Endometrial Pathology Flashcards
(18 cards)
When do endometrial polyps occur
Around/after the menopause
? cause of Endometrial hyperplasia
Oestrogen
Types of Endometrial hyperplasia
Simple, Complex and Atypical
Simple EH made up of
Glands and Stroma
Complex and Atypical EH both made up of
Crowded, focal glands
Atypical Endometrial hyperplasia is a precursor for
Endometrioid carcinoma
Precursor for Serous Carcinoma of the Endometrium
Serous intraepithelial carcinoma
Type 1 Endometrial Tumours (80%)
Endometrioid and mucinous
Type 1 tumours related to
Unopposed oestrogen
Type 2 Endometrial Tumours
Serous and clear cell
Type 2 patient group
Elderly, post-menopausal women
Type 1 genetic mutations
PTEN, KRAS and PIK3CA and ‘micro satellite instability’
Lynch syndrome inheritance
AD, MSI
Type 2 spread pattern
Fallopian tubes and peritoneal surfaces
Endometrioid cancer grading
<5% solid growth = G1, 6-50%=G2, >50%= G3
Carcinosarcoma pathology
High grade heterologous elements, with rhabdomyosarcomatous having the worst prognosis
Leiomyosarcoma often has
Spindle cell morphology
Endometrial stromal sarcomas pathology
Resembles endometrial stroma, presents with DUB and ovarian or lung mets.
