eruptive viruses Flashcards

(47 cards)

1
Q

What are the two main clinical types of viral infections with cutaneous manifestations?

A

Eruptive forms and tumoral forms

Eruptive forms include rashes, while tumoral forms involve viral-induced tumors.

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2
Q

What types of tumors are linked to human papillomaviruses (HPV)?

A

Warts and condylomas

HPV is associated with benign tumors like warts and condylomas.

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3
Q

What are the types of eruptions in viral infections?

A

Maculopapular, vesicular, and rarely pustular

Eruptive manifestations can present in various forms.

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4
Q

Name two childhood eruptive fevers linked to specific viruses.

A

Measles and rubella

These diseases are characterized by distinct rashes and systemic symptoms.

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5
Q

What is the basic reproduction rate (R0) for measles?

A

15 to 20

This indicates measles is highly contagious.

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6
Q

What is the incubation period for measles?

A

10 days

Symptoms typically begin after this incubation period.

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7
Q

What are Koplick’s spots associated with?

A

Measles

These spots appear inside the cheeks and are a classic sign of the infection.

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8
Q

What are the common complications of measles?

A

Bacterial superinfections, respiratory complications, and neurological complications

Severe complications can occur, especially in malnourished or immunocompromised children.

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9
Q

What is the primary method of virological diagnosis for measles?

A

Serology to detect IgM antibodies

This method allows for rapid diagnosis of measles infections.

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10
Q

What is the vaccination schedule for measles prevention?

A

First dose at 12 months, booster at 18 months

The vaccine is an attenuated virus that induces immunity.

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11
Q

What are the two transmission routes for rubella virus?

A

Direct airborne transmission and transplacental transmission

These routes highlight the contagious nature of rubella, especially in pregnant women.

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12
Q

What is congenital rubella syndrome (CRS)?

A

A polymalformative syndrome in fetuses due to rubella infection in pregnant women

CRS can lead to severe birth defects.

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13
Q

What is the incubation period for rubella?

A

14 to 20 days

This period precedes the onset of symptoms.

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14
Q

What is the characteristic rash associated with rubella?

A

Macular rash that begins on the face and spreads

The rash is not always consistent and can have atypical forms.

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15
Q

What is the primary immune response to rubella?

A

Humoral response (IgG, IgM, IgA)

This immune response provides definitive immunity against the virus.

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16
Q

What are common adenopathies associated with rubella?

A

Suboccipital, posterior cervical, and retro-auricular

These lymph node enlargements can persist for weeks.

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17
Q

What complications can arise from rubella?

A

Arthralgia and rarely neurological complications

Most cases resolve without significant sequelae.

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18
Q

What are the adenopathies associated with the rash?

A

Suboccipital, posterior cervical, and retro-auricular.

Adenopathies appear a week before the eruption and can persist for several weeks.

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19
Q

What is plasmacytosis and how is it detected?

A

Detected by blood count (greater than or equal to 5%).

It is characteristic but inconstant.

20
Q

What type of immune response is primarily involved in this disease?

A

Humoral (IgG, IgM, IgA).

This response gives definitive immunity.

21
Q

What are some rare complications of the disease?

A

Arthritis, encephalitis, thrombocytopenic purpura.

22
Q

In pregnant women, what can happen during primary infection?

A

The virus can cross the placental barrier, causing considerable damage to the unborn child.

23
Q

What is the malformative syndrome associated with embryopathy?

A

CRS (Congenital Rubella Syndrome) including malformations like cardiopathy, neurological damage, ocular damage, and deafness.

24
Q

What is the prognosis for infants affected by embryopathy?

A

Very high mortality during the first year of life (1 death in 5 cases) and uncertain psychomotor future.

25
What is the significance of IgG avidity testing?
To distinguish between primary infection and old infection.
26
What does an IgG index of less than 35% indicate?
Low IgG avidity: infections less than 2 months old.
27
What is the recommended timing for systematic screening during pregnancy?
In the first trimester (T1).
28
What indicates a probable old immunity in serological testing?
IgG + / IgM -.
29
What is the treatment for congenital rubella suspicion?
Detection of the viral genome from amniotic fluid and cord blood.
30
What is the primary prevention method for rubella?
Vaccination with a live, attenuated, injectable vaccine.
31
What is Parvovirus B19 associated with?
Eruptive diseases, particularly 5th disease and possible acute/chronic anemia.
32
What family and genus does Parvovirus B19 belong to?
Family: Parvoviridae; Genus: Erythrovirus.
33
What is the primary method of transmission for Parvovirus B19?
Airborne transmission.
34
What is the peak age for seroprevalence of Parvovirus B19?
Over 60% after the age of 50.
35
What are systemic signs of parvovirus infection?
Aches, malaise, fever, skin rash, and joint pains.
36
What is the typical presentation of the rash caused by Parvovirus B19?
Maculo-papular rash starting on the face and spreading to the trunk and extremities.
37
What does acute erythroblastopenia indicate?
Crisis in patients with chronic anemia, particularly sickle cell anemia.
38
What is the probability of fetal contamination if a pregnant woman is infected with Parvovirus B19?
10% probability of contamination.
39
What is the indirect diagnosis method for Parvovirus B19?
Serology detecting specific IgM indicates recent primary infection.
40
What is the treatment for parvovirus infection?
Symptomatic treatment (e.g., blood transfusions).
41
What virus causes epidemics in winter and spring in children aged 2 to 7?
Ourlian virus.
42
What is the typical clinical presentation of Ourlian virus infection?
Bilateral parotitis and moderate fever.
43
What diagnostic method is commonly used for Ourlian virus?
Serological technique to detect specific IgM.
44
What is the incubation period for Ourlian virus?
21 days on average.
45
What is the vaccine type available for Ourlian virus?
Live attenuated vaccine.
46
What are some complications of Ourlian virus infection?
Lymphocytic meningitis, orchitis, or pancreatitis.
47
What is the direct diagnosis method for Ourlian virus?
RT-PCR from saliva, nasopharyngeal swab, urine, or CSF samples.