Etiology Flashcards
in childhood asthma, what age is susceptibility determined?
during fetal development and the first 3-5 years of life
what are risk factors for developing childhood asthma?
family history or allergy & allergic disorders including hay fever, asthma and eczema
how many genes have been identified that play a role in the susceptibility and pathogenesis of asthma?
over 100
what do the 100 genes influence the production of?
IL-4, IL-5, IL-13, IgE, eosinophils, mast cells, adrenergic receptor, leukotrienes and bronchial hyper responsiveness
what has the gene ADAM 33 been associated with?
asthma and bronchial hyper responsiveness
what are other etiological factors?
exposure of susceptible children to airborne allergens such as pets, dust mites, cockroaches, mold, exposure to tobacco smoke in utero/early childhood
what has the NLSCY not found a difference between?
the prevalence of asthma between urban and rural areas
what are risk factors in adult onset asthma?
exposures to low molecular weight sensitizers (ie. isocyanates), infectious agents, allergens or pollution
specifically for women, what are some risk factors?
smoking, obesity, hormonal influences
what is the ethology of asthma?
multi modal
