Exam 1 and 2 Flashcards
(88 cards)
Wada Test
- clinical testing with amobarbitol
- injection to temporarily disrupt one cerebral hem (“sleeps”)
- used to ID sources of seizures
- gives insight in hem specialization
Macroscopic Anatomical Asymmetries/Differences
right protrudes in F, left in back
* right has volume in frontal region, left larger posterior in occipital region
* ^ bends longitud. fissure b/t two hem (Sylvian Fissure - related to size dif)
planum temporale: center of wernickes
* larger in left, overwhelm lang (dyslexia)
functional asymmetry:
correlates with planum temporale
* opp. hem explains handedness (correlated)
realistic asymmetry:
Left:
* lang, r motor/visual field, inference, logic, local representations
Right:
* visuospatial processing, facial process, spatial attention, l motor/visual field, global representation
Carotid artery serves one another (not circle of willis)
Anatomical Asymmetry: anterior bank r> left
posterior bank l > right
* functionally, no difference, 0 function
Microscopic Anatomical Asymmetries and Differences
homotopic areas correspond on 2 hem (lang - ant, post - Wernickes)
types asym:
* left hem neurons have longer dendrites
* spaces in column of left hem, dense in right hem
* no difference in spacing + connecting of columns
* left hem higher order processing
* larger gaps left hem = connection fibers
* cell size dif b/t hem (long range connect = refined)
* *result in action connectivity process
Hemispheric Communication
- homotopic: corresponding region in other hem (0 priming)
- heterotopic: different region in other hem
- ipsilateral: same side to brain
Split Brain Research:
- corpus callosum:
- connects both hems with commisures
- interhem. communication
- anterior = genu, middle = body, posterior: splenium (connects occipital lobe, larger tracts
- ^ fibers vary
- ^^ temporoparietal visual = small
- ^^sensorimotor = large
- maintain topographic organization
- DTI
- ^ all temporal, pareital, occipital transferred to opposite hemisphere
- ^^posterior third
- ^premotor and supplementary to middle third
- fatty tissue, myelin (dense tracts)
- organization projection:
- ^prefrontal, premotor (SMA), primary motor cortex, primary somatosensory cortex, parietal, occipital, temporal
Commisures
Anterior: smaller band of fibers connects 2 hemispheres
* inferior to anterior portion callosum
* olfactory tract
* connects temporal area, amygdala
* neospinothalamic
Posterior: interhem fibers (smaller)
* above cerebral aqueduct of 3rd ventricle
* tiny bulb
* pupillary light reflex
* same dimension
Purpose of GABA
axpn tracts (corpuscles) use GABA (inhibitory)
* send signals to each other through corpuscles
* evolutionary advantage (robust, adaptive)
* ^primary role of corp
Consequences of corpus callostomy
- separates vesicles from callosum
- arteries -> navigate or hemorrage
- rupture vesicles: leak CSF, no shock absorb
- methodological considerations: already damaged, need to verify comp transcort. section (doctor), more strict laterally than other modes (what goes in to ea. visual field)
Understand functional asymmetries
visuospatial: path for voluntary expression (split brain can’t control signal to left hem, left side), spontaneous expression originates in older parts of brain (basal ganglia)
attention versus visual perception: attentional/visual control maintain to opposite visual field (we dk), spatial info to integrate between hemispheres (transfer attent)
global and local: opposite hem with lesions are slower to look at same side target
hierarchal structures: configuration may be dense
theory of mind: in medial PFC, rhem, amygdala (understand all have thoughts, deisres, beliefs)
* split brain patients have different more realsoning (r hem -> fast, auto belief, l hem -> slow, deliberate reasoning)
Dichotic Listening Task
compare hemispheric specilization in auditory canal
* projected bilaterally (cochlear nuclear -> contralateral thalamus -> ipsilateral) where some think they hear only contra
* linguistic stimulation accurate in Right ear (right ear adv) for music, left ear for language
used to:
find double dissociations
recognize memory
voluntary attention
Hemispheric spec in non humans
- present in all vertebraes
- birds = limited hem commmunication, no corpus
- hypoglossal nerve help to communicate what’s food or not
- optic fibers cross contralateraly (local: LVF (RH), categorically: after discrim)
modularity
specilization process unit of NS
* perform spec computations
^modules for speech, aud, perception
* local networks perform to adapt to new demands
Hemispheric connections with handedness
- dom language in left = correlation
- l hem = larger WA (usually left hem dominance)
Agnosia, Visual Agnosia
visual: inability to recognize object, restricted to visual domain
agnosia: disturbance of perception recog cannot attribute to impairment in basic sensory process (single modality)
Object Constancy
can change some things in visual percep/situation
* computer can’t see what we can
* we see light orientation, environment
* robust constancy
View Invariant/Dependent
Dependent: requires many special req in memory
* memory template
* heavy burden in memory
* suppressed by expressions using novel object from templates
Invariant: observed in left fusiform, no matter view point (components)
* right fusiform only when object presented in the same view (templates)
repetition suppression: during fMRI where BOLD response to stim with each subsequent presentiation
(why should system increase energy if it remembers the same thing)
Shape Encoding
**recognize same shape, lines in different ways **
fusiform face
* difference between objects (familiar, novel, scrambled)
* ventral on OCT to familiar
* LOC shows further exhibition cue invariance regardless on motion (must be salient of obj)
* increases bold
Grandmother Cells
cell with high specialization and sits atop perceptual neutral network hierarchy
* gnostic unit cell selectivity, “this is grandma”
* allows sparse coding (represents many objects, invariant in enviroment)
* lowest level: edge detection
* highest level: complete object
* issue: activity from text, by recording from small number of neurons. if unit dies, where is the object recognition
* ensemble encoding (hypothesis): indicates specialization pattern of activity, multiple feature detectors -> parallel, many cells to recognize grandma, account for variations between object
Prospagnosia and Faces
**deficit in ability to recognize **
* association ability
processing: different neural mechanism from other objects, local potentiality (distinct), different parts process = equipotentiality
Unusual Views Test
judge if 2 images differ than viewpoints of same object
* right hem lesion = (posterior), worse than patients with left hem lesions
* implicit occipital lobe association in agnosia
Shadows test
Identify under shadowed perspective
* right hem lesion (posterior) worse than left hem
Integrative agnosia
can’t integrate points into whole
*no issue with shape match/unusual views test
* probably holistically
* arrange letters from random display
* hetero (slower) = serial
* *homogenous (boost in efficiency)= perial
* HJA: no difference, can’t do whole homo (our hetero)
Apperceptive Agnosia
different unit perception represents with long term of percepts
0 understanding of object due ot lesions
- perceptive difference (alexia) is not proportional to recognition
- match by function: decide if two objects function similar but infer
- posterior lesion fails
Associative Agnosia
perception and senses interact but no recognition
0 function, unable to visually pres object, 0 ability to identify