Endocrine

Question 1

Where do glucocorticoids and ACTH ACT?

Answer 1

Zona Fasciculata and Zona reticularis

Question 2

Where do mineralcorticoids and angiotension act?

Answer 2

Zona Gomerulosa

Question 3

Where do most ACTH secreting tumors in dogs arise from?

Answer 3

Zona Fasciculata

Question 4

In cushings disease what happens to the other adrenal gland?

Answer 4

It will have cortical atrophy due to negative feedback mechanism.

Question 5

What is the pathognomonic sign in cushings disease?

Answer 5

Calcinosis cutis

Question 6

What are some things you see with excess cortisol production?

Answer 6

Calcinosis cutis Hepatomegaly- steroid hepatopathy Hypertension Immunosupression-pyoderma, stinky Poor healing muscle atrophy Pu/Pd

Question 7

What causes a pot belly?

Answer 7

Muscle atrophy, fat redistribution, hepatomegaly

Question 8

Do all adrenal tumors cause cushings disease?

Answer 8

No , only functional tumors

Question 9

What is Conns syndrome and what species is it seen in?

Answer 9

Cats It is hyperaldosteronism caused by the zona glomerulosa

Question 10

In ferrets what will adrenal tumors secrete?

Answer 10

Ferrets have hyper estorgenism secreting Androgens not Cortisol

Question 11

Clinical signs seen in ferrerts with hyper estrogenism ?

Answer 11

Vulvular enlargement, anemia, endometrial hyperplasia, Pu/Pd , alopecia

Question 12

What is this an example of?

Answer 12

Adrenocortical adenoma/ adrenocarcinoma

Question 13

What is going on here and what is it caused by?

Answer 13

Bilateral adrenocortical hypertrophy/hyperplasia, which is caused by a pitutary adenoma

Question 14

What would a pitutary adenoma be secreting?

Answer 14

ACTH

Question 15

Are these functioning adrenal tumors?

Answer 15

No these are nodular , this is indicative of senile change and can be from old age. This is NOT productive

Question 16

In horses what is cushing disease caused by?

Answer 16

Pituitary adenomas are from pars intermedia

Question 17

Why are clinical signs in the horse different from the dog?

Answer 17

Because in the horse clinical signs are not a result of ACTH secretion generally it is from compression of the hypothalmus which causes clinical signs

Question 18

True or false in horses with pars intermedia you will see adrenocortical hyperplasia?

Answer 18

False NO adrenaocortical hyperplasia

Question 19

What is going on here and what does this result in?

Answer 19

rathkes pouch pituitary cyst resulting in pituitary dwarfism

Question 20

What disease will be seen in primary bilateral adrenocortical atrophy?

Answer 20

Hypoadrenocorticism- Addisons disease

Question 21

What type of tumor is this and where does it orginate from?

Answer 21

Pheochromocytoma which is a neuroendocrine tumor of the adrenal medulla

Question 22

What is happening in this picutre and what disease might be seen?

Answer 22

Adrenocortical atrophy, addisons

Question 23

This goat has this disease______which is know as thyroid______.

Answer 23

Goiter, thyroid hyperplasia

Question 24

True or false in goiter animals are hyperthyroid?

Answer 24

False hypo or euthyroid

Question 25

What woud you see on histo in thyroid hyperplasia?

Answer 25

Increase in thyroid follicles, proliferation and no colloid

Question 26

True or false: All proliferative lesions result in hyperfunction?

Answer 26

False

Question 27

What can decrease T4?

Answer 27

Lack of iodine Brassica plants, sulfonimides Excess dietary iodide Lack of iodine Interfearnce with production

Question 28

What lesions causeHYPOthyroidsm?

Answer 28

lymphocytic thyroiditis thyroid atrophy pitutary adenoma thyroid carcinoma

Question 29

These two signs would be seen in severe hypothyroidsm

Answer 29

Myxedema, atherosclerosis

Question 30

Lesions underlying hyperthyroidism in cats?

Answer 30

Nodular adenomatous thyroid hyperplasia 70% bilateral

Question 31

Causes of SECONDARY Hyperparathyroidism

Answer 31

High P/ Low Ca Renal disease - high P, low calcitriol Inadequate D3

Question 32

Cause of primary hyperparathyroidism?

Answer 32

PTH producing Neoplasia

Question 33

Causes of Pseudoparathyroidsm

Answer 33

PTH-RP producing neoplasms Ex: adenocarcinoma, lymphoma

Question 34

In pseudo hyperparathyroidsim will PTH be increased or decreased?

Answer 34

It will be decreased because of negative feedback and you will have increased Ca

Question 35

In a pancreatic islet cell carcinoma with a beta cell tumor will you see increased or decreased insulin?

Answer 35

Increased leading to hypoglycemia

Question 36

In diabetes mellitus due to pancretic hypofunction will insulin be increased or decreased? Glucose increased or deacreased?

Answer 36

Decreased insulin increased blood glucose

Question 37

What is going on with this cats pancreas?

Answer 37

Amyloidosis , results in islet cell atrophy, insulin deficiency , can be seen in cats without DM monitor

Question 38

Associated lesions with diabetes mellitus

Answer 38

Microangiopathy Nephropathy Retinopahty Gangrene Cataracts in dogs