Exam 1 and 2 Flashcards

(88 cards)

1
Q

Wada Test

A
  • clinical testing with amobarbitol
  • injection to temporarily disrupt one cerebral hem (“sleeps”)
  • used to ID sources of seizures
  • gives insight in hem specialization
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2
Q

Macroscopic Anatomical Asymmetries/Differences

A

right protrudes in F, left in back
* right has volume in frontal region, left larger posterior in occipital region
* ^ bends longitud. fissure b/t two hem (Sylvian Fissure - related to size dif)
planum temporale: center of wernickes
* larger in left, overwhelm lang (dyslexia)

functional asymmetry:
correlates with planum temporale
* opp. hem explains handedness (correlated)

realistic asymmetry:
Left:
* lang, r motor/visual field, inference, logic, local representations

Right:
* visuospatial processing, facial process, spatial attention, l motor/visual field, global representation

Carotid artery serves one another (not circle of willis)

Anatomical Asymmetry: anterior bank r> left
posterior bank l > right
* functionally, no difference, 0 function

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3
Q

Microscopic Anatomical Asymmetries and Differences

A

homotopic areas correspond on 2 hem (lang - ant, post - Wernickes)
types asym:
* left hem neurons have longer dendrites
* spaces in column of left hem, dense in right hem
* no difference in spacing + connecting of columns
* left hem higher order processing
* larger gaps left hem = connection fibers
* cell size dif b/t hem (long range connect = refined)
* *result in action connectivity process

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4
Q

Hemispheric Communication

A
  • homotopic: corresponding region in other hem (0 priming)
  • heterotopic: different region in other hem
  • ipsilateral: same side to brain
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5
Q

Split Brain Research:

A
  • corpus callosum:
  • connects both hems with commisures
  • interhem. communication
  • anterior = genu, middle = body, posterior: splenium (connects occipital lobe, larger tracts
  • ^ fibers vary
  • ^^ temporoparietal visual = small
  • ^^sensorimotor = large
  • maintain topographic organization
  • DTI
  • ^ all temporal, pareital, occipital transferred to opposite hemisphere
  • ^^posterior third
  • ^premotor and supplementary to middle third
  • fatty tissue, myelin (dense tracts)
  • organization projection:
  • ^prefrontal, premotor (SMA), primary motor cortex, primary somatosensory cortex, parietal, occipital, temporal
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6
Q

Commisures

A

Anterior: smaller band of fibers connects 2 hemispheres
* inferior to anterior portion callosum
* olfactory tract
* connects temporal area, amygdala
* neospinothalamic
Posterior: interhem fibers (smaller)
* above cerebral aqueduct of 3rd ventricle
* tiny bulb
* pupillary light reflex
* same dimension

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7
Q

Purpose of GABA

A

axpn tracts (corpuscles) use GABA (inhibitory)
* send signals to each other through corpuscles
* evolutionary advantage (robust, adaptive)
* ^primary role of corp

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8
Q

Consequences of corpus callostomy

A
  • separates vesicles from callosum
  • arteries -> navigate or hemorrage
  • rupture vesicles: leak CSF, no shock absorb
  • methodological considerations: already damaged, need to verify comp transcort. section (doctor), more strict laterally than other modes (what goes in to ea. visual field)
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9
Q

Understand functional asymmetries

A

visuospatial: path for voluntary expression (split brain can’t control signal to left hem, left side), spontaneous expression originates in older parts of brain (basal ganglia)

attention versus visual perception: attentional/visual control maintain to opposite visual field (we dk), spatial info to integrate between hemispheres (transfer attent)

global and local: opposite hem with lesions are slower to look at same side target

hierarchal structures: configuration may be dense

theory of mind: in medial PFC, rhem, amygdala (understand all have thoughts, deisres, beliefs)
* split brain patients have different more realsoning (r hem -> fast, auto belief, l hem -> slow, deliberate reasoning)

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10
Q

Dichotic Listening Task

A

compare hemispheric specilization in auditory canal
* projected bilaterally (cochlear nuclear -> contralateral thalamus -> ipsilateral) where some think they hear only contra
* linguistic stimulation accurate in Right ear (right ear adv) for music, left ear for language

used to:
find double dissociations
recognize memory
voluntary attention

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11
Q

Hemispheric spec in non humans

A
  • present in all vertebraes
  • birds = limited hem commmunication, no corpus
  • hypoglossal nerve help to communicate what’s food or not
  • optic fibers cross contralateraly (local: LVF (RH), categorically: after discrim)
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12
Q

modularity

A

specilization process unit of NS
* perform spec computations
^modules for speech, aud, perception
* local networks perform to adapt to new demands

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13
Q

Hemispheric connections with handedness

A
  • dom language in left = correlation
  • l hem = larger WA (usually left hem dominance)
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14
Q

Agnosia, Visual Agnosia

A

visual: inability to recognize object, restricted to visual domain

agnosia: disturbance of perception recog cannot attribute to impairment in basic sensory process (single modality)

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15
Q

Object Constancy

A

can change some things in visual percep/situation
* computer can’t see what we can
* we see light orientation, environment
* robust constancy

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16
Q

View Invariant/Dependent

A

Dependent: requires many special req in memory
* memory template
* heavy burden in memory
* suppressed by expressions using novel object from templates

Invariant: observed in left fusiform, no matter view point (components)
* right fusiform only when object presented in the same view (templates)

repetition suppression: during fMRI where BOLD response to stim with each subsequent presentiation
(why should system increase energy if it remembers the same thing)

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17
Q

Shape Encoding

A

**recognize same shape, lines in different ways **
fusiform face
* difference between objects (familiar, novel, scrambled)
* ventral on OCT to familiar
* LOC shows further exhibition cue invariance regardless on motion (must be salient of obj)
* increases bold

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18
Q

Grandmother Cells

A

cell with high specialization and sits atop perceptual neutral network hierarchy
* gnostic unit cell selectivity, “this is grandma”
* allows sparse coding (represents many objects, invariant in enviroment)
* lowest level: edge detection
* highest level: complete object
* issue: activity from text, by recording from small number of neurons. if unit dies, where is the object recognition
* ensemble encoding (hypothesis): indicates specialization pattern of activity, multiple feature detectors -> parallel, many cells to recognize grandma, account for variations between object

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19
Q

Prospagnosia and Faces

A

**deficit in ability to recognize **
* association ability

processing: different neural mechanism from other objects, local potentiality (distinct), different parts process = equipotentiality

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20
Q

Unusual Views Test

A

judge if 2 images differ than viewpoints of same object
* right hem lesion = (posterior), worse than patients with left hem lesions
* implicit occipital lobe association in agnosia

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21
Q

Shadows test

A

Identify under shadowed perspective
* right hem lesion (posterior) worse than left hem

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22
Q

Integrative agnosia

A

can’t integrate points into whole
*no issue with shape match/unusual views test
* probably holistically
* arrange letters from random display
* hetero (slower) = serial
* *homogenous (boost in efficiency)= perial
* HJA: no difference, can’t do whole homo (our hetero)

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23
Q

Apperceptive Agnosia

A

different unit perception represents with long term of percepts
0 understanding of object due ot lesions

  • perceptive difference (alexia) is not proportional to recognition
  • match by function: decide if two objects function similar but infer
  • posterior lesion fails
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24
Q

Associative Agnosia

A

perception and senses interact but no recognition
0 function, unable to visually pres object, 0 ability to identify

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25
Alexia
**reading disruption** *from a stroke* * dyslexia: gene distrub * frequency = reference to acq agnosia to indicate results
26
Category Specificity:
**recognition imparied, restricts class of object** *inability to recognize live things, normal in non-living* * *inanimate*: sensorimotor assists in recognition, kinesthetic codes * *semantic knowledge*: catergory (*living, non*), property (*function, visual*)
27
Category vs Property
**catergory** (*living, non*), **property** (*function, visual*) * *connectionist*: gave computational brain damage (animously judes, multidimensional represents space (visual process)) * *double dissociation*: lesion in visual semantic -> impairs living, lesion in functional semantic -> impairs non living (limited, stops lines of code but identify living through visual and functional representation)
28
Fusiform Face Area (FFA)
**functionally defined** *ventral surface* * fusiform gyrus: **local**: central surface, temporal lobe to *view facial stimulation*
29
Extrastriate Body Area (EBA)
**perceive human form** *damage = inability to recognize stability*
30
Analytic vs Holisitc Processing
**holistic::** parallel, expect face above line *engage in face process (not anaytic), whole vs. parts (ID whole faces are easier, no difference with houses) **analytic**: perceptive analysis emphasizes component parts of object (reading analysis are some letters, ASL, 2nd language
31
Parahippocampal Place Area
**area in hippocampus, regulation of temporal love repsonse to stimulate scenes vs places**
32
Decoding
**brain activity produces by stimulation to detect menthods** *fMRI detects OG stimulus* * shown stim -> space -> predicted BOLD * BOLD -> feature specifity-> stimulus predicted * based on neural activity
33
Occipital Face Area (OFA)
sensitive to faces
34
Fusiform Body Area (FBA)
recognizes body
35
Ventral vs Dorsal
**Ventral**: what *inferotemporal cortex* **Dorsal**: where *posteroparietal cortex (right hem)* * found in single cell recording (hand study) in ITC (lesion/behavioral study) * *optic ataxia* * bilateral fMRI activity * PET contrasts in object vs localization (2AFC, reveal dif neutral activity to task) * Perception for identity vs perception for activity (dissociation between awareness and perception, damage to ventral)
36
Optic Ataxia
**recognize object but 0 visual info to guide action** * 0 ability to avoid obstacles * innapropriate eye saccades * fail to bring object to fovea * dorsal pathway and patient DF = double dissociation * ***Hem Asymmetry*** in fMRI: depends on location of object, hand used to reach (ventral guides object, dorsal to judge task = spatial processes)
37
Balint's Syndrome
**attention vs awareness** *damage bilterally to regions of postoparietal and occipital* * dmall subset of objects perceived at a time * object mislocalized * regard to selective attention
38
Unilateral Spatial Neglect
**failure/sloweness in acknowledging object or evens in contralateral hem to lesions** *severe persists worse when association with damage to right parietal lobe* * 0 ability to draw on the left side * attends to one side * extinction when present stimulus in left and right visual field, only sees R * neglect in visual memory
39
Gaze Bias
Where's Waldo
40
Phenomena of Extinction
**failure to perceive or respond to a stimulus contralateral to a lesion (contralesional)
41
Voluntary vs Reflexive
**Voluntary: ability to intentionally look at something**:*book* **Reflexive: bottom up stimulus drive, sensory event captures attention**
42
Overt vs Covert
**Overt: observe action related to attention**: *look at this, your focus is here* **Covert: unobservable**: *pretending to look at something, actually looking from peripheral, in front of you, etc* (different from foviation)
43
Dichotic listening task
**involuntary listening**: *where is attention? but can recognize name* * cocktail party afffect
44
Bottleneck
not processing all inputs to gain access/pass attention to go into Short tem, Working or Long term
45
Limited Property
**concept of info processed = finite, processing capacity **; *need for system to select higher prior information for access to stage analysis*
46
Early attention capacity
**gating mechanism determines limited information passed for high level analysis** * E: stimulus selects further analysis (found irrelevant before perception analysis of stimulus complete (**top down**)
47
Early vs Late Models
Early: **sensory gating mechanism**: *select stimulus make to perceptively process* (**Top**) Late: **everything is encoded**, *perception process before selection* (**Bottom**)
48
# E Valid versus **Invalid** cues of attention
*2AFC task, measure reaction time* (right/wrong) **Valid**: meets expectations (can you attend to correct location faster?), behaviorally, nothing wrong, cue affects prep response. * *reaction time = behavioral, not reflecx, spec stages process (EEG)*
49
Endogenous vs Exogenous
**Endo**: control of attention by internal stimulus under voluntary control (*spatial para*) **Exo:**: (*reflex*) by external, not internal voluntary control (*startled, reacting*)
50
Voluntary Spatial Attention
**stimulus disp revelant physiological effect of sustained, spatial selective attention** *attention facility* = enhanced neural response at attended location (*enhanced if not at right place*) * noisy EEG = do average to get rid of noise, with control in mind, focus on left side of space, right hem increases BOLD signa*
51
Role of thalamic reticular nucleus (TRN) and **perigeniculate nucleus**
**TRN:** part of right nucleus (RN) surrounds leftgeniculate nucleus inputs from cortex, subcortex structure sends project to thalamic relay nucleus * mechanism for selective visual field location for current spot of attention (*need to react to threats*)
52
inhibition and return
**reflexive cuing task**: event related potential (ERP), enhanced on P1 (distraction to correct location) * distraction not relevant to attention after 300ms * slow motor response between distractor to target (reflex) * inhibitory recent attended location, after inhibited return to object * people response's are slow to stim. auto "spotloght"
53
Visual Search
**feature targets: early spatial attnetion freely moves**: *spotlight moving * **behavior**: precue attention to visual feature improved performance * **attention**: selection in mid-specialization cortex areas, alters perception processes of inputs before complete feture regions,* perception visuospatial atttention when location of targetn is not known before hand * **conjunction**: too many features to identify
54
**Theory of Attention**
* separate from other mechanisms of attention * network of areas * areas involved with attention have specific, assigned and different functions
55
Role of pulvinar thalamus
*large region of posterior thalamus* **many nuclei interconnectors of specific cortex regions** * chemical deactivator (neurotoxin) of pulv shows loss of covert spatial attention and stimulus filter (selection) - withdrawl attention from non-goal driven things * reveals rde covert attention, attent filter
56
Effector:
**part of body that can move** (every = opposite pairs muscles)
57
Biceps vs Triceps
**Anatagonist pair, regular arm position** *excitatory signal to flex (agonist) inhibs the antag via interneurons* **Bicep**: flex above elbow **Triceps**: bicep relaxed, extends forearm, descending commands
58
Alpha motor
inneverate skeletal muslce and cause contractions that create movement (bulk of a muscle) (**aka lower motor neurons**)
59
Muscle Spindles and Stretch Reflex
When muscles lengthen, spindles are stretched. Activates spindle and sends impulse to spinal cord. Activates motor neurons at spine that send impulse back to muscle.
60
Spinal Interneurons
project to other cells within the spinal cord. * modulate: motor, sensory, autonomic functions * composed of: **spinal interneurons, projection neurons (outside spine)** * propriospinal neurons, ascending and descending projections (same side = ipsilateral, different = contra)
61
Pyrimidal Path/corticospinal
tract: originates from cerebral cortex, divides into spinal tract and bulbar tract. Each carry efferent signals to spine or brain. Corticospinal sends signals to spine, controls move in limbs and trunk. * OG from primary motor cortex, P1, premotor cortex * receives fibers from somatosenosry, cingulate, parietal
62
Ataxia vs Apraxia
**Tax**: uncoordinated movements and balace, originally from weakness. From damage to cerebellum. Can't carry out proper movement - clumsy **Prax:**: inability to carry out purposeful movement from coord and muscle power. Can't make certain movements. Difficult to control.
63
Cerebellum
a large, highly convoluted (infolded) structure located dorsal to the brainstem at the level of the pons; maintains interconnectivity with other cortical areas, subcortical structures, and the cerebellum and spinal cortex
64
Supplementary motor area (SMA)
* Initiation of voluntary actions involves a **basal ganglia loop** that originate and terminate * facilitated by dopamine, which lowers the threshold for movement initiation (**self-initiated actions**) * determine whether an intention to act is translated into an actual movement * **reduced DA = akinesia **
65
intention vs resting tremor
66
Basal Ganglia = gatekeeper
The basal ganglia are a grouping of interconnected subcortical nuclei that mitigate and control functions ranging from voluntary movement, cognitive planning, emotions and reward functions, and even cognition and learning
67
Center Out law
68
Substantia Nigra
* midbrain dopaminergic nucleus which has a critical role in **modulating motor movement** and **reward functions** as part of the basal ganglia circuitry * to the putamen, called the nigrostriatal pathway, are critically involved in the motor deficits observed in Parkinson disease * forming synapses on multiple neuronal populations throughout the basal ganglia, but especially in the **putamen** * primary input into the ** basal ganglia circuitry ** and a critical element to these functions * **damage** = Parkinson disease, Huntington disease, Tourette syndrome, schizophrenia, attention-deficit hyperactivity disorder, and obsessive-compulsive disorder
69
Hemiplegia
* one-sided paralysis * **brain or spinal cord** injuries * a neurological condition characterized by the loss of voluntary movements on one side of the body; typically results from damage to the corticospinal tract, eithe rfrom lesions to the motor cortex or from white matter lesions that destroy the descending fibers
70
**Endpoint control**
a hypothesis concerning how movements are planned in terms of the desired final location; emphasize that the motor representation is based on the final position required of the limbs to achieve the movement goal
71
Central Pattern Generator
a neural network limited to the spinal cord that produces patterned motor outputs without descending commands from the cerebral cortex or sensory feedback
72
**Preferred Direction**
a property of cells in the motor pathway, referring to the direction of movement that results in the highest firing rate of the neuron; voxels have also been shown to have preferred directions in fMRI studies, indicating that such preferences can even be measured at the cell population level of analysis
73
**Population Vectors**
a statistical procedure to represent the activity across a group of neurons; reflect the aggregate activity across cells, providing a better correlation with the behavior than that obtained from the analysis of individual neurons
74
**Affordance Competition Hypothesis**
75
**Alien Hand Syndrome**
76
**Brain-Machine Interface**
a device that uses the interpretation of neuronal signals to perform desired operations with a mechanical device outside the body; for instance, signals recorded from neurons or EEG can be used to move a prosthetic arm
77
**Huntington's Disease vs Parkinson's**
H: a genetic degenerative disorder in which the primary pathology, at least in the early stages of the disease, is observed in the striatum (caudate and putamen) of the basal ganglia; prominent symptoms include clumsiness ad involuntary movements of the head and trunk; cognitive impairments are also seen and become pronounced over time P: a degenerative disorder of the basal ganglia in which the pathology results from the loss of dopaminergic cells in the substantia nigra; primary symptoms include difficulty in initiating movement, slowness of movement, poorly articulated speech, and, in some cases, resting tremor
78
**Hypokinesia and Bradykinesia**
H: a movement disorder characterized by the absence or reduction in the production of movement; prominent symptom of Parkinson's disease B: slowness in the initiation and execution of movements; prominent symptom in Parkinson's disease
79
**Mirror Neurons and their role**
neurons that show similar responses when an animal is performing an action or observing that action produced by another organism; hypothesized to provide a strong link between perception and action, perhaps providing an important basis for the development of conceptual knowledge
80
**Sensorimotor Adaptation**
a form of motor learning in which a learned skill is modified due to some change in the environment or agent **learning**: term that refers to the acquisition of a new motor skill or capability; motor learning can arise from maturation processes or intense, dedicated practicing
81
**Visuomotor Adaptation**
a form of sensorimotor adaption in which the visual feedback is altered, resulting in a mismatch between proprioception and vision; with practice, the motor system adjusts to compensate for the mismatch
82
**Forward Models**
a theoretical construct referring to the idea that the brain generates predictions of expected events; in motor control, the prediction of the expected sensory consequences of a movement
83
**Feature Integration, What is It?**
84
**Object Attention** What is it, Evidence?
85
**Role of Frontal Eye Field and Superior Colliculus**
86
**Biased Competition Model and Evidence**
87
ideational Apraxia
a severe form of apraxia in which the patient's knowledge about the intent of an action is impaired; for example, the patient may no longer comprehend the appropraite use for a tool, even though still capable of producing the required action
88
ideomotor apraxia
a form of apraxia in which the patient has difficulty executing the desired action properly; patients appear to have a general idea about how the action should be performed and how tools are uesd, but they are unable to coordinate the movements to produce the action in a coherent manner