Endocrine Flashcards
(116 cards)
1
Q
What hormones does the thyroid gland produce
A
3 hormones → T3, T4, calcitonin
2
Q
What does calcitonin do
A
↓ serum calcium (ca+) by taking calcium OUT of the blood and pushing it back into the BONE
3
Q
What do you need to make hormones
A
Iodine (dietary iodine)
4
Q
What do the thyroid hormones do
A
Give US energy!
5
Q
What is hyperthyroidism
A
Too much energy (graves disease)
* too much thyroid hormone
6
Q
S&S of hyperthyroidism
A
- Nervous and irritable
- ↓ attention span
- ↑ appetite
- ↓ weight
- sweaty /hot
- exopthalamos (bulging eyes)
- fast GI
*↑BP and ↑ pulse - arrhythmia/palpitations
- thyroid size enlarges
7
Q
How is hyperthyroidism diagnosed
A
*↑ T4 level
* ↓ TSH
* thyroid scan
** client must D/C any iodine containing meds 1 WEEK PRIOR to thyroid scan
* ultrasound/MRI/CT
8
Q
How is hyperthyroidism treated
A
- Anti-thyroids: Methimazole (Tapazole), propylthiouracil (PTU)
- Iodine compounds: Potassium Iodine (SSKI & Lugols solution)
- Beta blockers - supportive therapy: Propanolol (Inderal)
- Radioactive iodine therapy (1 dose)
- Surgery
9
Q
What anti-arrhythmic drugcontains high levelsof iodine and may affect thyroid function
A
Amiodlarone (Cordarone)
10
Q
Anti-thyroid meds: Methimazole (Tapazole), Propylthiouracil (PTU)
A
- Stops the thyroid from making thyroid hormones
** used pre-op to STUN the thyroid (helps ↓ bleeding) - want client to become euthyroid (eu= normal)
11
Q
What do iodine compounds like potassium iodine (SSKI & Lugals solution) do
A
• ↓ the size and vascularity of the gland
** all endocrine glands are VERY VASCULAR
** give in milk or juice and use a straw (stain teeth)
12
Q
How do beta blockers (Propanolol (Inderal)) help hyperthyroidism
A
• ↓ myocardial contractility
• ↓ cardiac output possible
• ↓HR & BP
• ↓ anxiety
• ↓ cardiac output possible
13
Q
Who should NEVER be given a beta blocker
A
Asthmatics or diabetics
14
Q
Radioactive iodine therapy (1 dose):
A
• Given PO (liquid or tablet form)
** rule out pregnancy 1st
• destroys thyroid cells → may cause hypothyroidism
• follow radioactive precautions
** stay away from BABIES for 1 WEEK
**don’t KISS anyone for 1 WEEK
** watch for THYROID STORM (thyrotoxicosis & thyrotoxic crisis)
* possible rebound effect of post-radioactive iodine
15
Q
What is a thyroid storm (thyrotoxicosis and thyrotoxic crisis)
A
Hyperthyroidism x100
16
Q
Surgical treatment of hyperthyroidism →thyroïdectomy (partial/complete)
A
• assess for recurrent laryngeal nerve damage by listening for HOARSENESS
•Could lead to vocal cord PARALYSIS
** when there’s paralysis of BOTH vocal cords airway OBSTRUCTION WILL OCCUR which req. IMMEDIATE TRACH → trach set at bedside
• put personal items near client
• teach client how to support their neck
* raise HOB to ↓ edema
* nutrition (pre & post-op): ↑ calorie needs
17
Q
Thyroidectomy(partial/complete) post op priority
A
HEMORRHAGE → check for BLEEDING at INCISION site & BEHIND NECK
*** report feelings of PRESSURE
18
Q
Trash set at bedside:
A
- Swelling
- recurrent laryngeal nerve damage (vocal cord paralysis)
** hypocalcemia → assess for parathyroid removal
**s&s → NOT sedated
19
Q
Hypothyroidism:
A
Too little thyroid hormone/energy
20
Q
S&S of hypothyroidism
A
- No energy
- fatigue
- no expression
- speech slurred
- ↑ weight
- slow GI
- cold
- amenorrhea
• you may have a totally immobile client
21
Q
How is hypothyroidism diagnosed
A
↓ thyroxine (T4)
↑TSH
• opposite labs of thyroid
• blood test for TSH is most commonly used
22
Q
How is hypothyroidism treated
A
- Levothyroxine (Synthroid), Liothyronine (Cytomel)
- take on an EMPTY STOMACH
- people with hypothyroid tend to have coronary artery disease (CAD)
***** WORRY about MI (heart attack)
** must take meds for FOREVER/rest of their lives
*↑ energy when starting meds
23
Q
What is Hashimoto’s disease
A
*When the immune system attacks the thyroid
( diff than hypo. Bc hypo is underactive/inadequate production)
* inflammation of the thyroid caused a leak which a hormones (hyperthyroid) → over time inflammation stops from thyroid producing enough hormones (hypo.)
* disease usually results in ↓ hormones production (hypo.)
24
Q
Parathyroids secrete what….
A
Parathyroid hormone (PTH)
25
What does (PTH) parathyroid hormone do?
Makes you PULL calcium from the BONE and place it into the BLOOD
**** this ↑ serum calcium levels
26
Too much PTH=
Not enough PTH=
Too much =↑ serum calcium levels
Too little = ↓ serum calcium levels
27
PTH and Ca+ have a direct relationship
↑PTH = ↑ Ca
28
Parathyroid problems
1. Hyperparathyroidism = hypercalcemia=hypophosphatemia
2. Hypoparathyroidism = hypocalcemia = hyperphosphatemia
29
S&S of hyperparathyroidism (hypercalcemia=hypophosphatemia)
Too much PTH
• serum calcium is ↑, serum phosphorus is ↓
*** calcium and phosphorus have an INVERSE RELATIONSHIP
*** client will appear SEDATED (hypercalcemia)
30
How is hyperparathyroidism treated?
* Partial parathyroïdectomy → when 2 parathyroids are taken out
*** ↓PTH secretion
*** monitor for HYPOCALCEMIA & RIGID MUSCLES
31
S&S of hypoparathyroidism =hypocalcemia = hyperphosphatemia
* Not enough PTH
*↓ serum calcium & ↑serum phosphorus
***NOT SEDATED
32
How is hypoparathyroidism treated
*IV calcium
* phosphorus binding drugs
33
What are the adrenal glands for
Need them to be able to handle stress
34
2 parts of the adrenal glands
Adrenal medulla and adrenal cortex
35
What hormones does the adrenal medulla produce
Epi & Nor-epi
36
Adrenal medulla problem:
Pheochromocytoma→ benign tumors thatsecrete epi and nor epi(hormones) in bonuses
*** tend to be familial → screen the family
37
Pheochromocytoma S&S
*↑ BP
* ↑HR
* palpitations
* flushing/ extremely diaphoretic
*H/A
38
How is pheochromocytoma diagnosed
•Catecholamine levels: VMA (vanillymandelic acid test) or metanephrine (MN) test
*MN test is the most commonly used and is ALTERED BY CAFFEINE
*** foods that alter the VMA test → anything with vanilla in it, Vit. B, fruit juices & bananas
• a 24 hr urine specimen is done to screen for ↑levels of epi & nor-epi (AKA catecholamines)
*THROW away 1st void
**KEEP the LAST void
• any activities that ↑ epi & nor-epi should be avoided (no stress)
39
Pheochromocytoma treatment
Surgery to remove tumors
40
What should you AVOID doing in a client with pheochromocytoma
Palpating the abdomen → causes a sudden release of catecholamines & severe HTN
41
What hormones does the adrenal cortex produce
Glucocorticoids, mineralocorticoids and sex hormones
42
Adrenal cortex
Even though the body secrets steroids normally the adverse effects are more pronounced when the client is receiving oral or IV steroids
43
Glucocorticoids
* Change your mood → depressed, psychotic, euphoric, insomnia
* alters defense mechanisms →immunosurpressed →high infection risk
* help BREAKDOWN FATS&PROTEIN
****INHIBITS INSULIN →HYPERGLYCEMIC (monitor glucose)
** helps regulate glucose metabolism
44
Mineralcorticoids (aldosterone)
* Makes you RETAIN sodium (Na+) & water
* makes you LOSE potassium (K+)
45
Sex hormones
testosterone, estrogen and progesterone
46
Hirsutism, acne, irregular periods are caused by....
Too many sex hormones
47
Decreased axillary/pubic hair, ↓ libido
Not enough sex hormones
48
Adrenocorticotropin hormones (ACTH)
***Stimulate CORTISOL production
* cortisol is a hormone of adrenal cortex
* ↑ACTH = ↑ cortisol levels
*** too many steroids = hypercorticolism (same words )
49
Where are adrenocorticotropin hormones (ACTH) made
***Made in the PITUITARY
50
What is hypercortisolism
Same thing as too many steroids
51
Problems with the adrenal cortex
1. Not enough steroids
2. Shock
3. Hyperkalemia (high potassium)
4. hypoglycemia
52
What is Addison disease aka
Adrenocortical insuffiency - not enough steroids
53
Addison disease patho:
Not enough glucocorticoids,mineral corticoids or sex hormones
54
S&S of Addison’s disease
* Extreme fatigue
* N/V
* diarrhea
* hypotension (low bp)
* anorexia/weight loss
* confusion
* vitiligo → white patchy area of depigmented skin
* hyperpigmentation - bronzing color of skin
* ↓ sodium (Na+);↑potassium (K+) and hypoglycemia
55
Treatment of Addison’s disease
* Combat shock (losing sodium and water)
* ↑ sodium in diet
* processed fruit juice/broths ( ↑ in sodium)
*I&O and daily weights
* if losing sodium and water the BP WILL ↓ (less vol. Less pressure)
* losing weight
* fluid vol. Deficit
56
What meds are given to treat addiSon's disease
•Corticosteroids → given 2x/day in split doses
*** take 2/3 dose in morning; 1/3 dose at night
• fludrocortisone acetate → synthetic aldosterone
• prednisone (Winpred), hydrocortisone (Cortef), cortisone →all corticosteroids
57
Med precautions for addiSon's disease
* Daily weights and blood pressure MUST be monitored
** keep weight within 2-3 lbs (1-2kgs) (+ or -)normal weight
***REPORT weight gain >5lbs/week(2kgs)***
***MONITOR for blood pressure changes***
58
Severe hypotension and vascular collapse = _____________
Addisonian crisis
59
What can cause an addisonian crisis
Infections, emotional stress, physical exertion or stopping steroids abruptly
60
What causes cushings disease
Too many steroids (gluco corticoids, sex hormones, mineral corticoids)
61
Signs and symptoms of too many glucocorticoids
• Growth arrest
• thin extremities/skin (lipolysis
• ↑ risk of infection
• hyperglycemia
• psychosis to depression
• moon faced (fat redistribution;lipogenesis)
• buffalo hump (fat redistribution)
62
Too many sex hormones causes what:
* Oily skin/acne
* women with male traits (facial hair, deep voice, etc.)
63
Too many mineralcorticoids cause what?
* High BP
* chronic heart failure (CHF)
* weight gain
* fluid volume excess (FVE)
*** too many mineralcorticoids (aldosterone) makes serum potassium (K+) ↓
64
If you did a 24hr urine screen on A client with suspected Cushings what would come back
↑ cortisol levels
65
Urine screen for long term term steroids
* Glucose and ketones altered
66
Cushings treatment
* Adrenalectomy (removal of one or both adrenal glands)(unilateral or bilateral)
*** bilateral= life time replacement
*QUIET environment
* avoid infection
* pre-treatment diet: ↑ potassium (K+) ↑ protein ↑ calcium (Ca+); ↓ sodium (Na+)
***STEROIDS ↓ serum calcium (Ca+) by excreting through GI tract
**AVOID exposure to infections
67
Two types of diabetes
1. Type l→ insulin DEPENDENT →auto-immune response or idiopathic causing beta cell destruction →clients have LITTLE TO NO INSULIN
2. Type 2 →insulin RESISTANT →clients don't have enough insulin or good insulin
68
What type of diabetes is usually found by accident
Type 2
69
What type of diabetes is usually diagnosed in childhood
Type l
70
What type of diabetes appears abruptly despite years of beta(pancreatic) cell destruction
Type I
71
What type of diabetes requires clients to be evaluated for metabolic syndrome
Type 2
(Metabolic syndrome aka syndrome X)
72
Type _______ diabetics CANNOT have ORAL ANTIDIABETICS
Type I
73
What are the 3 P’s and what type of diabetes
* Polyria (excessive urination)
* polydipsia (excessive thirst)
* polyphagia (excessive hunger)
ALL SIGNS OF TYPE 1
74
Type I classification
* Little or no insulin
* usually diagnosed in childhood
* causes: autoimmune response
* first sign may be DKA
* appears abruptly despite years of beta cell destruction
*3P’s → polyuria, polyphagia, polydipsia
75
Normal blood glucose
70-99 mg/dL (3.9 - 5.5mmol/l) → normal without diabetes
76
Blood glucose with diabetes
<140 mg/dL (7.8 mmol/l)
80-130mg/dL (4.4-7.2 mmol/L)
77
Type 1 diabetes patho:
* You need INSULIN to carry glucose out of the blood and into the cell… since there's no insulin the glucose builds up in the BLOOD, the blood becomes HYPERTONIC and pulls fluid into the vascular space…the kidneys filter excess glucose and fluids (POLYURIA & POLYDIPSIA) the cells are STARVING so they start breaking down PROTEIN and FAT for energy (polyphagia)… when you break down fat you get KETONES (acid) now the client is ACIDOTIC (metabolic) → KUSSMAUL RESPIRATIONS (compensation)
78
Signs and symptoms of type l diabetes
* Polyuria → excessive urination
* polydipsia → excessive thirst
* polyphagia → excessive hunger
****POLYURIA think SHOCK 1st***
****3P’s = HYPERGLYCEMIA***
79
How is type 1 diabetes treated
ALWAYS NEED INSULIN
****NO ORAL hypoglycemia agents
80
Type 2 patho:
* Clients don't have enough INSULIN or they insulin they have is INADEQUATE
* clients are usually OVERWEIGHT
* can't make enough insulin to keep up with the glucose load client is taking in
*NOT as abrupt as type 1
*usually FOUND BY ACCIDENT (wounds won't heal, repeated vaginal infections, etc.)
* evaluate for METABOLIC SYNDROME (syndrome X)
81
Features of metabolic syndrome (MUST HAVE 3 OR MORE)
* Waist circumference:
>40 in. (101.6 cm) for MALES
>35 in. (88.9 cm) for FEMALES
* triglycerides
>150 mg/dL (1.60 mmol/L)
*HDL
< 40 mg/dL (1.036 mmol/L) for MALES
< 50 mg/dL (1.2295 mmol/L) for FEMALES
*BP
> 130/85
*FBS
>100 mg/dL (5.5 mmol/L)
82
Metabolic syndrome is known to ↑ risk level for dev. Of what
Type 2 diabetes and cardiovascular disease
83
How is metabolic syndrome treated
* Start with diet and exercise → then add oral agents
** some clients may require insulin
84
What type of diabetes resembles type 2
Gestational
85
Gestational diabetes
* Resembles type 2
* mom needs 2-3X more insulin than normal
*1st visit screening - if mom has RISK factors
*screen ALL MOMS at 24-48 WEEKS gestation***
86
What complications can a baby have from the mom having gestational diabetes
* ↑ birth weight
* hypoglycemia
87
General treatment of diabetes (type 1 and 2)
A. Diet: majority of calories should come from COMPLEX CARBS, then FATS, LASTLY PROTEIN
**carbs: 45% of diet
**fats: 30-40% of diet
**proteins: 15-20% of diet
• why WORRY about CARBS→ SUGAR destroys VESSELS just like FAT
•HIGH FIBER SLOWS DOWN GLUCOSE ABSORPTION in the intestines → ELIMINATES the SHARP RISE/FALLL in blood sugar
B. Exercise:
• wait until blood sugar normalizes to begin exercise
• to prevent hypoglycemia → EAT PRIOR
•exercise when blood sugar is HIGHEST
• exercise SAME TIME & SAME AMOUNT DAILY
C. Meds:
• prescribed for type 2
• oral or subcutaneous admin.
• improves how the body PRODUCES INSULIN and how the body USES INSULIN & GLUCOSE
• most widely used ORAL anti-diabetic is METFORMIN (GLUCOPHAGE)
***1st choice for most clients
*** may be used for weight control in type 2
*** some clients with pre-diabetes
88
Vascular damage is caused by…
Extremes in blood sugar
89
Metformin (glucophage)
* Favorite bc it ↓ glucose production and enhances how glucose enters the cell
*** does NOT stimulate the release of more INSULIN so NO HYPOGLYCEMIA with this med.
* hypoglycemia destroys vessels?
*may be prescribed in COMBO
* if metformin is not controlling blood glucose levels, another anti-diabetic will be prescribed possibly GLARGINE (Lantus)
90
What is the most common method of daily dosing
Basal bonus dosing
91
What is a combination of long acting and rapid acting insulin
* Long acting → given 1x/day
* rapid → given through out the day, before meals, in divided doses and it covers the food eaten at meals
***SNACKS ARE NOT REQ. But client MUST EAT when dosing the rapid, so have food available
92
When should clients eat
When insulin is at its peak → blood sugar is at its lowest
* always monitor a client on insulin for hypoglycemia
93
Client teaching for diabetes
** glucosated hemoglobin (HbA1C) : BLOOD TEST; gives an AVERAGE blood sugar for the past 3-4 months
** blood sugar INCREASES when STRESSED OR SICK →a normal pancreas can handle these fluctuation
** an ↑ in blood sugar when sick or stressed is NORMAL →helps to fight infections/stress
94
_________________ = DKA (diabetic ketoacidosis)
ILLNESS = DKA
95
Hemoglobin A1C goal
*Greater than or equal to 6.5% is DIAGNOSTIC for diabetes
***<7% is the DIABETIC GOAL
96
Normal HgbA1C
Less than or equal to 5.7%
97
What med should be held 48 hr pre and post-op
Metformin- ↑ risk of lactic acidosis
98
What is the initial dose of insulin based on
Clients weight
* average adult dose is 0.4-1 unit/kg/day
* dose adjusted until the blood sugar is normal and there is NO MORE GLUCOSE OR KETONES in the urine
99
Insulin times
* Rapid → onset: 15 mins; peak: 1 hour; duration: 2 to 4hrs
* regular/short → onset: 30min; peak:2-3 hours; duration: 3-6 hours
* intermediate → onset: 2-4 hours; peak: 4-12 hours; duration: 12 to 18 hours
* long acting →onset: 2 hours; peak: NONE; duration: up to 24 hours
* ultra long acting → onset: 6 hours; peak: none; duration: 36 hrs or longer
100
What type of insulin is clear vs cloudy
Regular (clear), NPH (cloudy)
*draw up CLEAR 1st
101
What type of insulinis clear and can'tbe mixed with any otherinsulin or given IV
102
What is the insulin standard
Regular (rapid may also be given IV)
* plan based on clients lifestyle and activity
* goal → keep the before meal glucose near normal at 80 - 130mg/dl
103
Insulin infusion pumps
* Alternative to daily injections
***ONLY RAPID ACTING insulin is used in INFUSION PUMPS
*obtain. BETTER CONTROL recieving a basallevel of insulin from the pump and bonuses of additional insulin as needed with meals or high blood sugar
104
What type of insulin is used in infusion pumps
Only RAPID acting
***OBTAINS BETTER CONTROL - receiving a basal level of insulin from the pump and boloses of additional insulin as needed with meals or ↑ in blood sugar
105
What is the standard insulin that can be given in IV fluids or as an IV ' infusion
REGULAR INSULIN
106
What is the ONLY INSULIN that can be given via SUBCUTANEOUS INSULIN INFUSION PUMP
Rapid acting insulin
107
Small computerized devices worn by the client that can provide BOTH, a CONTINUOUS (basal) dosing of rapid acting insulin and on demand (BOLUS) dosing
Insulin infusion pumps
108
Signs and symptoms of hypoglycemia
* Cold and clammy
* confusion
* shakey
*H/A
* nervousness
* nausea
* ↑ pulse
* hunger
109
If hypoglycemic...
Eat simple carbs
* snacks should be 15g of carbs
* glucose absorption delayed in foods with lots fat
*15-15-15 rule
110
15-15-15 rule
* Eat 15 g carbs
* wait 15 min.
* take blood sugar
* repeat as needed
111
Once the blood sugar is up
Complex Carbs and protein (PB crackers)
* if unconscious, likely hypoglycemia
***D50W ( hard to push, if you have A choice you need a LARGE BORE IV
*** injectable glucagon (Glucagen) → used when there's NO IV access; given IM
112
Hypoglycemia prevention
I. Eat
2. Take insulin regularly
3. Know S&S of hypoglycemia
4. Check blood glucose regularly
113
Hypoglycemia is blood glucose of ______ or less
70 or less
114
Complications of diabetes
A. Diabetic ketoacidosis (DKA) TYPE 1
* anything that ↑blood sugar can throw the client into DKA (illness, infection, skipping insulin)
*may be the 1ST SIGN OF DIABETES
*have all the usual S&S of type 1
B. Hyperosmolar hyperglycemic non-ketosis (HHNK) or hyperglycemia hyperosmolar state (HHS) TYPE 2
*looks likeDKA but NO ACIDOSIS
*making JUST ENOUGH insulin so they aren’t breaking down FAT
***no ketones, acidosis, kussmaul resp.
C. Vascular problems - will dev. POOR CIRCULATION EVERYWHERE due to vessel damage (sugar irritated—decreased blood flow) 1. Diabetic retinopathy 2. Nephropathy
D. Neuropathy
1. Sexual problems - impotence/ ↓ sensation
2. Foot/leg problems- pain/parenthesis/numbness
3. Neurogenic bladder….spontaneous emptying/doesn’t empty properly → incontinence or may not empty at all → retention
4. Gastroparesis-stomach emptying is delayed so there's an ↑risk for aspiration
E. ↑ risk of infection
115
Diabetic ketoacidosis patho:
* Absent or inadequate insulin → blood sugar sky rockets → polyuria, polyphagia, polydipsia → FAT BREAKDOWN (acidosis) → kussmaul resp. (Trying to compensate by blowing off co2) → more acidic = more LOC ↓
116
DKA treatment
* Find the cause
*HOURLY blood sugar and K+ levels
****ECG
***HOURLY U/O
*ABG’s
****IV INSULIN → insulin LOWERS blood sugar and potassium (K+) levels → DRIVES them OUT of the VASCULAR SPACE & into the cell
***IV FLUIDS…POLYURIA CAUSES SHOCK → start with NS…. Then when blood sugar gets down to about 250-300mg/dL…SWITCH to D5W to prevent hypoglycemia
* anticipate that the PCP will want to ADD POTASSIUM (K+) to the IV SOLUTION at some point
