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Flashcards in Exam 1 Deck (36)
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1

TNF and IL-1

mediate inflammation. Produced by mast cells, increase expression of E-selectin on endothelial surface. TNF can also cause septic shock. systemic function

2

IFN-alpha, beta

resistance to viral infections

3

IFN-gamma

Macrophage activation

4

IL-12

stimulates IFN-gamma production by NK and T cells

5

IL-15

Stimulates proliferation of NK cells

6

IL-10, TGF-beta

control of inflammation

7

CCL2/MCP-1

monocyte recruitment

8

CCL19/MIP-3beta

T-cell/DC migration in LN

9

CCL21/SLC

T-cell/DC migration in LN

10

CXCL8

Neutrophil recruitment

11

CXCL10

Effecter T cell recruitment

12

CXCL12

Naive B cells to LN

13

CXCL13

B cells migration to follicles

14

TNF-alpha and IL-1beta

inflammatory cytokines released by the NF-kB pathway

15

IL-4

B cell proliferation in response to extracellular pathogens

16

TLR-1

bacterial lipoproteins

17

TLR-2

bacterial lipoproteins and peptidoglycan

18

TLR-4

LPS

19

TLR-5

bacterial flagellin

20

TLR-6

bacterial lipoproteins

21

TLR-3

dsRNA

22

TLR-7

ssRNA

23

TLR-8

ssRNA

24

TLR-9

CpG DNA

25

IL-2

growth factor for T cells

26

IL- 6

induction of acute phase proteins

27

IgM

Induced by IL-2,4,5
1st Ab produced
found mainly in bloodstream
begins as a B-cell receptor
activates classical complement pathway

28

IgG3

Induced by IFN-gamma
can transplant across the placenta

29

IgG1

Induced by IL-4
can transplant across the placenta

30

IgG general

Can penetrate deep into tissues
most abundant Ab in blood
Provides bulk of immunity to blood-borne pathogens
only Ig that can cross placenta
phagocytosis