel thyroditis

Question 4

Post viral thyrioditis

Painful

Answer 4

De quervain ,sub acute

Question 5

Goiter
Hyperthyroidism
Exopthalmus

Excess circulating thyroid hormones
Tsk -r or tsab -diagnostic

Answer 5

Graves’ disease

Question 6

Inhibit t4-t3 peripheral conversion

Answer 6

PTU

Question 7

Inhibit TPO function
Reduce antibody level
Enhance rates of remission

Answer 7

Ptu, methimazole

Question 8

SSKI

Answer 8

Thyroid storm

Before surgery

Question 9

Plummer’s dse. (Toxic adenoma)

Answer 9

Hyperthyroidism from a single hyper functioning nodule

Question 10

Myxedema (gull disease)

Answer 10

Hypothyroidism in older or adult 
Slowing of physical and mental 
Cold intolerance 
Overweight 
Drop in symphathetic activity 
Constipation

Question 11

Major cause -release of inflammatory cytokines
Low ft3,normal t4,and tsh
Low t4-poor prognosis
Routine acutely I’ll patients- no need

Answer 11

Sick euthyroid syndrome

Question 12

Thyroid cancer risk factors associated with?

Head and neck irradiation

Iodine def.

Men 2

Answer 12

Papillary ca

Follicular ca

Medullary ca

Question 13

Mc thyroid cancer

Psammoma bodies

Answer 13

Papillary thyroid cancer

Question 14

Psammoma bodies

Answer 14

Papillary thyroid cancer

Meningioma

Question 15

Cannot be diagnosed in FNAB along with hurtle cell carcinoma
IODINE DEFICIENCY

Answer 15

Follicular

Dx : vascular and capsular invasion

Question 16

Production of calcitonin 
Local invasion is more common 
Para follicular cells 
FamiLial -MEN 2 
Poor prognosis: older,male,higher mitotic act., small cell type

Answer 16

Medullary thyroid cancer

Question 17

Lymphoma treatment

Answer 17

CHOP
- cyclophosphamide,vincristine, doxurubucin, prednisone
Regional radiation

Question 18

Poor prognostic fix for FTC

Answer 18

Distant metastasis 
>50
>4cm
Hurtle cell 
Marked vascular invasion

Question 19

Complete or near total insulin deficiency

Answer 19

T1DM

Question 20

Insulin resistant

Impaired insulin secretion

Answer 20

T2DM

Question 21

Ketosis prone

Answer 21

T1DM
1a -autoimmune
1b - iodiopathic

Question 22

GdM screening

Answer 22

24-8 weeks ago

Question 23

Risk factors for Type 2

Answer 23

Fam hx
Obesity >25
Physical inactivity

Hx 
> kg/9 lbs 
Hba1c 5.7-6.4
Hpn 
PCOS -Stein leventhal syndrome 
Hx of heart disease 
Triglycerides >250

Question 24

Criteria for diagnosis of DM

Answer 24

Symptoms PPP
\+
Rbs = >200mg/dl or 11.1 mmol\l
Fbs = > 126 mg/dl or 7 mmol/l
HbA1c - >6.5 %
2-hr plasma glucose >200 mg/dl OGTT

Question 25

Screening

Answer 25

Rbs Fbs OGTT

Question 26

Confirmatory

Answer 26

OGTT

Question 27

Monitoring

Answer 27

HbA1c | Fructosamine test \glycosylated albumin

Question 28

Reflects glycemic status over the prior 2 weeks

Answer 28

Fructosamine essay

Question 29

Hypoglycemia Low plasma glucose Relief of symptoms after giving glucose or sugars

Answer 29

Whipples triad

Question 30

``` Inadequate insulin administration Pregnancy Infarction Drug-coccaine Infection ``` ``` S/s Nausea,thirst Abdominal pain Sob Tachycardia Dehydration/phone Kussmauls breathing Acetone breath ```

Answer 30

Keto acidosis

Question 31

MODY 123456

Answer 31

``` 1 - HNF4@ 2- glucokinase gene 3 - HNF @1 4- IPF -1 5- HNF -1b 6 - neuroD1 ```

Question 32

Due to mutations in hepetonuclear Transcription factors

Answer 32

MODY 123

Question 33

Thyroid hormone synthesis normally begins at about

Answer 33

about 11 weeks AOG

Question 34

Thyroid size

Answer 34

12–20 g in size, highly vascular, soft in consistency

Question 35

Thyroid glands develops during what AOG

Answer 35

3rd week

Question 36

Thyroid medullary C cells

Answer 36

produce calcitonin

Question 37

Wolff- chaikoff effects

Answer 37

Iodine induced hypothyroidism

Question 38

Jod basedow effects

Answer 38

Iodine induced hyperthyroidism

Question 39

Treatment for hypothyroidism Goal of treatment ?

Answer 39

Levothyroxine Normalization of tsh

Question 40

Treatment recommended: pregnant/wishes to conceive, TSH

Answer 40

> 10 mIU/L

Question 41

state of thyroid hormone excess and is not synonymous with hyperthyroidism which is the result of excessive thyroid function.

Answer 41

Thyrotoxicosis

Question 42

Drug induced thyroiditis

Answer 42

Amiodarone