Exam 1

Question 1

Dobutamine

Answer 1

B1>B2=A1

Tx for Cardiac Failure

Question 2

Cheese (Tyramine) + MAOI =

Answer 2

Hypertensive crisis –> release of NE from storage vessicles

Question 3

Phenylephrine

Answer 3

A1>A2>B

Tx for Nasal Decongestant and anti-hypotension

Question 4

Phenoxybenzamine

Answer 4

Irreversibly blocks a1 and a2
Also blocks H1, Ach, and 5-HT
Tx for Pheochromocytoma

Question 5

Prazosin

Answer 5

A1 antagonist

Tx for BPH and Hypertension

Question 6

Tamsulosin

Answer 6

A1a specific antagonist

Tx for BPH w/o cardiogenic effects

Question 7

Echothiophate

Answer 7

Irreversible Organophosphate

RX for Glaucoma

Question 8

Pralidoxim (2-Pam)

Answer 8

Un-phosphorylates Ache to activate it.

RX for OD of anti-AchE

Question 9

Atropine

Answer 9

M1, M2, M3
Competative inhibitor
Combat ionotropic AchE inhibitor
OD tx’d with Physostigmine

Question 10

Ipratropium

Answer 10

Acts mainly on M3 in bronchial SMC and Glands
1st Line- COPD
2nd Line- Asthema

Question 11

Benztropine

Answer 11

3* amine

RX for Parkinson’s Disease

Question 12

Nicotinic Antagonists- Ganglion Blocking Agents

Answer 12

Hexamethonium and Mecamylamine

Block the Baroreflex in heart rate

Question 13

D-tubocurarine

Answer 13

Non-depolarizing neuromusculojunction antagonist
Competes with Ach for channel binding sites and prevents opening
OD tx’d with anti-AchE

Question 14

Succinylcholine

Answer 14

Phase 1: Binding Nm= Depolarization
Continued depolarization= Paralysis
Augmented by AcheE inhibitors

Phase 2: Endplate repolarizes but endplate is desensitized

Question 15

Phenylephrine

Answer 15

A1 selective

RX for Hypotension and Nasal Decongestant

Question 16

Clonidine

a-Methyldopa

Answer 16

A2 selectives- Can cause rebound hypertension
RX for Systemic Hypertension
Glaucoma

Question 17

Metaproterenol

Answer 17

B2 selective

RX for Obstructive Airway Disease

Question 18

Terbutaline

Answer 18

B2 selective

RX for Obstructive Lung disease

Question 19

Albuterol and Ritodrine

Answer 19

B2 Selective

RX for acute Bronchospasms and delays pre-term labor

Question 20

Fenoldopam

Answer 20

D1 Selective

Rx for Hypertensie Crisis

Question 21

Isoproterenol

Answer 21

B1=B2

RX for Brady, Torsades De Pointes, CHF, and MI

Question 22

Dobutamine

Answer 22

B1 selective therapeutically

RX for Cardiac Failure

Question 23

Epinephrine

Answer 23

A1,A2, B1,B2
RX for Anaphylaxis
Contraindications:
Patient’s receiving non-selective B Blocker= severe vasoconstriction

Question 24

Epinephrine Reversal

Answer 24

In presence of a antagonism-epinephrine’s effect on B2 receptors is enhanced== Vasodilation, ↓peripheral resistance and MAP
In presence of B receptor anagonism- Epininephrine’s effect on a1 is unopoosed == substantial ↑MAP

Question 25

Dopamine

Answer 25

D1, D2 Ineffective orally (MAO and COMT substrate) RX for Severe CHF, Cardiogenic and septic Shock Contraindications: Must correct hypovolemia prior to use

Question 26

Ephedrine

Answer 26

a1,2, b1,2 and Releasing Agent RX as decongestant Effects diminished by Reserpine and Guanethidine

Question 27

Phenoxybenzamine

Answer 27

A1>a2 antagonist Irreversibly blocks A1/2/H1/Ach/5-HT RX for Pheochromocytoma

Question 28

Prazosin

Answer 28

A1 antagonist | RX for hypertension and BPH

Question 29

Tamulsoin

Answer 29

A1a selective | RX for BPH

Question 30

Labetalol

Answer 30

B and A antagonist Decreases BP with limited change in HR. RX for hypertension

Question 31

Propanolol

Answer 31

B1, B2 non-selective Blocker Decreases HR and BP and Renin RX for Hypertension, Angina pectoris Hyperthyroidism

Question 32

Metoprolol

Answer 32

B1 selective Blocker Safer for asthmatics RX for hypertension, Angina pecoris arrythmias

Question 33

Pindolol

Answer 33

B1, B2 + intrinsic sypathomimetic Activity (WIll block catecholomines too)

Question 34

Carvediol

Answer 34

B Blocker w/ long half life | RX for Heart Failure