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SBM IV CT/MS > Everything Else > Flashcards

Flashcards in Everything Else Deck (37):
1

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MCP OA in a young person = think HEMOCHROMATOSIS

2

genotype assoc w/ RA

HLA-DRB1 - confers 4x risk for RA (Class II HLA w/ CD4

citrullinated peptides bind --> QKRAA

 

3

HLA Class II alleles (DR, DP, DQ) are most strongly assoc w/ what disease?

narcolepsy-cataplexy

4

Wolff's Law

force applied to bone surface --> bone deposition

force removed --> bone removed

5

longitudinal bone grows by....

endochondral ossification

6

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7

lamellar bone grows by....

appositional bone growth

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8

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osteon and haversian system

9

woven bone in adult

pathological!!

10

mortality one yr after hip fracture

35%

11

fill in table about ages, features, and subgroups of JIA 

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12

pathogenesis of synovitis (JIA)

  • villous hyperplasia of synovium
  • hypervascularity
  • infiltration of lymph + macrophages

13

sx of JIA

mostly synovitis >>>>>

  • joint contracture
  • +/- erosions,
  • +/- deformity and functional limitations

14

what kind of JIA has a high risk of uveitis?

oligoarticular, ANA+

screen in kids <7 w/ +ANA!!!

15

chilblain's perniosis

like the venous phase of raynauds.

  • venodilation --> pooling of blood in toes and non-specifc inflammation

16

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acrocyanosis - normal redistrib of blood flow in a newborn

17

anti-RNP +

assoc w/ mixed connective tissue disease

18

mixed connective tissue disease

  • inflammatory arthritis
  • raynaud's
  • morphea
  • DM or amyopathic DM

19

2 vasculitides in children

  • HSP
  • Kawasaki's

20

dx criteria for Kawasaki

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21

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strawberry tongue in Kawasaki

22

tx for Kawasaki

aspirin and IVIg --> reduces aneurysms to 5%

do echo @ baseline, 3, 7 weeks

continue aspirin for 3wks after last normal echo

23

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calcinosis in juvenile dermatomyositis

24

composition of type I collagen

trimer of 2 alpha-1 and 1 alpha-2 monomers

25

pleiotrophy

many effects of a single mutation (in one person's body)

26

genetic heterogeneity

different mutations can cause the same disease

27

variable expression

disease effects of an identical mutations may differ in different people

28

mutations assoc w/ OI

COL1A1 or COL1A2

29

osteomyelitis - histology findings

lots of neutrophils

30

what cancers metastasize to bone

Breast, lung, thyroid, kidney, prostate (BLT w/ kosher pickle)

31

32

disc herniation

  • young pt
  • normal disc height
  • radicular pain

usually through posterolateral corner of annulus

33

disc degeneration

  • middle aged subject
  • activity related mechanical back pain
  • referred pain to leg
  • instability catch

34

spinal stenosis

  • elderly pt
  • neurogenic claudication: standing --> leg pain w/ chopping cart sign
  • osteophytes --> disk narrowing

35

degenerative spondylolisthesis

  • middle aged or elderly, esp women
  • mech back pain + radiculopathy
  • L4-L5

36

what do fibroblast growth factors do in bone healing?

enhance callus formation: fibrous, cartilage, immature bone

37

what do cytokines do in bone healing?

stimulate bone resorption (esp IL-1)