ERTYTHROPOIESIS

Question 1

gives rise to the earliest colony of RBC called BFU-E

Answer 1

CFU-GEMM

Question 2

CFU-GEMM stands for

Answer 2

Colony Forming Unit - Granulocyte Eosinophil Monocyte - Megakaryocyte

Question 3

under what influence does the BFU-E develop into CFU-E colonies

Answer 3

• IL-3
• GM-CSF ( Granulocyte-macrophage colony-stimulating factor)
• TPO (thyroid peroxidase)
• Kit-Ligand

Question 4

what stimulates red cell production

Answer 4

erythropoietin

Question 5

in what cell is the erythropoietin produced

Answer 5

renal peritubular interstitial cells

Question 6

in what organ is the EPO produced

Answer 6

Kidney

Question 7

multi subunit colonies in the BFU-E

Answer 7

bursts

Question 8

immature form of RBC

Answer 8

reticulocyte

Question 9

if liver/ spleen synthesizes RBC instead of BM ( if it cannot synthesize blood)

Answer 9

Extramadullary Hematopoiesis

Question 10

it is the stage where protein and enzymes are accumulated for iron uptake and protoporphyrin synthesis is produced

Answer 10

pronormoblast

Question 11

globin production begins

Answer 11

pronormoblast

Question 12

stage where there is detectable Hgb synthesis

Answer 12

Basophilic normoblast

Question 13

last stage where nucleolus is found/ last stage of RNA synthesis

Answer 13

basophilic normoblast

Question 14

in the basophilic normoblast, Hgb synthesis occurs. What completely masks the minute amount of Hgb pigmentation

Answer 14

• many cytoplasmic organelles
• • incld. ribosomes
    – and a substantial amount of mRNA

Question 15

many loving colors resulting to a murky gray-blue color

Answer 15

polychromatophilic normoblast

Question 16

last stage which the cell undergoes mitosis

Answer 16

polychromatophilic normoblast

Question 17

1st stage wherein stain can be seen

Answer 17

polychromatophilic normoblast

Question 18

full blast Hgb synthesis

Answer 18

polychromatophilic normoblast

Question 19

Dawn of Hemoglobinization

Answer 19

polychromatophilic normoblast

Question 20

phenomenon wherein most iron and Hgb synthesis is taken in this stage,

Answer 20

Dawn of Hemoglobinization

Question 21

nucleus is completely condensed

Answer 21

orthochromatic normoblast

Question 22

pyknotic nucleus

Answer 22

orthochromatic normoblast

Question 23

nucleus will move to the cell membrane and into a pseudopod - like projection resulting to the loss of vimentin

Answer 23

orthochromic normoblast

Question 24

protein responsible for holding organelles in the proper location

Answer 24

vimentin

Question 25

enveloped extruded nucleus which is then engulfed by bone marrow macrophages

Answer 25

pyrenocyte

Question 26

what is on the surface of the splenocyte which acts as an "eat me flag"

Answer 26

phospgatidylserine

Question 27

small fragments of the nucleus left behind when the projection is pinched off before the entire nucleus is enveloped

Answer 27

Howell-Jolly bodies

Question 28

remnants of the nucleus containing DNA

Answer 28

Howell-Jolly bodies

Question 29

complete production of Hgb

Answer 29

reticulocyte

Question 30

t/f lacking a nucleus, the polychromatophilic erythrocyte can divide

Answer 30

false

Question 31

what is used to stain reticulocyte

Answer 31

supravital stain

Question 32

what is used to stain polychromatophilic erythrocyte

Answer 32

Wright stain

Question 33

thickness of erythrocyte

Answer 33

1.5-2.5 um

Question 34

size of the RBC's central palor

Answer 34

1/3 of the RBC

Question 35

reticulocytes are increased for compensation d/t high demands of the body

Answer 35

stress/shift

Question 36

storage form of iron that is H2O soluble and readily accessible

Answer 36

ferritin

Question 37

fro iron transfer from cells to blood

Answer 37

copper

Question 38

forms of copper

Answer 38

a. serum - ceruloplasmin b. erythrocuperin - erythrocyte bound copper

Question 39

component of Hgb that is excreted

Answer 39

Heme

Question 40

component of Hgb which is recycled fro Hgb synthesis

Answer 40

iron

Question 41

incorporated with vitamin B12 that stimulate erythropoiesis similar to the effect produced by EPO

Answer 41

cobalt