Everything

Question 0

E configuration is

Answer 0

Different side of the plane of the double bond

Question 1

Z configuration indicates

Answer 1

The same side of the plane of the double bond

Question 2

If during an addition reaction syn addition takes place what will the optical activity be

Answer 2

Only one set of enantiomers will form

Question 3

If anti addition takes place across a double bond what will the optical activity be

Answer 3

Only one enantiomer

Question 4

In reactions with a brominum ion what is the stereochemistry

Answer 4

Anti addition

Question 5

Rate of SN2 is dependent on what

Answer 5

Concentration of nucleophile and electrophile

Question 6

Which step of SN2 reaction is slow

Answer 6

Leavin group

Question 7

Rate of SN1 reaction is

Answer 7

Dependant on the concentration of the electrophile

Question 8

Four factors to consider when deciding between SN1 and SN2

Answer 8

Electrophile, nucleophile, leaving group, and solvent

Question 9

Type of electrophile that will favor SN1 vs SN2

Answer 9

For SN2 primary is the best because of steric hinderance. For SN1 tertiary is the best because its the most stable carbonation.

Question 10

Resonance stabilization in benzylic or allylic positions will favor

Answer 10

SN1

Question 11

Most important factor for SN1 vs SN2

Answer 11

Electrophile

Question 12

Second most important factor of SN1 vs SN2

Answer 12

Nucleophile

Question 13

Example of weak nucleophile

Answer 13

No negative charge, lone pairs.

Question 14

Moderate nucleophile

Answer 14

Stabilized negative charge. Such as the halogens or resonance stabilized.

Question 15

Strong nucleophile

Answer 15

Negative charge that is not stabilized

Question 16

How does the strength of a nucleophile affect SN1 and SN2

Answer 16

It doesn’t affect SN1 but a strong nucleophile significantly increases the rate of SN2 and a weak slows it down

Question 17

Excellent leaving groups

Answer 17

Once they have left they have no negative charge at all

Question 18

Good leaving groups

Answer 18

Once separated they have a negative charge that is very stable.

Question 19

Bad leaving groups

Answer 19

Once separated they have negative charge that is not stabilized

Question 20

How do you know if an SN1 reaction will proceed?

Answer 20

As long as the leaving group is more stable than the nucleophile

Question 21

Effect of leaving group on SN1 vs SN2

Answer 21

A good leaving group is positive for both but SN1 is more sensitive.

Question 22

An excellent leaving group will favor SN1 or SN2

Answer 22

SN1

Question 23

Polar aprotic solvents favor

Answer 23

SN2

Question 24

What is aprotic

Answer 24

Solvent does not have a proton on an electronegative atom so there are no hydrogens which dissociate

Question 25

Examples of polar aprotic solvents

Answer 25

Acetone, DMSO, DME, DMF

Question 26

What's the difference between an amide and an amide

Answer 26

An amide has a carboxylic O next to the amine

Question 27

What's the difference between an ester an an ether

Answer 27

An ester has an extra double bonded O

Question 28

What's an alkoxyl

Answer 28

-OR

Question 29

Diatereomers that differ at only one chiral carbon are called ____

Answer 29

Epimers

Question 30

If a ring closure happens at the epimeric carbon, ____ possible diastereomer are formed called ____

Answer 30

2, anomers

Question 31

The higher the heat of combustion, the _____ stable the molecule

Answer 31

Less

Question 32

Which halogen is most selective?

Answer 32

I

Question 33

Three steps of an E1 reaction

Answer 33

1. Acid proton the alcohol group making it a good leaving group 2. The group leaves and carbonation can rearrange 3. Water molecule deprotonates the carbonation

Question 34

Sayteff rule

Answer 34

The major product of elimination will be the most substituted alkene

Question 35

What mechanism does the synthesis of alkene from alcohol follow

Answer 35

E1 in the presence of a strong hot base

Question 36

What mechanism does the dehydrohalogenation follow to form an alkene

Answer 36

Either by E1 in the absence of a strong base or by E2 in the presence of a strong bulky base

Question 37

What are the two steps in an E1 dehydrohalogenation reaction

Answer 37

The halogen leaves as a leaving group. The weak base abstracts a proton forming a double bond

Question 38

The (most/least) reactive alkenes are the most thermodynamically stable

Answer 38

Most. This is because they have the lowest activation energy when forming carbocations.