Eqs

Question 1

Bioavailability

Answer 1

(AUCev/DOSEev)/(AUCiv/DOSEiv)

Question 2

Plasma Clearance

Answer 2

Dose/AUC

Question 3

Renal Clearance

Answer 3

fe*CLp

Question 4

Oral Clearance

Answer 4

F*Dose/AUC

Question 5

Hepatic Clearance

Answer 5

CLp - CLr

Question 6

Blood Clearance

Answer 6

CLp/(Cb/Cp)

Question 7

Drugs are secreted if

Answer 7

CLr > fu*GFR

Question 8

Drugs are reabsorbed if

Answer 8

CLr < fu*GFR

Question 9

Clearance

Answer 9

Vd*Kel

Question 10

half-life

Answer 10

0.693/Beta

Question 11

Concentration

Answer 11

Co*e^(-kt)

Question 12

Tissue Volume

Answer 12

Vp*K12/K21

Question 13

Plasma Concentration

Answer 13

Ae^(-alphat)+Be^(-betat)

Question 14

Mean Transport Time (oral)

Answer 14

AUMC/AUC

Question 15

Mean Transport Time (IV)

Answer 15

1/k

Question 16

Mean Residence Time

Answer 16

MTTiv

Question 17

Mean Arrival Time

Answer 17

MTTpo-MRT

Question 18

AUCtn-tn+1

Answer 18

deltat*[Cpn+Cp(n+1)]/2

Question 19

AUMCtn-tn+1

Answer 19

deltat[Cpntn+Cp(n+1)*t(n+1)]/2

Question 20

Duration of Effect 1

Answer 20

(1/k)ln((1+Amin)/Amin)

[Amin = minimum Amount (g)]

Question 21

Duration of Effect 2

Answer 21

(1/k)ln(Dose/(Cmin*Vd))

Question 22

High E Drugs increase QH

Answer 22

Increases Cl& F and Decreases AUCiv & half-life

Question 23

High E Drugs increase CLint

Answer 23

Decreases F and AUCoral

Question 24

High E Drugs increase fub

Answer 24

Increases Vdp & half-life, and Decreases F & AUCoral

Question 25

Low E Drugs Increase QH

Answer 25

No Change

Question 26

Low E Drugs increase CLint

Answer 26

Increases CL and Decreases half-life, AUCiv, & AUCoral

Question 27

Low E Drugs increase fub

Answer 27

Increases CL & Vdp and Decreases AUCiv &AUCoral | Will also change half-life depending on changes in CL and Vdp