Exam 1

Question 1

The analgesic properties of the opiates are primarily mediated by which receptors?

Answer 1

mu receptors

Question 2

The major effects of the opioids are mediated by what 5 families of receptors?

Answer 2

μ(mu), κ(kappa), σ(sigma), δ(delta) and ε(epsilon)

Question 3

receptor may be responsible for the hallucinations and dysphoria often associated with opiate use.

Answer 3

sigma

Question 4

mechanism of opioids

Answer 4

hyperpolarization results in the inhibition of subsequent nerve firing as well as presynaptic inhibition of the release of various pain mediators, such as substance P, which further modulates pain perception.

Question 5

Although the opioids have a broad range of effects, their primary use is to

Answer 5

relieve intense pain and the anxiety that follows such pain.

Question 6

opiopeptins

Answer 6

endogenous neurotransmitters such as the endorphins and the enkephalins

Question 7

The enkephalins interact more selectively with which receptors in the periphery.

Answer 7

delta