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Flashcards in Enterobacteriae GM - Rods Specific Deck (27)
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1
Q

Vibrio cholera

  • type
  • ID
  • Virulence
  • Disease
  • Location
A

Colonel Choleras Base cAMP
non-inflammatory
-MacConkey, blood, chocolate agar
-protein exotoxin (AB5), A toxin transfers ADP ribose to NAD on Gs, hyperactive CFTR and AC (more sodium into lumen), B subunit lets bind to enterocyte/endocytosed
-massive diarrhea/rice water stools/ 1-3 day death
-endemic to south asia

2
Q

non cholera vibrio (parahaemolyicus and vunificus)

  • type
  • transmission
  • disease
  • speical
A
Colonel Choleras Base cAMP-oysters 
non-inflammatory
-common in water-probably from selfish (esp oysters), wound and soft tissue infections
-diahhrea
-need salt (TCBS culture medium)
3
Q

E. coli ETEC

  • type
  • virulence
  • Disease
  • trx
A

E. colas soda fountain-Truck
Enterotoxigenic +non-inflammatory
-labile toxin (like cholera toxin), stable toxin (stem cGMP-more salt into lumen), adhesive pills ESSENTIAL
-travellers diarrhea (usually immune to local ETEC)
-replacement of water/salt+Antibiotics to shorten sickness

4
Q

E. coli EPEC

  • type
  • virulence
  • disease
  • trx
A

Entero-pathogenic +non-inflammatory

  • adhrere via pilli and nonpilli adhesin to enterocytes, type 3 secretions, cytoskeletal rearrangement
  • posibly bloody diahhrea for malabsorption and fever
  • replacement of water/salt+Antibiotics to shorten sickness
5
Q

E. coli EAEC

  • type
  • Virulence
  • what happens
  • Trx
A

enteroaggregative–aggregative +non-inflammatory

  • ST like toxin, hemolysin, adhesive pill
  • binds to apical side of enterocytes in clumps
  • replacement of water/salt+Antibiotics to shorten sickness
6
Q

Shigella (dysenteriae (most tox), flexneri,boydii, sonnei-least tox+mst common)

  • type
  • ID
  • Virulence
  • Sx
  • special
A

Inflammatory/Bloody Diarrhea

  • Diagnosed with rectal swab, green colonies on nekton agar, immotile, acid stable
  • Shiga toxin-cleaves 28S rososomal RNA no protein synthesis (A subunit of AB5), Pass thru M cells-attach to Epithelial cells and induce pahogcysosis with Type 3 secretory, use actin assembly to move to lateral cells
  • Bacillary dysentery, hemolytic urecemic syndrome (kills kidney cells and does hemolysis), four serogroups
  • genetically identical to E. coli
7
Q

E. coli EHEC

  • type
  • ID
  • Virulence
  • Sx
  • trx
A

E. colas soda fountain-hamberxer
Enterohemoragic–Inflammatory/Bloody Diarrhea
-Assayed for toxicity in vitro, O157:H7 is antigen associated with outbreaks (cattle reoivour)
-Verotoxin (shiga like toxin)
-emolytic uremiac syndrome (golumeroar damage and hemolysis)
-dont use antibiotics

8
Q

E. coli EIEC

  • type
  • 3 facts
A

Enteroinvasive-Inflammatory/Bloody Diarrhea

  • invasive as shigella
  • dysentery
  • no produce SLT or hemolytic urecemic syndrome
9
Q

Salmonella (non-typhoidal)-enteritidis

  • type
  • ID
  • Virulence
  • Sx
  • trx
A

Salmon Dinner
Inflammatory/ Diarrhea
-chikens are main reservoir/history, acid sensitive
-Use M cells, Type 3 secretion system has virulence factor, multiply in phagocytic vacuole
-fGastroenteritis, nausea voting, non-bloody diarrhea, fever
-just fluid/electrolye replacement (no antibiotic)

10
Q

Campylobacter jejune

  • type
  • ID
  • Virulence
  • Sx
A

Camping Guy with bears
Inflammatory/Bloody Diarrhea
-thermophilic, grow on Campy-BAP media, curved gm - rod, oxidase positive
-Labile toxin and cytotoxin
-dysentery like diarrhea+associated with Guillan Barre (ascending paralysis and loss of myelin), reactive arthritis

11
Q

Campylobacter fetus

  • type
  • ID
  • Virulence
  • Sx
A

Inflammatory/Bloody Diarrhea

  • Campy-BAP media, oxidase positive, curved gram - rod
  • S-layer to which C3B can’t bind (S-layer antigenic phase variation)
  • Oppurtunistic pathgogen-bactermina and intestinal abscesses
12
Q

Heliobacter pylori

  • type
  • ID
  • Virulence
  • Sx
  • trx
A

Helicopter Pilot
Inflammatory/Bloody Diarrhea
-Urease positive @ endoscopy/bioposy, curved cells, exhale CO2 from urease positive
- urease positive-makes environment alkaline, resides below protective layer of mucus, chromosomal pathogenicity island encoding cytotoxin, Type 4 secretion of exotoxin
-peptic ulcers, MALT/gastric lymphoma, inflammation
-PPI, Amoxicillin, macrolide (clarithomyacin)

13
Q

Salmonella typhi

  • ID
  • Virulence
  • Sx
  • trx
  • special
A

Salmon Dinner
Penetrating
-Bone marrow culture
-Vi antigen capsule, Enter through M cells,multiple in phagocytic vacuole of macrophages and then spread to reticuloendothelial system (via type 3 system on 2nd pathogenicity island)
-Bacterimia-infect liver, spleen, bone marrow, ulceration and necrosis of infected payer’s patches, hepatosplenomegaly, fever, headache etc.
-fluroquinolone
-tyhpid mary (chornic carrier in gallbladder)

14
Q

Yersinia (entercolitic-uncommon, tuberculosis-rare)

  • ID
  • Virulence
  • Sx
  • trx
A

Yersin’s pets
Penetrating (these two species are intestinal)
-grow a cold temp-psyhcrophile, primarily affect animals
-get in with M cells, exit intestine to lymph nodes and survive by binding to phagocytes (type 3), block phagocytosis by secreting proteins (type 3), induce phagocyte apoptosis
-severe pain and appendicitis, intense inflammation and ulceration of payer’s patch/mesetneric lymph nodes, surface antigen V and W are part of type 3
-Streptomycin (aminoglycoside) and tetracycline

15
Q

Non inflammatory Infections-5

A

Both types of cholera, ETEC, EPEC, EAEC

16
Q

Inflammatory/Bloody Diarrhea Infections-7

A

Shigella, EHEC, EIEC, Non-typhoidal salmonella, Campylobacter (both types), and Heliobacter pylori

17
Q

Penetrating Infections -2

A

All Yersinia and Salmonella typhi

18
Q

UTI causing bacteria

A

also cause neonatal bactermia/meingitis

E. coli
E. coli K1
E. faecium
S. saprophyticus

19
Q

Opportunistic/Nosocomial Infection-4

A

2 Enterobacter-cloacae and aeogenes, Klebsiella penumoniae, Sebratia marcesens

20
Q

Sebratia marcesens

A

Dinosaur one
Opportunistic/Nosocomial Infection
-produce OJ/Red pigments
-MDR

21
Q

Klebsiella pneumoniae

A
Dinosaur one
Opportunistic/Nosocomial Infection
-encapsulated-look shiny on agar, not motile
-community acq/nosocomial pneumonia's
-currant help sputum 
-MDR
-necrotizing penumonia
-odler adults with diabetes/alcholism/ chronic lung disease
-common UTI
22
Q

Enterobacter cloacae/aerogenes

A

Opportunistic/Nosocomial Infection

  • MDR
  • mobile!
23
Q

E. coli as UTI

  • virulence
  • characteristics
  • trx
A

E. cola’s soda fountain
80% uncomplicated UTI
-P fimbrae (adhesive), cystitis by traveling up GU tract, kidney problems
-Cystitis-urgency, freq, dysuria (pain)–Pyelonephiritis-fever, low back pain, leukocytes in urine, bacteria coated with Ab (P fimbrae is antigenic)
-Quntattive concentration (since normal flora) , dipstick detecting metabolic activity of bacteria

24
Q

E. Coli K1

A

K1 capsule resembles host and activates complement poorly
S pilli-S fimbrae binds to chloride plexus epithelium/brain ventricle
Irone acquisition system
Cytotoxic necrotizing factor
Neonatal septicemia and meningitis

25
Q

when antiobtiocs not recomended

A

DNA damage increases toxin production and worsens disease (mostly)

26
Q

Proteus mrabilis

  • ID
  • Disease
  • Trx
A

God of public restroom

  • Gm- with swarming motility, urease positive (makes struvite stones)
  • form staghorn caliculi, UTI, struvte stones, Fishy order
  • Sulonamides
27
Q

Type 3

A

method for phagocytosis