Exam 1 - 2nd half Flashcards Preview

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Flashcards in Exam 1 - 2nd half Deck (17):
1

phase I reactions usually convert the parent drug to a more _____ metabolite by introducing/unmaksing a _____

polar
functional group

2

CYP reaction - aromatic and aliphatic hydroxylations need a _______ R group to make an adequate site for hydroxylation

electron-withdrawing

3

CYP reaction - epoxidation needs a _____ carbon carbon bond with adjacent ____

unsaturated
R-groups

4

CYP reaction - oxidative dealkylations can occur on 3 different types of groups

N-
O-
S-

5

CYP reaction - N oxidation can occur on what 3 types of amines? And it needs a ______ R group on the N

primary, secondary or tertiary amine
electron-withdrawing group

6

CYP reaction - deamination occurs with _____ amines with ____ groups attached to the N atom

primary amines
alkyl groups

7

FMO reactions prefer the oxidation or ___ and ____ amines to the hydroxyl amines and _-oxides, they also catalyze _-oxidations

secondary and teriatry amines
N-oxides
S-oxidations

8

FMO reaction - N-oxidation with ____ amines that have a small alkyl group attached, it forms a _______

tertiary
N-oxide

9

Glucuronidation and sulfation often occur on same substrates (3 kinds) ____ _____ ____, or 2 kinds of sulfates ____ & ____. N-conjugates occurs on ____ or ____ amines

N, S, C
N & O sulfates
primary or secondary amines

10

GSH conjugation - all GST substrates contain an _____ atom and are _____ substrates

electrophilic atom
hydrophobic

11

GSH conjugation - most electrophilic substrates must contain a ________ group

a good leaving group

12

N-acetylation by cytosolic NATS occurs on _____ amines, ______ groups or ___aminds

aromatic amines
hydrazine groups
sulfonamides

13

pharmacogenetics is the study of ______ controlled variations in drugs response. Includes both genetic _____ and ____ genetic ___ that alter an individuals drug response

genetically
polymorphisms
rare
disorders

14

genetic polymorphisms are define as a ____ or _____ trait that exists in the population in at least ___ phenotypes, neither which are ___

Mendialsn or monogenic trait
2
rare

15

additive (co-dominant)

most common pattern
no domination of one allele over another
gene dosage effect

16

autosomal recessive

normal allele dominants over mutatn allele

17

autosomal dominant

mutant allele dominats over normal allel