endocrine

Question 1

What type of inheritance is multiple endocrine neoplasia?

Answer 1

Autosomal dominant

Question 2

How do you remember men type 1?and what features do they have?

Answer 2

3 P’s
Parathyroid 95%: hyperparathyroidism due to parathyroid hyperplasia
Pituitary 70%
Pancreas 50%: e.g insulinoma gastrinoma leading to recurrent peptic ulceration
Also adrenal and thyroid

Question 3

What type of gene is multiple endocrine neoplasia type 1?

Answer 3

MEN1 Gene

Question 4

What is the most common presentation of men type 1?

Answer 4

Hypercalcaemia

Question 5

How do you remember men type IIa? and what features do they have?

Answer 5

2 p’s
parathyroid 60%
phaemochromocytoma
Medullary cancer 70%

Question 6

What type of gene is men type IIa?

Answer 6

Ret oncogene

Question 7

How do you remember men type IIb? and what features do they have?

Answer 7

1 P
Phaeochromocytoma
Marfanoid body habitus
Neuromas
Medullary thyroid cancer

Question 8

What type of gene is men type IIb?

Answer 8

Ret oncogene

Question 9

Draw a venn diagram of men and their associated features

Answer 9

Question 10

What is the triad of thyroid acropachy?

Answer 10

Digital clubbing, soft tissue swelling of hands/feet, periosteal new bone formation