Erythrocytic Disorder Flashcards
(22 cards)
Is the rate at which RBCs sediment in a period of 1 hour
hematology test that is a non-specific
measure of inflammation
ESR
Cells are subjected to different concentrations of hypotonic solutions
OSMOTIC FRAGILITY TEST
Electronic field is generated around the micro-aperture in which blood cells passes
cells create resistance in the electronic field as they pass through calibrated micro-aperture creates electronic pulse to be generated, amplified, measured and then mathematically calculated to create numerical value
Electronic Impedance Variation Principle
Main function of hemoglobin
transport oxygen
Blood is diluted in a solution of potassium ferricyanide and potassium cyanide.
o The potassium ferricyanide oxidizes hemoglobin to hemiglobin (Hi; methemoglobin)
Cyanmethemoglobin (hemiglobincyanide; HiCN) method
technique may introduce
hemoconcentration, which will make hemoglobin concentration and cell counts too high.
Improper venipuncture
technique may introduce
hemoconcentration, which will make hemoglobin concentration and cell counts too high.
Improper venipuncture
Ratio of the volume of erythrocytes to that of the whole blood
Expressedeitherasapercentage(conventional)oras
a decimal fraction (SI units).
HCT
Storage of hct
In blood kept at room temperature, swelling of erythrocytes between 6 and 24 hours raises the hematocrit and MCV.
o Cell counts and indices are stable for 24 hours at 4°C
(Brittin, 1969).
The hematocrit reflects the concentration of red cells, not the total red cell mass.
T/F
True
red-gray layer between the red cells and
plasma
Buffy coat
The hematocrit is low in hydremia of pregnancy, but the total number of circulating red cells is not reduced.
T/F
True
Hematocrit is unreliable as an estimate of anemia immediately after a loss of blood or immediately following transfusions.
True
The hematocrit will be falsely low as a result of cell
shrinkage, but the hemoglobin and cell counts will not be
affected.
True
The hematocrit will be falsely low as a result of cell
shrinkage, but the hemoglobin and cell counts will not be
affected.
True
Is the average volume of red cells and is calculated from the hematocrit and red cell count
Mean cell volume
Content (weight) of Hb of the average cell
• Calculated from the Hb concentration and the red cell count
Mean cell hemoglobin
Two retic stain
Brilliant cresyl blue & methylene blue
Characterized by a marked hypoplasia of marrow
erythroid elements in the setting of normal granulopoiesis
and thrombopoiesis.
PURE RED CELL APLASIA
arisesecondarilytoneoplasms,
▪ particularly thymic tumors (thymomas) and large granular lymphocytic leukemia, drug exposures, or autoimmune disorders.
Pure red aplasia
Aplastic anemia manifestation
Associatedwithpancytopenia:
▪ Anemia
▪ Neutropenia, and
▪ Thrombocytopenia
The marrow failure stems from suppression or disappearance of multipotent myeloid stem cells.
The red cells are typically normocytic and normochromic, although slight macrocytosis is present
Splenomegaly is absent
Aplastic anemia
