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Year 2 > Endo drugs > Flashcards

Endo drugs Flashcards

(60 cards)

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1
Q

Levothyroxine side effect?

A

oesteoperosis - especially in post-menopausal women

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1
Q

Which cardio drug can cause blood sugars to increase?

A

thiazide diuretics
- reduces K reabsorption
- Less K-atp channel action
hence less insulin release

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2
Q

diazoxide

A

partial inhibition of K-ATP
used to treat hyperinsulinism

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3
Q

pegvisomant?

A

acromegaly tx
- after ocreotide

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4
Q

tolvaptam

A

treats SIADH

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5
Q

induce ovulation via meds

A

clomifene
FSH injections

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6
Q

surgical tx to induce ovulation

A

ovarian diathermy

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7
Q

clomifene mechanism of action

A

oestrogen receptor blocker
leads to increase LH/FSH production

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8
Q

tamoxifen mechanism of action

A

oestrogen receptor blocker
leads to increase LH/FSH production

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9
Q

complication of ovulation induction?

A

ovarian hyperstimulation syndrome
enlarged ovaries that can thrombus or rupture

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10
Q

cabergoline

A

dopamine agonist

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11
Q

bromocriptine

A

dopamine agonist

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12
Q

repaglinide

A

glinide
similar to SU, less risk of hypo

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13
Q

terparatide

A

recombinant parathyroid hormonete

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14
Q

terapatide indication

A

stimulates bone growth
very severe osteoporosis
T score -4

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15
Q

STI associated with infertility

A

chlamydia

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16
Q

HYPOatraemia
HYPERkalaemia
(hypoglycaemia)

A

Addisons

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17
Q

Parkinsons
hyperprolactinaemia
uterotonics
treated via?

A

dopamine AGonists

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18
Q

antiemetics
antipsychotics
are usually which type of drug?

A

dopamine ANTAGONIST

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19
Q

metoclopramide

A

dopamine antagonist

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20
Q

domperidone

A

dopamine antagonist

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21
Q

Ix for patient >50 with a fragility fracture?

A

DEXA scan, then start bisphosphonate treatment

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22
Q

diabetic drug contraindicated in hx of bladder cancer

A

thiazolidones

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23
Q

low Na
low K
low urea
dx?

A

SIADH

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24
inhibits cortisol synthesis
metyrapone
25
acarbose
alpha glucosidase inhibitor
26
acarbose mechanism of action
prevents glucose absorption in GIT gives patient IBS
27
duloxetine indication
neuropathic pain / neuropathy
28
pregabalin indication
neuropathic pain / neuropathy
29
treatment for central diabetes insipidus?
desmopressin
30
Denosumab
RANKL inhibitor MAB used to treat osteoporosis
31
denosumab mechanism of action
inhibits RANKL reduces activity of osteoclasts less bone reabsorbed
32
high Na low K normal urea
Conns syndrome (hyperaldosteronism)
33
drugs causing raised prolactin
anti-emetics - metoclopramide anti psychotics - phenothiazines
34
synthetic ADH?
desmopressin
35
tx for central DI
desmopressin (fake ADH)
36
Pancreatic tumour Pituitary tumour Parathyroid tumour
Men 1
37
Phaeochromocytoma Medullary thyroid cancer 50% parathyroid tumour
Men 2a
38
Phaeochromocytoma Medullary thyroid tumour neuroblastoma marfanoid features
Men 2b
39
Medical tx for pheochromocytoma
alpha blockade - 1st bb
40
synacthen?
synthetic ACTH should cause increase in cortisol
41
drug causes for HHS
steroids thiazide diuretics
42
phenoxybenzamine
alpha blocker pheochromocytoma
43
doxasozin
alpha blocker
44
tx for conns syndrome
spironolactone
45
1st line tx for prolactinoma
cabergoline
46
converts T4 for T3
deiodinase type II
47
glitazones
TZD
48
pioglitazone mechanism of action
activates PPARs affects fatty acid storage
49
liraglutide
GLP-1 agonist
50
liraglutide mechanism of action
bind to GLP-1 receptors slows gastric emptying glucose dependent insulin secretion
51
BP tx for pregnant women
labetalol nifedipine methyldopa
52
gliptins ie sitagliptin
DPP4 inhibitors
53
gliptins mechanism of action
inhibit DPP4 increases levels of GLP-1 and GIP pancreas releases more insulin
54
semaglutide (wegovy)
GLP-1 agonist
55
empagliflozin
SGLT2 inhibitor
56
empagliflozin mechanism of action
inhibits SGLT2 channel prevents glucose reabsorption in proximal convoluted tubule
57
phenoxybenzamine MOA
non selective alpha blocker first line over doxasozin
58
side effect of phenoxybenzamine
reflex tachycardia (enhances release of noradrenaline
59

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