Exam 1 drugs

Question 1

5 Fluorouracil: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 1

Drug class & target - antimetabolite, pyrimidine analog (uracil analog), interferes with pyrimidine nucleotide synthesis, also interfere with DNA/RNA function/replication

Phase of cell cycle - S

Dose limiting side effects -

Important drug interactions - Thymidine (negates effects), Leucovorate (increases effects)

Unique resistance mechanisms - downregulation of activating enzymes that convert 5-FU -> fd-UMP, upregulation of thymidylate synthase

Genetic or epigenetic testing - PDP enzyme breaks down 5-FU, ~5% of population may be deficient (increases toxicity)

Question 2

Cytarabine (Ara-C): Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 2

Drug class & target - antimetabolite, pyrimidine analog (cytosine), inhibits DNA polymerase, also interfere with DNA/RNA function/replication

Phase of cell cycle - S

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms - Downregulation of activating enzymes, upregulation of cytidine deaminase, downregulation of transporter to move drug into cells

Genetic or epigenetic testing -

Question 3

6-Mercaptopurine (6-MP): Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 3

Drug class & target - antimetabolite, purine analog, inhibits multiple enzymes to block synthesis of purine nucleotides

Phase of cell cycle - S

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms - TMPT inactivates 6-MP, ~10% children LOF (increases toxicity)

Genetic or epigenetic testing -

Question 4

Methotrexate: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 4

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 5

Chlorambucil: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 5

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 6

Cyclophosphamide: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 6

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 7

Mitomycin C: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 7

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 8

Cisplatin: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 8

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 9

Irinotecan: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 9

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 10

Doxorubicin: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 10

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 11

Etoposide: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 11

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 12

Bleomycin: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 12

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 13

Vincristine: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 13

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 14

Paclitaxel: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 14

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 15

Erubulin: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 15

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 16

Abiraterone: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 16

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 17

Tamoxifen: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 17

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 18

Fulvestrant: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 18

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 19

Prednisolone: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 19

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 20

Letrozole: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 20

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 21

Exemestane: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 21

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 22

Leuprolide: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 22

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 23

Imatinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 23

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 24

Ponatinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 24

Drug class & target -

Phase of cell cycle -

Dose limiting side effects -

Important drug interactions -

Unique resistance mechanisms -

Genetic or epigenetic testing -

Question 25

Midostaurin: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 25

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 26

Quizartinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 26

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 27

Crenolanib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 27

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 28

Sirolimus: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 28

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 29

Alectinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 29

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 30

Dabrafenib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 30

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 31

Trametinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 31

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 32

Vemurafenib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 32

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 33

Acalabrutinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 33

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 34

Gefitinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 34

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 35

Lapatinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 35

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 36

Afatinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 36

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 37

Tucatinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 37

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 38

Osimertinib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 38

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 39

Pembrolizumab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 39

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 40

Atezolizumab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 40

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 41

Ipilimumab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 41

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 42

Trastuzumab, Pertuzimab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 42

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 43

Cetuximab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 43

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 44

Bevacizumab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 44

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 45

Ramucirumab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 45

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 46

Rituximab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 46

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 47

Daratumumab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 47

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 48

Trastuzumab emtansine: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 48

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 49

Trastuzumab deruxtecan: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 49

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 50

Blinatumomab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 50

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 51

Mosunetuzumab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 51

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 52

Teclistamab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 52

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 53

Taquetamab: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 53

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 54

Sipuleucel-T: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 54

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 55

CAR-T: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 55

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 56

Olabarip: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 56

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 57

Palbociclib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 57

Drug class & target - CDK4/5 kinase inhibitor Phase of cell cycle - checkpoint inhibitor in G1 phase Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 58

Bortemzomib: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 58

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 59

5-azacytosine: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 59

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 60

Venetoclax: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 60

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -

Question 61

Pomalidomide: Drug class, target, phase of cell cycle, dose limiting side effects, important drug interactions, unique resistance mechanisms, genetic or epigenetic testing

Answer 61

Drug class & target - Phase of cell cycle - Dose limiting side effects - Important drug interactions - Unique resistance mechanisms - Genetic or epigenetic testing -