Exam 1 Flashcards
Selective serotonin reuptake inhibitors (SSRIs)
Citalopram Fluoxetine Sertraline Paroxetine Fluvoxamine Escitalopram Vilazodone
Tricyclic antidepressants
Amitriptyline
Desipripramine
Imipramine
Nortiptyline
Monoamine oxidase inhibitors (MAOIs)
Phenelzine
Tranylcypromine
Isocarboxazid
Atypical antidepressants (heterocyclics)
Bupropion Mirtazapine Nefazodone Trazodone Deplin
Serotonin norepinephrine reuptake inhibitors
Venlafaxine
Duloxetine
Desvenlafaxine
Adverse effects of SSRIs
Nausea, headache, agitation, insomnia, anxiety, sexual dysfunction, weight gain
What should the client watch for when taking SSRIs?
Serotonin syndrome
Avoid taking st. John’s wart which can increase the risk
For what drug must the patient try to minimize anticholinergic effects?
Tricyclic antidepressants
Chew gum, eat high fiber foods, increase fluid intake
What foods should be avoided when taking MAOIs?
Foods with tyramine: smoked meats, avocados, liver, dried fish, most cheeses, some beer and wine
Avoid all medications, cold cut meats, pickled foods, chocolate
Side effects of atypical antidepressants?
Headache, dry mouth, nausea, restlessness, insomnia
Avoid giving atypical antidepressants to what patients?
Those at risk for seizures
Side effects of SNRIs
Nausea, insomnia, weight gain, diaphoresis, sexual dysfunction
Use caution giving SNRIs to what patients?
Those with history of hypertension
Mood stabilizers- anti seizure medications
Valproic acid Carbamazepine Oxcarbazepine Levetiracetam Gabapentin Lamotrigine Topiramate
Bipolar disorder
Antianxiety medications
Lorazepam Clonazepam Alprazolam Diazepam Oxazepam Chlordiazepoxide Clonazepam
Bipolar disorder
Mood stabilizer- antipsychotics (conventional)
Chlorpromazine
Haloperidol
Thiothixene
Molindone
What can ECT be used for?
Major depressive disorder
Schizophrenia (with catatonic manifestations)
Schizoaffective disorder
Acute manic episodes (bipolar with rapid cycling)
ECT is contraindicated when?
Cardiovascular disorders
Cerebrovascular disorders
Electroconvulsive therapy
Uses electric current to induce grand mal seizure activity
How often does the patient get ECT?
2-3 times per week for a total of 6 to 12 treatments
Medication given before ECT
Atropine sulfate to control secretions
Muscle relaxant
Anesthetic
Complications of ECT
Short term memory loss
Headache, nausea, muscle soreness
Transcranial magnetic stimulation
Noninvasive therapy that uses magnetic pulsation to stimulate the cerebral cortex of the brain
How often does a patient receive TMS?
Daily for 4 to 6 weeks
What is TMS used to treat?
MDD
Side effects of TMS
Tingling sensation at site of electrode
Lightheadedness
Seizures rare
Vagus nerve stimulation
Electrical stimulation through vagus nerve to the brains through a device that is surgically placed
Believed to result in increased level of neurotransmitters
What is VNS used for?
Depression that isn’t treated by pharmacological treatments or ECT
Epilepsy
How often does the VNS device deliver pulsations?
Every 5 minutes for a duration of 30 seconds
Can be turned off using a special external magnet
Side effects of VNS
Voice changes Hoarseness Neck pain Dysphagia Dyspnea with physical exertion (turn off device when exersizing)
Mood stabilizer
Lithium carbonate
What do conventional antipsychotics treat?
Positive signs of schizophrenia
Mood stabilizers- antipsychotics (atypical)
Risperidone Olanzapine Arpiprazole Ziprasidone Quetiapine Clozapine
What are atypical antipsychotics used for?
Negative symptoms of schizophrenia
What are SSRIs used to treat?
MDD
What are MAOIs used to treat?
MDD
What are SNRIs used to treat?
MDD
When are TCA’s used?
When SSRIs and SNRIs don’t work or if depression is related to alcohol/cocaine withdrawal
Side effects of TCAs
Sedation
orthostatic hypotension
Anticholinergic effects (can’t pee, see, spit, shit)
Cardiotoxicity (tachycardia)
When are MAOIs used?
When SSRIs and SNRIs don’t work
Side effects of MAOIs
Hypertensive crisis
Seizures
What is the first line meds for depression?
SSRIs
Side effects of SSRIs
GI upset
Sleep difficulty
Decreased libido
Side effects of SSRIs and SNRIs
Anticholinergic effects
Serotonin syndrome
Symptoms of serotonin syndrome
Nausea, vomiting, diarrhea Fever Sweating Mental status change Can progress to cardiac arrest
Treatment for serotonin syndrome
Muscle relaxants
Serotonin blocker (cyproheptadine)
Nitrates, cardiac meds
Side effects of benzos
Respiratory depression
Drowsiness
Dizziness
Side effects of toxicity of valproic acid
GI issues
Side effects for toxicity of carbamazepine
Blurred vision and drowsiness
Side effects of lamotrigine
N/V
Headache
Dizziness
Steven Johnson’s syndrome
What is most frequently prescribed medication for bipolar disorder?
Lithium carbonate
Therapeutic range of lithium carbonate
0.6-1.2
Draw levels every 6 months
Symptoms of toxicity of lithium carbonate
Polydipsia Polyuria N/V Diarrhea Headache Muscle pain Rash
Side effects of antipsychotics
Neuroleptic malignant syndrome (first sign increased temp)
Extrapyramidal symptoms (EPS- increased risk for conventional antipsychotics)
Disordered water balance
Metabolic syndrome (more with atypical antipsychotics)
Types of EPS
Acute dystonia
Pseudoparkinsonism
Akathesia
Tardive dyskinesia
Why is clozapine heavily monitored?
Risk of agranulocytosis
Need to monitor WBC and infections symptoms