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Flashcards in Essentials Deck (35)
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1
Q

Phenytoin: P450 inhibitor or inducer?

A

Inducer

2
Q

Allopurinol: P450 inhibitor or inducer?

A

Inhibitor

3
Q

Carbamazepine: P450 inhibitor or inducer?

A

Inducer

4
Q

Rifampicin: P450 inhibitor or inducer?

A

Inducer

5
Q

Erythromycin: P450 inhibitor or inducer?

A

Inhibitor

6
Q

Trimethoprim: P450 inhibitor or inducer?

A

Inhibitor

7
Q

Valproate: P450 inhibitor or inducer?

A

Inhibitor

8
Q

Alcohol: P450 inhibitor or inducer?

A

Acute: inhibitor, chronic excess: inducer

9
Q

Phenobarbital: P450 inhibitor or inducer?

A

Inducer

10
Q

Omeprazole: P450 inhibitor or inducer?

A

Inhibitor

11
Q

Disulfiram: P450 inhibitor or inducer?

A

Inhibitor

12
Q

Gliclazide: P450 inhibitor or inducer?

A

Inducer

13
Q

Isoniazid: P450 inhibitor or inducer?

A

Inhibitor

14
Q

How long before surgery should lithium be stopped?

A

Day before

15
Q

How long before surgery should the cOCP be stopped?

A

4 weeks

16
Q

How long before surgery should potassium-sparing diuretics be stopped?

A

The day of

17
Q

How long before surgery should ACE inhibitors be stopped?

A

The day of

18
Q

Name a drug cause of hypokalaemia

A

Thiazide diuretics, loop diuretics

19
Q

Name a drug cause of hyperkalaemia

A

ACE inhibitors, potassium-sparing diuretics

20
Q

Name a drug that reduces production of platelets

A

Penicillamine

21
Q

Name a drug that increases destruction of platelets

A

Heparin

22
Q

Describe the features of early lithium toxicity

A

Tremor

23
Q

Describe the features of intermediate lithium toxicity

A

Fatigue

24
Q

Describe the features of late lithium toxicity

A

Arrhythmias, seizures, diabetes insipidus, renal failure, coma

25
Q

Describe the features of digoxin toxicity

A

Confusion, nausea, visual halos, yellow-tinted vision, arrhythmias

26
Q

Describe the features of phenytoin toxicity

A

Gingival hypertrophy, ataxia. nystagmus, peripheral neuropathy

27
Q

Describe the features of gentamicin/vancomycin toxicity

A

Nephrotoxicity, ototoxicity

28
Q

Name 2 drug causes of neutropaenia

A

Clozapine, carbimazole

29
Q

Describe the difference between carbimazole and carbamazepine

A

Carbimazole: anti-thyroid
Carbamazepine: anti-epileptic

30
Q

St John’s Wort: P450 inhibitor or inducer?

A

Inducer

31
Q

Smoking: P450 inhibitor or inducer?

A

Inducer

32
Q

Ketoconazole and fluconazole: P450 inhibitors or inducers?

A

Inhibitors

33
Q

SSRIs: P450 inhibitors or inducers?

A

Inhibitors

34
Q

Ritonavir: P450 inhibitor or inducer?

A

Inhibitor

35
Q

Amiodarone: P450 inhibitor or inducer?

A

Inhibitor