Epilepsy And Tremor Flashcards

1
Q

Features of essential tremor

A
Fine tremor 
Symmetrical 
More prominent on voluntary movement 
Worse when tired, stressed or after caffeine 
Improved by alcohol 
Absent during sleep
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2
Q

Differentials for tremor

A
Parkinson’s disease 
Multiple sclerosis 
Huntington’s chorea 
Hyperthyroidism 
Fever 
Medication - antipsychotics 
Essential tremor
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3
Q

Management of essential tremor

A

Propranolol

Primidone - barbiturate anti - epileptic medication

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4
Q

Seizure definition

A

Transient episodes of abnormal electrical activity in the brain

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5
Q

Investigations for epilepsy

A

EEG
MRI brain - tumours
Haematinics

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6
Q

Types of seizures

A
Generalised tonic clinic seizures 
Focal seizures 
Absence seizures 
Atonic seizures 
Myoclonic seizures 
Infantile spasms
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7
Q

Generalised tonic clonic seizures

A

Loss of consciousness
Tonic - muscle tensing
Clonic - muscle jerking

Tongue biting 
Incontinence 
Groaning 
Irregular breathing 
Post-ictal period
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8
Q

Post ictal period

A

Time after the seizure where the person is confused, drowsy and feels irritable or depressed

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9
Q

History of seizure

A

Before, during after
SOCRATES - onset, character, relieving factors, aggravating factors, time and duration

Symptoms:

  • tongue biting
  • incontinence
  • loss of consciousness
  • fever
  • de ja vu
  • hallucinations
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10
Q

Management of tonic clonic seizures

A

First line - sodium valproate

Second line - lamotrigine or carbamazepine

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11
Q

Focal seizures

A

Start in the temporal lobe, affecting hearing, speech, memory and emotions

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12
Q

Focal seizure presentation

A

Hallucinations
De ja vu
Flashbacks
Auto pilot

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13
Q

Management of focal seizures

A

First line: carbamazepine or lamotrigine

Second line: sodium valproate or levetiracetam

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14
Q

Absence seizures features

A

Typically children

Patient becomes blank and stares into space then abruptly returns to normal

Unaware of surroundings and won’t respond

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15
Q

How to initiate an absence seizure

A

Get child to blow tissue paper repeatedly

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16
Q

Management of absence seizures

A

Sodium valproate

Or ethosuximide

17
Q

Atonic seizures features

A

Drop attacks - brief lapses in muscle tone

Less than 3 minute episodes

18
Q

Which condition is atonic seizures associated with?

A

Lennox- Gastaut syndrome

19
Q

Management of atonic seizures

A

First line: sodium valproate

Second line: lamotrigine

20
Q

Features of myoclonic seizures

A

Sudden brief muscle contractions like a sudden jump

Usually awake

Normally in children as juvenile myoclonic epilepsy

21
Q

Treatment of myoclonic seizures

A

First line: sodium valproate

Second line: lamotrigine, levetiracetam or topiramate

22
Q

Infantile spasm features

A

West syndrome - clusters of full body spasms

Poor prognosis

23
Q

Treatment of West syndrome

A

Prednisolone

Vigabatrin

24
Q

Sodium valproate

A

GABA agonist

25
Side effects of sodium valproate
Teratogenic Liver damage and hepatitis Hair loss Tremor
26
Side effects of carbamazepine
Agranulocytosis Aplastic anaemia Induces P450
27
Phenytoin side effects
Folate and vitamin D deficiency Megaloblastic anaemia Osteomalacia
28
Ethosuximide side effects
Night terrors | Rashes
29
Lamotrigine side effects
Steven Johnson’s syndrome | Leukopenia
30
When to admit a seizure
Lasting more than 5 minutes ore more than 3 seizures in 1 hour
31
Status epilepticus
When seizure persists for > 5 mins | Medical emergency
32
Status Epilepticus management
A-E - secure airway - high concentration oxygen 15L - check blood glucose levels - IV lorazepam 4mg repeated after 10 minutes if seizure continues - if persists - phenobarbital or phenytoin
33
Medications in the community for status epilepticus
Buccal Midazolam | Rectal diazepam