EOR #6 pharm part 1 Flashcards
(42 cards)
Common indications for tiotropium
COPD
Asthma
MOA for tiotropium
Antagonizes binding of acetylcholine to M3 receptors on bronchial smooth muscle, resulting in bronchodilation which lasts greater than 24 hrs
Common adverse effects of tiotropium
Dry mouth Pharyngitis Sinusitis Upper RTI Throat irritation Hoarseness
Clinically significant drug interactions of tiotropium
Use with either bupropion or donepezil could lower the seizure threshold
Major counseling points of tiotropium
Store in a cool dry place away from kids and sunlight Unused capsules should remain in the blister strip and be used over the next 2 days If a dose is missed, take it as soon as possible – if it is closer to the time of your next dose than the missed dose, skip the missed dose and return to the normal dosing schedule
Use daily for maximum effectiveness
How to use product
Monitoring parameters of tiotropium
Pulmonary function tests
Proper technique
S/sx of asthma/COPD
Common indications for benazepril
Tx of HTN, either alone or in combo with other antihypertensives
CHF
MOA of benazepril
ACE-I
Common AEs of benazepril
Cough HA Dizziness Angioedema Fatigue Nausea
Renal or hepatic dose adjustments for benazepril
Renal- CrCL <30: initiate at 5 mg
BBW for benazepril
Fetal toxicity
Clinically significant drug interactions of benazepril
Use of NSAIDs should be avoided or limited, with monitoring of blood pressure control in this setting.
In patients with HF, NSAID use may be associated with an increased risk for fluid accumulation and edema. ARBs
Major counseling points of benazepril
Avoid nonprescription cough, cold, and allergy medications unless otherwise directed
Avoid salt substitutes containing potassium.
Report any sign of angioedema
Let physician know if pregnant or planning on becoming pregnant.
Monitoring parameters of benazepril
Decrease in BP HR Sx of CHF SCr Potassium
Common indications for celecoxib
Nonsteroidal anti-inflammatory
For the relief of osteoarthritis Relief of the signs and symptoms of rheumatoid arthritis in adults
For the management of acute pain and dysmenorrhea
MOA of celecoxib
Inhibits prostaglandin synthesis by decreasing the activity of the enzyme, cyclooxygenase-2 (COX-2), which results in decreased formation of prostaglandin precursors; has antipyretic, analgesic, and anti-inflammatory properties.
Common AEs of celecoxib
Diarrhea Dyspepsia Abd pain Flatulence Edema Bleeding
Renal or hepatic dose adjustments for celecoxib
Advanced renal disease: Use is not recommended, Moderate hepatic impairment: Reduce dose by 50%.
Severe hepatic impairment: Use is not recommended.
BBW for celecoxib
Celecoxib may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction (MI), and stroke, which can be fatal.
NSAIDs, including celecoxib, cause an increased risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Clinically significant drug interactions for celecoxib
May increase the effects of warfarin
Major counseling points of celecoxib
May be taken without regards to meals
Report any signs of ulcerations and bleeding to a physician
Avoid ASA or ASA containing products
Pay close attention to sudden mood change and suicidality
Monitoring parameters of celecoxib
Decrease the S/S of inflammatory conditions, rheumatoid arthritis, dysmenorrhea, improvement in S/S pain
Common indications of benzonatate
Symptomatic relief of cough
MOA of benzonatate
Tetracaine congener with antitussive properties Suppresses cough by topical anesthetic action on the respiratory stretch receptors
