Exam 1 Flashcards

(143 cards)

1
Q

Three general functions of epithelium

A

Provide a barrier

Absorption

Secretion

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2
Q

Three specialized functions of epithelium

A

Transport molecules across epi.

Prevent transport of material across epi. selective permeability

Sensory (taste buds, retina)

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3
Q

What are two things that various types of epithelium that are basic characteristic they share?

A

Cells are adjacent to each other

Associated with a complete or partial basement membrane

Avascular - obtain nutrition by diffusion

Associated with vascular CT

Held together by cell junctions

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4
Q

What is the difference between a complete basement membrane and partial?

A

Complete - basal lamina and reticular lamina

Partial - basal lamina only

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5
Q

What type of cells produce basal lamina?

Reticular lamina?

A

Epithelial

CT

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6
Q

Three functions of basement membrane

A

Provide surface for cell attachment

Filter

Limits stretch

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7
Q

What are the four type of cell junctions?

A

Zona Occludens

Zona Adherens

Macula Adherens

Gap Junctions

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8
Q

Describe Zona Occludens

2 functions

A

AKA Tight junction

Share intrinsic membrane proteins between adjacent cells

Strong attachments

Blocks materials from moving between cells

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9
Q

Describe Zona Adherens

2 functions

A

Adhesion Belt

Cadherins lining adjacent cells in presence of Ca

Strong attachment

Marginal Bands contribute to cell stability

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10
Q

Describe Macula Adherens

Function

A

Demasomes

Strong attachment

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11
Q

Describe Gap Junction

Function

Describe Junctional Complex

A

6 proteins arranged in cylinder shape

Strong attachment
Sharing or movement of materials

Sonula occludens - sonula adherens - macula adherens

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12
Q

What two things hold the epithelium to the basement membrane?

A

Hemidesmosomes and focal point contacts

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13
Q

What does simple epithelium mean and what are the types?

A

Single layer thick

Squamous

Cuboidal

Columnar

Ciliated Pseudostratified Columnar

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14
Q

Simple squamous locations

Description

Functions

A

Lung, Parietal layer of Bowman capsule in kidney, serosa outside organs

Single layer flat cells

Provide barrier, Living filter

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15
Q

Simple Cuboidal locations

Description

Functions

A

Exocrine ducts, thyroid follicular cells, kidney tubules

Single layer of cube cells, nucleus occupies much of cell cytoplasm, looks like square on slide

Secretion, Barrier, Absorption

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16
Q

Simple Columnar location

Description

Function

A

Stomach, SI, gallbladder, larger exocrine ducts

Singel layer, height, more cytoplasm than cuboidal, rectangle on slides

Barrier, Absorption, Secretion

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17
Q

Ciliated Pseudostratified Columnar epithelium (respiratory epi) location

Description

A

Trachea, respiratory region of nasal cavity, bronchi

Three cell types of various heights to look stratified

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18
Q

Ciliated Columnar Cells

A

Columnar that contain cilia anchored in the apex of the cell by basal bodies

Move mucus

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19
Q

Goblet cells

A

Modified columnar cell

Produce release mucus

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20
Q

Basal cells

A

Short pyramidal and does not reach surface

Act as stem cell before forming goblet cell or ciliated columnar

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21
Q

Describe Microvili and their function and location

A

Finger like projections at apical surface on some epithelial cells. Called brush border or striated border

Increase surface area for absorption

Kidney tubule cells, SI

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22
Q

Sterocilia describe

Function

Location

A

Extremely long microvilli, not related to true cilia

Increase surface area

Epididymis, chochlear hair cells

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23
Q

Cilia describe

Function

Location

A

Thin apical hair like extensions of cytoskeleton

Move something over a surface

Trachea and fallopian tube

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24
Q

Do Cilia have many mitochondria?

Do their basal bodies absorb and secrete?

A

Yes

No

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25
Describe Glycocalyx Produced by? Function? Location
Surface layer of glycoproteins and carbs that cover epithelium Epithelium cells Protection and cell recognition Stomach and SI
26
Definition of stratified epithelium What is it named after per type? What do ALL types have a common function of?
Epithelium that is two or more cell layers thick Shape of its superficial cells Protective function
27
Stratified Squamous location Describe Function Problems limitations (2)
Esophagus, oral cavity, tongue, vagina Multp layers tend to flatten out from basal layer to superficial which are flat and alive Protect from abrasion No protection from drying Limited thickness
28
Kertanized Stratifed Squamous location Describe Function
Skin Multiple layers tend to flatten from basal to superficial which is covered by nonliving layer of keratin Protection in dry environment
29
What are the 5 layers of epithelium of the skin?
Stratum basale (germinativum) Stratum Spinosum Stratum granulosum Stratum lucidum Stratum Corneum
30
Multiple layers of "spiny shaped" keratinocytes that produce lipids and keratohyalin vacuoles. Thickness varies
Stratum Spinosum
31
Uppermost 1-2 layers of flattened living keratinocytes that contain flattened condensed keratohylan vacuoles
Stratum Granulosum
32
1-2 layers which are mitotic and closest to the dermis
Stratum Basale (germinativum)
33
Layer of dead cells, keratin and lipids. thickness of this layer varies but has three functions.... What are three
Stratum corneum Prevent water loss Provide barrier to micronbes Protect from abrasion
34
Thin layer of recent dead or dying keratinocytes present only in thick skin. This is not easy to see
Stratum lucidum
35
How do epidermal pegs (rete ridges) and dermal papillae contribute strength to Stratum Corneum?
Increasing surface area for attachment of the epithelium to the ct below
36
What is the duration of a cell life cycle?
28 days
37
What do Melanocytes do? Layer found in? How they function?
Protect against UV Stratum Basale Melanosomes (with pigment they produced) pinch off ends of cytoplamsic projections - > taken up by karatinocytes
38
What 4 things influence skin color?
Size of melanosomes Number of melanosomes Placement of melanin within cell Eumelanin vs. pheomelanin (brown/black) vs. (reddish)
39
What do langerhan cells do? Layer found in? Also can be found in?
Recognize external foreign antigens Stratum spinosum Esophagus and vagina - stratified squamous
40
Merkel cells function found layer? Associated with?
Provide touch receptors Stratum basale Associated with free nerve endings
41
What happens to number of melanocytes when exposed to uv light repeatedly? Langerhand cells?
Increase Decrease
42
Stratified cuboidal location description Function
Larger ducts in sweat and salivary glands Two layers, basal layer flattened, superficial cuboid. Not common Barrier and protection/structure
43
Strratified Columnar location Description Function
Large ducts in pancreas, part of male urethra, conjunctiva of eye Two layers, basal flat to cuboid, superficial is columnar. Very rare Protection/structure Barrier Transition to another epithelium type
44
Transitional (Urinary) = Urothelium location Describe Function
Most of urinary tract Multiple layers Protection that stretches Barrier
45
Specializations of Transitional (Urothelium) Why important?
Fenestrated basment Larger rounder superficial cells Well developed zone occludens Fenestrated basement - not much for cells to attach to Barrier to nitrogenous waste
46
Unusual superficial cell feature of Urothelium? Cells obtain more O2 why?
Some are bi-nucleate When stretched, diffusion distance decrease
47
Patchy skin lesions Accelerated keratinocyte life cycle Cells accumulate in stratum corneum Inflammation in dermal papillae Cyclic and etiology unknown
Psoriasis Vulgaris
48
Spots with extra pigment, fair skin especially Increase in melanin without increase in melanocyte numbers Tend to fade in winter and darken in sun
Freckles
49
Patches which lack melanocytes Unknown cause but associated with systemic disease
Vitiligo
50
Discoloration due to Proliferation of melanocytes
Moles (naevi)
51
Melanocytes become mitotically active and invade dermis Very invasive and metastatic Treatment : surgery and chemo
Malignant Melanoma
52
What are the two categories of epithelial glands?
Endocrine and Exocrine
53
Components directly involved with primary function Ex biceps- skeletal ells
Parenchyma
54
Components providing mechanical and metabolic support Ct, Nerve, Blood vessels, Lymphatics
Stroma
55
What are the three methods of subclassifiying Exocrine secretion
Morphology Secretion Method Product secreted
56
Describe Options for Morphology
Secretory : tubular vs acinar (avelolar) Duct arrangements - Ubranched or branched
57
Describe options for Secretion method
Merocrine (eccrine) Holocrine Apocrine
58
Name and examples Most common method of secretion Secretion by exocytosis so no cytoplasm or membranes in secretory product No cell damage or odor
Merocrine (eccrine) Goblet, salivary, pancreas, sweat glands
59
name and examples Cell matures and dies Secretory product - intact vacuoles and parts of cell Odor
Holocrine - Sebaceous glands, tarsal glands of eye lid (meibomian glands)
60
Cell damage is minimal Secretory product - intact vacuoles and some cell cytoplasm and membrane Odor
Apocrine ``` Lactating mammary glands, some adult sweat glands, ceruminous glands in external auditory canal Ciliary glands (molls) glands in eyelid ```
61
Options for classifying based on Product Secreted
Acinus - smallest division of gland, group surrounding cavity Serous Demilune - Small group of serous cells attached to mucus acinus Myoepithelial cells - cells with epithelial origin that are contractile, cells wrap around acini and ducts may become exocrine glands - found in salivary sweat lacrimal and mammary glands!
62
These glands produce proteins Pancreas, parotid gland, chief cells Often produce enzymes Trapezoid cells Nucleus usually round Cellspick up stain
Serous Glands
63
These cells produce mucus Goblet cells, mucus cells, minor salivary glands in tongue and palate Stain light Nucleus usually perish and flat in cell
Mucus glands
64
Glands produce serous and mucus Sublingual, submandibular, salivary See above Serous demilunes are possible
Mixed glands
65
Three parts of Exocrine Regulation
Myoepithelial cells - each has an ANS fiber Hormonal Blood supply = increase flow, increase O2, increase secretion opposite if low blood flow
66
Functions of CT 4?
Provide structural support Provide medium for exchange Defense/Protection Storage of adipose - energy source
67
4 Characteristics of CT
Most derived from mesenchyme Support cells separated by matrix Support cells produce matrix Cells adhere to matrix
68
Important general trait of Glycosaminoglycans (mucopolysaccharides)
Hydrophilic
69
Sulfated GAGS like keratin sulfate, chondrotin sulfate, heparin and dermatin sulfate two points of interest
Smaller molecules Convalently bonded to proteins
70
Three points of interest of non-sulfated GAGs like Hyaluronic Acid (HA or Hyaluronan)
Larger molecules Forms dense molecular network Hold Much H20
71
2 positive aspects of inflammation one negative
Increased fluidity which aids cell movement Increase number of defensive cells Swelling can damage vessels/lymphatics and nerves and cells
72
Four types of Ground Substance
Glycosaminoglycans = mucopolysaccharides Proteoglycans = protein core with many sulfated GAGs attached Adhesive Glycoproteins like laminin and fibronectin Other
73
Three types of fibers
Collagen Elastic Reticular
74
Collagen many types or few? Most common? Type 1 Account for __ percent of total body collagen C1 is knowns for tensile strength but... Serious pathologies can occur from what?
Many yes 90 no stretch Improper production of Collagen 1
75
As you age what happens to Collagen fiber production? If not enough Vit C?
Slows and weaker fibers produced Weaker coll 1 more rapid fiber breakdown
76
Elastic fibers composed of __ and ___ Can stretch by ___ percent of resting length Important in blood vessels and ___ Commonly produced by ___ and smooth muscle cells Simpler fiber than C1 so easier to make More or less fibers as you age? Greater or fewer pathologies with this type of fiber?
Elastin and microfibrils 150% Lungs Fibroblasts Less Fewer
77
Hereditary condition of CT bones muscle ligaments and skeletal structures where undeveloped elastic fibers result in Irregular unsteady gate Tall lean body long extrems Abnormal joint flexibility, flat feet stoop shoulder and dislocation of optic lens 4th important one?
Marfan's Syndrome Aorta usually dilated and may become weakened allowing aneurysm to develop
78
Reticular fibers same as... Easy or hard to produce Last __ days Pathologies? Aging effects? ___ fiber produced during wound healing
Collagen 3 Easy 3 days None Not affected First
79
7 Cells in CT
``` Fibroblast Fibrocyte Myofibroblast Adipocytes Plasma cell Macrophage (histiocyte) Mast Cell ```
80
Fibroblast usually derived from... Very important in ordinary CT? Generally a ___ cell but can move about a little May occasionally divide and primary during.... May change into other cell types under special conditions explain
Mesenchyme cells Yes Fixed Wound healing Adipocytes Chondrocytes during cartilage formation Osteoblasts during some pathologies
81
Describe Fibroblast structural functions What type of cells? When mature are almost ___ and contain fibrocytes ___ percent as strong as original tissue
Produce and maintain matrix by making GAGs, fibers etc Healing by producing cytokines and enzymes (collagenase) Avascular 70
82
2 Defensive functions of fibroblasts
Produce cytokines and enzymes Can phagocytize
83
Fibrocyte mature less active so they appear... __ lived cell with ___ energy and oxygen requirements Can do what... Cant do what...
Flatter Long/ lower Make ground substance, GAGS, reticular fibers Make collagen 1 and elastic fibers
84
Myofibroblasts possess features of ____ and ____ Functions 2
Fibroblasts and smooth muscle cells Wound closure Tooth eruption
85
Adipocytes do or do not divide/change into other cell types Derived from.... Function in lipid storage and...
D not Mesenchyme Produce other factor and hormones
86
Plasma cells do or do not divide? Long or short lived Found in CT and _____ Found in blood? Derived from ___ lymphocytes Large cells with a spherical ___ nucleus Function?
NOT Short Lymphatic tissue/organs no B Clock faced Produce antibodies
87
Macrophages (Histiocytes) Large cells with kidney bean shape nucleus often contain ___ in cytoplasm Divide? Derived from... Very important ___cell Party of what system? All members arise from common ancestor in ____ ____ and are able to phagocytize and display particular receptors Example Memnbers
Residual bodies Yes Mesenchyme Defensive Monuclear Phagocyte or Reticulendothelial system (RES) Bone Marrow Kupffer cells, alveolar macrophages, monocytes, microglia, langerhan cells, osteoclasts
88
Four functions of Macrophages
Phagocytosis of debris and microorganisms Act as APC, present info about foreign antigen to helper t cells Create foreign body giant cell = permeant fusion of many macrophages. This forms in response to sizable foreign object, and some pathogens Release cytokines and other products
89
Mast cells large contain... Found in ____ by small blood vessels under epithelium Divide? Lifespan? Derived from... Once thought to be derived from?
cytoplasmic ganules CT proper Occasionally days to months bone marrow precursor Basophils
90
Three functions of Mast cells?
Mediate Inflammation, Immediate hypersensivity response, Anaphylaxis, Asthma Release primary mediators Histamine, Heparin, and Eosinophil Chemotactic Factor (ECF) and Nutrophil Chemotactic Factor (NCF Produce and release secondary mediators Leukotrienes
91
Effects of Histamine
Increase permeability of capillaries and venules Cause vasodilation of small arteries, increasing blood to affected area Cause contraction of any visceral smooth muscle in area
92
Effects of Heparin
Counteracts effects of Histamine
93
Which is on switch and off switch?
Histamine = Flash on Heparin = slow off
94
Efects of ECF and NCF?
ECF - attracts eosinophils NCF - attract neutrophils for phagocytosis
95
What inhibits leukotrienes, produces factor that inhibits mast cell degranulation, Phagocytize IgE and secretes Histaminase? Therefore they will help to ___ effects of histamine and leukotrienes
Eosinophils Limit
96
Leukotriene effects
Same as histamine but 1000s of times stronger. Amplifies and prolongs the effect of histamines.
97
What three things will activate mast cells?
Direct mast cell trauma Phagocytosis IgE-allergin complex
98
Describe what happens at first and second exposure for primary and secondary immune response
1 - Elicits IgE formation which binds to mast cells 2 - Allergin binds to "sensitized" mast cells and mast cells degranulate
99
Describe the Mast cell mediated event of a basic inflammatory reaction - cut in the skin
Stimulus - direct trauma and phagocytosis Mast cells degranulate Histamine reacts fast and increases permeability of capsules and venules, also vasodilates arterioles Leukotrienes extend and amplifies histamine Heparin and ECF react last to counteract histamine, attract eosinophils
100
Describe the Immediate Hypersensitivy response of Simple allergy
Stimulus Mast cells degranulate and produce various substances Localized inflammatory response at sight of allergen contact
101
Describe steps of Anaphylaxis
Stimulus Systemic mast cell and basophil degranulation and secretion Systemic inflammatory response Anaphylactic Shock = Circulatory shock -> cardiovascular collapse caused by blood loss
102
Describe two types of asthma Stimulated by
Extrinsic - allergen known, childhood onset Intrinsic - adult onset, often allergen unknown IgE allergen complex Fatigue mental and physical, emotions, endocrine, etc.
103
Primary problem with asthma seccondary difficulties caused by
Leukotriene release --> smooth muscles in bronchioles can completely close Inflamm in lungs can interfere with gas exchange
104
Leukocytes which ones? Become macrophages Similar to mast cells Humoral and cell mediated immunity Phagocytosis Can destroy parasitic worm/ allergin
Monocytes Basophils Lymphocytes Neutrophils Eosinophils
105
Mesenchyme cells are adult __ cells Have sparse pale staining cytoplasm with ____ shape nucleus Functcion? Divide? Exist in adults?
Stem cells Oval To change into another cell type Yes but numbers decrease as you age
106
Reticular cells are derived from ___ cells Function?
Mesenchyme cells Make reticular fibers. When needed on temp basis - fibroblasts make IE wound healing Permanent basis - reticular fibers made by ret cells
107
4 characteristics of Loose Connective Tissue
(1) Large number of cells and many cell types Fewer fibers More ground substance Quite vascular
108
Two types of Lose Connective tissue
Loose areolar - greater and lesser omenta "fillers" Loose irregular - Dermis - papillary layer; often directly beneath epithelium in organs
109
4 characteristics of Dense connective tissue
Many fibers Fewer cells and cell types Less ground substance Less vascular
110
4 types of Dense CT
Dense Irregular - dermis reticular layer nerve sheath organ capsule Dense Regular - Tendon, ligament, aponeuroses Reticular CT - lymphatic and endocrine organs Adipose - around kidney and heart, hypodermic and bone marrow
111
What are the two general CT rules?
1 - greater number of cell types therefore greater healing potential 2- Increased vascularity therefore increased healing potential
112
Three types of Specailized CT
Cartilage Bone Blood
113
Three mechanisms of protection are...
Surface protection - skin, mucus, acidic vagina Acute Inflammation - non specific process ; neutrophils macrophages and eiosinophils Immune Response - Two main types
114
What are the two main types of Acquired Immunity (adaptive immunity)
Humoral and Cell mediated
115
Usually a response to invading bacteria Mediated by B cells and plasma cells with T involvement Involves antibody production
Humoral Immunity
116
Usually responds to viruses, fungi, or foreign cells Mediated by T cells Does not depend on B cell participation
Cell Mediated Immunity
117
Three functions of the Immune System
Storage of Lymphocytes Increase numbers of lymphocytes Provide a favorable environment for establishing immunity
118
What are the characteristics of Diffuse Lymphatics? Lymphatic Organs?
No or incomplete capsule Humoral Immunity Has a capsule Humoral and Cell mediated
119
Provide an environment where lymphocytes become immunocompetent (ex Thymus and bone marrow) Provide environment where lymphocytes can contact foreign antigens and interact with each other (lymph nodes and spleen)
Primary Lymphoid Organ Secondary
120
What does MALT stand for? Located?
Mucosal-Associated Lymphatic Tissue GI tract, Respiratory and Urogenital tracts
121
Where is secretory IgA secreted onto? Found where? __ important line of defense agains infection __ specific
Free epithelial surfaces Tears, saliva, gut lumen, nose, vagina First Antigen
122
Igas can neutralize what two things? Also do what to microbial adhesion to host cell?
Viruses and bacterial toxins Decrease
123
What is GALT? BALT?
Gut-Associtated Lymphatic Tissue Bronchial-Associated Lymphatic Tissue
124
Explain the types of Tonsils
A.With epithelial folds = Pleated tonsils 1. Pharyngeal Tonsils (inflammed callled adenoids B. With Tonsilar Crypts 1. Palatine Tonsils (Faucial Tonsils) - boundary of oral cavity and oropharynx 2. Lingual Tonsils
125
Advantages and Disadvanteages for Palatine Tonsils
A - more area for antigen detection. Lymph nodule formation D - Decripts - > bacteria thrive - > Inflammative tonsillitis
126
Tonsillar ring around openings to the Digestive and respiratory systems are called?
Waldeyer's Ring
127
Two major functions of Lymph Nodes
Filtration of Lymph using phagocytosis Establish humoral and cell mediated immunities
128
5 major parts of lymph node
Capsule Afferent lymphatics Efferent lymphatics Hilum System of sinuses
129
Sinuses that pass through Marginal sinus... Cortex region... Deep cortex (paracortex) Medulla region
Subcapsular sinus Cortical sinus Deep cortical sinus Medullary sinus
130
Three regions of a lymph node
Cortex Paracortex (Thymus dependent zone) Medulla
131
Cells within all regions and sinuses of lymph node are supported by system of...
Reticular fibers that are produced by reticular cells
132
List lymph node cortex cells Primary cell type in region? Activity in region
Macrophages, reticular cells, dendritic, T, plasma cells B cells Phagocytosis and Humoral immunity
133
Lymph nodules which one? Without germinal centers, older nodule with no B cell division, Naive B cells or B memory cells hanging out With germinal centers, formed in response to particular antigen, active B cell division. Lite center is germinal and dark periphery is mantle
Primary Lymphoid Nodule Secondary Lymphoid Nodule
134
List cells in Paracortex (Thymus Dependent Zone) of Lymph node Primary type Activity
Macrophages, reticular, dendritic, Some B and plasma T cells Long term storage for T cells Cell mediated immunity Phagocytosis
135
What important structures are lined with cuboid cells, function to facilitate passage of B and T cells from blood to lymph node, and The paracortex thins with its infection
HEV - High Endothelial Venules
136
Medulla Cell list Primary cell type Activity
Macrophages, dendritic cells, some b and T Plasma cells Humoral immunity and Phagocytosis
137
Medullary sinus vs cord Numerous and lower cell density Areas of higher cell density
Medullary sinuses Meduallary cords
138
How many lobes of the thymus extend over the great heart vessels? It is the primary ___ organ When does involution begin? Little functioning thymus let by age Function?
Two Lymphoid first few years of life, speeds up at puberty 25 Establishment of immunocompetent T lymphocytes - recognize foreign antigen properly, develop self tolerance
139
Epithielioreticular cells Produce reticular fibers? Offer support using.... Secrete.... Function...
NO Long cytoplasmic processes Thymic hormones and cytokines Influence T cell maturation, division, and activities
140
Epithelioreticular cells form thymic corpuscles (hassal's bodies) Always in the... Size and number ___ a lot Size number ___ w age Function
Medulla Vary Increase Secretion of cytokines that influence local cells
141
Blood thymic barrier consist of what 4 things
Continous capillary Thick basal lamina Macrophages Epithelial reticular cells
142
Why does the Cortex stain more dark than the medulla in the thymus?
Larger number of T cells
143
Lymphocytes produced in bone marrow Enter thymus as immunoincompent T cells Leave blood at corticomedullary line Migrate to periphery of cortex Migrate back toward medulla T cells enter medulla & finish final stages of testing
????