Endocrine

Question 0

FSH, Inhibin, & E Labs in 45XO syndrome

Answer 0

⬆️FSH
⬇️Inhibin
⬇️Estrogen (thus ⬆️ osteoporosis risk)

Question 1

Very tall infertile male with diminished testicular size and recent development of breast tissue bilaterally.

• Dx?
• Next step?

Answer 1

Klinefelter’s syndrome (47 XXY)

Bx the breast tissue b/c of ⬆️ risk of male breast cancer

Question 2

55 yo male with found to have A1c of 8.2%, Cr 1.42, BMP normal, LFTs normal.
-what diabetic mediations are contraindicated in this patient?

Answer 2

Metformin (biguanides)

Glyburide, Glipizide (sulfonylureas)

Question 3

Hx if head and neck radiation, now with thyroid nodular that takes up iodine.
-Dx?

Answer 3

Papillary carcinoma

Question 4

Least common thyroid cancer, is associated with increased calcitonin, MEN-II

• Dx
• Tx

Answer 4

Medullary carcinoma

-total thyroidectomy

Question 5

Adverse effects of PTU

Answer 5

Vasculitis
Rash 
Arthralgias
Hepatitis
Agranulocytosis

Question 6

Anti thyroid medication that is preferred during the first trimester

Answer 6

PTU

Methimazole is a fetal teratogenic