ERYTHROPOIESIS PPT

Question 1

Erythrocyte has one true function:

Answer 1

to carry oxygen from the lung to the tissues, where the oxygen is released.

Question 2

RBCs are formally called

Answer 2

erythrocytes

Question 3

nucleated RBC precursors, normally restricted to the bone marrow

Answer 3

Erythroblasts/ normoblasts

Question 4

Morphologic identification of blood cells depends on a ________

Answer 4

well-stained peripheral blood film or bone marrow smear

Question 5

Commonly used stain/s, in identification of erythroid precursors.

Answer 5

Modified Romanowsky stain (Wright or Wright- Giemsa)

Question 6

The stage of maturation of any blood cell is determined by careful examination of the:

Answer 6

nucleus and the cytoplasm.

Question 7

The most important features in the
identification of RBCs are the:

Answer 7

-Nuclear chromatin pattern (texture, density, homogeneity),
- Nuclear diameter
-Nucleus-to-cytoplasm (N:C) ratio
-Presence or absence of nucleoli,
-Cytoplasmic color

Question 8

The nucleus is round to oval, containing
one or two nucleoli. The purple red chromatin is open and contains few, if any, fine clumps.

Answer 8

Pronormoblast (Rubriblast)

Question 9

The nucleus takes up much of the cell (N:C
ratio of 8:1) in ______

Answer 9

Pronormoblast (Rubriblast)

Question 10

The cytoplasm in Pronormoblast (Rubriblast) is dark blue because of the concentration of?

Answer 10

ribosomes and RNA along the periphery.

Question 11

The pronormoblast undergoes mitosis and gives rise to ?

Answer 11

two daughter pronormoblasts

Question 12

More than one division is possible before maturation into basophilic normoblasts.

Answer 12

Pronormoblast (Rubriblast) Division.

Question 13

Location of Pronormoblast

Answer 13

Bone marrow

Question 14

The pronormoblast begins to accumulate the components necessary for ______ production.

Answer 14

hemoglobin production

Question 15

In pronormoblast the_________ necessary for iron uptake and protoporphyrin synthesis are produced.

Answer 15

proteins and enzymes

Question 16

Globin production begins.

Answer 16

Pronormoblast (Rubriblast) celluar activity

Question 17

Length of time in Pronormoblast stage.

Answer 17

lasts slightly more than 24 hours.

Question 18

The chromatin begins to condense, revealing clumps along the periphery of the nuclear membrane and a few in the interior.

Answer 18

Nucleus of Basophilic Normoblast (Prorubricyte)

Question 19

Basophilic Normoblast (Prorubricyte)
Cytoplasm. When stained, the cytoplasm color may be ________than in the pronormoblast, hence the name basophilic for this stage.

Answer 19

deeper, richer blue

Question 20

N:c ratio decreases to about 6:1

Answer 20

Basophilic Normoblast (Prorubricyte)

Question 21

Basophilic Normoblast (Prorubricyte)
Division. The basophilic normoblast undergoes mitosis, giving rise to?

Answer 21

two daughter cells

Question 22

Basophilic Normoblast (Prorubricyte) location?

Answer 22

Bone marrow

Question 23

Basophilic Normoblast (Prorubricyte)
Cellular activity?

Answer 23

Detectable hemoglobin synthesis

Question 24

Basophilic Normoblast (Prorubricyte). Length of time in this stage.

Answer 24

lasts slightly more than 24 hours.

Question 25

The chromatin pattern varies during this stage of development, showing some openness early in the stage but becoming condensed by the end.

Answer 25

Polychromatic (Polychromatophilic) Normoblast (Rubricyte) Nucleus.

Question 26

the condensation of chromatin reduces the diameter of the nucleus , N:C ratio decreases from 4:1 to?

Answer 26

1:1 by the end of the stage

Question 27

no nucleoli are present.

Answer 27

Polychromatic (Polychromatophilic) Normoblast (Rubricyte) Nucleus.

Question 27

no nucleoli are present.

Question 28

Polychromatic (Polychromatophilic) Normoblast Cytoplasm. The color produced is a mixture of pink and blue, resulting in

Answer 28

murky gray-blue

Question 29

Polychromatic normoblast stage refers to the combination of multiple colors or "many colors" referred as:

Answer 29

polychromatophilic

Question 30

This is the last stage in which the cell is capable of undergoing mitosis.

Answer 30

Polychromatic (Polychromatophilic) Normoblast (Rubricyte)

Question 31

Cellular activity. Hemoglobin synthesis increases, and the accumulation begins to be visible as a pinkish color in the cytoplasm.

Answer 31

Polychromatic (Polychromatophilic) Normoblast (Rubricyte)

Question 32

Length of time in Polychromatic (Polychromatophilic) Normoblast (Rubricyte)

Answer 32

stage lasts approximately 30 hours.

Question 33

The nucleus is completely condensed (i.e., pyknotic) or nearly so.

Answer 33

Orthochromic Normoblast (Metarubricyte)

Question 34

Orthochromic Normoblast (Metarubricyte) Cellular activity. Hemoglobin production continues on the remaining ribosomes using messenger RNA produced earlier. Late in this stage, the_____ ejected from the cell

Answer 34

nucleus

Question 35

Orthochromic Normoblast (Metarubricyte) Length of time in this stage.

Answer 35

lasts approximately 48 hours.

Question 36

Beginning at the polychromatic erythrocyte or reticulocytes stage, there is

Answer 36

no nucleus

Question 37

Can be compared with that of the late orthochromic normoblast in that the predominant color is that of hemoglobin yet with a______due to some residual ribosomes and RNA.

Answer 37

bluish tinge

Question 38

Lacking a nucleus, the polychromatic erythrocyte or reticulocytes

Answer 38

cannot divide

Question 39

The polychromatic erythrocyte or reticulocytes resides in the?

Answer 39

bone marrow for about 1 to 2 days

Question 40

polychromatic erythrocyte or reticulocytes then moves into the_____ for about 1 day before reaching maturity.

Answer 40

peripheral blood

Question 41

The _______completes production of hemoglobin from a small amount of residual messenger RNA using the remaining ribosomes.

Answer 41

polychromatic erythrocyte or reticulocytes

Question 42

Polychromatic (Polychromatophilic) Erythrocyte or Reticulocyte Length of time

Answer 42

remains a polychromatic erythrocyte for about 3 days

Question 43

Polychromatic (Polychromatophilic) Erythrocyte or Reticulocyte with the first 2 days spent in the___

Answer 43

bone marrow

Question 44

Polychromatic (Polychromatophilic) Erythrocyte or Reticulocyte, the third day spent in the____ although possibly sequestered in the spleen.

Answer 44

peripheral blood,

Question 45

No nucleus is present in mature RBCs.

Answer 45

Erythrocyte

Question 46

The mature circulating erythrocyte is a biconcave disc measuring 7 to 8 mm in diameter.

Answer 46

Erythrocyte

Question 47

Erythrocytes on a Wright-stained blood film, it appears as _______stained cell with a central pale area that corresponds to the concavity.

Answer 47

salmon-pink

Question 48

The _____ is about one-third the diameter of the ERYTHROCYTE cell.

Answer 48

central pallor

Question 49

The ______ cannot divide.

Answer 49

erythrocyte

Question 50

Mature RBCs remain active in the circulation for

Answer 50

approximately 120 days.

Question 51

leads to their removal by the spleen as described subsequently.

Answer 51

Aging Erythrocytes

Question 51

Orthochromic Normoblast (Metarubricyte) cytplasm . The increase in the _____________ color of the cytoplasm reflects nearly complete hemoglobin production.

Answer 51

salmon pink

Question 51

The orthochromic normoblast is present only in the ______ in healthy states.

Answer 51

bone marrow