Phenytoin: P450 inhibitor or inducer?
Inducer
Allopurinol: P450 inhibitor or inducer?
Inhibitor
Carbamazepine: P450 inhibitor or inducer?
Inducer
Rifampicin: P450 inhibitor or inducer?
Inducer
Erythromycin: P450 inhibitor or inducer?
Inhibitor
Trimethoprim: P450 inhibitor or inducer?
Inhibitor
Valproate: P450 inhibitor or inducer?
Inhibitor
Alcohol: P450 inhibitor or inducer?
Acute: inhibitor, chronic excess: inducer
Phenobarbital: P450 inhibitor or inducer?
Inducer
Omeprazole: P450 inhibitor or inducer?
Inhibitor
Disulfiram: P450 inhibitor or inducer?
Inhibitor
Gliclazide: P450 inhibitor or inducer?
Inducer
Isoniazid: P450 inhibitor or inducer?
Inhibitor
How long before surgery should lithium be stopped?
Day before
How long before surgery should the cOCP be stopped?
4 weeks
How long before surgery should potassium-sparing diuretics be stopped?
The day of
How long before surgery should ACE inhibitors be stopped?
The day of
Name a drug cause of hypokalaemia
Thiazide diuretics, loop diuretics
Name a drug cause of hyperkalaemia
ACE inhibitors, potassium-sparing diuretics
Name a drug that reduces production of platelets
Penicillamine
Name a drug that increases destruction of platelets
Heparin
Describe the features of early lithium toxicity
Tremor
Describe the features of intermediate lithium toxicity
Fatigue
Describe the features of late lithium toxicity
Arrhythmias, seizures, diabetes insipidus, renal failure, coma
Describe the features of digoxin toxicity
Confusion, nausea, visual halos, yellow-tinted vision, arrhythmias
Describe the features of phenytoin toxicity
Gingival hypertrophy, ataxia. nystagmus, peripheral neuropathy
Describe the features of gentamicin/vancomycin toxicity
Nephrotoxicity, ototoxicity
Name 2 drug causes of neutropaenia
Clozapine, carbimazole
Describe the difference between carbimazole and carbamazepine
Carbimazole: anti-thyroid
Carbamazepine: anti-epileptic
St John’s Wort: P450 inhibitor or inducer?
Inducer
Smoking: P450 inhibitor or inducer?
Inducer
Ketoconazole and fluconazole: P450 inhibitors or inducers?
Inhibitors
SSRIs: P450 inhibitors or inducers?
Inhibitors
Ritonavir: P450 inhibitor or inducer?
Inhibitor
Amiodarone: P450 inhibitor or inducer?
Inhibitor