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Flashcards in Exam 1 Deck (36)
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1
Q

TNF and IL-1

A

mediate inflammation. Produced by mast cells, increase expression of E-selectin on endothelial surface. TNF can also cause septic shock. systemic function

2
Q

IFN-alpha, beta

A

resistance to viral infections

3
Q

IFN-gamma

A

Macrophage activation

4
Q

IL-12

A

stimulates IFN-gamma production by NK and T cells

5
Q

IL-15

A

Stimulates proliferation of NK cells

6
Q

IL-10, TGF-beta

A

control of inflammation

7
Q

CCL2/MCP-1

A

monocyte recruitment

8
Q

CCL19/MIP-3beta

A

T-cell/DC migration in LN

9
Q

CCL21/SLC

A

T-cell/DC migration in LN

10
Q

CXCL8

A

Neutrophil recruitment

11
Q

CXCL10

A

Effecter T cell recruitment

12
Q

CXCL12

A

Naive B cells to LN

13
Q

CXCL13

A

B cells migration to follicles

14
Q

TNF-alpha and IL-1beta

A

inflammatory cytokines released by the NF-kB pathway

15
Q

IL-4

A

B cell proliferation in response to extracellular pathogens

16
Q

TLR-1

A

bacterial lipoproteins

17
Q

TLR-2

A

bacterial lipoproteins and peptidoglycan

18
Q

TLR-4

A

LPS

19
Q

TLR-5

A

bacterial flagellin

20
Q

TLR-6

A

bacterial lipoproteins

21
Q

TLR-3

A

dsRNA

22
Q

TLR-7

A

ssRNA

23
Q

TLR-8

A

ssRNA

24
Q

TLR-9

A

CpG DNA

25
Q

IL-2

A

growth factor for T cells

26
Q

IL- 6

A

induction of acute phase proteins

27
Q

IgM

A
Induced by IL-2,4,5
1st Ab produced
found mainly in bloodstream
begins as a B-cell receptor
activates classical complement pathway
28
Q

IgG3

A

Induced by IFN-gamma

can transplant across the placenta

29
Q

IgG1

A

Induced by IL-4

can transplant across the placenta

30
Q

IgG general

A
Can penetrate deep into tissues
most abundant Ab in blood
Provides bulk of immunity to blood-borne pathogens
only Ig that can cross placenta
phagocytosis
31
Q

IgA

A

induced by TGF-beta

most common in mucus secretions

32
Q

IgE

A

Induced by IL-4
important in allergic reactions, sensitizes mast cells
important in parasitic infections
can cause hypersensitivity disorders

33
Q

IgD

A

expressed by naive B cells and acts as an Ag receptor

we don’t really know what it does

34
Q

DAF

A

regulatory protein of complement

blocks C2-C4 interactions and causes dissociation of C4b2a OR C3bBb (classical or alternative pathway)

35
Q

CR1

A

regulatory protein of complement

dissociates C4b2a OR C3bBb, with Factor 1, it cleaves C4b or C3b, phagocytosis when bound to C3b (all pathways)

36
Q

Properdin

A

Stabilizes the interactions of the alternative complement pathway