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Clinical Chemistry II > Endocrinology MCQ Part 2 > Flashcards

Endocrinology MCQ Part 2 Flashcards

(64 cards)

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1
Q

A patient shows the following data: T4 concentration of 8 ug/dL and T3 uptake of 30%. What is the condition?

A

Euthyroidism

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2
Q

Which secretion is involved in calcium homeostasis?

A

Thyroid hormone

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3
Q

Which is an advantage of T4 assay over PBI (protein bound iodine) test?

A

Prevent contamination of extraneous iodine

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4
Q

Cretinism in infants is caused by

A

hypothyroidism

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5
Q

Which of the parameters are decreased in hypothyroidism?

  1. T4
  2. T3
  3. Resin T3 Uptake
  4. TSH
A

1,2,3,4

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6
Q

Majority of the thyroid hormones in blood are bound with:

A

Thyroxine –binding albumin

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7
Q

Majority of plasma thyroxine ( T4) is:

A

Bound to globulin

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8
Q

Which of these antibodies are associated with auto-immune thyroiditis?
A. Neither microsomal nor thyroglobulin antibodies
B. Microsomalantibodies
C. Thyroglobulinantibodies
D. Both microsomal and thyroglobulin antibodies

A

D.

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9
Q

The gold standard for the assessment of thyroid function is the measurement of

A

TSH

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10
Q

The metabolically active thyroid hormone is

A

T3

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11
Q

The methods for determining thyroid hormones are as follows, EXCEPT:
A. Ash method protein bound iodine
B. Chromatography
C.Radioactive tracer method
D.Colorimetric method

A

B

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12
Q

Increase values of Thyroxine (T4-RIA) is usually associated with the following, EXCEPT:
A. Hyperthyroidism C.Nephrosis
B. Acutethyroiditis D.Graves’disease

A

Nephrosis

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13
Q

The following are thyroid function tests, EXCEPT:
A. Freethyroxine B.FreeTriiodothyronine C.Thyroglobulin D. Testosterone

A

Testosterone

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14
Q

One of the following is NOT associated with hyperthyroidism;
A. Decreased calcium
B. Increased T3
C. Increased PBI
D. Decreased Cholesterol

A

Decreased calcium

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15
Q

Thyroid function tests exclude:

A

ACTH

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16
Q

Hyperthyroidism has been associated with the following, EXCEPT
A. Increased cholesterol
B. Increased T3
C. Increased sugar level
D. Increased T4

A

Increased cholesterol

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17
Q

Assay of T3 & T4 levels, and TSH maybe done by this method, EXCEPT:
A. Spectrophotometer
B. Radioimmunoassay
C. Flame photometer
D. Gamma counter

A

Flame photometer

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18
Q

Hypothyroid test is shown in:

A

Decrease resin T3 & T4

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19
Q

Test for T3 and T4 can be determined by

A

RIA AND EIA TECHNIQUE

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20
Q

Methods for determining T3 and T4 exclude

A

Hemagglutinin

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21
Q

Patient has a TSH result markedly elevated. This maybe due to:

A

Primary hypothyroidism

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22
Q

Determine the free thyroxine index (FT4I) using the given data:
Total T4 = 10 microgram/dL
Resin T3 uptake of patient = 27%
Resin T3 uptake of serum pool = 30%

A

9.0

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23
Q

The use of iodized salt serves to provide iodine for the synthesis of:

A

Thyroid hormone

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24
Q

Normal T3 in serum and normal T4 is interpreted as:

A

Euthyroidism

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25
What is the primary purpose of thyroidal radioiodine uptake test?
Differentiate the causes of hyperthyroidism
26
In hyperthyroidism, resin T3 uptake is:
Increase
27
The radioactive count in RT3U test in hypothyroidism is expectedly:
Significantly lower
28
The parent compound of steroid hormones is
Cholesterol
29
Presence of a very high titer for long acting thyroid stimulator antibodies is highly suggestive of what disorder:
Graves disease
30
The major function of thyroid gland is:
Production of thyroid hormone
31
In the chemical tests for urinary steroids, the first step is hydrolysis using an A. enzyme B. acid C. both A & B D. neither A nor B
Enzyme and acis
32
The organic reagent used to hydrolyze steroid hormones in the sample is
Enzyme
33
The reference method for the assay of steroid hormones is
HPLC
34
The method used to quantitate ketogenic steroids is
Zimmermann
35
Which adrenal tissue produces secretions which react with DNPH-sulfuric acid?
Fascicular cells
36
The major transport protein of cortisol which binds 90% of circulating cortisol is
Transcodtin
37
The best time to collect a blood sample for testosterone measurement is
8 am
38
The hormones referred to as 18-carbon steroids with unsaturated A ring are
Estrogen
39
The major androgen produced in the adrenal cortex is
dehydroepiandrosterone
40
In secondary hypocortisolism, plasma ACTH is
Decreased
41
42. The 17-ketosteroids include all of the following except A. androsterone B. androstenedione C. DHEA D. testosterone
Testosterone
42
Dexamethasone suppression test is used to
establish the cause of hypercortisolism
43
The following are true regarding the Zimmerman reaction except A. the reaction requires an acidic medium B. red-purple product is measured at 520nm C. dinitrobenzene is the chromogen D. used to assess androgen production in adrenals
Reaction requires an acidic medium
44
The Kober method is performed to
assess estrogen production by adrenals
45
Transcortin is able to bind all of the following hormones except A. cortisol B. progesterone C. aldosterone D. estradiol
Estradiol
46
The predominant hormone in the menstrual luteal phase is
Progesterone
47
Which hormone-function dyad is incorrect? A. estrogen stimulates uterine endometrium to proliferate or thicken and negative feedbacking to the pituitary gland B. FSH–stimulatesmeiosisinovaries;releaseoftheovum C. Progesterone–maintainslevelsofestrogen D. LH–developmentoftheovumintoacorpusluteum
A
48
The predominant estrogen in a gestating woman is
Estriol
49
The predominant estrogen in post-menopausal women is
Estrone
50
Pituitary secretion of ACTH is inhibited by levels of
Cortisol
51
In the Porter-Silber reaction, the 17,21-dihydroxy-20-ketone side chain reacts with
Phenylhydrazine
52
The most potent estrogen which is considered the true ovarian hormone is
Estradiol
53
All of the following glands secrete steroid hormones except A. ovaries B. pituitary gland C. placenta D. adrenal cortex
Pituitary gland
54
The placenta secretes numerous hormones both protein and steroid. Which of the following hormones is not secreted by the placenta?
LH
55
Because of infertility problems, a physician would like to determine when a woman ovulates. The physician orders serial assays of plasma progesterone. From these assays the physician can tell when ovulation occurs because
after ovulation, progesterone rapidly increases
56
Which of the following is the major mineralocorticoid?
Aldosterone
57
The adrenal medulla secretes which of the following in greatest quantity:
Epinephrine
58
In a patient who is suspected of having pheochromocytoma, measurement of which of the following would be most useful?
VMA
59
The highest levels of gonadotropins occur
atthemidpointofthemenstrualcycle
60
The reference method for the assay of catecholamines is
HPLC
61
In a patient who is suspected of overproducing serotonin, the measurement of which of the following would be most useful?
5’HIAA
62
In a patient who is suspected of overproducing dopamine, measurement of which of the following would be most useful?
HVA
63
In the Zimmerman reaction, the chromogen is
Dinitrobenzene
64
The determination of estrogens by the Kober reaction requires which clinical sample?
24 hour urine

Clinical Chemistry II (45 decks)

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