Exam 1 Flashcards
(24 cards)
CYP2C9*2
Reduced function
CYP2C9*3
No function
drug-gene pairs of clinical interest (CYP2C9)
warfarin, NSAIDs, phenytoin
CYP2C19*2
No function
CYP2C19*3
No function
CYP2C19*17
Increased function
drug-gene pairs of clinical interest (CYP2C19)
clopidogrel, PPIs, SSRIs (citalopram, escitalopram, sertraline), TCAs (amitriptyline), voriconazole
CYP2D6*3
No function
CYP2D6*10
Reduced function
CYP2D6*1xN and 2xN duplications
Increased function
drug-gene pairs of clinical interest (CYP2D6)
codeine/tramadol, SSRIs (paroxetine, fluvoxamine), SNRIs (venlafaxine), TCAs (amitriptyline, nortriptyline), tamoxifen
UGT1A1*6, *28 and *37
Reduced function
UGT1A1*36
Increased function
Drug-gene pairs of clinical interest (UGT1A1)
Atazanavir, Irinotecan, bilirubin
CYP2D6*4
No function
CYP2D6*5
No function
CYP2D6*6
No function
CYP2D6*17
Reduced function
TPMT*2, 3A, 3B, 3C
No function
UGT1A1*6
Reduced function
UGT1A1*28
Reduced function
UGT1A1*37
Reduced function
UGT1A1*36
Increased Function
CYP2D6*41
Reduced function
