Exam 1 Flashcards
The two factors used to classify burns are
- Depth of Burn
2. Total Body Surface Area
Paralytic ileus, anorexia/nausea, and ______ aka curiling’s ulcers are the GI complications seen in burn patients
stress ulcers
Which solution is commonly given post-burn
Ringer’s Lactate solution
The goal weight of a burn pt, is to maintain at _______% of pre-burn weight
maintain 90-110% pre-burn weight
- Debridgement of dead skin (whirlpool)
- escharotomy (surgical incision to
Lessen contraction) - Antibiotics
- Skin grafts
Wound treatment techniques
What is the recommended Kcal:N ratio for burn pts and how to calculate it
80-100:1 or 100-150:1
Which micronutrients is particularly important in large burns and aids in immune response and wound healing with a recommendation of 5000 IU per 1000 calories?
Vitamin A
Which micronutrients is particularly important in large burns and is a coenzyme in collagen synthesis and immune fx and has a recommendation of 1g/day, given as 500 mg twice daily?
Vitamin C
Which micronutrients is particularly important in large burns and is a cofactor in energy metabolism and protein synthesis and has a recommendation of 220mg zinc sulfate/day?
Zinc
What is grafting with own skin from other part of body?
autograft
What is grafting with same species of cadaver or another person?
homograft?
What is a grafting of another species often pig
heterograft
What is a grafting of a silastic material?
artificial skin
What is a grafting of a silastic material?
artificial skin
What is the transient phase, lasting hours up to 3-5 days when everything in body function decreases?
Ebb Phase
What is the phase where acute and adaptive phase; length of phase depends on severity of injury
flow phase
what phase includes:
- hypovolemic shock
- ↓ tissue perfusion
- ↓ metabolic
- ↓ kcal
- ↓ oxygen consumption
- ↓ blood pressure
- ↓ body temp
Ebb phase response
What phase includes:
- Catabolism predominates
- ↑glucocorticoids
- ↑glucagon
- ↑catecholamines
- ↑excretion of nitrogen
- ↑metabolic rate
- ↑ oxygen consumption impaired use of fuels
Acute Phase response
Which micronutrients is particularly important in large burns?
Vitamin A, Vitamin C, Zinc
What phase includes:
- Catabolism predominates
- ↑glucocorticoids
- ↑glucagon
- ↑catecholamines
- ↑excretion of nitrogen
- ↑metabolic rate
- ↑ oxygen consumption impaired use of fuels
Acute Phase response
What are hormone-like proteins, secreted by many cell types, which regulate the intensity and duration of immune responses?
cytokines
Fever causes an increase in the metabolic rate by what amount?
13% per °C
&
7% per °F
What are the characteristics of SIRS?
Body temp >38°C / >100.4°F
or
90beats/min
Respiratory rate > 20 breaths/min (tachypnea)
Hyperventilation
WBC > 12,000 mm3 or 10% bands (immature neutrophils in the absence of chemotherapy)
MODS generally begins in what organ?
lungs
What is the effect of glucagon on hepatic glycogenolysis and glyconeogenesis?
Increases both at expense of protein synthesis
What is the effect of cortisol on skeletal amino acids?
mobilizes them
How do catecholamines affect the metabolic rate?
Increases it
There are changes in nutrient metabolisms with metabolic stress, and alteration in PRO affects branched-chain amino acids because it
accelerates oxidation of them from skeletal muscle
There are changes in nutrient metabolisms with metabolic stress, an alteration in CHO affects blood glucose how?
by increasing it
There are changes in nutrient metabolisms with metabolic stress, what is the max rate of glucose oxidation in stress?
7 or 15 mg/kg/min
epidermis, dermis, and subcutaneous tissue are the
three layers of the skin
What are limited to the epidermis and upper portions of the dermis and heal by regeneration, no scar tissue or loss of function?
partial thickness wounds
What are limited to the epidermis and upper portions of the dermis and heal by regeneration, no scar tissue or loss of function?
partial thickness wounds
What is total destruction or loss of epidermis, dermis and subcutaneous tissue and may involve destruction of muscle and bone, and heals by scar formation?
full thickness wounds
What are the three classical steps in the process of wound healing?
- Inflammatory Phase
- Proliferative Phase
- Collagen Remodeling Phase
Which AA helps in protein synthesis and collagen deposition?
Argenine
in healing, what vitamin is involved during the inflammatory phase by stimulating epithelializaton and increasing collagen deposition by fibroblasts?
Vitamin A
in healing, what vitamin is involved in synthesis of collagen connective tissue protein?
Vitamin C
In healing, what mineral is a cofactor for enzymes necessary for protein and collagen formation and tissue growth?
Magnesium
In healing, what mineral is essential for cross-linking and strengthening of the collagen framework?
Copper
in healing, what mineral is involved in the immune function, DNA synthesis, protein nd collagen synthesis, cellular proliferation, and wound healing?
Zinc
What are the two main hormones produced by the thyroid gland?
T3 ( tri-iodthyronine)
&
T4 ( thyroxine)
Which of the two main hormones is the most active form the body can use?
T3