Exam 1

Question 1

TNF and IL-1

Answer 1

mediate inflammation. Produced by mast cells, increase expression of E-selectin on endothelial surface. TNF can also cause septic shock. systemic function

Question 2

IFN-alpha, beta

Answer 2

resistance to viral infections

Question 3

IFN-gamma

Answer 3

Macrophage activation

Question 4

IL-12

Answer 4

stimulates IFN-gamma production by NK and T cells

Question 5

IL-15

Answer 5

Stimulates proliferation of NK cells

Question 6

IL-10, TGF-beta

Answer 6

control of inflammation

Question 7

CCL2/MCP-1

Answer 7

monocyte recruitment

Question 8

CCL19/MIP-3beta

Answer 8

T-cell/DC migration in LN

Question 9

CCL21/SLC

Answer 9

T-cell/DC migration in LN

Question 10

CXCL8

Answer 10

Neutrophil recruitment

Question 11

CXCL10

Answer 11

Effecter T cell recruitment

Question 12

CXCL12

Answer 12

Naive B cells to LN

Question 13

CXCL13

Answer 13

B cells migration to follicles

Question 14

TNF-alpha and IL-1beta

Answer 14

inflammatory cytokines released by the NF-kB pathway

Question 15

IL-4

Answer 15

B cell proliferation in response to extracellular pathogens

Question 16

TLR-1

Answer 16

bacterial lipoproteins

Question 17

TLR-2

Answer 17

bacterial lipoproteins and peptidoglycan

Question 18

TLR-4

Answer 18

LPS

Question 19

TLR-5

Answer 19

bacterial flagellin

Question 20

TLR-6

Answer 20

bacterial lipoproteins

Question 21

TLR-3

Answer 21

dsRNA

Question 22

TLR-7

Answer 22

ssRNA

Question 23

TLR-8

Answer 23

ssRNA

Question 24

TLR-9

Answer 24

CpG DNA

Question 25

IL-2

Answer 25

growth factor for T cells

Question 26

IL- 6

Answer 26

induction of acute phase proteins

Question 27

IgM

Answer 27

``` Induced by IL-2,4,5 1st Ab produced found mainly in bloodstream begins as a B-cell receptor activates classical complement pathway ```

Question 28

IgG3

Answer 28

Induced by IFN-gamma | can transplant across the placenta

Question 29

IgG1

Answer 29

Induced by IL-4 | can transplant across the placenta

Question 30

IgG general

Answer 30

``` Can penetrate deep into tissues most abundant Ab in blood Provides bulk of immunity to blood-borne pathogens only Ig that can cross placenta phagocytosis ```

Question 31

IgA

Answer 31

induced by TGF-beta | most common in mucus secretions

Question 32

IgE

Answer 32

Induced by IL-4 important in allergic reactions, sensitizes mast cells important in parasitic infections can cause hypersensitivity disorders

Question 33

IgD

Answer 33

expressed by naive B cells and acts as an Ag receptor | we don't really know what it does

Question 34

DAF

Answer 34

regulatory protein of complement | blocks C2-C4 interactions and causes dissociation of C4b2a OR C3bBb (classical or alternative pathway)

Question 35

CR1

Answer 35

regulatory protein of complement | dissociates C4b2a OR C3bBb, with Factor 1, it cleaves C4b or C3b, phagocytosis when bound to C3b (all pathways)

Question 36

Properdin

Answer 36

Stabilizes the interactions of the alternative complement pathway