Exam 1 Flashcards Preview

Pharm 2 > Exam 1 > Flashcards

Flashcards in Exam 1 Deck (7)
Loading flashcards...
1

The analgesic properties of the opiates are primarily mediated by which receptors?

mu receptors

2

The major effects of the opioids are mediated by what 5 families of receptors?

μ(mu), κ(kappa), σ(sigma), δ(delta) and ε(epsilon)

3

receptor may be responsible for the hallucinations and dysphoria often associated with opiate use.

sigma

4

mechanism of opioids

hyperpolarization results in the inhibition of subsequent nerve firing as well as presynaptic inhibition of the release of various pain mediators, such as substance P, which further modulates pain perception.

5

Although the opioids have a broad range of effects, their primary use is to

relieve intense pain and the anxiety that follows such pain.

6

opiopeptins

endogenous neurotransmitters such as the endorphins and the enkephalins

7

The enkephalins interact more selectively with which receptors in the periphery.

delta