Endocrine Pharm Flashcards Preview

KCSU17 Patho/Pharm Submodule 1 > Endocrine Pharm > Flashcards

Flashcards in Endocrine Pharm Deck (19)
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1
Q

brand name, MOA

Calcitrol

A

Rocaltrol

Vitamin D synthetic analog

increases gut absorption of Calcium

secondary hyperparathyroidism

2
Q

Phos-lo

brand name, MOA

A

Binds to PO4++ to increase secretion via GI

secondary hyperparathyroidism

3
Q

Levothyroxine

brand name, MOA

A

Synthroid

Synthetic T4

used to treat hypothyroidism, ultimately reduces TSH levels

give full dose to children, decrease dose 50% or 25% to avoid cardiac shock

4
Q

I 131

A

radioactive iodide

injected into and permanently destroyed the thyroid

hyperthyroidism, can not be used on pregnant women

5
Q

Propanolol

brand name, MOA

A

Inderal

beta blocker, blocks adrenergic effects of hyperthyroidism

(tachycardia, increased EF, heat and weight loss)

only provides symptom relief

6
Q

Methimazole

brand name, MOA

A

Tapazole

blocks synthetic thyroid hormone synthesis

hyperthyroidism, can have nasty side effects

7
Q

Fludrocortisone

A

florinef

artificial aldosterone

adrenal insufficiency

must be dosed properly to prevent passing out or swelling

8
Q

Spironolactone

A

Aldactone

aldosterone antagonist

blocks effects of aldosterone at the kidney

hyperaldosteronism caused by adrenal hyperplasia

9
Q

hydrocortisone

A

cortef

artificial cortisone

adrenal insufficiency

dose 2/3 in morning and 1/3 in evening bc of natural cortisol surge in morning

10
Q

Insulin glargine

A

lantus

slow basal coverage

lasts all days, 1x/day no peaks

11
Q

NPH insulin

A

slow onset
basal coverage

inexpensive

lasts for 12 hours 2x/day

some peaks

12
Q

regular insulin

A

slower onset

lasts 5-7 hours

main use is for a drip following DKA

13
Q

Insulin inspro

A

Aspart

acts faster than regular insulin

must be taken at longest 20 min before meal to avoid hypoglycemia (carb front load meals)

can be used for insulin pump

14
Q

Canagliflozin

A

Class: SGLUT 2

Invokana

inhibits glucose reabsorption by the kidney (pee all glucose out)

T2DM

weight loss, increases risk for DKA, UTI

15
Q

Pioglitazone

A

class: TZD
Actone

increases glucose uptake in muscle, fat

decreases glucose production by the liver

T2DM

weight gain, many contraindication

16
Q

stigaliptin

A

Class: insulin mimetic
Januvia

inhibits breakdown of endogenous GLP

slows food break down, full longer

weight loss, must be injected

17
Q

Exenatide

A

Byetta

class: insulin mimetic

glucagon like peptide, promotes glucose secretion, inhibits glucagon release, slows gastric emptying

weight loss, feel full longer only releases insulin when needed (no hypoglycemia)

must be injected

18
Q

Glipizide

A

Glucatrol

class: slufonylureas

stimulates pancreatic beta cells to make more insulin

cheap and powerful

causes hypoglycemia and weight gain

19
Q

metformin

A

decreases glucose output from liver

sensitized peripheral cells to insulin

can’t be giving with elevatecreatinine

first line, no hypoglycemia, promotes weight loss, SE: diarrhea