Epigastric Abdominal Pain Flashcards
Describe the timeframe for serum amylase testing relative to acute pancreatitis onset. (3)
Within 2 hours of onset - amylase rises rapidly
12-72 hours - amylase levels peak
3 or more days - amylase levels return to normal
Describe the timeframe for serum lipase testing relative to acute pancreatitis onset. (2)
24 hours after onset - serum lipase levels peak
8-14 days - levels remain elevated
What is the contemporary classification of acute pancreatitis severity?
-Mild acute pancreatitis —> no organ failure or local/systemic complications
-Moderate severe acute pancreatitis —> transient organ failure resolving within 48 hours (i.e AKI); may also have local complication
-Severe acute pancreatitis —> persistent organ failure/multi-organ failure
What are the two types of acute pancreatitis?
-Interstitial Oedematous Pancreatitis - pancreatic parenchyma is inflamed/oedematous
-Necrotising Pancreatitis - necrosis of pancreatic parenchyma and/or peripancreatic tissue, which may become infected.
What is the possible progression of Interstitial Oedematous Pancreatitis? (3)
Interstitial Oedematous Pancreatitis —> Acute Peripancreatic Fluid Collection (APFC) —> Pseudocyst
What is a pseudocyst?
A homogenous fluid-filled collection with a cyst wall, that may compress surrounding structures.
What is the possible progression of Necrotising Pancreatitis? (3)
Necrotising Pancreatitis —> Acute Necrotic Collection (ANC) —> Walled Off Necrosis (WON)
What is Acute Necrotic Collection (ANC)?
An inhomogenous collection of fluid (both intra- and/or extra-pancreatic) and solid components, occurring within 4 weeks of necrotising pancreatitis.
What is Walled Off Necrosis (WON)?
An inhomogenous collection of fluid and solid components/necrotic tissue with a cyst wall (unlike ANC in which there is no wall).
