Endo Repro Last Flashcards

(996 cards)

1
Q

Early pregnancy loss, ectopic and Rh isoimmunization

A

Ok

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2
Q

First trimester

A

First day of last period (FDLMP)-13+6 weeks

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3
Q

Second trimester

A

14-27+6 weeks

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4
Q

Third trimester

A

28-42

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5
Q

Estimate date of confinement

A

40 weeks after FDLMP

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6
Q

Abortion

A

<20 weeks

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7
Q

Preterm delivery

A

20-36+6 weeks

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8
Q

Full term

A

37-42 weeks

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9
Q

Postdates

A

> 42 weeks

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10
Q

What percent of pregnant women have vagina bleeding in early preg

A

40%

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11
Q

What d if girl present with vaginal bleeding

A

Pregnancy test

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12
Q

What is a negative hCG

A

<5 mIU/L

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13
Q

HCG level at time of expected menstruation

A

100 IU/L

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14
Q

HCG ___ every __ days

A

Doubles

2

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15
Q

What hCG level can we see gestational sac? :Discriminatory level”

A

1500-2000 mIU/L

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16
Q

Fetal pole seen what hCG

A

5200, 5 weeks

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17
Q

What is abnormal rise in hCG of less then 53% in 48 hours

A

Abnormal IUP or ectopic

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18
Q

Spontaneous abortion percent

A

10-15%

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19
Q

Biochemical pregnancy

A

Refers to the presence of hCG 7-10 days after ovulation but in whom menstruation occurs when expected
-when both clincial biochemical pregnancies are considered evidence suggests that 50% of all conventions end in abortions

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20
Q

Abortus

A

Loss before 20 weeks or less than 500 grams

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21
Q

Most common cause of first trimester SAB

A

Chromosomal abnormalities
45 CO most common abnormality
Trisomy 16 most commontrisomy

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22
Q

Threatened abortion

A

Vaginal bleeding and closed cervic

25-50% result in lsos

Treatment is expected management

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23
Q

Inevitable abortion

A

Vaginal bleeding and the cervic is partially dilated

Loss inevitable

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24
Q

Incomplete abortion

A

Vaginal bleeding, cramping lower abdominal pain with dilated cervix

Passage of some but not all products

Treat with suction D and C

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25
Complete abortion
Passage of all with closed cervic With resolution of pain, bleeding and pregnancy symptoms No treatment needed
26
Missed abortion
Fetus has expired and remains int he uterus Usually no symptoms Coagulation problems may develop, check fibrinogen levels weekly until SAB occurs or proceed with suction D and C Expectant management vs misoprostol vs D and C
27
Septic abortion
Fever, uterine and cervical motion tenderness, purulent discharge, hemorrhage, and renal failure Retained infected products
28
Treat septic abortion
IV antibiotics and D and C
29
Blighted ovum
Anembryonic gestation Gestational sac to large to not have embryo >25 mm
30
Induced or elective abortion
Roe v wade 1971 Suction D and C is most common in first trimester
31
Anembryoinc gestation (blighted ovum)
Fertilized egg develops a placenta but no embryo
32
How see anembryonic gestation
US reveals empty gestational sac
33
Treat anembryonic gestation
Expectant management Medical management -misoprostol D and C
34
Suction D and C
Uses suction to remove products of conception Surgical D and C is a more successful primary therapy then medical or expectant management
35
Recurrent abortions
Defined as three successive SAB Excluding ectopic and molar pregnancies 1% of pregnant women Often no identifiable cause can be found
36
Recurrent abortions: infection
Mycoplasma, chlamydia, listeria, or toxoplasmosis rarely identified Can be treated with antibiotics
37
Recurrent abortions: smoking and etoh
Increase SABS | 4 fold increase risk. If smoke 20 cigarettes a day and consume 7 alcoholic beverages per week
38
Recurrent abortions: medical disorders
DM, Hypothyroidism, SLE< antiphospholipid ab syndrome and hypercoagulability sources Factor V Leiden defiency, antithrombin III, protein C and S, prothrombin G20210A, ANA, anticardiolipin antibody, methylene tetrahydrofolate reductase
39
Recurrent abortion maternal age
>40 lots 56% Increase with maternal age
40
Recurrent abnortions: uterine abnormalities
Congenital anomalies (DES) Submucosal fibroids, uterine septum Intrauterine synechiae (asherman)
41
Recurrent abortion: cervical incompetence
Second trimester loss Painless dilation and delivery
42
Risk factors cervical incompetenance
Uterine anomalies,previous trauma, and history of conization
43
Treat cervical incompetence
Cervical circulate
44
Recurrent abortions chromosomal abnormalities
45 XO most common Trisomy 16 most common trisomy
45
Recurrent abortio karyotype gets
Recommended for both parents bc 3% chance that one parent is an asymptomatic carrier of a genetically balanced chromosomal translocation Detect balanced reciprocal or robertsonian translocations that could be passed on
46
Recurrent abortions antiphospholipid syndrome
Most common Has been associated with recurrent fetal loss, preeclampsia, venous and arterial thromboembolism and stroke
47
Tests for immunological factors
Lupus anticoagulant Anticardiolipin antibodies IggIgm Anti B2 glycoproteins 1 antibodies iggigm
48
Treat immunological
Prophylactic dose of heparin and low dose asprin
49
Ectopic pregnancy
Fallopian tubes, abdomen, cervix, ovary, uterine cornua
50
% ectopic
1.5%
51
How ectopic pregnancy happen
Trophoblastic implant into the mucosa of the Fallopian tube and rapidly erode through to underlying blood vessels -if the bleeding is extensive it can create a pressure necrosis of the overlying tubal serosa resulting in acute rupture and significant hemoperitoneum
52
Leading cause maternal death 1st trimester
Ectopic pregnancy
53
Natural vs art locations
Natural-tubal Art-some tubal more ampullae and cornual Also get ovarian /abdominal (heterotopic more), more cervical But both most tubal
54
Risk factors ectopic pregnancy
History tubal infection (G or chlamydia) Previous ectopic Previous tubal reconstructive surgery or sterilizaiotns DES IUD preg IVF or ART Smoking
55
Differential ectopic
Threatened or incomplete abortion Ruptured hemorrhagic corpus luteum cyst Acute PID Adnexal torsion Degenerating leiomyoma
56
Nongynecological ectopic pregnancy
Acute appendicitis Pyelonephritis, renal calculi Pancreatitis
57
Triad ectopic pregnancy
Prior missed menses Vaginal bleeding Lower abdominal pain
58
Ectopic pregnancy signs
Usually 1 visit before diagnosis -follow hcg and TVUS Ab pain, spotting, bleeding
59
PE ectopic: possible
Uterus soft and normal size May not feel any adnexal mass US-thickened endometrial stripe (arias Stella reaction) Rarely do you see the ectopic preg)
60
Symptoms probable ectopic pregnancy
Lower ab pain vag spotting Abdominal adnexal tenderness or cervical motion tenderness US-variable amounts of fluid in cul de sac May see ectopic
61
Acutely ruptured ectopic pregnancy
Severe abdominal pain and dizziness from intraperitoneal preg Distended and acute tender abdomen , cervical motion tenderness, sign of hemodynamically instability US-empty uterus with free fluid
62
Hcg Doubles every 48 hours
Indicates a normal IUP Some 66% Slowest is 53%
63
<53% rise in hCG
Consistent with ectopic pregnancy or nonviable IUP
64
Can an ectopic pregnancy have normal rising HcG
Yup
65
Falling hCG
Most likely blighted ovum, spontaneously resolving ectopic ,abnormal pregnancy
66
Discriminatory zone
1500-2000 IU/L should see an intrauterine great sac
67
What see with transvaginal US
IUP Extrauterine preg Nondiagnostic-follows with hCG a
68
When repeat US
Hcg in discriminatory zone
69
Manage ectopic preg
Methotrexate-folic acid antagonist whihc inhibits DNA synthesis and cell replication
70
Follow up methotrexate
Check hCG levels day 4 and 7 -if 15% continue to follow weekly until negative If plateau or fall slow, give another dose Increase-surgical intervention
71
What avoid when on methotrexate
Folate containing vitamins
72
Success rate methotrexate
70-90%
73
Absolute contraindications methotrexate
IUP, breastfeeding, immunodeficiency, alcoholism, liver disease, hepatic renal failure
74
Relative contraindicatiosn mtx
Gestational sac>3.5 cm Embryonic cardiac motion HCG>6000
75
Expectant management
Stable and symptoms are resolving Follow hCG and give strong ectopicprecaution
76
A lot of ectopic with hCG< 1000
Not rupture and resolve spontaneously
77
Laparotomy
Preferred for hemodynamically unstable
78
Laparoscopy
Stable patient
79
Salpingectomy
Entire Fallopian tube when damage
80
Salpingostomy
Incision is made parallel to the axis of the tube over the site of implantation and incision is left open to heal by secondary intention Most studies reveal salpingostomy results in better long term tubal fcuntion
81
Salpingostomy
Incision is sutured
82
What do after surgery
Repeat hCG 3-7 days post op
83
Salpingostomy risk
20% risk residual trophoblastic tissue
84
Thesis isoimmunization
Rh negative women with RH positive fetus
85
Rh complex
C,D,E,c,d,e
86
>905 of cases of Rh isoimmunization
Antibodies to D antigens
87
Who most common Rh D negative
Caucasion>african American> Asian an Native American
88
Rh sensitization
IgM initially then igg that cross placenta and into fetus Bind fetal rbc and hemolysis
89
Mild hemolysis
Fine bc increase erythropoietin
90
Severe hemolysis
Resulting in hydrops fetalis from congestive heart failure and intrauterine fetal deat
91
RhoGAM
Prophylactic Rh immune globulin prevent maternal production of antibodies
92
Fetomaternal hemorrhage that can lead to isoimmunization
Most commonly occur during routine uncomplicated vaginal deliveries Factors that can increase the volume of fetomaternal hemorrhage -c section, placenta previa or abrupton and manual extraction of placenta
93
1-2% of Rh isoimmunization occur in the antepartum period
Abortion, abdominal trauma, ectopic preg, obstetrical procedures
94
Prevent rh isoimmunization
Rhogam decrease availability to RHD to maternal immune system
95
Prevent Rh isoimmunization
More than 1 dose in some populations | -do kleinhauer-betke test which identifies fetal rbc in maternal blood and will determine if rhogam is necessary
96
All pregnant women wha test
ABO blood group, Rh D type and antibody screen
97
What is women rh neg and anti d antibody tigers are positive (sensitized)
Test father for antigen status If he is rhd negative, no further workup or treatment is necessary bc the fetus will be rh negative If positive for rh d - homozygous, all with be rh + - heterozygous-50% will be Fetal rhd status determined by cell free fetal DNA in maternal plasma or invasively with the fetal antigen testing
98
Maternal rh antibody tigers
Screening tool to estimate the severity of fetal hemolysis in rh disease
99
Titers less than 1:8
Usually indicate the fetus is not in serious jeopardize | Recheck titers in 4 weeks
100
Titers>1:16
Further evaluation | Detailed US to detect hydrops and Doppler studies of the idle cerebral artery
101
US fetal hydrops
Ascites, pleural effusion, pericardial effusion, skin scalp edema, polyhydramnios
102
US isoimmunization
Doppler assessment of peak systolic velocity in the fetal mca most valuable Do ever 1-2 weeks from 18-35
103
Fetal MCA
Value peak systolic velocity >1.5 MOM for gestational age Predictive of moderate to severe fetal anemia Need to proceed with percutaneous umbilical blood sampling to assess true hemoglobin concentration Intrauterine transfusion if indicated
104
Amniotic fluid in isoimmunization
Before MCA Doppler Find bilirubin analysis with spectral analysts 450nm which correlated with cord blood hemoglobin of newborn at birth
105
Issue of amniotic fluid spectrophotometer in isoimmunization
Amniocentesis can increase the severity of fetomaternal transfusion and worsen the disease
106
Manage severe fetal anemia: what is it
HCT below 30% or 2 Sd below mean for gestational age
107
Teat severe fetal anemia
Intrauterine transfusions between 18-35 weeks Use group O Rh neg packed rbc - <20 weeks intraperitoneal transfusion - IV transfusion into umbilical vein are preferred secondary to therapeutic effects are more rapid and reliable - repeat transfusion 1-3 weeks
108
Survival rate after transfusion
85%
109
Antepartum testing
Twice weekly non stress test or biophysical profiles Serial growth scans q 3-4 weeks
110
After 35 weeks
The risk of intrauterine transfusions may be greater then that of a preterm 35 week Consider delivery and transfuse
111
Each subsequent pregnancy after the first affected pregnancy is likely to manifest more severe fetal/neonatal hemolytic disease and at an earlier gestation -90% risk of hydrops
Ok
112
Visit by all patient who are considering pregnancy
Risk assessment(smoking cessation, etoh ,illicit drugs) Health promotion (nutrition, folic acid, weight) Medical intervention(DM management) Psycosocial intervention (stress reduced, 10% are abused during preg)
113
When start folic acid
At least 1 month before
114
Why manage glucose
SAB, morbidity, fetal malformation, fetal macrosomia, IUFD
115
G1p1002
Given birth 1 set of twins both alive
116
G4p1123
One term infant, one set of preterm twins and 1 miscarriage and 1 ectopic 2 living kids
117
Systolic murmur, splitting and S3, palmar erythema, spider angiomatosis, linea nigra, striae gravidarum, Chadwick’s sign
Normal in preg
118
What get for prenatal labs at 1st visit
Cbc, type and screen rubella immunity (cavvinate post partum if not0, syphilis, hepatitis B surface ag, HIV, cervical cytology and gonorrhea, DM, urine culture
119
Albumin, calcium, glucose, cr, protein, na, urea nitrogen, folic acid blood
Decrease
120
Fibrinogen
Increase
121
Urine
Cr no chance, protein increase, cr clearance decreased
122
Amy last
Increased
123
Alt ast
No chance
124
Hematocrit, leukocyte factors 7-10
Increase
125
Platelets hemoglobin
Decrease
126
Gestational ae
Number of weeks elapsed since first day of LMP and date of delivery
127
Serum hcg value preg
<5 no Above 25 positive 100-time of next menses
128
First 20 days hcg
Doubles every 2 days
129
When see gestational sac
5 weeks, hcg 15000-2000
130
Fetal pole when seen
6 weeks, hcg 5200
131
Cardiac activity
7 weeks, 17500
132
Naegels rule
LMP minus 3 months and add 7 days-but only in 28 day cycle ppl
133
How use US to determine date of delivery
Crown rump length (CRL) between 6-11 weeks can determine due date within 7 days At 12-20 weeks measuring femur length, biparietal diameter and abdominal circumference can determine due date within 10 days Third trimester due date can be off up to +/- 3 weeks
134
How PE estimate exam
Size of uterus
135
Who needs genetic counseling
Over 35 Previous child.family history of birth defects or known genetic disorder Previous birth mental retarded Previous dead baby Multiple fetal lossses Abnormal serum marker Consanguinity Maternal conditions Exposure to teratogens Abnormal US Genetic disorder
136
Down’s syndrome
Meiosis nondisjucntion 47 chromosome extra 21 If have a Down’s syndrome have 1% cance of another
137
Chromosomal studies (karyotype) on couples after 3 or more spontaneous abortions
3-5% will have balanced translocation Should get counseling on having kid with an unbalanced translocation and therefore be offered prenatal diagnosis (chorionic villus sampling/amniocentesis)
138
Most common class of spontaneous abortion
Autosomal trisomy (16)
139
Most common single chromosomal abnormality in SAB
45 xo
140
AD dosirders
Tuberous sclerosis, neurofibromatosis, achondroplasia, craniofacial synstosis, adult onset POCS, muscular dystrophy
141
AR
Ray sachs, sickle cell, alpha and beta thalassemia, cystic fibrosis
142
Who is offered CF screen
1/25 ppl carry the AR tait 15% undiagnosed All preg women
143
Sex linked
Duchene muscular dystrophy, fragile x
144
Fragile x
Most common inherited mental retardation Second most common mental retardation a fter Down’s syndrome
145
How get x linked disorder
No male male transmission Unaffected females carry Effect males
146
Multifactorial inherited
Cleft lips, heart defects, pylorus stenosus, neural tube
147
Neural tube defects
Folic acid
148
When screen and uploads
1st and 2nd
149
1st trimester screening
Maternal age, fetal nuchal translucency (NT) thickness (echo free area at back of neck between 10 and 14 weeks-high thickness chromosomal and congenital abnormalities) Hcg Pregnancy associated plasma protein a PAPPA
150
Elevated bhcg and low pappa
Down’s syndrome
151
Increased nuchal translucency
Also downs
152
Second trimester triple screen
Bhcg, estriol, alpha fetoprotein Detect trisomy 21
153
Second trimester quadruple screen
Bhcg, estriol, afp, inhibiton a Trisomy 21
154
Combined 1st and 2nd trimester screening
Report results after 2nd trimester Improve detection rate
155
Cell free fetal dna
9-10 weeks Tests cell free fetal dna, thought to be from apoptosis of trophoblastic cells that have entered the maternal circulation
156
What cell free dna good for
Trisomy 21 Trisomy 18 Trisomy 13 Sex chromosome NOT NEURAL FETAL DEFECTS LIKE NT
157
Who cell cell free dna
High risk | -old, prior trisomy preg, family history chromosomal abnormalities, US abnormal, positive fist trimester screen
158
If positive
Anniocenteisis or Chorionis villi sampling
159
Amniocentesis
16-20 weeks | .3% miscarriage
160
Chorionic villi sampling
11 weeks | 1% miscarriage
161
Teratology
Study abnormal fetal development
162
Thalidomide
Phocomelia
163
Pregnancy and lactation labeling rule
PLLR | Removed letters changed content and format for information to assist health care provides in assessing benefit vs risk
164
PLRR
Pregnancy subsections 8.1-preg Pregnancy subsection 8.1 breastfeeding Females and male reproductive potential 8.3
165
Fetal susceptibility to teratology
Genetic make up of mom and fetus and environment Multifactorial
166
Low dose
Fine
167
Intermediate dose
Organ malformation
168
High dose
Abortion
169
Most vulnerable time
17-56 days during organogenesis
170
4 th month and after
Growth delay and not malformation
171
Organogenesis
Malformation
172
Most common teratogen
Alcohol Fetal alcohol syndrome
173
Antianxiety
Meprobamate or chlordiazepoxide Congenital anomalies
174
Antineopalstic
Aminopterin and methotrexate are both folic acid antagonists =before 40 lethal Later UIGR, craniofacial, mental retard
175
FAS
Growth restriction Facial abnormalities(low ears, smoot philitrum, thin upper lip, short palpebral tissues, flat midface) CNS dysfunction -microcephalic, mental retardation and behavior disorders
176
Alkalyating
Iugr, fetal death, cleft lip, microphthalmia, limb reduction, poorly developed external genetalia
177
Anticoagulatnts
Coumadin cross placenta, heparin doesnt
178
Coumadin
SAB, IUGR, CNS mental retardation, stillbirth, craniofacial features, fetal warfarin syndrome
179
Anticonvulsants
Usually epileptic women benefits of seizure prevention weighed against teratogenicity of the drug
180
Diphenylhydantoin
Fetal hydantoin syndrome | -craniofacial , limb reduction, FHS, mental defiency, cardiovascular anomalies
181
Valproic acid
Spina bifida Cardiac, skeleton, craniofacial abnormalities
182
Carbamazepine
Spina bifida, craniofacial defects, fingernail hypoplasia
183
Phenobarbital
Neonatal withdrawal and neonatal hemorrhage
184
Estrogen and progesterone
Masculinization of female external genetalia
185
DES
Treat threatened abortion Risk cervical and uterine issue Cancer Male-testicular abnormalities, infertility and malignancy T uterus
186
Retinoids
CNS CVD Craniofacial defects SAB, congenital malformations 50%
187
Tobacco smoke
low birth weight IUGR SAB, fetal death, neonatal death and prematurity
188
Illicit drugs
Opiate-experience withdrawal
189
Infectious agents virus bacteria
Congenital malformations, growth restriction, fetal death, mental retardation
190
CMV
Proposes, depressed nasal bridge, triangular mouth
191
Radiation
Dose dependent 2-6 weeks Before 2 lethal or none Less than 5 rads of exposure no risk
192
How deal with n/v
``` Small frequent meals Avoid greasy fried food Room temp soda and saltnines Acupuncture Medes ```
193
Heartburn
From relaxation of esophageal sphincter by progesterone | -donut lie down after meals, elevate head of bed, small frequent meals, antacids, H2O blockers
194
Constipation
Decrease in colonic activity Increase water, fiber, fruits, and vegetables, stool softened
195
Hemorrhoids
Increase in venous pressure in rectum Rest, sti bath, stool softener, elevat legs, avoid cnstipation
196
Leg crams
Last half preg, calves at night Massage stretch
197
Backache
Avoid weight gain, exercise/stretch, comfortable shoes, pillows, heat massage
198
How often go to doctor
Every 4 weeks until 28 then ever 2 weeks tilll 36 and weekly until delivery
199
What get at routine visit
Bp, weight, urine protein, uterine size, fetal heart rate (Doppler)
200
Quickening
First sensation of miovement 20 weeks
201
Near term
Evaluate fetal lie and fetal position
202
20 weeks
Fetal survey ultrasound
203
28 weeks
Gestational diabetes and repeat hemoglobin and hematocrit Rhogam injection to Rh negative patients Tdap give between 27-36 weeks
204
35 week
Screening for group b step carrier with vaginal culture-treat in labor if positive
205
Kick counting
Monitor how often
206
Nonstress test
Reactive-2 accelerations of at least 15 beats above baseline lasting at least 15 seconds during 20 minutes of monitoring
207
Contractions tress test
Give oxytocin to establish at least 3 contractions in a 10 min period. If late decelerations are noted with the majority of contractions the test is positive and delivery is warranted
208
8-10
Reassuring
209
6
Deliver if at term
210
4 or less
Onreassuring consider delivery
211
Still birth reactive non stress test
2/1000
212
Negative contraction stress test still birth
.3/1000
213
Biophysical profile
.8/1000
214
Normal labor and delivery
Gynecoid
215
Gynecoid
Round at inlet Wide transverse diameter Wide suprapubic arch Head into the occiput anterior position Good for deliver
216
Android
Males and 30% females Wides transverse diameter closer to scrum Prominent ischial spines Narrow pubic arch Fetal head to occiput posterior position Arrest of descent common Bar prognosis for delivery
217
Anthropoid
Ape pelvis 20% Larger AP then transverse Creasy long narrow oval with narrow pubic arch Fetal head anterioposterior diameter Usually in OP position Good delivery
218
Platypelloid
Flat gynecoid pelvis 3% of females Short AP and wide transverse diameter Wide bispinous diameter Wide suprapubic arch Fetal head has to engage in transverse diameter Poor prognosis for delivery
219
Diagonal conjugate
Inferior pubic symphysis to sacral promontory | >11.5 ok
220
Obstetric conjugate
Diagonal-2 cm Narrowest fixed distance through which the fetal head must pass through during a vaginal delivery
221
What palpate
Sacral and iscial spine
222
Pelvic outlet
Measure ischial tuberosities and pubic arch
223
Iscial tuberosities distance between
8.5 cm distance ok
224
Infrapubic angle
Place thumb next to each inferior pubic ramus and estimate the angle at which they meet >90 good
225
Radiographically MRI CT
Rare only do if history or clincial indication of pelvic abnormalities or pelvic trauma
226
Initial evaluation
Review prenatal records, identify complications, confirm gestational age, review labs, history, PE
227
Focused history
Frequency contractions, loss fluid, vaginal bleeding
228
Fetal lie
Reference to maternal spine Longitudinal, transverse, oblique
229
Fetal presentation
Vertex, breech, transverse, or compound
230
Leopoldo maneuver
1. Palpate fundus 2. Palpate or spine and fetal small parts 3. Palpate what is presenting in the pelvis with suprapubic palpation 4. Palpate for cephalic prominence
231
Dilation
Check at internal os
232
Effacement
Thinning cervix occurs and is reported as % change in length Normal 3-5 cm Thick 100% effaced
233
Station
Degree of descent of the presenting part of fetus Measured in cm from presenting part to ischial spines When the bony portion of the head reaches the level of the ischial spines the station is zero -5 to 5 cm
234
First stage labor
Onset labor to complete cervical dilation Latent and active
235
Second stage
Complete cervical dilation to delivery
236
Third stage
Delivery of infant to delivery of placenta
237
Fourth stage
Delivery of placenta to stabilization of patient
238
Phases of first stage
Latent active
239
Latent
Onset of labor and slow cervical dilation
240
Active
Faster rate of dilation and usually begins when cervix is dilated to 4 cm Admit for labor
241
Duration 1st stage primiparas and multiparas
6-18 hrs 2-10 hours
242
Rate cervical dilation primiparas and multiparas
1.5 cm per hour
243
When may patient ambulated
Head engaged and reassuring monitoring is noted I in bed be left lateral recumbent
244
Fluids
IV to hydrate give meds if need
245
Labs
Cbc and t ands
246
Maternal monitoring
Vitals q 1-2 hours
247
External fetal monitoring
Continuous Intermittent if uncomplicated or complicated differs
248
Monitor uncomplicated
Q 30 min in active phase of first stage Q 15 min in second stage of labor
249
Monitoring if complicated
Q15 min in active phase Q15 min during the second stage
250
How get most accurate tracing
Internal monitoring
251
How get uterine activity
External tocodynamometer Internal pressure catheter Can get strength of contractions and help xyytocin augmentation
252
Vaginal exam
Active phase q2 hrs record dilation, effacement, station
253
Amniotomy
Augment labor, allows assessment of meconium status Risk cord prolapse, prolonged rupture is associated with chorioamnionitis
254
Second stage
Descent of the presenting part through the maternal pelvis and culminates in delivery Increase in bloody show and desire to bear down with contractions
255
Duration second stage
Primiparas without epidural 2 hours With 3 hours Multiparas without epidural 1 hour Multiparas 2 hours
256
Engagement
Presenting part at zero station
257
Descent
Brought about by the force of uterine contractions and maternal valsava efforts
258
Flexion
OA baby’s chin to chest thus changing the presenting part from occipitofrontl to the smaller suboccipitobregmativ
259
Internal rotation
At ischial spines Fetal head enters pelvis int ransverse diameter, rotates so the occiput turns anteriorly or posteriorly toward the pubic symphysis
260
Extension
Crowning occurs when the largest diameter of the fetal head is encircled by the vaginal introitus +5 Head is born by rapid extension
261
External rotation
Delivered head now returns to its original positiona t the time fo engagement to align itself with the fetal back and shoulders
262
Expulsion
Anterior shoulder then delivers under the pubic symphysis, followed by the posterior shoulder and the remainder of the body
263
Maternal position second stage
Avoid supine Dorsal lithotomy
264
Bearing down second stage
With each contraction, the mother should hold her breath and bear down with expulsion efforts
265
2nd stage fetal monitoring
Continuous Q15 with no risk factors Q5 minutes during seconds tage with risk
266
Vaginal exam 2nd stage
Access descent and confirm position
267
Delivery head
2 nurses and physician Antiseptic soap vulva Episiotomy Facilitate with modified rotten maneuver Head out bulb suction oral cavity and use index finger to assess nuchal cord -if loose can manually reduce over the infants head if tight clamp and cut
268
How deliver shoulder
Anterior shoulder with gentle downward traction on fetal head Posterior shoulder by elevating the head Support head, bulb suction, dry and stimulate
269
Cord
Clamp x2 and cut | Obtain cord blood specimen
270
Deliver placenta
Third stage then inspec and repair
271
Indications episiotomy
Likelihood of spontaneous laceration seems high To expedite delivery by enlarging the vaginal outlet
272
Midline episiotomy
Common Risk of extension 3rd or 4th degree Less postpartum pain
273
Meidolateral episotomy
Greater blood loss More difficult to repair More postpartum pain Increase risk of dyspareunia
274
Rotten maneuver
Fingers of the right hand are used to extend the head while counterpressure is applied to the occiput by the left hand to allow for a more controlled delivery Or just support perineum
275
FIRST DEGREE LACERATION
SUPERFICIAL LACERATION INVOLVING THE VAGINAL MUCOSA AND OR PERINEAL SKIN
276
SECOND DEGREE
LACERATION EXTENDING INTO THE MSUCLES OF THE PERINEAL BODY BUT DOES NOT INVOLVE THE ANAL SPHINCTER
277
THIRD DEGREE
LACERATION EXTENDS INTO OR COMPLETELY through the anal sphincter but not into the rectal UC osa
278
Fourth degree
Involves the rectal mucosa
279
Third stage
Interval between delivery of the infant and delivery of placenta
280
Retained placenta
Placenta not delivered in 30 minutes
281
Signs placental separation
Gush of blood from vagina Lengthening of umbilical cord Fundus of uterus rises up Change in shape of the uterine fundus from discoid to globular
282
What do
Apply counter pessure between symphysis and fundus Do not pull cord until classic signs noted
283
Inappropriate pulling cord
Uterine inversion
284
Fourth stage
Monitor patient Vitals Uterine fundal checks and assess for vaginal bleeding Postpartum hemorrhage commonl occurs during this time -uterine stony, retained placenta, unprepared vaginal or cervical laceration
285
Cervical ripening
Do before labor
286
Augmentation
Artificial stimulation of labor which already began Vs induction of labor
287
Indication induction
Abruptio placenta, chorioamnionitis, fetal demise, preeclampsia, eclampsia, gestational HTN, prom, postterm pregnancy, maternal medical conditions, fetal compromise
288
Contraindications induction
``` Unstable fetal Acute fetal distress Placenta previa or vasa previa Previous classical c section or transfundal uterin surgery HIV high viral load, active herpes ```
289
Bishop score
Cervical dilation, cervical effacement, station, cervical consistency cervical position
290
Biochip<6
Unfavorable
291
Bishop>8
Probability of vaginal delivery after labor induction is similar to that of spontaneous labor
292
Cervical dinoprostone
E2 vaginal insert Not in previous c section
293
Misoprostol cytotoxicity
E1 Oral or vaginal Can’t be removed Not in previous c section
294
Mechanical dilators
Foley bulb catheter Laminara japonicum
295
Pitocin infusion
Synthetic oxytocin stimulate contraction IV Induction and augmentation In normal saline IV and stopped if fetal distress 1-30 mu/min
296
Uterine tachysystole
More than 5 contractions in 10 min | Side effect
297
Antidiuretic effect
Pitocin ADH has effect can lead to increase water reabsorption -convulsion and coma
298
Uterine muscle fatigue
Prolonged pitocin increase risk | -post partum hemorrhage secondary to uterine stony
299
Obstetric anesthesia
Pain relied sage for baby
300
Maternal mortality due to anesthesia
1:500000
301
Uterine blood flow
Blood flow to uterus may decrease To uterus with anesthesia from hypotension Need adequate hydration
302
What do if hypotension anesthesia
Vasopressor
303
Pain uterine contractions
Visceral pain t10-t12 through l1
304
Perineum pain
Somatic s2-4
305
Regional anesthesia
Low of pain below t10 Epidural, spinal
306
Local
Perineum, pudendal block
307
Early labor anesthesia
Morphine, fentanyl, meperidine nalbuphine Not for labor pain women work bc moa is sedation Opoids cross placenta
308
Regional
T8-t10 and below Local anesthesia and narcotic
309
Epidural
Most effective catheter in epidural space l2-l3 , l3-l4, l4-L5 then placed over needle
310
Spinal
Single shot analgesia which provide excellen pain relief for limited procedures Limited use in labor since a single shot
311
Regional ae
Hypotension , spinal HA, fever, spinal hematoma, abscess
312
Contraindications regional
Coagulopathy, heparin within 12 horus, bacteremia, ICP, skin infection
313
Local
1-2% lidocaine for 20-40 min Before episiotomy or laceration repair
314
AE local
Hypotension, seizures, cardiac arrhythmias
315
Pudendal ae
Intravascular injection, hematoma infection
316
General
Propofol Loss of consciousness need airway management 16 fold increase maternal mortality
317
All inhaled anesthetics
Cross placenta and associated with neonatal respiratory depression
318
When do general
Emergent cases | Regional anesthesia
319
Fetal heart rate monitoring
To look for for patterns that may be frequently associated with delivery of infant with poor outcomes
320
For benefit
No increase operative deliveries and c section no change in neuro damage
321
Who do for
Reassurance Would have to get nurse Still goor warning of potential problems
322
External monitoring vs internal
Internal Rome accurate
323
External
Doppler US< pressure sensiiive tacodynanmometer
324
Doppler US
On maternal abdomen overlying fetal heart Records reflected sound waves fromt he fetal heart back to transducer
325
Pressure sensitive tocosynanmometer transducer
Detects and records contractions Useful for measuring the frequency of contractions but not the strength
326
Internal
Fetal scalp electrode Intrauterine pressure catheter
327
Fetal scalp electrode
R wave peaks of the fetal echocardiogram Maternal and fetal movement will not alter the quality of signal Rare cases of fetal pustules Not for HIV
328
Intrauterine pressure catheter
Soft plastic catheter placed transcervically Gives precsise measurement of the intensity of uterine contractions in millimeters of mercury
329
What does internal require
Membranes to be ruptured
330
Fetal oxygen reserve is only enough to meet its metabolic needs for ___
1-2 min
331
When is blood flow from maternal circulation stopped
Every contraction Can tolerate without hypoxia bc adequate oxygen exchange occurs still between contractions
332
A fetus who is marginal
Can’t tolerate stress of contractions and will become hypoxic
333
Hypoxia in fetus
Chemoreceptors and baroreceptors in the peripheral arterial circulation of the fetus influence the FHR by giving rise in contraction related or periodic FHR changes Anaerobic metabolism, Peruvian and lactic acid and fetal acidosis
334
PH fetal scal normal and acidosis
7.25-7.3 | <7.2
335
How do uterine contractions effect HR
Blood flow ceases Increase or decrease Decrease
336
Normal uterine activity
5 contractions or less in 10 minutes over 30 minutes
337
Tachysystole
>5 in 10 min over 30 min Presence or absence FHR decelerations
338
How measure contractions
Peak to peak
339
Normal contractions
3 in 8 minutes | Occurring 2-3 mintues
340
MVU
>200 Montevideo units (sum of the contractions in a 10 minute period) for at least 2 hours
341
Baseline FHR
Increments of 5 bpm during 10 minute Assess between contractions
342
Normal
110-160 bpm
343
Tachycardia
Baseline>160 bpm
344
Bradycardia
<110 bpm
345
Tachycardia
>160
346
Bradycardia
<110
347
Causes tachycardia
``` Fetal hypoxia Meds-oxytocin Arrhythmias Prematurity Maternal fever Fetal infection-chorioamnionitis most common cause1 ```
348
Bradycardia
Fetal hypoxia, obstetric anesthesia, pitocin, maternal hypotension, prolapsed or prolonged compression of the umbilical cord, heart block
349
Chemoreceptors tachycardia
In response to hypoxia
350
Baroreceptors
Vagus in response to changes in fetal bp
351
Absent
Amplitude undetected
352
Minimal
<5 bpm
353
Moderate
6-25 bpm
354
Marked
Amplitude>25 bpm
355
Decreased variability
Indicators of fetal stress Persistent late decelerations Hypoxia and acidemia -lack of oxygen and the build up acid in the fetus depresses the fetal heart rate and cns
356
Decreased variability
Prematurity, sleep, maternal fever, fetal tachycardia, fetal congenital anomalies, maternal hyperthyroidism, drugs
357
Accelerations
Abrupt increase in the FhR and is a normal reassuring response >32 weeks HE>15 bpm above baseline for 15 sec or more <32 weeks HR>10 bpm above baseline for 10 sec or more
358
Prolonged acceleration
>2 min
359
Change in baseline
If acceleration lasts >10 min
360
Cause accelerations
Spontaneous fetal movement | Vaginal exam
361
Deceleratiosn
FHR decreases in response to uterine contractions Early, variable, late
362
Early deccelerations
Head compression-fetal autonomic response to increased ICP caused by transient compression of the fetal head Not associated with fetal distress The nadir of the deceleration occurs at the same time as the peak fo the contraction and thi s. Amirror image
363
Cause early deceleration
Pressure on fetal skull increase ICP->decrease cerebral blood flow->activates central vagus nerve-> produces decrase in HR->recovering occurring as pressure is relieved
364
Variable decelerations
Secondary to umbilical cord compression Abrupt decrease in FHR-can occur before, during or after contraction starts Decrease in FHR >15 bpm lasting >15 sec and <2 min in duration Onset depth and duration an vary with successive uterine contractions
365
Variable decelerations abuse
Cord compression
366
Slight cord compression
Obstruct umbilical vein which returns re oxygenated blood to fetal heart
367
Response to cord comrpession
Increase in fhr to compensate for lack of blood return and the slowly diminishing oxygen supplies -
368
Shoulder
Slight fhr decrase followed by major drop
369
Late decelerations
Uterine placental insuffiency Most ominous deceleration-repetitive late decelerations usually indicate fetal metabolis acidosis and low arterial pH Nadir of the deceleration occcurs after the pea of contraction
370
Cause late deceleration
Excessiveuterine activity | Maternal supne hypotension
371
Prolonged deceleration
Decrease in FHR from baseline that is >15 bpm >2 min but <10 min Disruption of oxygen transfer from the environment to the fetus at one or more points along the oxygen pathways Maternal pushing
372
Change in baseline prolonged decelaeration
>10 min
373
Sinusoidal pattern
Smooth sine wave like undulating pattern in fhr Fetal anemia
374
Category 1
Baseline 110-160 bpm Moderate variability no late or variable decelerations May have acccelerations and early decelerations
375
Tracing category 1
Normal
376
Manage category 1
Intermittent CEFM
377
Category II
Intermittent: variable decelerations <50% of contractions Recurrent variable decelerations >50% of contractions
378
Category II intermittent
Normal outcome
379
Category II recurrent variable
Umbilical cord compression with acidemia impending Moderate variability and or accelerations suggest fetus is not acidemia
380
Manage intermittent category II
No intervention required
381
Treat recurrent category II
Alleviate cord comrpession repositioning amnoiinfusion Modify pushing efforts push with every other ctx
382
Amnioinfusion
Instillation of normal saline can alleviate cord compression 250-1000 cc infused 15 cc/min Continuous infusion of 100-200 cc/hour
383
How infuse amnioinfusion
Transcervical IUPC
384
Category iI
Minimal or absent variability Recurrent late decelerations Prolonged decelerations Tachycardia, bradycardia Variable late or prolonged decelerations occurring with maternal pushing efforts
385
Etiology category II
Fetal sleep, meds, acidemia, UPI:hypotension, tachysystole, maternal hypoxia Rapid fetal descent , cord comrpession, tachysystole Prematurity , chorioamnionitis, epidural , cord prolapse, cord comrpession UPI
386
Manage categor II
Promote fetal oxygenation | Decrease oxytocin
387
Tachysystole category II
Spontaneous labor, induction or augmentation
388
Goals tachysystole
Reduce uterine activity Lateral positioning, IV bolus, decrease oxytocin, tocolytic (tertbutaline)
389
Absent baseline variability(recurrent late decelerations, recurrent variable decelerations, bradycardia0 Sinusoidal pattern
Increased risk of fetal acidemia Increased risk of hypoxemia and acidemia
390
Manage
Prepare for delivery Fetal scalp stimulation
391
Fetal scalp stimulation
Poke it with finder | If an acceleration of 15 bpm lasting 15 seconds occurs the fetal pH value almost always is 7.33 or greater
392
How fetal scalp stimulation show difference between fetal sleep from acidosis
When teal tracing shows reduced variability but no decelerations
393
Category III
How many minutes is standard of care to deliver this infant | Idk
394
Operative delivery with category II tracing
Get consent, get team, assess transit time and location for operative deliver, ensure IV access, review labs, assemble neonatal resuscitation personnel
395
Normal FHR good?
98% fetal wellbeing
396
Does electronic fetal monitoring result in reduction of cerebral palsy
False positive >99%
397
Abnormal patterns or non reassuring FHR can occur into e absence of fetal distress
False positive rate is 80%
398
Do most patient sithe nonreassuring FHR give birth to healthy infants
Yup
399
Watch end for reading
Please
400
Medical conditions in pregnancy
Ok
401
Geational DM
7% get glucose intolerance
402
Screen GDM when
24-48 weeks 50 gm on hour glucose challenge (>130-140 abnormal) May perform an earlier screen if risk
403
If abnormal 50 gm one hour oral gloat glucose challenge (>130-140)
Follow 3 hour 100 gm oral load glucose tolerance test | -fail three hour with 2 or more abnormal values
404
Risk factors for development of GDM
Obesity, history, family history DM, glucose intolerance
405
Maternal complications
Increase risk of gestational HTN Increase risk preeclampsia Greater risk of c delivery Increase risk Dm later in life
406
Fetal complication GDM
Macrosomia, neonatal hypoglycemia, hyperbilirubinemia, operate delivery, shoulder dystocia, birth trauma
407
Antepartum management
Diabetic teaching, blood glucose monitoring, fetal testing, US for fetal weight get c section is over 4500 gm
408
When can u wait for spontaneous labor or estimated due date
Testing, growth, glycemic control are good
409
Diet controlled
No treat
410
Medication control intrapartum
Hourly glucose monitoring Need between 80-120 Continuous fetal monitoring in labor
411
Increasing glycosylated hemoglobin levels HgBA1C in period of embryogenesis, sixfold increase risk of congenital anomalies
Birth defects
412
Maternal complications
Worsening nephropathy and retinopathy, increased risk of developing preeclampsia, greater risk of diabetic ketoacidosis
413
Fetal complications
Increase risk of spontaneous abortions, anatomic birth defects, fetal growth restriction and prematurity
414
White classification
Class a1 and a2
415
A1
Gestational diabetes, diet controlled
416
A2
Gestational diabetes; insulin or oral meds controlled
417
What want fasting glucose
Less than 95 mg/dl
418
Two hour postprandial
Less than 120
419
Exercise after meals
Half an hour
420
Antepartum maternal evaluation
Renal-24 hour urine collections every trimester Cardiac ekg Ophthalmic detailed eye exam in first trimester Glycemic control (dail finger stick blood glucose and hgba1c0
421
Fetal evaluation antepartum
Early dating US Detailed fetal anatomy US and echo Biochemical testing for congenital malformations in first trimester 11-13 weeks or quad screen at 16-21 weeks Fetal growth US every 2-4 weeks Fetal testing every weeks tarting 32 weeks
422
Postpartum management
Insulin requirements drop significantly after delivery of placenta Insulin dependent patients typically require about 2/3 of pregnancy dose of insulin GDM frequently do not need further treatment With GDM-need 2 hour glucose tolerance 6 to 12 weeks postpartum to look for preexisting disease
423
Hyperthyroidms
Similar to preg so hard to see symtpoms
424
Diagnose hyperthyroidism
T4 up and TSH down
425
Treat maternal hyperthyroidism
Radioactive iodine contraindicated PTU and methimazole in 2 or 3 (aplasia cutis in 1st) PTU-liver toxicity so only 1st
426
Fetal effects hyperthyroidism
Meds cross placenta and fetal hypothyroid an goiter an come Risk of prematurity, IUGR, preeclampsia and stillbirth
427
Thyroid storm trigger
Infection, labor, c secretion, noncompliance with medication
428
Symptoms thyroid storm
Hyperthermia, tachycardia, perspiration, high output cardiac failure,
429
Maternal mortality thyroid storm
25%
430
Treat thyroid storm
Beta blockers-propranolol Sodium iodide PTU Dexamththasone Replace fluid Bring t down
431
Hypothyroidism
Normal preg
432
Untreated hypothyroidism
Spontaneous abortion, preeclampsia, abruption, low birth weight infants, still birth, lower intelligence leees (cretinism)
433
Treat hypothyroidism
Levothyroxine Monitor tsh and free t3/t4
434
Neonatal thyrotoxicosis
Due to transplacental transfer of thyroid stimulating antibodies Transient Mortality 16%
435
Neonatal hypothyroidism
Defiency results in generalized development retardation causes -thyroid dysgenesis Inborn error of thyroid function Drug induced
436
Rheumatic heart disease
Mitral stenosis High risk of developing heart failure, subacute bacterial endocarditis and thromboembolic disease
437
Congenital heart disease
Atrial and ventricular septal defects, primary pulmonary htn, t of fallout, transposition of great vessels -if corrected in childhood no consequences
438
Primary pulmonary htn
Contraindications to pregnancy due to decompensation during pregnancy and a high mortality rate, epidural anesthesia is preferred and vaginal delivery ma be an option for these patients
439
Cardiac arrhythmias
Most frequently supraventricular tachycardia Benign A fib.flutter more worrisome for underlying cardiac disease
440
Postpartum cardiomyopathy
No underlying cardiac disease Develops typically within last weeks of pregnancy or within 6 months postpartum Women with preeclampsia, htn and poor nutrition
441
Mortality rate postpartum cardiomyopathy
10%
442
Prenatal manage cardiac disease
Co managed with cardiologist!!!!! | Ekg, echo, avoid na, left lateral position, no strenuous, prevent anemia, avoid infection, fetal echo
443
Delivery cardiac disease
Vaginalis unless obstetric indications Antibiotic prophylaxis for endocarditis in high risk patients Acute cardiac decompensation with congestive heart failure is managed as a medical emergency
444
Immune idiopathic thrombocytopenia
Immunoglobulins attach to maternal platelets
445
Treat immune idiopathic thrombocytopenia
``` Begun after platelets from to 50000 Prednisone IV immunoglobulin if severe Platelet transfusion Splectomy ```
446
Baby risk immune idiopathic thrombocytopenia
Neonatal thrombocytopenia can occur due to placental transfer of antiplatelet antibodies
447
SLE
1/3 improve 1/3 same , 1/3 worse
448
Treat sle flares
Prednisone
449
Fetal complications sle
Preterm delivery restrictions Still birth Miscarriage
450
10% risk for neonatal lupus passive transfer of anti ro.ssa or anti la/SBS
SLE
451
Antiphospholipid syndrome
Presence of lupus anticoagulatn and or anticardiolipin antibody Associated with arterial or venous thrombosis
452
Pregnancy complications antiphospholipid syndrome
Increase risk of miscarriage Risk for developing preeclampsia Fetal growth restriction
453
Treated during pregnancy with heparin/low olecular weight heparin and low dose asprin
If history of thrombosis-full anticoagulation
454
Acute renal failure
Due to rpeexisting renal disease or pregnancy induced
455
Three types acute renal failure
Pre renal renal post renal
456
Pre renal
Acute blood or fluid loss
457
Renal
Usually preexisting disease or hypercoagulable state
458
Post renal
Rare, urologic obstructive lesions
459
What do if renal pro
Urine output, BUN:Cr, fractional excretion of Na, uring osmolality Cvs study-in labor need swan gang catheter Urologic-foley catheter, renal us to diagnose obstructive source
460
Treat pre renal
Retort volume Electrolytes, diuretic, flus restriction, hemodialysis
461
Post renal treat
Mechanics to remove the obstruction Left lateral position, urethral catheter, possible surgical intervention to remove stone
462
Chronic renal failure
Bad outcome | Cr>1.5-2 worsens prognosis
463
Treat chronic renal failrue
Monitor renal function with 24 hour urine collections for protein and cr clearance , manage htn, fetal surveillance with growth us and nonstress tests/biophysical profiles
464
Post renal transplant
Not recommended May lose graft function or experience rejection; best candidates are 1-2 years post transplant with stable cr and proteinuria without severe htn
465
Fetal complications post renal
Steroid induced adrenal and hepatic insuffiency, prematurity, intrauterine growth restriction
466
Asymptomatic bacteriuria
More likely to lead to cystitis and pyelonephritis in pregnant women From urinary stasis and glucosuria
467
Initial asymptomatic bacteriuria
Urine culture at initial prenatal visit
468
Most common Asymptomatic Bacteruria
E. coli
469
Treat asymptomatic bacteriuria
Antibiotic (3 or more if recurrent)
470
Pyelonephritis signs
Fever, costovertebral tender, malaise, WBC up
471
Issue pyelonephritis
Increase uterine activity and preterm labor Result in adult respiratory distress syndrome
472
Treat pyelonephritis
``` IV hydration Antibiotics Antipyretic Tocolytics Suppression remainder pregnancy ```
473
N/v in pred
8-12 weeks not known why
474
Treat n/v preg
Symptomatic
475
Hyperemeis gravidarum
Persistent nausea and vomiting >5% loss of pre preg weight, ketonuria, dehydration
476
Who get hyperemesis gravidarum
Occurs more frequently in first pregnancy, multiple pregnancies, trophblastic disease
477
Treatment hyperemesis gravidarum
Outpatient management fails then may need hospitalization for IV fluids, electrolytes, glucose, vitamins and Anti-emetic Severe-may need nasogastric feeding or parental nutrition
478
Gerd common how treat
Small meals, avoid lying down after meals, elevate head when sleeping, antacids, H2O blocs
479
Peptic ulcer
Preg may improve Diagnose symptoms, and only endoscopy if severe or signs of gi bleeding
480
Treat peptic ulcer
No caffeine, alchol tobacco, spicy foods Antacids, H2O blockers/proton pump Treat H pylori
481
Mendelsons syndrome
Acid aspiration syndrome Preg women get from delayed gastric emptying and icnreased intrabadominal intra gastris pressure
482
Treat mendelsons
Supplemental o2, maintain airway, treat for acute respiratory failure
483
Prevent mendelsons
Decrease acid ins tomach Do not feed in labor
484
Ibd
Fine in pred, IC more active If bowel disease active at time of conception may increase miscarriage
485
Treat ibd preg
Acute exacerbation is same as non preg
486
Intrahepatic cholestasis of pregnancy
Cholestasis and pruritis is second half ofpregnancy
487
ICP associated
Can recur with each pregnancy Association with oral contraceptives and multiple gestation Benign course for maternal consequences Increase risk of meconium strained amniotic fluid and fetal demise
488
Symptoms ICP
Itching without abdominal pain r rash Labs reveal elevated serum bile acids and occasionally elevated liver enzymes
489
Treat icp
Local treatment cold baths, bicarbonate washes Use ursodeocycholic acid Fetal surveillance and delivery at early term
490
Acute fatty liver of pregnancy
Scary! Diffuse fatty infiltration of liver resulting in hepatic failure 1 per 14000 pregnancies
491
Symptoms scute fatty liver
Ab pain, nv, jaundice , irritability, polydipsia/pseudodiabetes insipidus, HTN.proteinuria in 50% of cases
492
Lab finding acute fatty liver
Increase prothrombin time and partial thrombophlebitis time, elevated bilirubin, ammonia and uric acid and elevation of liver transaminase
493
Treat acute fatty liver
Termination pregnancy Supportive care-IV fluids with 10% glucose, FFP and cryoprecipitate
494
Maternal fetal mortality acute fatty liver
Yup both about 10-20%
495
If survive acute fatty liver
Full recovery
496
Anemia
Physiology decreas in hgb/hematocrit during pregnancy Hematocrit less than 30% or a HgB concentration less than 10 g/dL
497
Most common reason for iron defiency
Screened at initial prenatal visit and again 26-28 weeks Treat iron supplementation-oral or IV
498
Preg is hypercoagulably
5 fold increase in venous thrombosis and greatest risk is fist 5 weeks postpartum
499
Superficial thrombophlebitis
Most common in patients with varicose gains, obesity and little physical activity Most common in calf, will not result in pulmonary emboli
500
Symptoms hpercoagulable
Most common in patients with varicose veins, obesityand littlen physical activity Most common in calf, will not result in pulmonary emboli
501
Symptoms hypercoagulable state
Swelling, ternderness
502
Treat pregnancy hypercoagulable
Bed rest , pain medication, local heat, no need for anticoagulants, wear support hose
503
Dvt
1/2000 antepartum 1/700 antepartum
504
Symptoms dvt
More common in the left leg than the right Pain in the calf with dorsiflexion May also have dulla Che, tingling or pain with walking
505
Diagnose dvt
50% asymptomatic compression US with Doppler MRI suspect pelvic thrombosis
506
Treat dvt
Anticoagulation Low molecular weight or unfractioned heparin -PTT values with heparin and factor Xa values with lovenox Coumadin for 6 weeks postpartum nut not during preg
507
Pulmonary embolism
Maternal mortliaity -80% untreated treated 1% From dvt
508
Symptoms pulmonary embolism
Pleuritic chest pain, shortness of air, air hunger, palpitations, hemoptysis
509
Signs pulmonary embolism
Tachypnea, tachycardia, low grade fever, pleural friction rub, chest splinting, pulmonary rales, accentuated pulmonic valve second heart sound
510
Pulmonary embolism
Ekg, chest x ray, arterial blood gas, ventilation perfusion scan, helical computed tomography
511
Treat pulmonary embolism
Anticoagulation
512
Thrombophlebitis work up for dvt or pulmonary emboli
Lupus anticoagulatnts, anticardiolipin antibody, factor v Leiden, protein c and s, antithrombin III, prothrombin G20210A
513
All patients with history of thromboembolism need what
Prophylactic anticoagulant
514
Asthma
Most common pregn pulmonary disease! 1.3 better 1.3 same 1/2 worse
515
Severe asthma problem
Miscarriage, preeclampsia, intrauterine fetal demise, intrauterine fetal growth restriction, preterm delivery
516
Treat asthma
``` Mile-SABA Mild persistence-low dose inhaled CS Moderate persistent0saily inhaled corticosteroid combined with long acting inhaled beta agonist Severe persistent-add systemic CS Maternal monitoring ```
517
Fetal monitoring asthma
Serial growth US, NST.biophyscial profiles, deliver for fetal growth restriction or maternal deterioration
518
Labor and delivery asthma
Stress dose of IV steroids if using daily inhaled or high potency oral for more than 3 weeks
519
Tension HA
Most common Give acetaminophen
520
Migraines
Highes prevenalce in childbearing years Improve preg Neurology can be helpful
521
Multiple sclerosis
Diagnose at 30 Fewer and less severe pregnancy but may exacerbate post partum Increased risk LBW, C section
522
Seizure rate in preg
Not alter
523
Treat seizure
If seizure fre 2 years propr to conception may stop Monotherapy at lowest dose
524
Med for seizure
Alt eratogen
525
Valproate
Noooooooooooo
526
Most common preg ant seizure
Dilatin phenobarbital
527
What give women on anti epileptics
1-4 mg of folic acid
528
Anti epileptic complications preg
Preeclampsia, placental abruption, hyperemesis, premature labor, intrauterine fetal demise, congenital cleft lip and palate and cardiac anomalies
529
Depression
Arise and recur postpartum in 10%
530
Risk factors post partum depression
Personal or family history depression History of abuse Drug use History of personality disorder
531
Treat post partum depression and anxiety
Counseling Antidepressants -not 1st trimester and if 3rd may get neonatal withdrawal
532
Post partum depression
70-80% from hormonal fluctuations get maternal blues | 10-15 depression
533
Treat post partum
Counseling an medication
534
Risk post partum depression
Depression during pregnancy Younger women
535
Operative
Non spontaneous Vaginal forceps assisted, vacuum extracted /c section
536
Operative vaginal delivery
Direct traction with vacuum extractor or forceps
537
Maternal indications for operative vaginal
Maternal exhaustion/lack of expulsion effort Inability to have expulsive effort -spinal cord injuries, neuromuscular disorders Need to avoid maternal expulsive efforts-certain cardiac conditions, cerebrovascular disease
538
Fetal indications for operative vaginal delivery
Non reassuring fetal status (bradycardia, repetitive heart rate decelerations)
539
Other indications operative vaginal delivery
Prolonged second stage of labor Nulliparous>2 hours without regional anesthesia or>3 hours with regional anesthesia Multiparous >1 hour without regional anesthsia or> 2 hours with regional anesthesia
540
Prerequisites for maternal vaginal delivery
Adequate analgesia, lithotomy position, bladder empty, verbal or written consent
541
Fetal prerequisites for operative vaginal delivery
Vertex presentation, fetal head must be engaged (biparietal diameter at 0 station), position fothe fetal head must be known with certainty, station fo hte fetal head must be> 2
542
Ureteroplacentla criteria prerequisites for operative vaginal delivery
Cervix fully dilated, membranes ruptured, no placenta previa
543
Outlet operative vaginal delivery
Scalp visible without labia separation Fetal skull reached the pelvic floor Sagittal suture is in the anteroposterior diameter or right or left occiput anterior or posterior position Fetal AED at perineum Rotation not exceed 45 degrees
544
Low operative vaginal delivery
Leading potent of the fetal head is at +2 station or more and is not on the pelvic floor
545
Midpelvis and high forceps operative vaginal delivery
Fetal skill is above +2 Not ever indicated today
546
If you aren’t positive of position
Don’t do forceps
547
If they don’t articulations easily-reapply. If they still don’t articulate well
Don’t apply
548
Always
Make sure no vaginalis tissues or the cervic are caught in the forceps Blades should dit the fetal head evenly, should lie against the fetal head so that they cover the space between the orbits and ears
549
Traction is applied into e plane of least resistance and follows the pelvic cord-if not come early
Stop
550
Maternal complications forceps
Lacration of vagina/cervic, episiotomy extension, pelvic hematoma, urethral and bladder injuries, uterine rupture
551
Fetal complications forceps
Facial laceration, forcep marks, brachial plexus injur, skull fracture, intracranial hemorrhage, seizures
552
Vacuum
Indications requirements exactly same Advantage-little maternal analgesia
553
Contraindications vacuum
Gestational age less than 34 weeks Suspected fetal coagulation disorder Suspected fetal macrosomia Breech
554
How do vacuum assisted vaginal delivery
Applied to fetal head with a mechanical pump Steady traction No rocking or torque on the device No rocking or torque on the device Incidence of serious complication is about 5%
555
3 checks for forceps
No material tissue trapped int he cup, cup should be placed int he midline of the sagittal suture, the vacuum port of the suction cup should point toward hte occiput
556
What o with vacuum between contractions
Release suction
557
How many pop offs ok
No more than 2
558
How long can we vacuum
No mroe than 20 minutes
559
Can u turn or twist device
No
560
Complication vacuum vs forceps
More failures deliveries Fewer perineal injuries Icnreased incidence of delta cephalohematoma More scalp lacerations and bruising
561
C section
Delivery of a fetus through a surgical incision of the anterior uterine wall Rate is climbing
562
Fetal indication c sectio
Nnonreassuring fetal heart rate Reach presentation/transverse presentation Very low birth weight Active herpes Immune theomocytopenia purpura Congenital anomalies
563
Maternal fetal indications c section
Cephalopelvic disproportion Failure to progress Placental abruption Placenta previa
564
Maternal indications c section
Obstructive benign and malignant tumors Large vulvar condyloma Abdominal cervical cerclage Prior vaginal colporrhaphy Conjoined twins Maternal requires
565
Intraoperative complications c section
Uterine artery lacerations, bladder injuries, urethral injures, GI injury, uterine atony, placenta accretion, c hysterectomy
566
Post op complications c sectio
Nendoyometritis Wound-infection, separation, dehiscence Urinary complications, ileus diarrhea, thromboembolic disorders (pulmonary emboli/dvt), septic pelvic thrombophlebitis
567
Preterm labor
After 20 weeks before 37
568
Diagnose preterm labor
Uterine contractions with cervical change or cervical dilation of 2 cm and/or 80% effaced
569
Leading cause of infant mortality
Prematurity
570
Socioeconomic factors PTL
``` African Americans Decreased access prenatal care High stress Poor nutrition Genetics ```
571
Medical obstetric PTL risk
``` Previous History SAB Bleeding 1st trimester UTI/genital infections Multiple gestation Polyhydramnios, Incompetent cervix ```
572
Pathways to prevent PTL
Infection Placental-vascular Psychosocial Uterine stretch
573
Infection
Bacterial vaginosis Group B strep Gonorrhea, chlamydia
574
Treat infection
Antibiotics,
575
Link between infection and what that is a risk for preterm
Cervical length
576
Cervical length 3.5 cm or up RR 2.4 Cervical length 2.5 cm RR 6.2
Relative risk of PTL increases as cervical length decreases
577
How assess cervical length
US Fetal fibronectin (FFN)-released from the BM of the fetal membranes Released in response to disruption of the membranes as with uterine activity, cervical shortening or infection
578
Placental vascular pathway
Immunologic component Vascular component Low resistance connection of spiral arteries
579
Stress strain pathway
Mental and physical stress increase cortisol and catecholamines
580
Cortisol
From adrenal | Stimulates early placental CRH known to help in labor
581
Catecholamines
Affect blood flow an can cause uterine contractions
582
How treat stress strain
Nutrition and stress reduction
583
Risk factors for uterin stretch
Polyhydramnios | Multiple gestation
584
Symptoms PTL
Cramps, backache, pelvic pressure, increase in discharge/bloody discharge, uterine contractions
585
What do when present
Initial-cervical exam to see dilation, effacement and fetal presentation Look for correctable prob like infection External monitoring for uterine activity and fetal HR Oral or IV hydrate Reevaluate cervic in an hour Culture for groups strep and gonorrhea and chlamydia (once diagnosis CBC, urinalysis and urine culture) US
586
Hydrationa d bed rest
Works 1/5
587
I f 2 cm an or80 % effaced or made cervical change what do
Tocolysis Mg sulfate Nifedipine Prostagladin synthase inhibitors
588
Mg sulfate
Yes Competes with ca for entry into the cell at time of depolarization IV NEUROPROTECTIVE (cerebral palsy, ) If less Han 32 weeks
589
AE MG sulfate mom
``` Feeling of warmth and flushing NV Respiratory depression -seen with serum levels 12-15 Cardiac conduction ```
590
AE fetal mg sulfate
Loss of msucle tone, drowsiness, low APGARs
591
Nifedipine
Oral suppress preterm labor Minimal side effects Inhibits slow, inwar current of ca during the second phase of the action potential
592
Prostagladin synthetase inhibtiors
Inhibits prostagladin production that induce myometrial contractions Used on a short term basis Indomethacin-oral orrectal
593
AE indomethacin
Oligohydramnios, preterm closure of fetal ductus arteriosus and cause pulmonary HTN
594
Indomethacin fetal risk
Necrotizing enterocolitis and intracranial hemorrhage
595
NSADIS
Can decrease uterine activity Not for primary tratment When not meet diagnosis preterm labor or after discontinuing mg to decrease prostagladin procuction
596
When give glucocorticoids for fetal lung maturation
24-34 weeks gestation | Effects last 7 days
597
Pregnant women between 34 0/7 weeks and 36 6/7 weeks at risk preterm within 7 days and no antenatal corticosteroids
Single course of betamethasone
598
Vertex presentation PTL
Vaginal delivery preferred | -some recommended c section for very low birt weight
599
If breech presentation
Increased risk of cord prolapse of compression as well s head entrapment with vaginal delivery therefore most will c section
600
Prevent PTL
Progesterone IM Women with previous PTL/PPROM Smooth msucle relaxant is the thorny
601
Vaginal progesterone
Used in women with shortened cervix <2.5
602
Pessary Arabian pessary
Women with short cervix
603
PROM
Rupture before labor onset at any gestational age
604
Risk factor PROM
Vaginal/cervical infections Abdominal membranes Incompetent cervix Nutritional defiencies
605
Diagnose PROM
History! Loss of fluid and amniotic fluid in vagina
606
Why not check cervix of PROM presumed
Infection
607
How confirm rupture
Sterile speculum
608
3 tests to confirm PROM
Pooling Nitrazine paper Ferning
609
False positive nitrazine
Urine, semen, cervical mucous, blood, vaginitis
610
False negative nitrazine
Remote PROM with no remaining fluid | Minimal leak
611
Intact amniotic sac
Barrier to infection preventing chirioamniotitis
612
Maternal risk PPROM
Endomyometritis Sepsis Failed induction due to unfavorable cervix
613
PROM less than 24 weeks
Pulmonary hypoplasia and structural abnormalities from position
614
Amniotic fluid index less than 5
Oligohydramnios and no fluid is called anhydramnios
615
Conservative management PPROM
Continue preg until lung mature Assess lung maturity with vaginal poor of amniotic fluid Most deliver at 34 weeks
616
When do most PPROM deliver
34 weeks
617
Diagnose PROM
Maternal temp 100.4 Fetal maternal tachycardia Tender uterus Foul smelling amniotic fluid/purulent discharge
618
Antibiotic PPROM
IV ampicillin and erythromycin 48 hours | Amoxicillin and erythromycin and amoxicillin 5 days
619
Tocolytic PPROM
Sure
620
Steroids PPROM
Reduce risk RDS up to 34 weeks
621
When type I pneumocytes ok
24 weeks start making surfactant
622
How tel FLM
Phosphatidylinositol and phosphatidylglycerol from amniocentesis
623
L/S ration
Greater than 2 is mature Lecthicin increase rapidly after 35 weeks
624
What is phosphatidylglycerol is present
Mature lungs
625
Rapid test FLM
Lamellar body number density assessment 2 hours (6-12 for amniocentesis) More sensitive and predictive
626
IUGR
Below the 10% for a given gestational age
627
Causes IUGR
Maternal, placental, fetal
628
Maternal IUGR
``` Poor nutritional intake/maternal low body weight Smoking Drug abuse Alcoholism Cyanosis heart disease Pulmonary insuffiency Antiphospholipid syndrome Hereditary theomvophilias Collagen vascular disease ```
629
Placental IUGR
Insufficient substrate transfer through placenta as well defective trophoblast invasion
630
Conditions that may result in placental insuffiency
HTN, renal disease, placental or cord abnormalities such as velamentous cord, diabetes
631
Fetal IUGR
Inadequate substrate -TORCH Congenital anomalies, multiple gestations, chromosomal abnormalities
632
Diagnose IUGR
PE fundal height US biometry Amniocentesis, percutaneous umbilical blood sampling Doppler studies
633
Diagnose IUGR
Serial fundal measurement is primary screening tool
634
What do if fundal height lags more than 3 cm behind the gestational age then order an
US
635
US is routinely for high risk conditions that predispose to IUGR
HTN, renal disease, diabetes, drug abuse, antiphospholipid syndrome, lupus
636
Pre pregnancy IUGR prevent
Optimize disease processes
637
Antepartum manage IUGR
Decrease modifying factors-improve nutrition, sop smoking, bed rest Deliver before fetal compromise but after fetal lung maturity monitor: Non stress test twice weekly, biophysical profile, Doppler studies of umbilical artery
638
Nonstress test
Patient lateral tilt position, the fetal heart rate is monitored with an external transducer. The tracing is observed for fetal heart rate accelerations that peak at least 15 beats per minute above the baseline and last 15 seconds from baseline to baseline. It may be necessary to continue the tracing for 40 min
639
When omit nonstress test
All four US components normal
640
Fetal breathing movements
One or more episodes of rhythmis fetal breathing movements of 30 seconds or more within 30 mintues
641
Fetal movement
Three or more discrete body or limb movements within 30 minutes
642
Fetal tone
One or more episodes of extension of a fetal extremity with return to flexion or opening or closing of a hand
643
Amniotic fluid volume
A single vertical pocket of amniotic fluid exceeding 2 cm is considered evidence of adequate
644
Each 5 components given score
2
645
Composite score
8-10
646
6
Equivocal
647
4
Abnormal
648
Doppler study umbilical artery
Vascular impedance Umbilical flow velocity waveform of normally growing fetuses is characterized by high velocity diastolic flow, whereas with intrauterine growth restriction, there is a dimunition of umbilical artery diastolic flow
649
What do is suspect IUGR
US-if ok no intervention | US-abnormal intervene
650
US IUFR and greater than 38-39 weeks
Deliver
651
US IUFR less than 38-39 weeks
Antenatal testing normal-continue pregnancy | Antenatal testing abnormal -delivery
652
Antenatal testing normal
Continue preg
653
Antenatal testing not normal
Deliver
654
C secretion with IUGR
May benefit Will need continuous fetal monitor
655
After birth IUGR
Monitor neonatal blood glucose bc these neonates have less hepatic glycogen stores Monitor respiratory status as respiratory distress syndrome is more common
656
Prognosis IUGR
Greater risk DM, HTN, atherosclerosis as adults
657
Post term preg
Over 42 weeks 10% with a 2-3x high perinatal mortality
658
Postmaturity syndrome
Related to aging and infarction of the placenta Loss of subcutaneous fat, long fingernails, dry and peeling skin and abundant hair
659
Post term also at risk with what
Macrosomia, abnormal labor, shoulder dystocia and c section
660
Postterm pregnancy etiology
Unsure dates, fetal adrenal hypoplasia, anencephalic fetuses, placental sulfatase defiency, extra uterine pregnancy
661
41st week
Begin antenatal testing to include twice weekly NST and biophysical profile If testing abnormal or oligohydramnios induce labor (AFI lesss than 5 cm)
662
42 week
Induction of labor Induction of labor at 41 weeks preferred plan
663
IUFD
Intrauterine fetal demise Fetal death after 2 weeks but before onset of labor
664
Most causes IUFD
Unknown
665
Diagnose IUFD
Suspect if patient complains of absence of fetal movements or if unable to Doppler fetal tones Confirm by US with lack of fetal activity and absence of fetal cardiac activity
666
IUFD watchful expectancy
Only up till 28 weeks gestation, spontaneous labor will occur in 2-3 weeks of fetal demise
667
Manage IUFD
Most will require cervical ripeningwith prostagladin/laminaria/misoprostol/oxytocin
668
Manage IUFG monitoring of coagulopathy
Patients with IUFD are at risk of disseminated intravascular coagulopathy: need to follow complete blood count, fibrinogen level, PT/PTT/INR
669
Laminaria
Open up cervix
670
Follow up IUFD
Look for cause TORCH, parvovirus, listeria, anticardiolipin......
671
IUFD and future preg
Greater risk reoccurrence
672
HTN pregnancy
10%
673
Maternal risk HTN
MI, cardiac failure, cerebral vascular accident, renal failure, hepatic failure
674
Fetal complications HTN
Fetal growth restriction, preterm birth, placental abruption, stillbirth, neonatal dearth
675
Normal bp
<120/8-
676
Stage I
Systolic 130-129 or | Diastolic between 80-89
677
Stage 2
Systolic at least 140 or diastolic at least 90 mmHg
678
Chronic
Present before or during 1st half of preg
679
Gestational htn
After 20 weeks
680
Preeclampsia
Occurs after 20 weeks gestation and coexists with proteinuria
681
Eclampsia
New onset seizure activity associated with preeclampsia
682
Superimposed preeclampsia
Transposed onto chronic HTN
683
Evaluate chronic HTN
Rule out causes Look for maternal end organ damage -CBC, glucose, complete metabolic profile, 24 hour urine collection for total protein, EKG Assess fetal wellbeing -US, screening , growth US monthly after 28 weeks, antepartum fetal testing to begin 32-34 weeks gestation
684
Mild HTN (less than 160/110)
Initiate antihypertensive if reach threshold Visit every 2-4 weeks until 34-36 weeks and then weekly Antepartum fetal monitoring Deliver 39-40 weeks
685
Severe HTN (greater than 160/110)
Methyldopa, labetalol, nifedipine
686
When associated with renal disease
24 hr urine collection
687
Antepartum fetal surveillance
Growth US every 3-4 weeks | Nonstress tests and or biophysical profiles
688
Severe htn when deliver
38 weeks
689
HTN without preeclampsia
After 20 weeks gestation 48-72 hrs after delivery Resolves by 12 weeks
690
Diagnose preeclampsia
HTN, proteinuria, edema
691
Symptoms preeclampsia
Scoroma, blurred vision, epigastric and/or right upper quadrant pain, HA
692
Risk preeclampsia
``` <20 >35 Primigravid Multiple gestation DM Thyroid HTN chronic Collagen vascular disease Antiphospholipid syndrome Highest of it ```
693
Bran preeclampsia
Cerebral edema
694
Heart preeclampsia
Absence of normal intravascular volume expansion reduction in circulating blood volume
695
Lungs preeclampsia
Noncardiogenic pulmonary edema | -changes in colloid osmotic pressure, capillary endothelial integrity, and intravascular hydrostatic vessels
696
Liver preeclampsia
Sinusoidal fibrin depositio in periportal areas with surrounding hemorrhage and portal capillary thrombi Subscapularis hematoma-> liver rupture Stretching of glisson’s capsule results in right upper quadrant pain
697
Kidney preeclampsia
Swelling and enlargement of glomerular capillary endothelial cells Narrowing of capillary lumen
698
Eyes preeclampsia
Retinal vasospasm | Retinal edema
699
Mild preeclampsia
Proteinuria >300 mg/24 hr uring but less than 5 gm/24 hr or single specimen uring protein: cr ration of .3 mg/dL Asymptomatic
700
Severe preeclampsia
Proteinuria 5gm/24 hr or 3+ protein on two random urine dips at least 4 hours apart Oliguria from renal insuffiency Symptomatic-cerebral or visual, pulmonary edema, epigastric or right upper quadrant pain, elevated liver enzymes, thrombocytopenia
701
Oliguria
Renal insuffiency
702
What do if have preeclampsia
HISTORY of htn or renal disease Address HA, ab pain, n/vom vaginal bleeding, vision
703
PE finding preeclampsia
Brisk reflexes, clonus, edema
704
Lab finding preeclampsia
Increased hematocrit, LD, ALT AST, uric acid Thrombocytopenia (low paltelet0
705
Manage severe preeclampsia les than 37 weeks
Bed rest, 1 BPP or twice NST weekly antepartum testing Fetal growth US every 3-4 weeks Office visits and laboratory evaluation Possible hospitalization
706
Manage severe preeclampsia 37-40 weeks
If favorable cervix induction If unfavorable cervix use a cervical ripening agent to begin induction
707
Manage immediate severe features preeclampsia
Immediate hospitalization, delivery if greater than 34weeks Hydralazine, labetalol, nifedipine If less than 37 weeks administer corticosteroids and work towards delivery as long as patient and fetus are stable
708
Intrapartum management
Vaginal delivery Cervical ripening agents and pitocin as necessary Mg sulfate for seizure prophylaxis Pain management as with delivery useless thrombocytopenia then may not be able to receive an epidural
709
Mg sulfate
Loading dose for preeclampsia 4 gm Maintenance dose 2 gm/hr Therapeutic value 5-9 mg/dL
710
Why not give mg sulfate over 7-8 mg/dL
Loss patellar reflexes, respiratory paralysis, cardiac arrest
711
How revers mg sulfate
Calcium glucoronate
712
Fluid restriction with mg sulfate
Prevent overload
713
Eclampsia
1-3 per 1000 patients Most seizures 1-2 min and 24 hours before delivery
714
What do eclampsia
Protect airway is first
715
First line treatment eclampsia
Mg sulfate
716
Persistent aclampsia
Lorazepam
717
HELLP
Hemolysis, elevated liver , low platelets Severe preeclampsia patients and 50 % eclampsia
718
Symptoms HELLP
Right upper quad pain, epigastric pain, n/v , HTN, proteinuria
719
Prevent eclampsia
Asprin
720
Relaxation uterus
Increase cAMP
721
Contraction uterus
Increase intracellular Ca | Promote interaction of actin and myosin causing uterine contractions
722
Two segments of the uterus during labor
Upper segment-actively contracts and retracts to expel the fetus the lower segment-along with cervic becomes thinner and passive
723
Cervix change in labor
Soft pliable, dilateble structure -these structural changes from collagenous is, incrase in hyaluronic acid, decrease in dermatan sulfate which favors increased water content
724
Labor
Regular uterine contraction of sufficient intensity, frequency, and duration to bring about demonstratable effacement and dilation of the cervix
725
First stage of labor
Onset of contractions to full dilation of cervix
726
Second stage
Full dilation of cervix to delivery of the infant
727
Third stage
Delivery of the infant to delivery of placenta
728
Latent phase
Cervical softening and effacement occurs with minimal dilation
729
Active phase
Starts when cervix is dilated to 4 cm This phase of labor includes both cervical dilation and ultimately, descent of the presenting fetal part Acceleration phase Deceleration phase
730
Protraction of a phase of labor
Slower than normal
731
Arrest disorder of labor
Complete cessation of progress
732
An arrested latent phase
Labor has not begun
733
Dysfunctional labor
Rates of dilation and descent exceed times of normal labor
734
Normal limits of latent phase for nulliparous and multiparous
Up to 20 hrs Up to 14 hrs
735
Prolonged latent phase effect
Little
736
Etiology of prolonged latent phase
Without substantial cervical change Excessive use of sedatives or analgesics Fetal malposition
737
Manage abnormal latent phase
Rest | Morphine
738
Normal limits of fetal descent nulliparous and multiparous
Nulliparous 1 cm/hr | Multiparous 2 cm/hr
739
Protraction of fetal descent (active phase)
Less then what is expected
740
No change in descent has occurred in 1 hr
Arrest has occurred
741
Risk of perinatal mortality latent vs active phase
No increased risk
742
Etiology of active phase abnormalities
Inadequate uterine activity Cephalopelvc disportion Fetal malposition Anesthesia
743
Dystocia
Difficult labor/dysfunctional labor
744
Three P of active phase of labor
Power, passenger, passage
745
When not make a diagnosis of dystocia
Not be made before an adequate trial of labor has been tried
746
Augmentation
Refers to stimulation of uterine contraction when spontaneous contraction have failed to result in progressice cervical dilation or descent of the fetus
747
When consider augmenting
Contractions less than 3-10 minute period and or intensity is less then 25 mmHg
748
What give for protraction
Oxytocin After look at maternal pelvis, fetal position, station, maternal and fetal status
749
Intrauterine pressure catheter for assessing 3P of active phase
Soft plastic catheter placed transcervically Gives precise measurement of the intensity of the uterine contractions in mmHg
750
IUPC requires what
Membranes to be ruptured
751
Benefits. IUPC
Augment labor, allows assessment of meconium status
752
Risk IUPC
Cord prolapse, prolonged rupture is associated with chorioamnionitis
753
Minimal effective uterine activity
3 contractions in a 10 minutes period averaging 25 mmHg abover baseline
754
Montevideo units (MVU)
Calculated by measuring the peaks of contractions in mmHg in a 10 min period
755
>200 MVU
For at least2 hours
756
Before c section
Document adequate contractions at least for 4 hours
757
Pitocin
FDA approved medicine for labor stimulation
758
MOA pitocin
Stimulates uterine contractions | Increase intracellular Ca in
759
When is uterus most sensitive to pitocin
20-40 weeks
760
How long for pitocin to take effect
20-30 min
761
Cephalopelvic disproportion
Disparity between the size of the maternal pelvis and the fetal head that preculdes vaginalis delivery CPD causes a failure of descent and sometimes engagement of the head Nulliparous women who present in labor wth an unengaged head indicate an increased likelihood of CPD
762
Gynecoid and anthropoid pelvis have good prognosis for delivery
Pubis are how>90 Ischial tuberosity>8.5 Diagonal conjugate>11.5 Prominence of ischial spines
763
Presentation other than ___ are abnormal in labro
Vertex occiput anterior (OA
764
How get to OA
Fetal head enters and engage the maternal pelvis in occipitotransverse position then rotated to OA
765
What if no go to AO
Rotate to OP or stay OT
766
Macrosomia, shoulder dystocia, fetal anomalies
Also dystocia
767
Persistent OT
No rotate to OA Caused by CPD, android or platypelloid pelvis, relaxed pelvic flood (epidural
768
Transverse arrest of descent
Persistent OT position with arrest of descent for a period of 1 hr or more
769
Why arrest OT
Deflection positions the occipitofrontal diameter 11 cm becomes presenting diameter +1 +2 stations
770
Occipitofrontal
11 cm Head deflected Seen in OT and OP
771
Manage OT if pelvis adequate, infant not macrosomia and contractions are inadequate
Oxytocin | Rotation manuallly or keilland forceps
772
Manage OT if pelvis inadequate or infant macrosomia
C section
773
Persistent OP position
Most go to OA in labor OP labor usually normal if not may have prolonged second stage , more back discomfort
774
Manage OP
Prolonged labor in second stage Delivery of head often occurs spontaneously Or operative vaginal delivery -vacuum or forceps
775
Macrosomia
Over 4500 g | Account for 1.5% of births
776
Large for gestational age
Birth weight equal to or greater then 90% for a given gestational age
777
How diagnostic macrosomia
US imprescise
778
Hydrocephalus
May cause enlargement of the head that makes vaginal delivery impossible Usually see with US
779
Fetal ascites or enlargement of fetal organs (liver) can result in a dystocia secondary to enlarged fetal abdomen
Immune. Hydrops Rh isoimmunization is most common Nonimmune hydrops-caused by congenital infections, chromosomal abnormalities or fetal arrhythmias
780
Locked twins
Baby a breech, baby b vertex
781
3 p
Power passage passenger
782
LGA
Birth weight >90% for gestational age
783
Macrosomia
>4500 grams
784
Risk factors for macrosomia
Maternal diabetes, previous history, maternal pre preg obesity, weight gain, mulitparity, male fetus, >40 weeks, maternal birth weight, maternal height, maternal age <17 years , +50 g glucose screen with a negative 3 hr
785
Maternal morbidity with macrosomia
C section Post partum hemorrhage and significant vaginal lacerations
786
Fetal morbidity and mortality
Shoulder dystocia, fracture clavicle, damage to nerves of brachial plexus (c5, c6) resulting in era duschenne , brachial plexus injuries are rare and majority resolve without any permanent injury
787
Brachial plexus injuries and macrosomia
Increase 21x
788
Err duschenne
Upper arm palsy Most common brachial plexus injury C5 c6
789
Klumpke
Lower arm palsy | Damage c8-t1
790
Paralysis entire arm
All four nerve roots
791
>5000 grams non diabetic | >4500 grams diabetic
C section
792
Shoulder dystocia
Delivery that requires additional obstetric maneuvers following failure of gentle downward traction on the fetal head to effect delivery of the shoulders
793
Cause of shoulder dystocia
Impaction of the anterior fetal shoulder behind the maternal pubic symphysis or the impaction of the post shoulder on the sacral promontory
794
Turtle sign
Retraction of the delivered fetal head against the maternal perineum
795
Antepartum risk factors shoulder dystocia
``` Fetal macrosomia Maternal diabetes Obesity Post term gestation Short stature Previous history macrosomia Previous history of shoulder dystocia ```
796
During labor risk for shoulder dystocia
Labor induction Epidural analgesia Prolonged labor Operative vaginal deliveries
797
Neonatal risk shoulder dystocia
Erbs most common, klumpke, fractured clavicle or humerus, hypoxic, death
798
Mcroberts maneuver
Hyperflexion and abduction of the maternal hips
799
Suprapubic pressure
May dislodge the impacted anterior shoulder Do not apply fundal pressure
800
Zavanelli maneuver for shoulder dystocia
Cephalic replacement, last resort, poor prognosis significant risk of fetal morbidity and mortality
801
Rubin maneuver shoulder dystocia
Place pressure on an accessible shoulder to push it toward the anterior chest wall fo the fetus to decrease the bisacrominal diameter and free the impacted shoulder
802
Woods corkscrew maneuver
Apply pressure behind the posterior to rotate the infant and dislodge he anterior shoulder
803
Zavanelli maneuver
Last resort Fetal head manually returned to its prostitution position Slowly replaced int he vagina by steady upward pressure Delivery is by emergent c section
804
What do with shoudler dystocia
Obstetric emergency Call for help, team Can NOT be predicted or prevented and most accurate in absence of macrosomia
805
Predict shoulder dystonia
Can’t
806
Initial maneuver shoulder dystocia
Mcroberts and suprapubic
807
Dizygotic twins
Two separate ova are fertilized by two separate sperm Distinct pregnancies coexisting in same uterus Each have own amnion, chorion and placenta
808
Monozygotic twins
Arise from cleavage of a single fertilized ovum at various stages during embryogenesis Arrangement of fetal membranes and placentas will depend on the time at which hte embryo divides
809
Time of cleavage
``` Scab 0-3 dichorionic dimniotic 4-8 days monochorionic diamniotic 9-12 monochorionic, monoamniotic >13 days conjoined twins ```
810
Most monozygotic twins are what
Monochorionic diamniotic
811
Most serious
Monochorionic monoamniotic Not separating amnions Cord entanglement , mortality 50-80%
812
Craniopagus
Joined at the cranium
813
Thoracopagus
Joined chest wall most common
814
Ischiopagus
Joined at the coccyx and sacrum
815
Dizygotic twins influence
2x more likely after 35 Familyhistory Most spontaneous twins dizygotic
816
When suggest multiple gestations
HCG higher than normal Uterus palpated larger Pregnancy has occured after ovulation induction or in vitro fertilization Confirmwith US
817
Increased risk of what with monozygotic
``` Congenital anomalies Weight discordance Twin twin transfusion syndrome Neurologic sequelae Preterm delivery Fetal demise ```
818
Determination of zygomatic is the most important step after after diagnosing twins
Diagnosing
819
Dizygotic
Different fetal gender Visualization of a thick amnion chorion septum Peak or inverted V sign at the bae of the septum
820
Monozygotic
Dividing membrane is fairly thin
821
If US is not definitive in determining zygomatic
Inspect placenta after delivery DNA analysis
822
Conjoined twins
Cleavage occurs 13-15 days 1 in 70,000 deliveries (ratio of females to males is 3:10 Mortality rates 50% C section Advancement of imaging allows mapping of shared organs and more successful surgical separation procedures Elective termination if cardiac or cerebral fusion is identified
823
Interplacental vascular anastomoses
90% occur in monochorionic twins Most common type is arterial arterial followed by arterial-venous and then venous venous Vascular communications between the 2 fetuses through the placenta can cause several problems -abortion polyhydramnios, TTTS, fetal malformations
824
Twin twin transfusion
Results secondary to uncompensated arterial-venous anastomoses in a monochorionic placenta -which leads to a net transfer of blood flow going from one twin to the other
825
Fetal complications donor twin
Hypovolemia, hypotension, anemia, oligohydramnios, growth restriction
826
Recipient twin TSS
Hyperbole is, polyhydramnios rhomboids, HTN, polycythemia, edema, and cardiomegaly , congestive heart failure
827
Baby bad twin twin transfusion
Both twins are at risk of demise bc of heart failure
828
Diagnose TTTS
US
829
Donor twinUS
Smaller stuck appearance | Oligohydramnios
830
Recipient twin US
Larger Polyhydramnios Ascites
831
Treat TTTS
Serial amniocentesis with amniotic fluid reduction Laser photocoagulation of the anastomoses vessels on the placenta
832
Fetal malformations arterial to arterial anastomosesarterial blood flow fromt he donor twin enters the arterial circulation of hte recipient twin The reversed blood flow may cause thrombosis within critical organs or atresia due to trophoblastic embolization
Recipient twin being perfused in a reverse direction with poorly oxygenated blood fails to develop normally. It is known as acardiac twin (ACARDIAC)
833
ACARDIAC twin
Fully formed lower extremities | No anatomic structures cephalic of the abdomen
834
Umbilical cord abnormalities
Primarily associated with monochorionic twins Absence of umbilical artery Velamentous umbilical cord insertions occur more frequently
835
Absence of umbilical artery
Associated with renal agenesis
836
Retained dead fetus syndrome
Incidence of single fetal death in utero up to 5% If gestation is 20 weeks or greater retained dead fetus syndrome can develop - disseminated intravascular coagulopathy in the mother - check platelets and fibrinogen levels weekly
837
Vanishing twin syndrome
Vanishing twin syndrome if gestation is <12 weeks and dead fetus reabsorbed
838
Maternal polyhydramnios
Polyhydramnios anemia, HTN, preeclampsia, gestational diabetes, preterm labro, c section, postpartum hemorrhage, uterine atony
839
Fetal complications of multiple gestations
Prematurity, malpresentaiton, placental previa, placental abruption, PROM, umbilical cord prolapse, IUGR, congenital, incrase perinatal morbidity and mortality
840
Manage first and second trimester
2 week office visits | US cervical length assessments
841
Third trimester
Cervical length of less than 25 mm at 24-28 weeks doubled the risk for premature birth in twins Serial US to check for intrauterine growth q 4-6 weeks begin at 24 weeks. Looking for discordant fetal growth —defined by a 20% reduction in fetal weight of the smallest fetus compared with the largest Antepartum testing testing (NSTs or weekly BPPs) Often patients will be placed on bed rest
842
Monoamniotic twins should be delivered 32 weeks
Secondary to increase risk for lethal cord entanglement Hospitalization at 26 weeks, antenatal steroids, and fetal heart rate monitoring several times daily
843
Most twins deliver when
35-36 weeks
844
If no complications when deliver twins
38 weeks
845
What have before intrapartum management
Delivery room equipped for c section Large IV bore needle, blood products Capability to monitor fetal heart rates Anesthesiology US to determine precise presentations of the twins Two pediatricians/NICU personnel one for each Abby Nurses
846
Vertex vertex presentations
Presenting twin is designated twin a and secondtwin b After delivery 1st cord clamped and cut Vaginal exam to assess station of second -second twin is at increased risk of cor prolapse, placental abruption and malpresentation Careful attention to fetal monitoring is necessary After seen twin delivers obtain cord samples and deliver placenta Be prepared for hemorrhage
847
Vertex transverse and vertex breech are usually delivered by
C section
848
Breech breech and breech vertex twins are delivered
C section
849
High perinatal mortality in singletons
Secondary to prematurity and congenital anomalies RDS, intracranial hemorrhage Birth asphyxia-second twin 2 x the perinatal mortality then the first born twin and are 4x more likely then first to die from birth trauma complications
850
Stillbirths
2x more frequently then in singletones
851
Cerebral palsy
Most in twins
852
Size twins
Shorter and lighter until 4 years old
853
Triplets quadruples
ART,
854
Prematurity increases
As number of fetus grow
855
Deliver triplets
C section
856
Fetal malpresentation most common
Breech
857
Breech
Fetal butt or lower extremities presents into the maternal pelvis
858
Most common factor for breech
Prematurity
859
Diagnoseis breech
US, Leopoldo, pelvic exam
860
Frank
Most common presentation Thighs flexed Lower extremities are extended at knees
861
Complete breech
Thighs are flexed | Lower extremities are flexed
862
Incomplete breech
1 or both thighs are extended | 1 or both feet are below the bout
863
External cephalic versio
Applying pressure to moms abdomen to turn the fetus in either a forward or backward somersault to achieve a vertex presentation
864
Who gets ECV
36 weeks
865
Contraindication ECV
Placental previa Non reassuring fetal monitoring Oligohydramnios Previous uterine surgery that is contraindication for vaginal delivery
866
Where do ECV
Hospital equipped for c section
867
Prepare for ECV
``` NPO 7 hrs IV access Continuous monitor NST BPP Confirmbreech with US Consider tocolytics ```
868
Vaginal delivery breech
``` Frank or complete >37 weeks 2500-4000 grams Fetal head flexed Adequate maternal pelvis No maternal or fetal contraindications for vag Anesthesia ```
869
Standard care breech
All c section
870
Assisted breech vaginal delivery: two hands
NO aggressive traction can cause deflection of the fetal vertex and increase risk of head entrapment or nuchal arm entrapment
871
Assisted breech vaginal delivery: after spontaneous expulsion to scapula one hand
YES external rotation of each thigh combined with opposite rotation of the fetal pelvis restyles in flexion of the knee and delivery on the leg
872
Wrap towel around fetus for better traction
When scapula appears under the symphysis. | The operator reache over the left shoudler , sweeps the arm across the chest and delivers the arm
873
Delivery head breech
Gentle traction maintain cephalic flexion by applying pressure on fetal maxilla NOT fetal mandible
874
Forceps for breech
Piper forceps
875
Breech presentation delivery
C section preferred esp pre term | Don’t want fetal asphyxia
876
Outcomes breech
Perinatal mortality higher than forvertex fetuses | Lethal congenital anomalies, prematurity, birth trauma and asphyxia are common
877
Brown presentation
Presenting part of the fetus is between the facial orbits and anterior fontanelle - presenting diameter is the supraoccipitomental diameter - frontal bones are te point of designation
878
Brow presentation change before birth
Usually to a face presentation through extension or vertex presentation throug flexion
879
Persistent brow
Vaginal delivery impossible CSECTION
880
Persistent brow
C section
881
Brown supraoccipitoental diameter vs vertex
13. 5 | 9. 5
882
Face presntation
Fulle xtension of the fetal head and neck with occiput against upper back
883
Incidence face
1.500 Can be seen in frequently with fetal malformations -anencephaly is seenin 1/3 of face presentation
884
Fetal chin is chosen as point of definition for face
Most present mentum anterior and can deliver vaginally Can NOT deliver vaginally menum posterior presentation -will need to proceed with c section
885
Face trachelobregmatic diameter face vs vertex
12.6 cm | 9,5 cm
886
Face
C section
887
Compound presentations
Fetal extremity found prolapsed alongside the presenting fetal part (head) Premature
888
Compound presentation with failureto progress, cord prolapse, non reassuring fetal status
C section
889
Initial evaluation antepartum hemorrhage if bleeding profusely
Knowledgeable team for hemodynamically stability and correct cause 2 large bore IV Access vitals, bleeding, mental status
890
What history for antepartum hemorrhage
Known bleeding disorders, liver disease, anatomic abnormalities, and abnormal placentation
891
Labs for profuse post partum hemorrhage
CBC and coagulation profile Serial H and H Type and crosmatch
892
Type and crossmatch 4 units of blood
PRBC
893
When can you do a digital exam
Avoid until placenta previa has been ruled out by US
894
Sterile speculum exam
Genital lacerations or cervical lesions
895
Digital exam
Cervical dilation
896
How assess entire situation
US-placenta location, rsetnation of fetus | Amount of bleeding, maternal status, gestational age, continuous electronic fetal monitoring
897
Vaginal bleeding before 20 weeks cause
Abortion ectopic clot
898
Vaginal bleeding after 20 weeks upper genital tract
Placental abruption Placenta previa Uterine rupture Vasa previa
899
Vaginal bleeding lower genital tract
``` Bloody show labor Cervical polyps Infection Trauma Cancer vulvar varicosities Blood dyscrasia ```
900
Placenta previa
Implantation of placenta over cervical os | Most common placental prob
901
Presentation placenta previa
Painless vaginal bleeding
902
Risk factors placenta previa
Maternal age >35 Multiparity geation Cocaine smoking Prior previa, previous c section
903
Marginal placenta previa
Edge of the placenta extending to the margin of cervical os But does not cover the os
904
Partial placenta previa
Partial occlusion of the cervical os by the placenta
905
Complete placenta previa
Cervical os completely covered by the placenta Most serious type and is associated with greater blood loss
906
Classic presentation placenta previa
Painless bleeding at 30 weeks
907
How diagnose placenta previa
US
908
What do if have since 4-5% have is at 24 weeks
Repeat US at 30 weeks
909
Do msot placenta previa resolve
90% by 32-25 weeks by placental migration
910
Which previa least likely to resolve
Third trimester
911
Manage preterm preg with placenta previa
Fetal maturation is goal Manage in hospital and bed rest and if bleeding stops cn go home but 70% recur bleed
912
Placenta previa. 36-37 weeks
C section if fetal lung maturity
913
If unstoppable labor and placenta previa, fetal distress, or hemorrhage
C section immediately regardless of gestational age
914
How stabilize patient with placenta previa
Hospitalize, IV access 2 large bore needles if bleeding profuse H/H type and cross PT PTT fibrinogen RH neg-kleihauer-betke test, give rhogam if need
915
How prepare for catastrophic hemorrhage
Serial blood draws , NPO statins, type and cross 4 units
916
Placenta previa prepare for preterm delivery
Prior to 34 weeks give antenatal steroids (betamethasone) tocolysis can be used in stable
917
Placenta accretion
Abnormal firm attachment to the superficial lining of the myometrium Most common
918
Placenta incretins
Invades myometrium
919
Placenta percreta
Through the myometrium into the uterin serosa Least common
920
Previa without prior uterine surgery | Incidence of accreta is 4%
Ok
921
Risk factors
Previous c section C hysterectomy
922
Placenta abruption
Premature separation of the normally implanted placenta Most common third trimester bldeeding Painful bleeding, uterine tenderness, uterine hyperactivity, and fetal distress and/or death
923
Symptoms placenta abruption
Painful bleeding, uterine tenderness, uterine hyperactivity, fetal distress and /or death
924
Risk factors placental abruption
Maternal HTN* Cocain Blunt trauma Polyhydramnios and multiparity Previous abruption
925
Diagnose placenta abruption
Painful vaginal bleeding, uterine tenderness and uterine hyperactivity and fetal distress or death US can detect, but better for previa
926
Manage placenta abruption
Monitor fetal and maternal condition s
927
If both stable
Vaginal delivery—rapid delivery often ensues after abruption If remote from vaginal delivery with signs of fetal distress or uncontrolled bleeding proceed with c section
928
Abruption os mst common cause of DIC in pregnancy Results from the release of thrombophlebitis from the disrupted placenta and subplacental decidua causing consumptive coagulopathy DIC occurs in 20%
Ok
929
Stabilize placenta abruption patien
HostpiatIV access 2 large bore 16 guage if bleeding profusely H/H type and cross PT PTT fibrinogen, platelets RH neg consider kleihauer Bette test, give rhogam if indicated
930
Prepare for catastrophic hemorrhage
Serial blood draws NPO status Type and cross 4 units
931
Prepare for preterm delivery
Prior to 34 weeks give antenatal steroids | Tocolysis can be used to stabilize
932
Couvelaire uteris with placenta abruption
Extravasation of blood into the uterus | Causing red and purpl discoloration of the serosa
933
Uterine rupture
Complete separation of the uterine musculature through all layers
934
Cause uterine rupture
Spontaneous, traumatic ,associated ith previous uterine scar
935
Uterine rupture sequelae
Fetal mortality or permanent neurologic sequelae
936
Risk factors uterine rupture
Prior uterine incision Injudicious use of oxytocin Trauma External cehoali version Multiparity
937
Diagnose uterine rupture
Rupture associated with sudden onset of intense abdominal pain vaginal bleeding Abnormal fetal heart rate pattern of cessation of fetal heart tones Regression Fetal parts may be easily palpable on abdominal exam
938
Manage uterine rupture
Immediate laparotomy and delivery of fetus If feasible repair ruptured site If large rupture may have to do c section
939
Uterine rupture and future preg
C section Recurrence rate! Upper segment recurrent more common than lower though
940
Fetal bleeding in 3rd trimester causes
Rupture fetal vessel secondary to velamentous insertion of umbilical cord
941
Most common cause of third trimester bleeding
Rupture of fetal vessel
942
How does cord insert
At a distance away from the placenta and its vessels must transverse between the chorion and amnion without the protective Wharton’s jelly
943
Vasa previa
Unprotected vessels pass over the cervical os
944
Signs vessel rupture
Acute vaginal bleeding with a change in fetal heart rate .
945
What do if rupture
Diagnose rapidly and proceed to delivery
946
Define postpartum hemorrhage
>500 cc following vaginal birth | >1000 cc following a c section
947
Primary postpartum hemorrhage
In first 24 horus | Secondary to uterine atony
948
Secondary postpartum hemorrhages
24 hours to 12 weeks | Can occur with subinvolution of the uterus, sloughing of the Escher or retained products
949
Can core than half of all maternal deaths occur in_
24 hours
950
Leading cause of maternal death worldwide
Postpartum hemorrhage
951
Etiology primary postpartum hemorrhage
Uterine atony Retained placenta espicially accreta Defects in coagulation Uterine inversion
952
Secondary etiology
Subinvolution of placental site Retained products of conception Infection Inherited coagulation defects
953
Risk factors postpartum hemorrhages
``` Prolonged labor Augmented labor Precipitous laborhistory of postpartum hemorrhages Placental abruption Placental previa Vag delivery ```
954
Uterine atony post partum hemorrhages
Immediately preceding or after delivery of placenta Most PPH are due to it Excessive blood loss most commonly result when the uterus fails to contract after delivery of placenta. Palpation-boggy uterus
955
Risk factor uterine atony
Enlargement of the uterus Abnormal labor Conditions which interfere with contraction of the uterus -leiomyoma and mg sulfate
956
Effects hemostasis after separation of the placenta is dependent on what
The myometrium to comrpession the severed vessels(spiral arterioles and decidua veins)
957
Manage uterine atony
Bimanual massage uterus Oxytocin, methylergovinins, hemabate, dinoprostone, misoprostol Uterine packing or large volume balloon catheter Interventional radiology Surgical measure/hysterectomy
958
Bimanual massage
Confirms diagnosis Boggy! Massage of the uterine corpus can dismiss bleeding, expel blood clots and allow time for other measured to be implemented
959
Uterine packing
4 inch gauze layer back and forth from one course to other using sponge stick Large volume balloon
960
Interventional radiology
Patient has stable vitals and persistent bleeding may be a candidate for arterial embolization
961
Surgery
Is last resort, if patient desires future fertility may try to lighten uterine arteries If unstable proceed with total abdominal hysterectomy
962
Second most common cause of postpartum hemorrhage
Trauma during delivery
963
What do if genital tract trauma
Inspect for vaginal, perineal, periurethral and cervical lacerations Repair surgical
964
Retained placenta
Most of secondary PPH have it -bleeding is secondary to inability of uterus to maintain a contraction and involuted normally around the placental tissue
965
Risk factor retained placenta PPH
Previous c section, leiomyoma, prior d and c, and accessory placenta lobe
966
Treatment retained placenta
Manual removal if bleeding is profuse +/- uterine curettage with or without US guidance be careful not to perforate
967
Uterine inversion
Top of fundus descends into the vagina and sometimes through the cervix -if occurs before placenta is delivered DO NOT remove placenta until inversion is corrected
968
Iatrogenic uterine inversion
Improper management of third stage
969
Uterine inversionsymptom
Copiousbleeding and hypovolemia shock
970
Treat postpartum hemorrhroage
Anesthesiologist Manually replace the uterus Once replaced start oxytocin to cause the uterus to contract Rarely paratotomy
971
Amniotic fluid embolism
80% mortality rare | Caused by infusion of amniotic fluid into maternal circulation
972
Characterization amniotic fluid embolism
Respiratory distress, intense bronchospasm, cyanosis, cardiovascular collapse, hemorrhage, coma
973
Treat amniotic fluid embolism
Respiratory support, correct the hypovolemia shock and replace coagulation factors
974
Von williebrans
Inherited coagulopathy with prolonged bleeding times | Factor VIII defiency
975
Treat Von williebrand
Factor VIII concentrate or cryoprecipitate
976
Idiopathic thrombocytopenia
Platelets function abnormally and have a shortened life span Causes thrombocytopenia an tendency to bleed Circulating antiplatelet antibodies of igg type can occasionally cross placenta resulting in fetal and neonatal thrombocytopenia
977
Treat idiopathic thrombocytopenia
Require platelet concentration infusions
978
Puerperal sepsis
Following delivery women can develop a febrile morbidity
979
Febrile morbidity
Temps100.4 or higher that occurs for more than 2 consequetive days during first 10 postpartum das
980
Most fevers
Endometriosis
981
After delivery , the pH of the vagina becomes more alkaline
Neutralizing effects of amniotic fluid, blood, and decreased population of lactobacilli -
982
Alkaline pH after birth
Favors growth of aerobic organisms About 48 hours after delivery the endometrial and placental remnants produce a favorable intrauterine environment for the production of anaerobic bacteria
983
Most organisms that cause peurperal infection
Anaerobic organisms Cocci, (peprostrep, peptococcus, streptococcus) Mixed with abcteriodes fragilis Aerobic-e coli
984
Predisposing factors for puerperal sepsis
Poor nutrition and hygiene Anemia PROM Prolonged rupture of membranes Prolonged labor
985
Clinical features peurperal sepsis
Postpartum fever and increasing uterine tenderness on postpartum day 2 OT 3 are the key clinical findings -purulent lochia, child, malaise, anorexia
986
Diagnose peurperal sepsis
Careful history and physical | Extreapelvic causes of fever should be excluded
987
Treat peurperal sepsis
Antibiotic treatment Anaerobic coverage since more scommon Ampicillin and gentamicin Major pathogen resistant to this is bacteriodes fragilis, which is sensitive to clindamycin
988
Septic pelvic thrombophlebitis
Physiologic conditions for the pathogesis of thrombosis Endothelial damage, venous stasis, hypercoagulable state of preg
989
Ovarian vein thrombophlebitis
Fever and ab pain within 1 week after delivery or surgery
990
Clincial ovarian vein thrombophlebitis
Fever, abdominal pain, localized to the side of the affected vein
991
How see ovarian vein thrombophlebitis
Ovarian vein on radiography
992
Deep septic pelvic vein theombophlebitis
Unlocalized fever int he first few days that is non responsive to antibiotcs
993
Clincial deep septic pelvic vein theombophlebitis
So not appear CLINCIALLY ill
994
See deep septic pelvic vein theombophlebitis
No radiographically evidence of thrombosis | Diagnosis of exclusion
995
Treat septic pelvic theombophlebitis
Anticoagulation is though to prevent further thrombosis Unfractioned heparin or low molecular weight heparin Discontinue after resolution of fever x 48 hrs
996
If ovarian vein thrombosis is seen radiographicallytrat
Anticoagulatnts 6 weeks | Repeat imaging to evaluate for persistence