End of Chapter Questions: CSF Flashcards

1
Q
The functions of CSF include all of the following except:
A. Removing metabolic wastes
B. Producing an ultrafiltrate of plasma
C. Supplying nutrients to the CNS
D. Protecting the brain and spinal cord
A

B. producing and ultrafiltrate of Plasma

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2
Q
The CSF flows through the:
A. Choroid plexus
B. Pia mater
C. Arachnoid space
D. Dura mater
A

C. Arachnoid Space

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3
Q
Substances present in the CSF are controlled by: 
A. Arachnoid granulations
B. Blood–brain barrier 
C. Presence of one-way valves
D. Blood–CSF barrier
A

B. Blood-brain barrier

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4
Q
What department is the CSF in the third tube routinely sent to?
A. Hematology 
B. Chemistry 
C. Microbiology 
D. Serology
A

A. Hematology

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5
Q
The CSF tube that should be kept at room temperature is:
A. Tube 1
B. Tube 2
C. Tube 3
D. Tube 4
A

B. Tube 2 (Microbiology)

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6
Q
The presence of xanthochromia can be caused by all of the following except:
A. Immature liver function
B. RBC degradation
C. A recent hemorrhage
D. Elevated CSF protein
A

C. A recent hemorrhage

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7
Q
A web-like pellicle in a refrigerated CSF specimen indicates:
A. Tubercular meningitis
B. Multiple sclerosis
C. Primary CNS malignancy
D. Viral meningitis
A

A. Tubercular meningitis

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8
Q

Given the following information, calculate the CSF WBC count:
Cells counted: 80
Dilution: 1:10
Large Neubauer Squares Counted: 10

A

C. 800

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9
Q
A CSF WBC count is diluted with:
A. Distilled water
B. Normal saline
C. Acetic acid
D. Hypotonic saline
A

C. Acetic Acid

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10
Q
A total CSF cell count on a clear fluid should be:
A. Reported as normal
B. Not reported
C. Diluted with normal saline
D. Counted undiluted
A

D. Counted undiluted

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11
Q
The purpose of adding Albumin to CSF before cytocentrifuging is to:
A. Increase the cell yield
B. Decrease the cellular distortion
C. Improve the cellular staining
D. Both A and B
A

D. A and B

A. Increase cell yield, B. Decrease cellular distortion

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12
Q
The primary concern when pleocytosis of neutrophils and lymphocytes is found in CSF is: 
A. Meningitis
B. CNS malignancy
C. Multiple sclerosis
D. Hemorrhage
A

A. Meningitis

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13
Q
Neutrophils with pyknotic nuclei may be mistaken for:
A. Lymphocytes
B. Nucleated RBCs
C. Malignant cells
D. Spindle-shaped cells
A

B. Nucleated RBCs

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14
Q
The presence of which of the following cells is increased in a parasitic infection?
A. Neutrophils
B. Macrophages
C. Eosinophils
D. Lymphocytes
A

C. Eosinophils

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15
Q
Macrophages appear in the CSF after:
A. Hemorrhage
B. Repeated spinal taps
C. Diagnostic procedures
D. All of the above
A

D. All of the above

A. Hemorrhage, B. Repeated spinal taps, C. Diagnostic procedures

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16
Q
Nucleated RBCs are seen in the CSF as a result of: 
A. Elevated blood RBCs
B. Treatment of anemia
C. Severe hemorrhage
D. Bone marrow contamination
A

D. Bone marrow contamination

17
Q
After a CNS diagnostic procedure, which of the following might be seen in the CSF?
A. Choroidal cells
B. Ependymal cells
C. Spindle-shaped cells
D. All of the above
A

D. All of the above

A. Choroidal cells, B. Ependymal cells, C. Spindle-shaped cells

18
Q
Hemosiderin granules and hematoidin crystals are seen in:
A. Lymphocytes
B. Macrophages
C. Ependymal cells
D. Neutrophils
A

B. Macrophages

19
Q
Myeloblasts are seen in the CSF:
A. In bacterial infections
B. In conjunction with CNS malignancy
C. After cerebral hemorrhage
D. As a complication of acute leukemia
A

D. As a complication of acute leukemia

20
Q
Cells resembling large and small lymphocytes with cleaved nuclei represent:
A. Lymphoma cells
B. Choroid cells
C. Melanoma cells
D. Medulloblastoma cells
A

A. Lymphoma cells

21
Q
The reference range for CSF protein is:
A. 6 to 8 g/dL
B. 15 to 45 g/dL
C. 6 to 8 mg/dL
D. 15 to 45 mg/dL
A

B. 15-45 g/dL

22
Q
CSF can be differentiated from serum by the presence of:
A. Albumin
B. Globulin
C. Prealbumin
D. Tau transferrin
A

D. Tau transferrin

23
Q
In serum, the second most prevalent protein is IgG, in CSF, the second most prevalent protein is: 
A. Transferrin
B. Prealbumin
C. IgA
D. Ceruloplasmin
A

B. Prealbumin

24
Q
Elevated CSF protein values can be caused by all of the following except:
A. Meningitis
B. Multiple sclerosis
C. Fluid leakage
D. CNS malignancy
A

C. Fluid leakage

25
Q
The integrity of the blood-brain barrier is measured using the: 
A. CSF/serum albumin index
B. CSF/serum globulin ratio
C. CSF albumin index
D. CSF IgG index
A

A. CSF/serum Albumin index

26
Q
Given the following results, calculate the IgG index:
CSF IgG: 50mg/dL
Serum IgG: 2g/dL
CSF Albumin: 70mg/dL
Serum Albumin: 5g/dL
A

C. 1.8

27
Q
The finding of oligoclonal bands in the CSF and not in the serum is seen with:
A. Multiple myeloma
B. CNS malignancy
C. Multiple sclerosis
D. Viral infections
A

C. Multiple Sclerosis

28
Q
A CSF Glucose of 15mg/dL, WBC count of 5000, with 90% neutrophils, and protein of 80mg/dL suggests:
A. Fungal meningitis
B. Viral meningitis
C. Tubercular meningitis
D. Bacterial meningitis
A

D. Bacterial meningitis

29
Q
A patient with a blood glucose of 120mg/dL would have a normal CSF glucose of 
A. 20 mg/dL
B. 60 mg/dL
C. 80 mg/dL
D. 120 mg/dL
A

C. 80 mg/dL

30
Q
CSF Lactate will be more consistently decreased in:
A. Bacterial meningitis
B. Viral meningitis
C. Fungal meningitis
D. Tubercular meningitis
A

A. Bacterial meningitis

31
Q
Measurement of which of the following can be replaced by CSF glutamine analysis in children with Reye syndrome?
A. Ammonia
B. Lactate
C. Glucose
D.α-Ketoglutarate
A

A. Ammonia

32
Q
Before performing a Gram Stain on CSF, the specimen must be: 
A. Filtered
B. Warmed to 37°C
C. Centrifuged
D. Mixed
A

C. Centrifuged

33
Q
The test of choice to detect neurosyphilis is the;
A. RPR
B. VDRL
C. FAB
D. FTA-ABS
A

D. FTA-ABS