Exam 1 Flashcards

1
Q

MR - Brain
Why are patient studies useful?

A

They are a major source of knowledge about the brain and mind

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2
Q

MR - Brain
Define agnosia

A

Loss of ability to recognize objects, people, sounds, shapes, or smells; that is, the inability to attach appropriate meaning to objective sense-data

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3
Q

MR - Brain
Define aphasia

A

A general term relating to loss of language ability

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4
Q

MR - Brain
Define apraxia

A

A general term for disorders of action

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5
Q

MR - Brain
Define amnesia

A

A lack of mnenomic abilities

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6
Q

MR - Brain
Define Ataxia

A

Poor coordination and unsteadiness due to failure to regulate the body’s posture, and strength and direction of limb movements

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7
Q

MR - Brain (not essential)
There are many subtypes of neurological disorders such as agnosia, give examples and definitions of three subtypes

A

Form agnosia - patients percieve only parts of details, not the whole object

Finger agnosia - The inability to distinguish the fingers on the hand. Present following lesions to occipital lobe.

Simultanagnosia - Patients can recognize objects or details in their visual field, but only one at a time

Associative agnosia - Patients can describe visual scenes and classes of objects but still fail to recognize them.

Apperceptive agnosia - Patients are unable to distinguish visual shapes and so have trouble recognizing, copying, or discriminating between different visual stimuli.

Prosopagnosia - also known as facial blindness

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8
Q

MR - Brain
What can the existence of selective deficits tell us?

A

They can tell us something about the way function is organised in the brain

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9
Q

MR - Brain
Define ‘dissociated’ in terms of cognitive functions

A

Seperated to a degree from each other through selective impairment

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10
Q

MR - Brain
Dissociation studies require what?

A

A minimum of two groups and two tasks. Comparison between patient/control groups shows deficit.

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11
Q

MR - Brain
What are the limitations of single dissociation?

A

In this study, its possible that the poor performance of patients was caused by another factor, such as a deficit in concentration, and that their test of declarative memory required more concentration than our test of nondeclarative.

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12
Q

MR - Brain
What is the benefits of testing for double dissociation?

A
  • Provide strong evidence that there are cognitive processes critical for task X that are not critical for task Y, and vice versa, and that brain area A is critical for task X but not for task Y etc.
  • Double dissociations provide evidence that the observed differences in performance reflect functional differences between the groups, rather than unequal sensitivity of the two tasks.
  • Participants don’t have to be perfectly intact on either task, they just need to be significantly better at one task than the other
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13
Q

MR - Brain
What are the limitations of patient studies? (5)

A
  1. Assumption of modularity
  2. Lesions extensive and varied
  3. Lesion anatomy inaccurate, connections not considered
  4. Individual differences in functional anatomy
  5. Poor temporal resolution
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14
Q

MR - Brain
Limitations of patient studies: Explain ‘Assumption of modularity/modularity of function’

A
  • Assumption that mental processes occur with a high degree of isolation from other mental processes and when one area is damaged other regions do not adapt their function
  • Brain plasticity: In reality the brain reorganizes quickly. Intact regions change their behaviour so it is difficult to infer function of damaged region
  • Processes/dynamics neglected: It is neurons, not black boxes, that perform the function - but how?
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15
Q

MR - Brain
Limitations of patient studies: Explain ‘lesions extensive and varied’

A
  • Most work done with patients who have large lesions
  • Lesions often damage several function centres, so there are few patients with ‘pure’ deficits
  • Lesion size and location variable, hard to find a group of similar patients. Inferences from single patients are weak
  • Individual differences in recuperative history
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16
Q

MR - Brain
Limitations of patient studies: Explain ‘Lesions anatomy inaccurate and connections not considered’

A
  • Anatomical scans show regions that are destroyed, but intact regions may not be functioning
  • Regions may be disconnected from other regions that provide input
17
Q

MR - Brain
Limitations of patient studies: Explain ‘Individual differences in functional anatomy’

A
  • We assume that an anatomical region of the brain does the same function in all individuals
  • Clearly violated assumption - e.g. Wada test indicates left hemisphere predominates in language processing in most, but not all, individuals
  • Variability of function across individuals reduces the power of group studies
18
Q

MR - Brain
Limitations of patient studies: Explain ‘Poor temporal resolution and experimental control’

A
  • Even if patient studies establish which regions are necessary for a task, and its inferred cognitive processes, it is not possible to infer the stages of processing
  • A memory deficit may arise from a failure of encoding, retention or recall
  • There is no experimental control over lesion location, but animal studies using experimental ablation can provide this
  • Other methods overcome these limitations
19
Q

MR - Brain
What are the benefits of patient studies?

A
  • Show which areas are necessary for a particular cognitive function (double dissociation)
  • Show cognitive, emotional, social consequences of a deficit
  • Cost and time effective, single case studies are possible (eg HM, no experimental design necessary, exploratory observations possible)
  • Can be done right (overlay plots and control groups) to limit criticism
20
Q

MR - Brain
Why can we not localise speech production in this (Broca’s) area?

A
  • Damage is not limited by functional boundaries
  • Lesion might be smaller than functional module
  • Interindividual differences in brain organisation
  • Result might reflect increased vulnerability of region to injury (eg because of vasculature)
  • Area might just be interconnected with the actually relevant area (indirect disruption)
21
Q

MR - Brain
What does fMRI stand for?

A

Functional Magnetic Resonance Imaging

22
Q

MR - Brain
How do MRI machines work (the physics)?

A
  • Uses a magnetic field (Bo) and radio energy to produce an image
  • A large magnet (50,000 x Earth) aligns nuclei that have a net magnetic moment (from odd number of protons/neutrons)
  • Nuclei absorb and re-emit radio frequency energy
23
Q

MR - Brain
How is an image acquired in an MRI?

A
  • Nuclei spin around the main magnetic field
  • RF pulse (oscillating magnetic field) tips M out of alignment with Bo and synchronises the phase of spins
  • M gradually returns to alignment and spins lose phase coherence. These changes are detected as the ‘MRI’ signal
24
Q

MR - Brain
What can mapping changes over time look at?

A
  • Grey matter volume
  • Commisural myelination
25
Q

MR - Brain
What does BOLD stand for? (in fMRI)

A

The Blood Oxygen Level Dependent (BOLD) response

26
Q

MR - Brain
What is BOLD?

A

It is the basis of fMRI

The neural events are evident from a change in the blood level in the brain (haemodynamics) - Simple explanation