Endocrine System Flashcards

1
Q

integrated network of multiple organs derived from different embryologic origins that release hormones ranging from small peptides to glycoproteins, which exert their effects either in neighboring or distant target cells

A

Endocrine System

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2
Q

What is responsible for coordinating and integrating cellular activity within the whole body?

A

Endocrine System

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3
Q

Endocrine system is controlled by?

A

1) Hormones delivered through circulation
2) Hormones produced locally
3) By direct neuroendocrine stimulation

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4
Q

What 3 components make up the core of the endocrine system?

A

Endocrine glands
Hormones
Target organ

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5
Q

Ductless glands that secrete hormones to interstitial space to reach circulation

A

Classical Endocrine Glands

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6
Q

These are not anatomically connected and are scattered throughout the body

A

Classical Endocrine Glands

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7
Q

Communication among different organs is done by release of hormones or neurotransmitters

A

Classical Endocrine Glands

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8
Q

What are the 9 classical endocrine glands?

A

hypothalamus, pinneal, parathyroid, thyroid, adrenal, ovarian, testicle, pancreas, hypophysis (adeno & neuro)

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9
Q

What are the nonclassical endocrine glands?

A

heart, intestines, kidney, placenta, adipose tissue

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10
Q

Chemical properties released in very small amounts that exert a biological action on a target cell

A

Hormones

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11
Q

Can act in distant sites or locally

A

Hormones

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12
Q

What are the 6 types of chemical messengers?

A

neurotransmitter, endocrine hormones, neuroendocrine hormones, paracrines, autocrines, cytokines

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13
Q

Are released by AXON TERMINALS of NEURONS into the synaptic junctions and act locally to control NERVE functions

A

Neurotransmitter

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14
Q

Are released by GLANDS or specialized cells into the circulating blood and influence the function of target cells at ANOTHER LOCATION in the body

A

Endocrine hormones

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15
Q

Acetylcholine and Dopamine

A

Neurotransmitters

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16
Q

Insulin and Cortisol

A

Endocrine hormones

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17
Q

Are secreted by NEURON stimulation into the circulating blood and influence the function of target cells at ANOTHER LOCATION in the body

A

Neuroendocrine hormones

18
Q

ADH, TSH, Epinephrine

A

Neuroendocrine hormones

19
Q

Are secreted by cells into the extracellular fluid and affect NEIGHBORING target cells of a DIFFERENT type

A

Paracrines

20
Q

Fibroblast growth factor

A

Paracrines

21
Q

Are secreted by cells into extracellular fluid and affect the function of the SAME cell

A

Autocrines

22
Q

IL-6 in cancer and IL-1 in monocytes

A

Autocrines

23
Q

Are peptides secreted by cells into extracellular fluid and can function as autocrine, paracrine, or endocrine hormone (immune cells)

A

Cytokines

24
Q

Interleukins, released from T helper cells

A

Cytokines

25
Q

Are synthesized as a larger molecule (pre-hormone) inside the golgi apparatus and packaged into secretory granules awaiting secretion

A

Peptide hormone or structure protein

26
Q

Circulate unbound in the blood

A

Structure protein or peptide hormone, and Amines

27
Q

bind to receptors in the cell membrane (hormone-receptor complex activate a second messenger)

A

Structure protein or peptide hormone

28
Q

Are derived from the amino acid TYROSINE (hydrophilic)

A

Amines

29
Q

bind to cell membrane or nuclear receptor

A

Amines

30
Q

Are derived from CHOLESTEROL

A

Steroid hormones

31
Q

Are produced by adrenal cortex, gonads, and placenta (ex. cortisol, aldosterone, progesterone, testosterone)

A

Steroid hormones

32
Q

Are transported by proteins (lipophilic; ex. albumin)

A

Steroid hormones

33
Q

Bind to intracellular receptors (enter cells by diffusion and bind to receptors in cytosol or nucleus)

A

Steroid hormones

34
Q

What are the 2 types of hormone transport?

A

Free or unbound form

Bound to carrier proteins

35
Q

Hormone Transport: free/unbound

A

active
bind to receptor
exert the biological effects

36
Q

Hormone Transport: bound to carrier protein

A

serve as circulating reservoirs (replenish the concentration of free hormones)
liver is responsible for production of most of the proteins

37
Q

Organ that contains cells that express hormone specific receptors and that respond to hormone binding by a demonstration biologic response

A

Target organ

38
Q

Cell surface receptors (used by peptide and amine hormones)

A

Hormone receptors

39
Q

Intracellular receptors (cytoplasmic, nuclear) used by steroid hormones, thyroid, retinoid hormones, and vitamin D

A

Hormone receptors

40
Q

Rate of the removal of the hormone from the blood

A

Hormone clearance

41
Q

Hormone clearance is done in 4 ways. What are they?

A
  1. metabolic destruction of tissues
  2. binding with tissues
  3. excretion by liver into bile
  4. excretion by kidney into urine