Exam 1 Flashcards
(16 cards)
What are the 6 steps for the WHO Drug Prescribing process?
- Define the patients problem
- Specify the therapeutic objective
- Choose the treatment
- Start the treatment
- Educate the patient
- Monitor effectiveness
What are the 7 criteria an NP should consider before prescribing a medication?
- Pharmacodynamic factors
- Pharmacokinetic factors
- Therapeutic factors
- Safety
- Cost
- Patient factors
- Provider factors
What are 5 patient factors to consider before prescribing a medication?
- Previous adverse reactions
- Health beliefs
- Current drug therapies
- Patient age
- Pregnancy
What is pharmacokinetics?
What the body does to the drug
What is pharmacodynamics?
What is pharmacodynamics?
What the drug does to the body
What does the mnemonic I Can PresCribE A Drug stand for?
Indications
Contraindications
Precautions
Cost/Compliance
Efficacy
Adverse effects
Dose/Duration/Direction
Drug development is based on what 3 concepts?
Medical need
Disease prevalence
Likelihood of success
1 in every 1k is selected for progression to the clinic
What are 4 chemical starting points for medications? Which is most common?
Plants
Animals
Humans
Lead components sources from targeted synthesis directed to bind unknown structures of receptors and enzymes (most common)
What is the purpose of preclinical trials in medication development? (4)
Provide:
Basic safety
Bioavailability
Pharmacokinetics
Initial efficacy data
What are the parts of drug development?
Preclinical
Phase I
What is the purpose of phase I in medications development? (4)
Evaluate safety and tolerability
Evaluate pharmacodynamics
Evaluate pharmacokinetics
First administration of product to healthy human volunteers
Where are enteric coated medications absorbed?
Intestines
What kind of allergic reaction is anaphylaxis?
Type I “immediate hypersensitivity reaction”
