Endo - Histo Flashcards
anterior pituitary:
- routine hematoxylin and eosin stained sections show a colorful array of cells
- varied cells - stains for releasing hormones w/ini cells of pituitary (5 diff’t types of cells)
- pituitary adenoma
Craniopharyngioma
Adamantinomatous: children, squamous epithelium, wet keratin and calcification, cysts contain “machine oil”
Craniopharyngioma
Papillary: found in adults; lack keratin, calcification and cysts
parathyroid gland H&E stain:
- chief cells
- oxyphil cells
- parathyroid hormone receptors
PRIMARY HYPERPARATHYROIDISM:
- well-circumscribed, tan, brown nodule
- rim of compressed, non-neoplastic parathyroid tissue separated by fibrous capsule present
- composed of nearly all chief cells & few oxyphil cells
more on primary hyperparathyroidism, showing hyperplasia (sporadic/component of MEN syndrome)
skeletal changes seen in PRIMARY HYPERPARATHYROIDISM;
- Resultant bone comprised of widely-spaced thin trabeculae and in severe cases marrow with hemorrhage, cyst formation and fibrosis (osteitis fibrosa cystica)
- Can form masses (brown tumors) composed of giant cells and hemorrhagic debris.
Thyroid
- C cells (parafollicular cells)
- Secrete the hormone Calcitonin
- Lowers serum calcium by promoting bone absorption of calcium and inhibiting bone resorption by osteoclasts
- Goitrogens
what disease?
Graves disease
- symmetrical diffuse hyperplasia of thyroid gland; soft, meaty cut surface
- in UNTREATED cases, can see tall follicular epithelial cells; forming papillae that encroach on colloid; pale colloid w/ scalloped margins
which disease?
HASIMOTO THYROIDITIS
- diffusely enlarged with intact capsule
- pale yellow-tan, firm, nodular cut surface
- mononuclear inflammatory infiltrate with well formed germinal centers, atrophic follicles, Hürthle cell change and fibrosis
what pathology?
MULTINODULAR GOITER - on the RIGHT
- colloid-rich follicles intermixed w/ areas of follicular hyperplasia (no distinct capsule)
- Cut surface shows irregular nodules w/ hemorrhage, fibrosis, cystic change, and calcification
what pathology?
FOLLICULAR ADENOMA
- Encapsulated lesion, averages 3 cm;
- composed of uniform-appearing follicles containing colloid
what carcinoma?
papillary carcinoma of thyroid gland
what type of carcinoma?
FOLLICULAR CARCINOMA of thyroid gland