Endo

Question 1

Antidiabetics causing weight gain

Answer 1

1. Sulfonylureas
2. Meglitinides
3. Thiazolidinediones - Pioglitazone

Question 2

Antidiabetics causing weight loss

Answer 2

GLP1 Ag - Exenatide, Liraglutide

Question 3

Antidiabetics causing hypoglycemia

Answer 3

1. Sulfonylureas

2. Meglitinides

Question 4

Metformin S.E.

Answer 4

1. Diarrhea

2. Lactic acidosis

Question 5

Antidiabetics causing edema + HF

Answer 5

Thiazolidinediones - Pioglitazone

Question 6

Antidiabetics causing nasopharyngitis

Answer 6

DPP4 inhib - Sitagliptins

Question 7

Antidiabetics causing inc in C-peptide

Answer 7

1. Sulfonylureas
2. Meglitinides

Less common w
GLP1 Ag + DPP4 inhibitors

Question 8

Drug used for DKA

Answer 8

Regular insulin IV x rapid control + SC.

Question 9

Which drugs exacerbate + mask hypoglycemic Sx?

• MOA

Answer 9

NS beta blockers

• inhibit NE/Epi mediated neurogenic Sx : tremors, tachycardia, anxiety/ arousal but do not inhibit ACh mediated sweating, hunger and paresthesia

0 Neuroglucopenic Sx : dec glucose in CNS- beh changes, confusion, visual disturbance, stupor, seizure

Question 10

Drugs dec periph conversion of T4 to T3

Answer 10

1. Glucocorticoids
2. PTU
3. Beta blockers
4. Ipodate (contrast agent)

Question 11

Drugs dec Iodine uptake by thyroid

Answer 11

Oxoanions - Perchlorate, Pertechnate

• inhibit Na-Iodide symporter

Question 12

Drugs dec iodine organification and coupling?

Answer 12

Thioamides - PTU, Methimazole

Question 13

Which drug inhibits mt glycerophosphate dehydrogenase in liver?

Answer 13

Metformin

Question 14

Drug dec endogenous insulin and C-peptide secretion by dec postprandial hypoglycemia

Answer 14

Acarbose

Dec gluc absorbtion

Question 15

Effect of estrogen in thyroid?

Answer 15

Estrogen inc TBG - dec T4+T3 — stimulates thyroid gland to produce new TSH - inc total T4

Question 16

Drugs dec Uric acid clearance

Answer 16

1. Thiazides
2. Cyclosporine
3. Tacrolimus

Question 17

Drugs dec Uric acid levels

Answer 17

1. XO inhib - Allopurinol

2. Probenecid (uricosuric)

Question 19

Anti hyperlipidemics causing inc Triglycerides

Answer 19

Bile acid resine - Cholestyramine, Colestipol, Colesevelam

Question 20

Anti hyperlipidemics dec TGL

Answer 20

1. Fibrates - Gemfibrozil, Fenofibrate (I line)
2. Niacin
3. Omega 3 FA

Question 21

Tx of post-thyroidectomy hypocalcemia?

Answer 21

Calcitriol

Question 22

Drugs dec PTH

Answer 22

Cincalcet — activates CASR to dec PTH release:

Question 23

Drugs dec absorbtion of phosphatase

Answer 23

Sevelamer

Question 24

Sympathomimeticnagents used for weight loss?

Answer 24

1. Phentermine
2. Diethylpropion
3. Benzphentamine

• release NE
  SE: high wt REGAIN.
  CI: CVD pts

Question 25

Lipase inhibitor used for wt loss

Answer 25

Orlistat

Question 26

Antidepressants used for wt loss?

Answer 26

1. Bupropion | 2. Naltrexone

Question 27

Anti hyperlipidemics inc HDL?

Answer 27

1. Fibrates | 2. Niacin

Question 32

Drugs dec LDL

Answer 32

1. Statis - inc LDL receptor recycling | 2. Ezetimibe -

Question 33

Only human recombinant insulin

Answer 33

1. Regular insulin | 2. Neutral protamine Hagedorn (NPH)