Endocrine: Pituitary Flashcards Preview

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Flashcards in Endocrine: Pituitary Deck (10):
1

Recombinant growth hormones and their indications

SOMATREM
SOMATROPIN

INDICATIONS:
1. Pituitary dwarfism
2. AIDS Wasting
3. Short bowel syndrome dependant on TPN

2

Recombinant GHRH and indiactions

SERMORELIN
HEXARELIN

Pituitary dwarfism

3

GH Receptor antagonist and Indication

PEGVISOMANT

Acromegaly

4

Recombinant IGF 1 and IGF 1 binding protein 3 complex and indications?

MECA SERMIN

Growth failure not responsive to GH (cuz due to IGF deficiency)

5

Somatostatin analogues

OCTreotide
LANreotide (i.m.)
VAPreotide
PASIreotide (indicated in Cushing's)

Seglitide

6

Somatostatin indications

(SOMATO)statin

Secretory diarrhoea
Oesophageal varices (because vasoconstrictor)
Malignancy of pancreas : insulinoma and glucagonoma
* Acromegaly *
TSH secreting adenoma
OD of sulphonylurea

7

Dopamine (PIH) D2 agonists and indications

Bromocriptine, pergolide,
CABERGOLINE
QUINAGOLIDE

Indications: DOPAMine

Diabetes mellitus type 2 (only bromocriptine)
Oversecretion of prolactin (infertility and galactorrhoea)
Parkinsonism
Acromegaly
Milk secretion inhibition (if newborn is dead)

8

Gonadorelins meaning and examples

Synthetic GnRH

LEUPROLIDE
Nafarelin- also nasal
Busurelin- also nasal
Goserelin- s.c. Implant
Histrelin
Deslorelin
Triptorelin

9

Gonadorelins indications

PULSATING ADMINISTRATION (increases GnRH)
1. Anovulatory cycles
2. Hypogonadotropic hypogonadism
3. Cryptorchidism
4. Delayed puberty

CONTINUOUS (decreases GnRH)
1. Precocious puberty
2. PCOD
3. Prostatic cancer
4. Fibroids (you read this in anatomy)
5. Endometriosis

10

GnRH antagonists and indications

Cetrorelix
Abarelix
Ganirelix
Dagarelix

Indications:
Endometriosis
Fibroids
IVF me controlled ovum-stimulation