Erythrocyte Physiology Flashcards
(27 cards)
4 functions of blood?
deliver nutrients, remove waste, hemostasis (hormones, thermoreg), immunity
3 layers of centrifuged blood?
plasma, WBC, formed elements
what’s contained within plasma?
electrolytes, proteins, small organic molecules, lipids
what are the proteins carried in plasma? where are they made?
albumin, globulin, enzymes; liver
what is the norm hematocrit level for women?
35-45%
what is the norm hematocrit for men?
40-50%
where does erythropoiesis take place?
bone marrow
what is the primary organ that senses oxygen levels? secondary?
kidneys; liver
HIF leads to the production of what?
EPO (and transferrin)
function of transferrin?
transports oxygen in blood
what kind of pathway is the receptor for EPO connected to
Jak2/Stat5
EPO does what 2 functions?
stem cell activation into proerythroblasts; increase maturation rate of committed erythrocytic precursors
what are the requirements for erythropoiesis?
general nutrition, iron availability, vit B12, folic acid
what anemia occurs with iron deficiency?
microcytic anemia
what is required for B12 absorption?
Intrinsic factor
what kind of anemia results due to B12 def?
pernicious, macrocytic
what kind of anemia results due to folate def?
macrocytic
how many mL oxygen can be carried by 1 gm of Hb?
1.34
normal person has how many grams Hb?
15
norm person carries how much oxygen?
20.1 mL O2/1 dL blood
oxygen content is equal to?
oxygen capacity x % saturation
what kind of glycolysis is used by RBCs?
anaerobic
what does ATP get used for in RBCs?
flexibility of membrane, ion transport, maintain Fe2+ (instead of Fe3+), prevent oxidation of Hb
two processes to destroy RBCs?
Hemolysis: rupture of cell
Phagocytosis: spleen or macrophages (iron recycled and heme broken down to bilirubin)
