Endocrine Drugs Flashcards Preview

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Flashcards in Endocrine Drugs Deck (21)
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1
Q

Sermorelin

A

GHRH analog

2
Q

Somatropin

A

Recombinant human GH

SE: leukemia, hypothyroidism, insulin resistance, arthralgia

Increases CYP450 (deduce serum level of drugs)

3
Q

Somatrem

A

Recombinant human GH, one extra AA so its more stable/less allergic

SE: leukemia, hypothyroidism, insulin resistance, arthralgia

Increases CYP450 (deduce serum level of drugs)

4
Q

Mecasermin

A

Recombinant IGF-1

5
Q

Octreotide

A

SS analog, inhibits GH secretion

SE: sinus brady, conduction disturbances, hypoglycemia, gallstone

Decreases cyclosporin levels, increases bromocriptine

6
Q

Lanreotide

A

SS analog, inhibits GH secretion

In Europe

7
Q

Pegvisomant

A

GH receptor competetive anatgonist, dec. IGF-1 levels

Tx of acromegaly refractory to other tx

8
Q

Bromocriptine

A

DA receptor agonist, inhibits pituitary prolactin release

Tx of amenorrhea, galactorrhea, infertility, etc, parkinsons

SE: Orthostatic HTN, pulmonary fibrosis, pleural effusion

9
Q

Cabergoline

A

DA receptor agonist, inhibits pituitary prolactin release

Tx of amenorrhea, galactorrhea, infertility, etc, parkinsons

SE: Orthostatic HTN, pulmonary fibrosis, pleural effusion

Less nausea than bromocriptine

10
Q

Pergolide

A

DA receptor agonist, inhibits pituitary prolactin release

Tx: Parkinsons

SE: Orthostatic HTN, pulmonary fibrosis, pleural effusion

11
Q

Urofollitropin

A

Purified FSH from urine of postmenopausal women

Used for ovulation induction

SE: ovarian hyperstimulation syndrome, ascites, gynecomastia, ovarian cancer

12
Q

Follitropin

A

Recombinant form of human FSH

Used for ovulation induction

SE: ovarian hyperstimulation syndrome, ascites, gynecomastia, ovarian cancer

13
Q

Gonadorelin

A

GnRH analog with short t1/2, pulsatile secretion stimulates release of LH and FSH

Used to diagnose hypogonadism, stimulate ovulation, infertility in men

SE: anaphylaxis with multiple administrations, lightheadedness, flushing

14
Q

Goserelin

A

GnRH analog with longer t1/2, inhibits FSH and LH, desensitizes receptors

Used to tx endometriosis, fibroids, prostate cancer, breast/ovarian cancer, amenorrhea and ifnertility in women with PCOS

15
Q

Histrelin

A

GnRH analog with longer t1/2, inhibits FSH and LH, desensitizes receptors

Adjunctive in prostate cancer, breast/ovarian cancer, amenorrhea/infertility in PCOS

16
Q

Leuprolide

A

GnRH analog with longer t1/2, inhibits FSH and LH, desensitizes receptors

Keep LH low in controlled ovarian hyperstimulation, endometriosis, uterine fibroids, central precocious puberty, advanced breast/ovarian cancer, PCOS

17
Q

Nafarelin

A

GnRH analog with longer t1/2, inhibits FSH and LH, desensitizes receptors

Keep LH low in controlled ovarian hyperstimulation, endometriosis, uterine fibroids, central precocious puberty, advanced breast/ovarian cancer, PCOS

18
Q

Triptorelin

A

GnRH analog with longer t1/2, inhibits FSH and LH, desensitizes receptors

Adjunctive in prostate cancer

19
Q

Ganirelix

A

GnRH receptor antagonist

Keep LH surge low for IVF

SE: ovarian hyperstimulation, ectopic pregnancy, thrombotic disorder, spontaneous abortion

20
Q

Cetrorelix

A

GnRH receptor antagonist

Keep LH surge low for IVF

SE: Ovarian hyperstimulation syndrome, anaphylaxis

21
Q

Abarelix

A

GnRH receptor antagonist

Metastatic prostate cancer

SE: QT interval prolongation