Epstein Barr Virus

Question 1

Human Herpes 4 Virus

Answer 1

Epstein Barr virus

Question 2

A viral infection in developed countries presenting with 2 peaks:
1. prominent in Children 1-6years, and
2. Adolescences 14-20 years.

Answer 2

Epstein Barr or HHV 4

Question 3

What’s the early age of infection with Epstein Barr virus?

Answer 3

<2 years

Question 4

What is classic mononucleosis caused by epstein bar virus? ?

Answer 4

Classic infectious mononucleosis is characterized by a constellation of symptoms including glandular fever, sore throat, swollen lymph nodes, fatigue, enlarged Spleen and Liver, typically lasting for several weeks to months.

Question 5

What’s complication is caused by Epstein Barr virus on the immunocompromised?

Answer 5

– lymphoproliferative syndrome
- Burkitt’s lymphoma

*Lymphoproliferative Syndrome-Group of disorders characterized by abnormal proliferation (growth) of lymphocytes

Question 6

What’s the transmission route of Epstein Barr virus?

Answer 6

Contact with saliva

Question 7

What conditions are caused by Epstein Barr virus on AIDS patients?

Answer 7

• Oral Leukoplakia (characterized by the presence of white patches or plaques on the mucous membranes of the mouth, including the inner cheeks, gums, tongue, and the floor of the mouth)
• Chronic interstitial pneumonitis (grp of diseases causing lung fibrosis/scaring

Question 8

What is a nasopharnxy carcinoma caused by Epstein Bar Virus?

Answer 8

Nasopharngeal carcinoma

Question 9

How is Epstein Barr virus diagnosed?

Answer 9

• Direct detection:
  -PCR for DNA
  -Immunohistochemistry for viral proteins
• Serology
  -IgG-> past infection
  -IgM-> recent primary infection

Question 10

What’s the possible treatment for Epstein Barr virus?

Answer 10

• No effective antiviral treatment!
• Acyclovir and ganciclovir may reduce viral shedding, no effect clinically

Question 11

Possible prevention techniques for Epstein Barr virus?

Answer 11

None, no vaccine