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DENT 317 - Oral Pathology > Epithelial Pathology > Flashcards

Epithelial Pathology Flashcards

1
Q

Incubation period of HPV

A

3 weeks to 2 years

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2
Q

5 factors contributing to the likelihood of developing HPV

A
  • Impaired immune function
  • Smoking
  • Old age
  • Hand warts
  • Oral sex
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3
Q

8 modes of transmission of HPV

A
  • Sexual
  • Non-sexual person to person
  • Salivary transfer
  • Contaminated objects
  • Autoinoculation
  • Breastfeeding
  • Perinatal transmission
  • Possible pre-natal
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4
Q

Describe the general progression of an HPV lesion

A
  1. Normal skin/mucosa - virus latent in nuclei of basal epithelial cells (episomal); low copy numbers
  2. HPV lesions - HPV-DNA in various cell layers –> increased copy number –> shedding of mature virions
  3. HPV-induced malignant transformation is rare
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5
Q

Define squamous papilloma

A
  • Benign exophytic growth of stratified squamous epithelium
  • Usually solitary soft “cauliflower” like growth
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6
Q

Describe the appearance of a squamous papilloma

A
  • Usually max 0.5 cm
  • Sessile or pedunculated
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7
Q

Usual locations of squamous papilloma (5)

A
  • Soft palate
  • Uvula
  • Ventral tongue
  • Dorsal tongue
  • Lips

NOTE: Any site may be affected

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8
Q

Describe the physical constituents of squamous papilloma

A
  • Papillary layer of squamous epithelium
  • Central core of fibrovascular connective tissue
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9
Q

Treatment for squamous papilloma

A
  • Surgical excision with a small amount of normal tissue
  • Scissors excision works well
  • Recurrence uncommon

NOTE: Lesions have been left untreated for years with no reported malignant transformation, enalrgement or dissemination to other parts of oral cavity

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10
Q

Cause of squamous papilloma

A

Weak HPV types (HPV6 and HPV11)

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11
Q

Define verruca vulgaris

A

Focal benign HPV-induced hyperplasia of epithelium

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12
Q

Describe the clinical appearance of verruca vulgaris (6)

A
  • May be similar to a squamous papilloma
  • Painless papule or nodule with rough pebbly surface
  • Pedunculated or sessile
  • Pink, yellow or white
  • Usually <5mm
  • Multiple or clustered lesions common
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13
Q

Cause of verruca vulgaris

A

HPV 2 is present most often HPV 4

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14
Q

Virulence of verruca vulgaris

A
  • May spread to other parts of the skin or mucosa by autoinoculation
  • Children most affected
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15
Q

Describe the progression of verruca vulgaris

A
  • Low rate of recurrence
  • Will not transform into malignancy
  • 2/3 disappear spontaneously within 2 years
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16
Q

4 treatments for oral verruca vulgaris

A
  • Excisional biopsy
  • Laser
  • Cryotherapy
  • Electrosurgery
17
Q

3 treatments for verruca vulgaris on the skin

A
  • Topical salicylic acid
  • Lactic acid
  • Liquid nitrogen
18
Q
A

DENT 317 - Oral Pathology (6 decks)

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