Epidemiology Flashcards

(52 cards)

0
Q

Which of the following is not an advantage of the prospective cohort study?

A

It usually cost less than a case control study

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1
Q

What is epidemiology?

A

Epidemiology is the study of the distribution and determinants of disease in human populations.

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2
Q

Retrospective cohort studies are characterized by all of the following except?

A

The required sample size is smaller than that I needed for a Prospective of cohort study

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3
Q

A major problem resulting from the lack of randomize in a cohort study is

A

The possibility that a factor that led to the exposure, rather then the exposure itself, might have caused the disease.

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4
Q

In a study of a disease in which all cases that developed where ascertained, if the relative risk for the association between a factor and the disease is equal to or less than 1.0, then:

A

There is no association or a negative association between the factor and the disease

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5
Q

Controls are needed in case control study because

A

They provide a comparable estimate of the frequency of exposure in the absence of disease

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6
Q

The strength of an association between a factor and a disease is best measured by

A

Relative risk

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7
Q

All of the following are important criteria when making casual inferences except

A

Predictive value

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8
Q

Which of the following is an approach to handling confounding

A

Individual matching, stratification, group matching, and Adjustment

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9
Q

Which of the following is an advantage of the case control study

A

It may be used to study etiology of a rare disease

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10
Q

In 1945, there were 1000 women who worked in a factory painting radio dials on watches. The incidence of bone cancer in these women up to 1975 work compared with that of 1000 women who worked as telephone operators in 1945. 20 of the radio dial painters and four of the telephone operators developed bone cancer between 1945 and 1975 this study is an example of a

A

Cohort study

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11
Q

Residents of three villages with three different types of water supply were asked to participate in a survey to identify cholera carriers. Because several cholera had occurred in the recent past, virtually everyone present at the time submitted to examination. The proportion of the residents in each village were carriers was computed and compared. Classify this study?

A

Cross-sectional study

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12
Q

In a case control study, which of the following is true

A

The proportion of cases with the exposure is compared with the proportion of controls with the exposure. The investigator may choose to have many comparison groups. Recall bias is a potential problem.

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13
Q

Several studies have found that approximately 85% of cases of lung cancer are due to cigarette smoking. This measure is an example of?

A

Attributed risk

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14
Q

Factor A, B, or C can each individually cause a certain disease without the other two factors, but only when followed by exposure of factor X. Exposure to factor X alone is not followed by the disease, but the disease never occurs without the absence of exposure to factor X. Factor x is

A

A necessary but not sufficient cause

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15
Q

Factor A, B, or C can each individually cause a certain disease without the other two factors, but only when followed by the exposure to factor X. Exposure to factor X alone is not followed by the disease, but the disease never occurs in the absence of exposure X. Factor A is?

A

Neither necessary or sufficient

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16
Q

What does group matching mean in the case control study

A

Group matching allows for both cases and controls to be comparable to all possible factors. An example can be that 25% of cases are married then 25% of controls must also be married

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17
Q

What does the confounding factor mean in an epidemiological study?

A

Confounding factor is a factor that is accompanied by a known factor that causes a disease.

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18
Q

What does bias mean and what are the major biases and and epidemiological study?

A

Information bias, selection bias, and confounding. To favor or to conclude without actual evidence.

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19
Q

When is odds ratio a good estimate of relative risk

A
  1. When the cases studied are representative, with regard to history of exposure, of all people with the disease in the population from which the cases were drawn.
  2. When the controls studied are representative, with regard to history of exposure, of all people without the disease in the population from which the cases were drawn.
  3. When the disease being studied does not occur frequently
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20
Q

What made John Snow’s work on Cholera noteworthy?

A

He was one of the first person to use methods based on population-based patterns of disease and take effective action in the prevention of future disease.

21
Q

Epidemic means that a disease is or has

A

Has an excess of normal expectancy than previous years

22
Q

Which of the following is a characteristic of single exposure, common vehicle outbreak?

23
Q

After infection with HIV, the virus multiplies and progressively destroys immunocompetent Cells. Early in this phase, there are few signs or symptoms in the host. This period of disease is called

A

Incubation period

24
An epidemic might occur as a result of
An increase in the pathogenicity of an agent, and increase in the susceptibility of the population, or changes in the environment that favor the agent.
25
Age adjusted death rates are used to
Eliminate the effects of differences in the age distributions of populations in comparing death rate
26
Which of the following is an advantage of active surveillance?
More accurate due to reduced reporting burden of healthcare providers.
27
A pandemic means that a disease
Affects a large number of countries simultaneously
28
A double-blind study of a vaccine is one in which
Neither observer nor subjects know which subject receives the vaccine and which subject receives the placebo
29
The major purpose of the random assignment of subjects in a clinical trial is to
Reduce selection bias in the allocation of treatment
30
An advertisement in a medical journal stated that 2000 subjects with sore throat were treated with our new medicine. Within four days, 94% were asymptomatic. The advertisement claims that the medicine was effective. Based on the evidence given above the claim is
May be incorrect because no control or comparison group was involved in the study
31
Which of the following is a good index of the severity of a short term acute disease?
Case fatality rate
32
All of the following are potential benefits of randomized clinical trial except
The external validity of the subject is increased
33
The following vaccine trial was performed where 1000 randomly selected children, of these 80% never afflicted with the disease. Which is the most correct conclusion regarding the efficacy of the vaccine
No conclusion is possible since no follow-up was made of non-vaccinated children
34
Iceberg concert of disease states that
Most of the underlying symptoms are not detected only those of clinical significance can be seen.
35
Herd immunity is
The susceptibility of a population of acquiring a disease as a result of vaccination or immunity of others within the population.
36
Can you design a clinical trial to test a new drug for treatment of lung cancer?
Yes by randomly dividing into two groups
37
What is the definition of person year and can you give an example
If two subjects are observed for five years each it is equivalent to 10 years. the number of people observed times the duration in which they were observed
38
What is incidence rate
No. of new cases of a disease over a period of time --------------------------------------------------------------- Population at risk of the disease in the time period
39
What is prevalence?
No. of cases of a disease present in the population at a specified time ----------------------------------------------------------------------- No. of persons in the population at that specified time
40
What is mortality rate
Total No. of deaths from all causes in 1 year ---------------------------------------------------x 1,000 No. of persons in the population at midyear
41
What is case fatality rate
No. of deaths due to the disease in a specified time period --------------------------------------------------------------------x 100 No. of cases of the disease in the same time period
42
What is proportionate mortality rate? (PMR)
Deaths assigned to the disease in a certain year --------------------------------------------------------x 100 Total deaths in the population in the same year
43
What is standard mortality rate? SMR
Observed no. of deaths per year ---------------------------------------x 100 Expected no. of deaths per year
44
What is sensitivity?
Sensitivity is the ability of the screening test to give a positive finding in those developing the disease. It is expressed as a percentage: People with the disease detected by screening test --------------------------------------------------------------- x 100 Total number of people tested with the disease
45
What is specificity?
Specificity is the ability of the test to give a negative finding when the subjects tested are not developing the target outcome. It is also expressed as a percentage: People without the disease who are negative to the screening test ---------------------------------------------------------------------------x 100 Total number of people tested without the disease
46
What is relative survival rate
Relative survival rate = Observed survival in people with the disease ---------------------------------------------------------------- Expected survival if disease were absent
47
What is efficacy?
(Rate in those who received placebo) – (Rate in those who received the vaccine) -------------------------------------------------------------------------------- Rate in those who received the placebo
48
What is relative risk
a / (a + b) | ------------------- c / (c + d
49
What is odds ratio?
Odds Ratio = ad/bc
50
What is attributable risk
Attributable Risk (Incidence in exposed group) – (Incidence in nonexposed group)
51
What proportion of the risk in exposed persons is due to the exposure?
(Incidence in exposed group) – (Incidence in nonexposed group) --------------------------------------------------------------------------- Incidence in exposed group